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The Cellular Secretome And Organ Crosstalk

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The Cellular Secretome and Organ Crosstalk

The Cellular Secretome and Organ Crosstalk Book
Author : Juergen Eckel
Publisher : Academic Press
Release : 2018-06-12
ISBN : 0128097191
Language : En, Es, Fr & De

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Book Description :

The Cellular Secretome and Organ Crosstalk focuses on the release of peptides and proteins from different organs and their specific functions in metabolic regulation and cell- and organ crosstalk. The book is written for experts in the field, however, for each topic, helpful references are included. The book also includes technical sections that summarize the state-of-the-art of secretome and crosstalk analysis. This book fulfills the need for a resource that comprehensively describes the current knowledge of secretome biology in health and disease. Communication between different organs involves lipids and other small molecules and a host of proteins and peptides comprising the secretome of different organs (organokinome). More than 600 adipokines have been identified, and an increasing number of hepatokines and myokines have recently been discovered with mostly unknown physiological impact. Importantly, an aberrant signature of the organokinome may be critically underlying a variety of metabolic diseases and may determine the individual susceptibility to disease development. Summarizes our current knowledge on the secretome of different cells and tissues Dissects auto-, para- and endocrine functions of major secreted peptides and proteins Analyzes the secretory malfunction of different cells and its impact for disease development Authored by a leader in the field, presenting a coherent view on this very complex topic

Scientific Principles of Adipose Stem Cells

Scientific Principles of Adipose Stem Cells Book
Author : Lauren Kokai,Kacey Marra,J. Peter Rubin
Publisher : Academic Press
Release : 2021-09-01
ISBN : 0128193778
Language : En, Es, Fr & De

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Book Description :

Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine. Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included. The book is written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and those seeking advanced information on adipose stem cells. Coverage of basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell niche Includes important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotype An entire section dedicated to ASC biology, additional sections will be devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications

The Role of the Muscle Secretome in Health and Disease

The Role of the Muscle Secretome in Health and Disease Book
Author : Céline Aguer,Emanuele Loro,Domenico Di Raimondo
Publisher : Frontiers Media SA
Release : 2020-11-19
ISBN : 288966130X
Language : En, Es, Fr & De

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Book Description :

Download The Role of the Muscle Secretome in Health and Disease book written by Céline Aguer,Emanuele Loro,Domenico Di Raimondo, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Current Challenges for Targeting Brown Fat Thermogenesis to Combat Obesity

Current Challenges for Targeting Brown Fat Thermogenesis to Combat Obesity Book
Author : Takeshi Yoneshiro,Matthias Johannes Betz,Patrick C. N. Rensen,Rosalia Rodriguez-Rodriguez
Publisher : Frontiers Media SA
Release : 2020-12-28
ISBN : 2889662829
Language : En, Es, Fr & De

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Book Description :

Download Current Challenges for Targeting Brown Fat Thermogenesis to Combat Obesity book written by Takeshi Yoneshiro,Matthias Johannes Betz,Patrick C. N. Rensen,Rosalia Rodriguez-Rodriguez, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A New Component of Skeletal Muscle Secretome Impact on Beta Cells and Prevent TNF a and Cytomix Effect on Beta cells

A New Component of Skeletal Muscle Secretome Impact on Beta Cells and Prevent TNF a and Cytomix Effect on Beta cells Book
Author : Bouzakri Karim
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A new positive component of skeletal muscle secretome impact on beta cells and prevent TNF-alpha and cytomix effect on beta cells.Karim Bouzakri, Julien Cherfan, Harzo Hamdard, Carole Mura, Claude Peronet, and Michel Pinget.UMR DIATHEC, EA 7294, Centre Europu00e9en du2019Etude du Diabu00e8te, Universitu00e9 de Strasbourg (UdS), Boulevard Renu00e9 Leriche 67200 Strasbourg, FranceBackground and aims: Inter-organ crosstalk including possible communication between skeletal muscle and beta cells is an important component of normal physiology that may contribute towards the pathophysiology of type 2 diabetes. Indeed, skeletal muscle cells secrete different sets of soluble proteins (myokines) which could act positively or negatively (in health and disease respectively) on the function of distant tissues including pancreatic islets. We have observed that conditioned medium from skeletal muscle of healthy individuals has positive effects on beta cell function. A new myokine, was identified as a cytokine regulated by muscle fiber type. The major aim of this study was to explore the impact of our new myokine (Myo X) on primary sorted beta cells under control conditions and after exposure to TNF-u03b1 or insulin resistance condition medium from skeletal muscle cells.Materials and methods: All studies were performed using sorted rat primary beta cells and human islets exposed to Myo X for 24h. Glucose-stimulated insulin secretion (GSIS) and glucagon secretion was measured by radioimmunoassay and ELISA after 1h at 2.8 mmol/l and/or 1h at 16.7mmol/l glucose. Cell death and proliferation were measured by TUNEL assay and BrdU incorporation respectively. To study the potential beneficial/protective effects of our myokine, beta cells were exposed to it for 24h alone or with addition 20 ng/ml TNF-u03b1 alone or insulin resistance condition medium from skeletal muscle cells. Data are mean u00b1 SE for 5-8 independent experiments.Results: Myo X treatment of rat primary beta cells and human islets for 24h increased GSIS (control: 12.4 u00b1 3.2% content/h; 1u00b5g/ml Myo X: 15.08 u00b1 3.8%*; 10 u00b5g/ml Myo X: 14.1 u00b1 1.8%*; *p

Organ Fibrosis Pathogenesis Biomarkers and Therapeutic Targets

Organ Fibrosis  Pathogenesis  Biomarkers and Therapeutic Targets Book
Author : Henricus A. M. (Rick) Mutsaers,Rikke Norregaard,Peter Olinga
Publisher : Frontiers Media SA
Release : 2022-01-05
ISBN : 2889719499
Language : En, Es, Fr & De

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Book Description :

Download Organ Fibrosis Pathogenesis Biomarkers and Therapeutic Targets book written by Henricus A. M. (Rick) Mutsaers,Rikke Norregaard,Peter Olinga, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pericyte Biology in Different Organs

Pericyte Biology in Different Organs Book
Author : Alexander Birbrair
Publisher : Springer
Release : 2019-04-01
ISBN : 3030110931
Language : En, Es, Fr & De

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Book Description :

The present book is an attempt to describe the most recent developments in the area of pericyte biology which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of thirteen detailed chapters on what we know so far about pericytes in distinct organs in physiological and pathological conditions. Further, it provides an update on the most novel functions attributed to these cells and will introduce a newer generation of researchers and scientists to the importance of these cells, ranging from their discovery in different organs through current state-of-the-science. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and vascular research. This volume explores pericytes' physiologic roles in different tissues, ranging from the pancreas, lungs and liver through skeletal muscle, gut, retina and more. Together with its companion volumes Pericyte Biology in Disease and Pericyte Biology – Novel Concepts, Pericyte Biology in Different Organs presents a comprehensive update on the latest information and most novel functions attributed to pericytes. To those researchers newer to this area, it will be useful to have the background information on these cells' unique history. It will be invaluable for both advanced cell biology students as well as researchers in cell biology, stem cells and researchers or clinicians involved with specific organs.

Crosstalk between the osteogenic and neurogenic stem cell niches how far are they from each other

Crosstalk between the osteogenic and neurogenic stem cell niches  how far are they from each other  Book
Author : Wanda Lattanzi,Maria Concetta Geloso
Publisher : Frontiers Media SA
Release : 2016-03-14
ISBN : 2889197778
Language : En, Es, Fr & De

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Book Description :

Somatic stem cells reside in definite compartments, known as "niches", within developed organs and tissues, being able to renew themselves, differentiate and ensure tissue maintenance and repair. In contrast with the original dogmatic distinction between renewing and non-renewing tissues, somatic stem cells have been found in almost every human organism, including brain and heart. (HSCs) and mesenchymal stem cells (MSCs), that intensely interacts. HSCs represent the common precursors of all mature blood cells. (Bone, cartilage, blood vessels, adipose tissue, and.), And in the case of the skeletal muscle Supporting connective stroma). Despite this high plasticity, the claim that MSCs could be capable of transdifferentiation along non-mesodermal linesages, including neurons, has been strongly argued. Adult osteogenic and neurogenic niches display wide differences: embryo origin, microenvironment, progenitors' lifespan, lineages of supporting cells. Although similar pathways may be involved, it is hard to believe that the osteogenic and neurogenic lineages can share functional features. The outbreak of the disease is the most important cause of neurodegeneration and neurological disorders, including the development of neurological disorders. Based on this research, the research group is interested in the development of new technologies, and in the field of research and development. The results of the study are summarized in the following sections: In vivo transplantation, has been covered.

Novel Therapies for Combating Bone Diseases through Advances in Bone Remodeling

Novel Therapies for Combating Bone Diseases through Advances in Bone Remodeling Book
Author : Chao Liang,Jiake Xu,Changjun Li
Publisher : Frontiers Media SA
Release : 2022-01-17
ISBN : 2889718271
Language : En, Es, Fr & De

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Book Description :

Download Novel Therapies for Combating Bone Diseases through Advances in Bone Remodeling book written by Chao Liang,Jiake Xu,Changjun Li, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Biology and Therapeutic Application of Mesenchymal Cells Set

The Biology and Therapeutic Application of Mesenchymal Cells   Set Book
Author : Kerry Atkinson
Publisher : John Wiley & Sons
Release : 2017-01-17
ISBN : 1118907515
Language : En, Es, Fr & De

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Book Description :

The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. • Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications • Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models • Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues • Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine. About the Author Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.

Macrophages in Liver Disease

Macrophages in Liver Disease Book
Author : Ruchi Bansal,Pranoti Mandrekar,Sujit K. Mohanty,Ralf Weiskirchen
Publisher : Frontiers Media SA
Release : 2020-10-08
ISBN : 2889660389
Language : En, Es, Fr & De

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Book Description :

Download Macrophages in Liver Disease book written by Ruchi Bansal,Pranoti Mandrekar,Sujit K. Mohanty,Ralf Weiskirchen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chronic Renal Disease

Chronic Renal Disease Book
Author : Paul L. Kimmel,Mark E. Rosenberg
Publisher : Academic Press
Release : 2019-08-28
ISBN : 0128158778
Language : En, Es, Fr & De

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Book Description :

Chronic Renal Disease, Second Edition, comprehensively investigates the physiology, pathophysiology, treatment and management of chronic kidney disease (CKD). This translational reference takes an in-depth look at CKD with no coverage of dialysis or transplantation. Chapters are devoted to the scientific investigation of chronic kidney disease, the most common problems faced by nephrologists in the management of chronic kidney disease, specific illnesses in the CKD framework, and how the management of CKD in a polycystic kidney disease patient differs from other CKD patients. This award-winning reference features a series of case studies, covering both clinical aspects and pathophysiology. Questions are open ended, progressively more difficult, and repetitive across different patient clinical problems and different chapters. The cases and questions included will be useful for medical students, residency board reviews, and clinician teaching or conference preparation. Includes case studies and questions which can be used as a teaching tool for medical students and resident Provides coverage of classification and measurement, epidemiology, pathophysiology, complications of CKD, fluid/electrolyte disorders in CKD, CKD and systemic illnesses, clinical considerations, therapeutic considerations, and special considerations

Mesenchymal Stromal Cells as Tumor Stromal Modulators

Mesenchymal Stromal Cells as Tumor Stromal Modulators Book
Author : Marcela Bolontrade,Mariana García
Publisher : Academic Press
Release : 2016-10-24
ISBN : 0128031034
Language : En, Es, Fr & De

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Book Description :

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

Skeletal Muscle Immunometabolism

Skeletal Muscle Immunometabolism Book
Author : Nicolas J. Pillon,Miguel Luiz Batista Júnior,Arthur J. Cheng,Lykke Sylow,Capucine Trollet
Publisher : Frontiers Media SA
Release : 2021-06-29
ISBN : 2889669211
Language : En, Es, Fr & De

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Book Description :

Download Skeletal Muscle Immunometabolism book written by Nicolas J. Pillon,Miguel Luiz Batista Júnior,Arthur J. Cheng,Lykke Sylow,Capucine Trollet, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Model organisms in inflammation and cancer

Model organisms in inflammation and cancer Book
Author : Yiorgos Apidianakis,Dominique Ferrandon
Publisher : Frontiers E-books
Release : 2014-12-17
ISBN : 2889193705
Language : En, Es, Fr & De

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Book Description :

A link between inflammation and cancer was initially made by Rudolf Virchow back in the 19th century. Nowadays many cancers are considered dependent on inflammatory responses to microbial and damaged-self stimuli and both arms of immunity, innate and adaptive, are playing a role in promoting cancer. Moreover, besides environmental factors, opportunistic pathogens contribute to inflammation and cancer. Nevertheless, microbial influence on chronic disease is sometimes difficult to discern, especially in the context of polymicrobial communities, such as those found in the digestive tract. In this light, model organisms provide important insights into immune and growth signals that promote cancer, and suggest therapies that will selectively target potentially harmful microbes or modulate host responses. A number of review and opinion articles in this series address novel aspects and paradigms of the interactions between the microbiota and the host in relation to inflammation and cancer.

Multicellularity in the Cardiovascular System

Multicellularity in the Cardiovascular System Book
Author : Paolo Madeddu,Gabor Foldes
Publisher : Frontiers Media SA
Release : 2019-03-25
ISBN : 2889457923
Language : En, Es, Fr & De

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Book Description :

Download Multicellularity in the Cardiovascular System book written by Paolo Madeddu,Gabor Foldes, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cancer Models

Cancer Models Book
Author : Michael Breitenbach,Jens Hoffmann
Publisher : Frontiers Media SA
Release : 2019-02-05
ISBN : 288945701X
Language : En, Es, Fr & De

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Book Description :

Cancer research, like research on other diseases, highly depends on representative and reliable model systems. In the Research Topic “Cancer Models”, we collected original papers and review articles addressing the topic of tumor modeling from molecular biology, biochemistry, microorganisms, cells and organoids, fishes, animals and xenografts, up to computational cancer models and patient data analysis. This representative eBook describes that there is not a single molecular defined tumor but rather a heterogenic and highly variable complex of different individual diseases. This is what makes research on cancer so difficult, expensive, and explains the broad number of models needed for research. Our authors describe new next-generation sequencing-based methods to analyze complex patterns of chromosomal aberrations in order to understand the molecular biology of tumorigenesis as well as the role of cellular senescence and dormancy in the aetiology of tumor formation and development of therapy resistance of tumors. The current developments on 3D cultures are thoroughly reviewed, as these models help to overcome the current limitations of cell cultures and allow a more accurate mimicry of the native cancer tissue, including cellular heterogeneity and restore specific biochemical and morphological. Reviews about tumor models in zebrafish, different transgenic mouse strains and pigs conclude the book. In the final two chapters of this volume, the authors discuss the theoretical and mathematical models developed in cancer research.

Ex Vivo Engineering of the Tumor Microenvironment

Ex Vivo Engineering of the Tumor Microenvironment Book
Author : Amir R. Aref,David Barbie
Publisher : Springer
Release : 2016-12-09
ISBN : 3319453971
Language : En, Es, Fr & De

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Book Description :

This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo. Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time.

Safety Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies

Safety  Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies Book
Author : Guido Moll,Martin Johannes Hoogduijn,James A. Ankrum
Publisher : Frontiers Media SA
Release : 2020-07-24
ISBN : 2889636003
Language : En, Es, Fr & De

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Book Description :

Download Safety Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies book written by Guido Moll,Martin Johannes Hoogduijn,James A. Ankrum, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Principles of Regenerative Medicine

Principles of Regenerative Medicine Book
Author : Anthony Atala,Robert Lanza,Tony Mikos,Robert Nerem
Publisher : Academic Press
Release : 2018-08-09
ISBN : 0128098937
Language : En, Es, Fr & De

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Book Description :

Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies. Comprehensively covers the interdisciplinary field of regenerative medicine with contributions from leaders in tissue engineering, cell and developmental biology, biomaterials sciences, nanotechnology, physics, chemistry, bioengineering and surgery Includes new chapters devoted to iPS cells and other alternative sources for generating stem cells as written by the scientists who made the breakthroughs Edited by a world-renowned team to present a complete story of the development and promise of regenerative medicine