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Target Validation In Drug Discovery

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Target Identification and Validation in Drug Discovery

Target Identification and Validation in Drug Discovery Book
Author : Jürgen Moll,Sebastian Carotta
Publisher : Humana Press
Release : 2019-04-12
ISBN : 9781493991440
Language : En, Es, Fr & De

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Book Description :

This second edition book explores breakthrough technologies in the field of drug target identification and validation. The volume emphasizes particularly revolutionary technologies, such as CRISPR-related screening, “big data,” and in silico approaches, as well as in vivo applications of CRISPR and best uses of animal models in drug development. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Fully updated and authoritative, Target Identification and Validation in Drug Discovery: Methods and Protocols, Second Edition is an ideal guide for molecular and cellular biologists, pharmacologists, pathologists, bioinformaticians, clinical researchers, or investigators, as well as experts in other fields that need a quick overview of these state-of-the-art technologies.

Target Validation in Drug Discovery

Target Validation in Drug Discovery Book
Author : Brian W. Metcalf,Susan Dillon
Publisher : Elsevier
Release : 2011-04-28
ISBN : 9780080465975
Language : En, Es, Fr & De

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Book Description :

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Target Discovery and Validation

Target Discovery and Validation Book
Author : Alleyn T. Plowright
Publisher : John Wiley & Sons
Release : 2019-12-31
ISBN : 3527345299
Language : En, Es, Fr & De

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Book Description :

The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.

Target Discovery and Validation Reviews and Protocols

Target Discovery and Validation Reviews and Protocols Book
Author : Mouldy Sioud
Publisher : Humana Press
Release : 2010-10-28
ISBN : 9781617376993
Language : En, Es, Fr & De

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Book Description :

Target discovery is a field that has existed for several years but is so vibrant today because of the recent progress in our understanding of the molecular mechanisms of many human diseases and the technical advances in target identification and validation. More sophisticated gene profiling technologies, such as DNA microarrays and serial analysis of gene expression, permit rapid identification of lead targets. Moreover, analysis of gene networks in living organisms allows the identification of target genes that operate in defined physiological pathways. With the sequencing of several genomes completed and the rapidly growing gene expression databases, there is now greater impetus than ever before for in silico discovery of therapeutic targets. Also, recent advances in genetic technologies have increased our ability to generate mouse models for human diseases. The implications of these genetically modified animals in drug development are several, including identification of new drug targets, predicting efficacy, and uncovering possible side effects. Together, these recent technical advances should allow researchers to make the most informed choice early and advance the chosen targets toward clinical studies. Regarding cancers, any difference between a cancer and a normal cell could potentially be exploited as a therapeutic target. The hope is that drugs targeting specific constituents or pathways in cancer cells will provide more effective therapy, either alone or in combination with other currently used anticancer drugs. In addition to drug targets, identifying new target antigens remains as much of a challenge as improving tumor vaccines already in the clinic.

Imaging in Drug Discovery and Early Clinical Trials

Imaging in Drug Discovery and Early Clinical Trials Book
Author : Markus Rudin
Publisher : Springer Science & Business Media
Release : 2006-07-11
ISBN : 9783764377809
Language : En, Es, Fr & De

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Book Description :

This monograph examines the contribution of imaging modalities to the stages of drug discovery and development, from early target validation to their use in clinical development programs. Chapters are devoted to the description of the drug discovery process, to the various imaging modalities preclinically and clinically, to applications of imaging during the optimization of a lead compound, addressing issues such as bioavailability and efficacy, and during drug safety evaluation.

High content Screening for Drug Discovery and Target Validation

High content Screening for Drug Discovery and Target Validation Book
Author : Shauna Farr-Jones
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download High content Screening for Drug Discovery and Target Validation book written by Shauna Farr-Jones, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Prostate Cancer

Prostate Cancer Book
Author : Philippe E. Spiess
Publisher : IntechOpen
Release : 2011-11-25
ISBN : 9789533073316
Language : En, Es, Fr & De

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Book Description :

The present textbook highlights many of the exciting discoveries made in the diagnosis and treatment of prostate cancer over the past decade. International thought leaders have contributed to this effort providing a comprehensive and state-of-the art review of the signaling pathways and genetic alterations essential in prostate cancer. This work provides an essential resource for healthcare professionals and scientists dedicated to this field. This textbook is dedicated to the efforts and advances made by our scientific community, realizing we have much to learn in striving to some day in the not too distant future cure this disease particularly among those with an aggressive tumor biology.

In Silico Technologies in Drug Target Identification and Validation

In Silico Technologies in Drug Target Identification and Validation Book
Author : Darryl Leon,Scott Markel
Publisher : CRC Press
Release : 2006-06-13
ISBN : 1420015737
Language : En, Es, Fr & De

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Book Description :

The pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro procedures. In Silico Technologies in Drug Target Identification and Validation addresses the challenge of testing a growing number of new potential targets and reviews currently available in silico approaches for identifying and validating these targets. The book emphasizes computational tools, public and commercial databases, mathematical methods, and software for interpreting complex experimental data. The book describes how these tools are used to visualize a target structure, identify binding sites, and predict behavior. World-renowned researchers cover many topics not typically found in most informatics books, including functional annotation, siRNA design, pathways, text mining, ontologies, systems biology, database management, data pipelining, and pharmacogenomics. Covering issues that range from prescreening target selection to genetic modeling and valuable data integration, In Silico Technologies in Drug Target Identification and Validation is a self-contained and practical guide to the various computational tools that can accelerate the identification and validation stages of drug target discovery and determine the biological functionality of potential targets more effectively. Daniel E. Levy, editor of the Drug Discovery Series, is the founder of DEL BioPharma, a consulting service for drug discovery programs. He also maintains a blog that explores organic chemistry.

Prostate Cancer

Prostate Cancer Book
Author : Philippe E. Spiess
Publisher : IntechOpen
Release : 2011-11-25
ISBN : 9789533073316
Language : En, Es, Fr & De

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Book Description :

The present textbook highlights many of the exciting discoveries made in the diagnosis and treatment of prostate cancer over the past decade. International thought leaders have contributed to this effort providing a comprehensive and state-of-the art review of the signaling pathways and genetic alterations essential in prostate cancer. This work provides an essential resource for healthcare professionals and scientists dedicated to this field. This textbook is dedicated to the efforts and advances made by our scientific community, realizing we have much to learn in striving to some day in the not too distant future cure this disease particularly among those with an aggressive tumor biology.

Molecular Cancer Therapeutics

Molecular Cancer Therapeutics Book
Author : George C. Prendergast
Publisher : John Wiley & Sons
Release : 2004-04-02
ISBN : 9780471432029
Language : En, Es, Fr & De

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Book Description :

Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters progress from initial stages of drug target discovery to drug discovery, development, and testing in preclinical and clinical models. Topics include drug lead screening, drug-to-lead development, proof-of-concept studies, medicinal chemistry issues, intellectual property concerns, and clinical development. This invaluable reference promotes understanding of steps involved in developing drug leads for industrial partnering and development. It provides an overview of the strategies for discovery and validation of drug target molecules, and discusses cell- and molecule-based drug screening strategies, as well as mouse models for cancer. Coverage also includes how to refine drug leads for suitability in clinical testing, the special issues of clinical testing of molecular-targeted drugs, and intellectual property concerns.

High Content Screening

High Content Screening Book
Author : Steven A. Haney
Publisher : John Wiley & Sons
Release : 2008-01-18
ISBN : 9780470229859
Language : En, Es, Fr & De

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Book Description :

The authoritative reference on High Content Screening (HCS) in biological and pharmaceutical research, this guide covers: the basics of HCS: examples of HCS used in biological applications and early drug discovery, emphasizing oncology and neuroscience; the use of HCS across the drug development pipeline; and data management, data analysis, and systems biology, with guidelines for using large datasets. With an accompanying CD-ROM, this is the premier reference on HCS for researchers, lab managers, and graduate students.

Deriving Drug Discovery Value from Large Scale Genetic Bioresources

Deriving Drug Discovery Value from Large Scale Genetic Bioresources Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation,Roundtable on Genomics and Precision Health
Publisher : National Academies Press
Release : 2016-12-02
ISBN : 030944778X
Language : En, Es, Fr & De

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Book Description :

The process of discovering and developing a new drug or therapy is extremely costly and time consuming, and recently, it has been estimated that the creation of a new medicine costs on average more than $2 billion and takes 10 years to reach patients. The challenges associated with bringing new medicines to market have led many pharmaceutical companies to seek out innovative methods for streamlining their drug discovery research. One way to increase the odds of success for compounds in the drug development pipeline is to adopt genetically guided strategies for drug discovery, and recognizing the potential benefits of collecting genetic and phenotypic information across specific populations, pharmaceutical companies have started collaborating with healthcare systems and private companies that have curated genetic bioresources, or large databases of genomic information. Large-scale cohort studies offer an effective way to collect and store information that can be used to assess geneâ€"environment interactions, identify new potential drug targets, understand the role of certain genetic variants in the drug response, and further elucidate the underlying mechanisms of disease onset and progression. To examine how genetic bioresources could be used to improve drug discovery and target validation, the National Academies of Sciences, Engineering, and Medicine hosted a workshop in March 2016. Participants at the workshop explored the current landscape of genomics-enabled drug discovery activities in industry, academia, and government; examined enabling partnerships and business models; and considered gaps and best practices for collecting population data for the purpose of improving the drug discovery process. This publication summarizes the presentations and discussions from the workshop.

Model Organisms in Drug Discovery

Model Organisms in Drug Discovery Book
Author : Pamela M. Carroll,Kevin Fitzgerald
Publisher : John Wiley & Sons
Release : 2004-04-21
ISBN : 047087130X
Language : En, Es, Fr & De

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Book Description :

Fruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which "define" humans are conserved in Drosophila, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems. Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future. Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future. This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.

Special Topics in Drug Discovery

Special Topics in Drug Discovery Book
Author : Taosheng Chen,Sergio Chai
Publisher : BoD – Books on Demand
Release : 2016-11-30
ISBN : 9535127993
Language : En, Es, Fr & De

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Book Description :

Drug discovery involves multiple disciplines, technologies, and approaches. This book selects important topics related to drug discovery, including emerging tool (Chapter 1), cutting-edge approaches (Chapters 2, 3, and 4), examples of specific therapeutic area (Chapter 5), quality control in drug development (Chapter 6), and job and career opportunities in the pharmaceutical sector, a topic rarely covered by other books (Chapter 7). This book draws knowledge from experts actively involved in different areas of drug discovery from both industrial and academic settings. We hope that this book will facilitate your efforts in drug discovery.

Therapeutic Target Identification

Therapeutic Target Identification Book
Author : Marco Lakey
Publisher : Unknown
Release : 2021-03-25
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Does traumatic brain injury go away? Traumatic Brain Injury Effects Years Later How do you prove traumatic brain injury? Traumatic Brain Injury Treatment What is the most common traumatic brain injury? Types Of Traumatic Brain Injury What is the number one cause of traumatic brain injuries? A traumatic brain injury is a life-changing event, affecting an individual's lifestyle, ability to work, relationships--even personality. Whatever caused it--a car crash, work accident, sports injury, domestic violence, combat--a severe blow to the head results in acute and, often, lasting symptoms.

Therapeutic Target Identification

Therapeutic Target Identification Book
Author : Howard Hallczuk
Publisher : Unknown
Release : 2021-05-06
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Does traumatic brain injury go away? Traumatic Brain Injury Effects Years Later How do you prove traumatic brain injury? Traumatic Brain Injury Treatment What is the most common traumatic brain injury? Types Of Traumatic Brain Injury What is the number one cause of traumatic brain injuries? A traumatic brain injury is a life-changing event, affecting an individual's lifestyle, ability to work, relationships--even personality. Whatever caused it--a car crash, work accident, sports injury, domestic violence, combat--a severe blow to the head results in acute and, often, lasting symptoms.

Handbook of Drug Screening Second Edition

Handbook of Drug Screening  Second Edition Book
Author : Ramakrishna Seethala,Litao Zhang
Publisher : CRC Press
Release : 2009-06-24
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Building upon the foundation of basics discussed in the previous edition, the Second Edition provides a more in-depth look at the latest methods and technologies of advanced drug screening, an essential function of drug discovery. With extensively updated content and 21 new chapters, this text examines: quality and efficiency of drug target validation and potential drug compound selection reducing assay costs and improvement in assay technology data quality improvement trends in drug discovery how drug screening can minimize adverse drug effects recent advancements, including: high content screening; protein-protein interactions; high-throughput crystallization; lead optimization; chemoinformatics and microfluidics technologies; target validation by genomics, proteomics, and siRNA; structure-based drug design; automation; and medicinal chemistry

RNA Interference

RNA Interference Book
Author : Paul H. Johnson
Publisher : Wiley
Release : 2011-02-15
ISBN : 9780471771517
Language : En, Es, Fr & De

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Book Description :

RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.

Flow Cytometry in Drug Discovery and Development

Flow Cytometry in Drug Discovery and Development Book
Author : Virginia Litwin,Philip Marder
Publisher : John Wiley & Sons
Release : 2011-04-20
ISBN : 0470922788
Language : En, Es, Fr & De

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Book Description :

This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.