Skip to main content

Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments

Download Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments Full eBooks in PDF, EPUB, and kindle. Targeting Neuroinflammation In Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets And Neuropharmaceutical Developments is one my favorite book and give us some inspiration, very enjoy to read. you could read this book anywhere anytime directly from your device.

Targeting Neuroinflammation in Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets and Neuropharmaceutical Developments

Targeting Neuroinflammation in Central Nervous System Disorders  Uncovering Mechanisms  Pharmacological Targets  and Neuropharmaceutical Developments Book
Author : Mariela Fernanda Perez,Claudia Bregonzio,Maria Graciela Castro,Flavia Eugenia Saravia
Publisher : Frontiers Media SA
Release : 2022-01-20
ISBN : 2889741079
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

Download Targeting Neuroinflammation in Central Nervous System Disorders Uncovering Mechanisms Pharmacological Targets and Neuropharmaceutical Developments book written by Mariela Fernanda Perez,Claudia Bregonzio,Maria Graciela Castro,Flavia Eugenia Saravia, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Alzheimer s Disease Drug Development

Alzheimer s Disease Drug Development Book
Author : Jeffrey L. Cummings,Jefferson W. Kinney,Howard Fillit
Publisher : Unknown
Release : 2021
ISBN : 9781108975759
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

"Alzheimer's Disease Drug Development: A Research and Development Ecosystem captures the complexity of Alzheimer's disease (AD) drug develop and provides a comprehensive set of perspectives from the many stakeholders involved in discovering and developing new therapies for AD. There is no greater unmet therapeutic need for humanity than effective therapies for brain disorders. The suffering caused by these conditions and other neurodegenerative disorders is overwhelming and is burdened with substantial stigma. Therefore, I have devoted my professional life to changing the way brain disorders such as schizophrenia, depression, AD, among others are not only treated, but also viewed by society. From my time with the National Institutes of Health, Janssen and Johnson & Johnson where I serve as the Global Head of Science for Minds, my colleagues and I recognize there is still much to uncover about brain disorders due to the rich complexity of the brain and the challenges in accessing it. But that is not a reason to stop - especially as we enter the golden age of neuroscience, driven largely by scientific breakthroughs and accelerated regulatory pathways"--

Inflammation and Epilepsy New Vistas

Inflammation and Epilepsy  New Vistas Book
Author : Damir Janigro,Astrid Nehlig,Nicola Marchi
Publisher : Springer Nature
Release : 2021-05-18
ISBN : 3030674037
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

This book provides comprehensive information, both for clinicians and scientists, on the basic mechanisms, clinical features, and therapeutic approaches to epilepsy as an inflammatory disease. Inflammation has been for many years considered as an etiologic player (and a therapeutic target) for a specific group of epilepsies. However, it turns out that this concept underestimated the impact of inflammation in seizure disorders. Many accepted therapies for non-inflammatory epilepsies act in part as an inflammatory drug. The CNS actively responds to acute immune challenges by altering body temperature, stimulating the HPA axis, as well as up- and down-regulating specific sympathetic pathways.

Mechanisms of Neuroinflammation

Mechanisms of Neuroinflammation Book
Author : Gonzalo Emiliano Aranda Abreu
Publisher : BoD – Books on Demand
Release : 2017-08-23
ISBN : 9535134515
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

"Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Neuroglia in Neurodegenerative Diseases

Neuroglia in Neurodegenerative Diseases Book
Author : Alexei Verkhratsky,Margaret S. Ho,Robert Zorec,Vladimir Parpura
Publisher : Springer Nature
Release : 2019-10-03
ISBN : 9811399131
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.

Neuroinflammation and Neurodegeneration

Neuroinflammation and Neurodegeneration Book
Author : Phillip K. Peterson,Michal Toborek
Publisher : Springer
Release : 2014-07-08
ISBN : 149391071X
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

State of the art reviews by experts in the fields of neuroscience, immunology, microbiology/infectious diseases and pharmacology addressing the convergence of the immune system (neuroinflammation) and the loss of neurons (neurodegeneration). Many of the diseases that are discussed in the book are of epidemic proportion, e.g., Alzheimer’s disease, Parkinson’s disease, stroke, viral encephalitides and substance abuse. In addition to discussions of the involvement of neuroinflammation and neurodegeneration in these disorders, scientific reviews are presented on the cells and mediators that participate in defense of and damage to the nervous system. With rare exception, no or inadequate treatment exists for the diseases discussed in this book. An underlying premise of the book is that understanding of their shared pathogenic mechanisms will lead to improved therapies. Given the rapid evolution of the field of Neuroimmune Pharmacology, readers will find this book to be the most timely and authoritative reference on the subject of each of its chapters.

Update on Dementia

Update on Dementia Book
Author : Davide Moretti
Publisher : BoD – Books on Demand
Release : 2016-09-28
ISBN : 9535126547
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.

Neuroprotection

Neuroprotection Book
Author : Matilde Otero-Losada,Francisco Capani,Santiago Perez Lloret
Publisher : BoD – Books on Demand
Release : 2020-11-26
ISBN : 1838804390
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.

Development and Engineering of Dopamine Neurons

Development and Engineering of Dopamine Neurons Book
Author : Jeroen Pasterkamp,Marten P. Smidt,J. Peter H. Burbach
Publisher : Springer Science & Business Media
Release : 2009-12-16
ISBN : 1441903224
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.

Molecular Mechanisms of Neurodegenerative Diseases

Molecular Mechanisms of Neurodegenerative Diseases Book
Author : Marie-Francoise Chesselet
Publisher : Springer Science & Business Media
Release : 2000-10-19
ISBN : 1592590063
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

Blood Brain Barrier in Drug Discovery

Blood Brain Barrier in Drug Discovery Book
Author : Li Di,Edward H. Kerns
Publisher : John Wiley & Sons
Release : 2015-02-02
ISBN : 1118788354
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

Nutrition and Immunity

Nutrition and Immunity Book
Author : Maryam Mahmoudi,Nima Rezaei
Publisher : Springer
Release : 2019-07-30
ISBN : 3030160734
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

This volume provides readers with a systematic assessment of current literature on the link between nutrition and immunity. Chapters cover immunonutrition topics such as child development, cancer, aging, allergic asthma, food intolerance, obesity, and chronic critical illness. It also presents a thorough review of microflora of the gut and the essential role it plays in regulating the balance between immune tolerance and inflammation. Written by experts in the field, Nutrition and Immunity helps readers to further understand the importance of healthy dietary patterns in relation to providing immunity against disorders and offering readily available immunonutritional programming in clinical care. It will be a valuable resource for dietitians, immunologists, endocrinologists and other healthcare professionals.

Cerebrovascular and Neurodegenerative Diseases New Insights into Molecular Cell Biology and Therapeutic Targets

Cerebrovascular and Neurodegenerative Diseases     New Insights into Molecular Cell Biology and Therapeutic Targets Book
Author : Sikha Saha,Sriharsha Kantamneni
Publisher : Frontiers Media SA
Release : 2020-01-30
ISBN : 2889634426
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

Download Cerebrovascular and Neurodegenerative Diseases New Insights into Molecular Cell Biology and Therapeutic Targets book written by Sikha Saha,Sriharsha Kantamneni, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Blood Cerebrospinal Fluid Barrier

The Blood Cerebrospinal Fluid Barrier Book
Author : Wei Zheng,Adam Chodobski
Publisher : CRC Press
Release : 2005-03-30
ISBN : 9781420023404
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

Despite the existence of two barrier systems in the brain, research over the last century has mostly focused on the blood-brain barrier rather than on the blood-CSF barrier. Today, there is a greater understanding of the function of the blood-CSF barrier and of the choroid plexus, a tissue that is the primary site of this barrier. With the growing number of studies that focus on the role of the blood-CSF barrier in CNS homeostasis and neurological disorders, a modern overview of the blood-CSF barrier is long overdue. The Blood-Cerebrospinal Fluid Barrier is exclusively devoted to the blood-CSF barrier. Internationally renowned experts discuss the most recent progress in the field of choroid plexus physiology and update our knowledge of the function of the blood-CSF barrier. The book begins with an overview of the development and morphology of the choroid plexus, and then covers various aspects of its function, such as the regulation of choroidal blood flow, ion transport, and the production and transport of polypeptides. Following an extensive section on the role of the choroid plexus in CNS disorders, the final section discusses in vitro, in vivo, and in situ models of the blood-CSF barrier. This unique book analyzes a wealth of new research on the proven and potential roles of the choroid plexus/blood-CSF barrier in the brain. It is a valuable resource that will foster future studies in neuroscience, pharmacology, and toxicology.

Pruritus An Issue of Dermatologic Clinics E Book

Pruritus  An Issue of Dermatologic Clinics  E Book Book
Author : Gil Yosipovitch
Publisher : Elsevier Health Sciences
Release : 2018-06-23
ISBN : 0323610811
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

This issue of Dermatologic Clinics, guest edited by Dr. Gil Yosipovitch, is devoted to Pruritus (Itch). Articles in this issue include: Pathophysiology of Chronic Itch; Work-up of Chronic Itchy Patient; Management of Prurigo Nodularis; Chronic Pruritus in the Geriatric Population; Diagnosis and Management of Neuropathic Itch; Female Genital Itch; End Stage Renal Disease Chronic Itch and its Management; Management of Chronic Hepatic Itch; Pruritus in Scabies; Pruritus Associated with Targeted Cancer Therapies and Their Management; Pruritus in Lymphoma and its Management; Pruritus in Pregnancy and its Management; Pruritus in Connective Tissue Disorders; Immunomodulating Agents as Anti Pruritics; Psychogenic Pruritus and its Management; and Drugs on the Horizon for Chronic Itch.

Neurodegeneration in Multiple Sclerosis

Neurodegeneration in Multiple Sclerosis Book
Author : M. Filippi,M. Rovaris,G. Comi
Publisher : Springer Science & Business Media
Release : 2008-02-01
ISBN : 8847003911
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.

Histamine in the brain

Histamine in the brain Book
Author : Jian-Sheng Lin,Pertti Panula,Maria Beatrice Passani
Publisher : Frontiers Media SA
Release : 2015-03-18
ISBN : 2889194345
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.

Advances in Neuropharmacology

Advances in Neuropharmacology Book
Author : Giacinto Bagetta,M. Tiziana Corasaniti,T. Sakurada,S. Sakurada
Publisher : Academic Press
Release : 2009-08-03
ISBN : 9780080953861
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

This volume provides a broad overview of important new advances in the field of Neuropharmacology. In 20 chapters, a selection of international contributors discuss topics including endocannabinoid function, pain, stress, astrocytes etc, and new possibilities for treatments of neurological diseases with neuropharmacological approaches. - Cutting-edge articles in neuropharmacology - Discusses new possibilities for treatments of neurological disorders - Very international authorship providing a global view of the state of research

Biomarkers of Brain Injury and Neurological Disorders

Biomarkers of Brain Injury and Neurological Disorders Book
Author : Kevin K. W. Wang,Zhiqun Zhang,Firas H. Kobeissy
Publisher : CRC Press
Release : 2014-10-28
ISBN : 1482239833
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.

Therapy Approaches in Neurological Disorders

Therapy Approaches in Neurological Disorders Book
Author : Mario Bernardo-Filho,Danúbia Da Cunha De Sá-Caputo,Adérito Seixas,Redha Taiar
Publisher : BoD – Books on Demand
Release : 2021-07-14
ISBN : 1839686685
Language : En, Es, Fr & De

DOWNLOAD

Book Description :

Neurological disorders are conditions affecting the central or peripheral nervous system, with undesirable consequences for the quality of life. This book highlights and discusses several approaches for managing these conditions and improving the functional capacity and quality of life of patients, including whole-body vibration exercise, biofeedback, sagittal plane spine alignment, allopathic and non-allopathic medications, phytotherapy, and more.