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Targeted

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Targeted

Targeted Book
Author : Stephen Hunter
Publisher : Simon and Schuster
Release : 2022-01-18
ISBN : 1982169796
Language : En, Es, Fr & De

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Book Description :

"After being accused of reckless endangerment and forced to answer to the U.S. Congress, master sniper Bob Lee Swagger must protect political hostages in a once-in-a-lifetime standoff"--

Targeted

Targeted Book
Author : Brittany Kaiser
Publisher : HarperCollins
Release : 2019-10-22
ISBN : 0062965808
Language : En, Es, Fr & De

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Book Description :

In this explosive memoir, a political consultant and technology whistleblower reveals the disturbing truth about the multi-billion-dollar data industry, revealing to the public how companies are getting richer using our personal information and exposing how Cambridge Analytica exploited weaknesses in privacy laws to help elect Donald Trump—and how this could easily happen again in the 2020 presidential election. When Brittany Kaiser joined Cambridge Analytica—the UK-based political consulting firm funded by conservative billionaire and Donald Trump patron Robert Mercer—she was an idealistic young professional working on her fourth degree in human rights law and international relations. A veteran of Barack Obama’s 2008 campaign, Kaiser’s goal was to utilize data for humanitarian purposes, most notably to prevent genocide and human rights abuses. But her experience inside Cambridge Analytica opened her eyes to the tremendous risks that this unregulated industry poses to privacy and democracy. Targeted is Kaiser’s eyewitness chronicle of the dramatic and disturbing story of the rise and fall of Cambridge Analytica. She reveals to the public how Facebook’s lax policies and lack of sufficient national laws allowed voters to be manipulated in both Britain and the United States, where personal data was weaponized to spread fake news and racist messaging during the Brexit vote and the 2016 election. But the damage isn’t done Kaiser warns; the 2020 election can be compromised as well if we continue to do nothing. In the aftermath of the U.S. election, as she became aware of the horrifying reality of what Cambridge Analytica had done in support of Donald Trump, Kaiser made the difficult choice to expose the truth. Risking her career, relationships, and personal safety, she told authorities about the data industry’s unethical business practices, eventually testifying before Parliament about the company’s Brexit efforts and helping Special Counsel Robert Mueller’s investigation into Russian interference in the 2016 election, alongside at least 10 other international investigations. Packed with never-before-publicly-told stories and insights, Targeted goes inside the secretive meetings with Trump campaign personnel and details the promises Cambridge Analytica made to win. Throughout, Kaiser makes the case for regulation, arguing that legal oversight of the data industry is not only justifiable but essential to ensuring the long-term safety of our democracy. Targeted includes 20-30 photos.

Creation of Novel Targeted Antimicrobial Peptides

Creation of Novel Targeted Antimicrobial Peptides Book
Author : Randal Hojem Eckert
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Creation of Novel Targeted Antimicrobial Peptides book written by Randal Hojem Eckert, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

An Employment targeted Economic Program for Kenya

An Employment targeted Economic Program for Kenya Book
Author : Robert Pollin,Mwangi wa Gĩthĩnji,Mwangi Wa Githinji,James Heintz
Publisher : Edward Elgar Pub
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Contents: Brief Highlights of Major Proposals Summary of Major Findings and Proposals 1. Introduction 2. Employment Conditions and Living Standards 3. Profile of Non-agricultural Household Enterprises 4. Labor Costs, Labor Market Institutions and Employment Expansion 5. The Rural Sector: Institutional Reform for Development 6. Investing in Roads and Water Infrastructure 7. Monetary Policy, Inflation Control, and Interest Rates 8. Exchange Rate Policy and Foreign Trade 9. Restructuring Kenya's Financial System 10. Fiscal Policy: How to Pay for New Pro-employment Initiatives 11. A Restatement of Goals and Strategies Appendix 1: Earnings Function for Household Enterprises Appendix 2: Supply Shock Inflation Appendix 3: Exchange Rate Overvaluation Model Acronyms Bibliography Index

Cost effectiveness of Targeted Reemployment Bonuses

Cost effectiveness of Targeted Reemployment Bonuses Book
Author : Christopher J. O'Leary
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cost effectiveness of Targeted Reemployment Bonuses book written by Christopher J. O'Leary, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Legitimate Target

Legitimate Target Book
Author : Amos Guiora
Publisher : Oxford University Press
Release : 2013-04-25
ISBN : 0199969736
Language : En, Es, Fr & De

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Book Description :

In Legitimate Target, A Criteria Based Approach to Targeted Killing, Amos Guiora proposes that targeted killing decisions must reflect consideration of four distinct elements: law, policy, morality, and operational details, thus ensuring that it complies with principles of domestic and international laws.

Characterization and Optimization of ATTEMPTS a Targeted Drug Delivery System to Reduce Bleeding Risk During Thrombolytic Therapy

Characterization and Optimization of  ATTEMPTS   a Targeted Drug Delivery System to Reduce Bleeding Risk During Thrombolytic Therapy Book
Author : Sarita Surendra Naik
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Characterization and Optimization of ATTEMPTS a Targeted Drug Delivery System to Reduce Bleeding Risk During Thrombolytic Therapy book written by Sarita Surendra Naik, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Discovery and Utility of Chemical Probes in Target Discovery

The Discovery and Utility of Chemical Probes in Target Discovery Book
Author : Paul Brennan,Saleta Vazquez-Rodriguez
Publisher : Royal Society of Chemistry
Release : 2020-11-25
ISBN : 1788015894
Language : En, Es, Fr & De

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Book Description :

Numerous genetic methods can be utilised to link a phenotype to a single molecular target but annotated small molecule chemical probes and even entire chemogenomic libraries are increasingly being used as a complementary approach. This book will comprehensively cover the state of the art in chemical probes and best practice for use in target discovery, illustrated throughout with examples. Ideal for students and established biochemists, the book will also cover new technologies for probe discovery, new probe modalities, the new field of probes for RNA targets and the mature field of kinase chemical probes.

Targeted Drug Strategies for Cancer and Inflammation

Targeted Drug Strategies for Cancer and Inflammation Book
Author : Ann L. Jackman,Christopher P. Leamon
Publisher : Springer Science & Business Media
Release : 2011-05-05
ISBN : 1441984178
Language : En, Es, Fr & De

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Book Description :

Folate pathways are essential in metabolism and macromolecule synthesis. Antifolate drugs that are largely transported via a high capacity folate transporter (i.e. the reduced-folate carrier) and inhibit folate-dependent enzymes include the dihydrofolate reductase inhibitor, methotrexate, and the thymidylate synthase inhibitors, raltitrexed and pemetrexed. Major advances in folate research made within the last decade include (i) the approval of pemetrexed for the treatment of lung cancer and mesothelioma, and (ii) the demonstration that cell membrane-anchored folate receptors (FR) are exploitable for cancer and inflammatory disease management. FRs are not widely distributed in normal tissues, except on some luminal surfaces; however, they are accessible to systemically administered agents when expressed on many cancers as well as on activated macrophages involved in various inflammatory diseases. High affinity folate-radioisotope conjugates have been developed for imaging pathogenic FR-positive diseases, including cancer. Since the FR transports folates via a low capacity but high affinity endocytic pathway, a variety of FR-targeted antifolate drugs and folate conjugates bearing a wide range of payloads (including cytotoxic drugs) are currently being developed which exploit this property. The FR is also being utilized in immunotherapy approaches for the treatment of overexpressing cancers.

Targeted

Targeted Book
Author : ML Davila
Publisher : Unknown
Release : 2021-07-30
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Book 1 of the Targeted SeriesIt's bad enough a serial killer is on the loose. What happens when you become the object of that serial killer's affection? Detective Sydney Russo is no stranger to being targeted. Before it was just part of the job. Now she has someone she loves. Someone she'll fight to get back too. When the FBI is called in to help, they just add to the number of targets available. One agent, Mandy Pendergast, bears a passing resemblance to some of the victims. Will that resemblance put her in the crosshairs as well? Time is running out. They have a 48 hour window before the killer chooses his next victim. The looming threat brings couples together and unites these groups as nothing else could. When the threat becomes reality, there is no question as to why they were Targeted.

Targeted Killing

Targeted Killing Book
Author : Markus Gunneflo
Publisher : Cambridge University Press
Release : 2016-05-12
ISBN : 1316552845
Language : En, Es, Fr & De

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Book Description :

Looking beyond the events of the second intifada and 9/11, this book reveals how targeted killing is intimately embedded in both Israeli and US statecraft, and in the problematic relationship between sovereign authority and lawful violence underpinning the modern state system. It details the legal and political issues raised in targeted killing as it has emerged in practice, including questions of domestic constitutional authority, the use of force in international law, the law of belligerent occupation, the law of targeting and human rights law. The distinctive nature of Israeli and US targeted killing is analysed in terms of the compulsion of legality characteristic of the liberal constitutional state, a compulsion that demands the ability to distinguish between legal 'targeted killing' and extra-legal 'political assassination'. The effect is a highly legalized framework for the extraterritorial killing of designated terrorists that may significantly affect the international law of force.

Advances in Targeted Cancer Therapy

Advances in Targeted Cancer Therapy Book
Author : Richard M. Schultz
Publisher : Springer Science & Business Media
Release : 2006-01-24
ISBN : 3764374144
Language : En, Es, Fr & De

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Book Description :

There have been tremendous advances in our understanding of molecular and tumor biology during the past few years. In the field of cancer therapeutics, it is expected that cytotoxic drug approaches will be gradually replaced with treatments based on biological targeted approaches. Hopefully these new targeted therapies will significantly increase efficacy and lack the devastating and troublesome side effects elicited by cytotoxic chemotherapy. This volume is the first book to cover the general topic of targeted cancer therapy. It presents a range of targets such as tumor angiogenesis, cell cycle control and cell signalling, COX-2, apoptosis/cell survival, invasion and metastasis and approaches like kinase inhibitors, antisense, and antibody-based therapeutics. The emphasis is on preclinical development, including target validation, development of biomarkers, strategies for combination approaches, and development of resistance. The particular challenges involved in translating these data to clinical application are discussed. This volume should be of broad general interest to researchers and clinicians involved in cancer therapy as well as other scientists interested in current strategies for cancer treatment.

Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors

Nanotechnology Based Targeted Drug Delivery Systems for Brain Tumors Book
Author : Prashant Kesharwani,Umesh Gupta
Publisher : Academic Press
Release : 2018-04-20
ISBN : 0128122498
Language : En, Es, Fr & De

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Book Description :

Nanotechnology-Based Targeted Drug Delivery Systems for Brain Tumors addresses brain anatomy and tumors and the progress and challenges in delivering drugs across the blood brain barrier. Several chapters are devoted to the latest technologies and advances in nanotechnology, along with practical solutions on how to design more effective nanocarriers for drug and gene delivery. This valuable resource prepares readers to develop novel drug delivery systems for the treatment of brain tumors that further promote the latest nanomedical technologies. Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors

Targeted

Targeted Book
Author : David Gideon
Publisher : Xlibris Corporation
Release : 2019-09-06
ISBN : 1984551027
Language : En, Es, Fr & De

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Book Description :

This is a true story of a pathological, serial workplace bully and is written by a proud survivor. Names have been changed to protect the innocent. It is a horrific tale of terror, manifested by a malevolent mind bent on selfish ambition. It is a story of how the monster worked his way into the victim’s confidence, learned his strengths and weaknesses, and even boasted to him what he was going to do before implementing his evil plan. It is a legend of how kindness and compassion are crushed by the sinister whispering campaign and how the bosses and managers were too terrified to act for fear of retaliation upon themselves. It is textbook psychological torture, and it’s a miracle that anyone could survive it. But it is also a book of hope, what you need to do, and of how to seek out help if you are confronted by such a bully. This is a book of reasoning and forgiveness. It is also to let us know that we are not alone. Such monsters do exist, and this is how to recognize them and thwart their insidious plots.

Handbook of Lung Targeted Drug Delivery Systems

Handbook of Lung Targeted Drug Delivery Systems Book
Author : Yashwant Pathak,Nazrul Islam
Publisher : CRC Press
Release : 2021-10-17
ISBN : 1000450767
Language : En, Es, Fr & De

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Book Description :

Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems

Handbook of Targeted Delivery of Imaging Agents

Handbook of Targeted Delivery of Imaging Agents Book
Author : Vladimir P. Torchilin
Publisher : CRC Press
Release : 1995-08-23
ISBN : 9780849383083
Language : En, Es, Fr & De

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Book Description :

This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chapters covering all aspects of targeted drug delivery-from the imaging theory and chemistry of imaging agents to their experimental and clinical use for targeted visualization of cancer, including ovarian, prostate, colorectal, and thyroid cancer, cardiovascular (atherosclerosis, myocardial infarction, and thromboses) and neurological diseases, infection, and inflammation sites. A special section discusses the targeted delivery of imaging agents into lymph nodes, which are often sites of metasteses during different malignant diseases. Monoclonal antibody-based targeted imaging agents are considered together with new approaches involving the use of labeled micelles, liposomes, and polymer-coated particles. The book describes the possible application of designer antibodies for the delivery of diagnostic agents, including the preparation, properties, labeling, and experimental use of multifunctional antibodies. The alternative improvement of antibody-directed targeting describes the application of avidin-biotin system for the delivery of imaging agents. Long circulating blood pool imaging agents are considered as a special group of organ-specific pharmaceuticals. The latest trends in the synthesis of immunoscintigraphic, MR, and CT agents are presented. This Handbook of Targeted Delivery of Imaging Agents is a must-have reference for all those who need to stay abreast of the latest developments in this hot field.

Targeted Cyber Attacks

Targeted Cyber Attacks Book
Author : Aditya Sood,Richard Enbody
Publisher : Syngress
Release : 2014-04-18
ISBN : 0128006196
Language : En, Es, Fr & De

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Book Description :

Cyber-crime increasingly impacts both the online and offline world, and targeted attacks play a significant role in disrupting services in both. Targeted attacks are those that are aimed at a particular individual, group, or type of site or service. Unlike worms and viruses that usually attack indiscriminately, targeted attacks involve intelligence-gathering and planning to a degree that drastically changes its profile. Individuals, corporations, and even governments are facing new threats from targeted attacks. Targeted Cyber Attacks examines real-world examples of directed attacks and provides insight into what techniques and resources are used to stage these attacks so that you can counter them more effectively. A well-structured introduction into the world of targeted cyber-attacks Includes analysis of real-world attacks Written by cyber-security researchers and experts

Targeted Learning

Targeted Learning Book
Author : Mark J. van der Laan,Sherri Rose
Publisher : Springer Science & Business Media
Release : 2011-06-17
ISBN : 1441997822
Language : En, Es, Fr & De

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Book Description :

The statistics profession is at a unique point in history. The need for valid statistical tools is greater than ever; data sets are massive, often measuring hundreds of thousands of measurements for a single subject. The field is ready to move towards clear objective benchmarks under which tools can be evaluated. Targeted learning allows (1) the full generalization and utilization of cross-validation as an estimator selection tool so that the subjective choices made by humans are now made by the machine, and (2) targeting the fitting of the probability distribution of the data toward the target parameter representing the scientific question of interest. This book is aimed at both statisticians and applied researchers interested in causal inference and general effect estimation for observational and experimental data. Part I is an accessible introduction to super learning and the targeted maximum likelihood estimator, including related concepts necessary to understand and apply these methods. Parts II-IX handle complex data structures and topics applied researchers will immediately recognize from their own research, including time-to-event outcomes, direct and indirect effects, positivity violations, case-control studies, censored data, longitudinal data, and genomic studies.

The Psychology of Micro Targeted Election Campaigns

The Psychology of Micro Targeted Election Campaigns Book
Author : Jens Koed Madsen
Publisher : Springer Nature
Release : 2019-09-26
ISBN : 3030221458
Language : En, Es, Fr & De

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Book Description :

This book examines the psychology behind micro-targeted tactics used in election campaigning and the advent of increasingly sophisticated dynamic Agent-Based Models (ABMs). It discusses individual profiling, how data and modelling are deployed to enhance the effectiveness of persuasion and mobilization efforts in campaigns, and the potential limitations of these approaches. Madsen particularly explores how psychological insight and personal data are used to generate individualised models of voters and how these in turn are applied to optimise persuasion strategies tailored to a specific person. Finally, the book considers the broader democratic dilemmas raised by the introduction of these tactics into politics and the critical civic importance of understanding how these campaigns function.This timely work offers fresh insights for students and scholars of political psychology, philosophy, political marketing, media, and communications.

Return Fire Moving Target Book 2

Return Fire  Moving Target  Book 2  Book
Author : Christina Diaz Gonzalez
Publisher : Scholastic Inc.
Release : 2016-09-27
ISBN : 0545773245
Language : En, Es, Fr & De

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Book Description :

WHO WILL CONTROL DESTINY? Cassie Arroyo has the ability to use the Spear of Destiny. And despite knowing the dangers of such a powerful object, she uses it to shape the future and save her father's life. The consequences of that small choice are larger than Cassie could ever have imagined. It produced a chain reaction - and now, in her visions of the future, Cassie sees chaos and death spreading across Rome. With the help of her friend Asher, Cassie is determined to fix the future she's created . . . but it's not going to be simple. The spear's been stolen by people who want to use it for their own dark purposes. Can Cassie recapture the spear before it's used against her? And will she be able to undo the harm she's caused, or will she only cast the world into greater chaos? Christina Diaz Gonzalez's Return Fire is a nonstop, action-packed adventure, full of mystery and intrigue, that will take you on a wild and wonderful ride across Italy.