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Systems Biomedicine

Systems Biomedicine Book
Author : Edison T. Liu,Douglas A. Lauffenburger
Publisher : Academic Press
Release : 2009-09-17
ISBN : 9780080919836
Language : En, Es, Fr & De

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Book Description :

Systems biology is a critical emerging field that quantifies and annotates the complexity of biological systems in order to construct algorithmic models to predict outcomes from component input. Applications in medicine are revolutionizing our understanding of biological processes and systems. Systems Biomedicine is organized around foundations, computational modeling, network biology, and integrative biology, with the extension of examples from human biology and pharmacology, to focus on the applications of systems approaches to medical problems. An integrative approach to the underlying genomic, proteomic, and computational biology principles provides researchers with guidance in the use of qualitative systems and hypothesis generators. To reflect the highly interdisciplinary nature of the field, careful detail has been extended to ensure explanations of complex mathematical and biological principles are clear with minimum technical jargon. Organized to reflect the important distinguishing characteristics of systems strategies in experimental biology and medicine Provides precise and comprehensive measurement tools for constructing a model of the system and tools for defining complexity as an experimental dependent variable Includes a thorough discussion of the applications of quantitative principles to biomedical problems

Comprehensive Systems Biomedicine

Comprehensive Systems Biomedicine Book
Author : Pietro Lio,Enrico Capobianco
Publisher : Frontiers E-books
Release : 2014-12-03
ISBN : 2889193748
Language : En, Es, Fr & De

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Book Description :

Systems Biomedicine is a field in perpetual development. By definition a translational discipline, it emphasizes the role of quantitative systems approaches in biomedicine and aims to offer solutions to many emerging problems characterized by levels and types of complexity and uncertainty unmet before. Many factors, including technological and societal ones, need to be considered. In particular, new technologies are providing researchers with the data deluge whose management and exploitation requires a reinvention of cross-disciplinary team efforts. The advent of “omics” and high-content imaging are examples of advances de facto establishing the necessity of systems approaches. Hypothesis-driven models and in silico validation tools in support to all the varieties of experimental applications call for a profound revision. The focus on phases like mining and assimilating the data has substantially increased so to allow for interpretable knowledge to be inferred. Notably, to be able to tackle the newly generated data dimensionality, heterogeneity and complexity, model-free and data-driven intensive applications are increasingly shaping the computational pipelines and architectures that quant specialists set aside of the high-throughput genomics, transcriptomics, proteomics platforms. As for the societal aspects, in many advanced societies health care needs now more than in the past to address the problem of managing ageing populations and their complex morbidity patterns. In parallel, there is a growing research interest on the impact that cross-disciplinary clinical, epidemiological and quantitative modelling studies can have in relation to outcomes potentially affecting the quality of life of many people. Complex systems, including those characterizing biomedicine, are assessed in both their functionality and stability, and also relatively to the capacity of generating information from diversity, variation, and complexity. Due to the combined interactions and effects, such systems embed prediction power available for instance in both target identification or marker discovery, or more generally for conducting inference about patients’ pathological states, i.e. normal versus disease, diagnostic or prognostic analysis, and preventive assessment (e.g., risk evaluation). The ultimate goal, personalized medicine, will be achieved based on the confluence of the system’s predictive power to patient-specific profiling.

New Challenges for Cancer Systems Biomedicine

New Challenges for Cancer Systems Biomedicine Book
Author : Alberto D'Onofrio,Paola Cerrai,Alberto Gandolfi
Publisher : Springer Science & Business Media
Release : 2013-01-25
ISBN : 8847025710
Language : En, Es, Fr & De

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Book Description :

The future of oncology seems to lie in Molecular Medicine (MM). MM is a new science based on three pillars. Two of them are evident in its very name and are well known: medical science and molecular biology. However, there is a general unawareness that MM is firmly based on a third, and equally important, pillar: Systems Biomedicine. Currently, this term denotes multilevel, hierarchical models integrating key factors at the molecular, cellular, tissue, through phenotype levels, analyzed to reveal the global behavior of the biological process under consideration. It becomes increasingly evident that the tools to construct such complex models include, not only bioinformatics and modern applied statistics, as is unanimously agreed, but also other interdisciplinary fields of science, notably, Mathematical Oncology, Systems Biology and Theoretical Biophysics.

Biomedicine and Alternative Healing Systems in America

Biomedicine and Alternative Healing Systems in America Book
Author : Hans A. Baer
Publisher : Univ of Wisconsin Press
Release : 2001
ISBN : 9780299166946
Language : En, Es, Fr & De

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Book Description :

Examining medical pluralism in the United States from the Revolutionary War period through the end of the twentieth century, Hans Baer brings together in one convenient reference a vast array of information on healing systems as diverse as Christian Science, osteopathy, acupuncture, evangelical faith healing, Santeria, southern Appalachian herbalism, and Navajo healing. In a country where the dominant paradigm of biomedicine (medical schools, research hospitals, clinics staffed by M.D.s and R.N.s) has been long established and supported by laws and regulations, the continuing appeal of other medical systems and subsystems bears careful consideration. Distinctions of class, Baer emphasizes, as well as differences in race, ethnicity, and gender, are fundamental to the diversity of beliefs, techniques, and social organizations represented in the phenomenon of medical pluralism. Baer traces the simultaneous emergence in the nineteenth century of formalized biomedicine and of homeopathy, botanic medicine, hydropathy, Christian Science, osteopathy, and chiropractic. He examines present-day osteopathic medicine as a system parallel to biomedicine; chiropractic, naturopathy, and acupunctur

Complex Systems Science in Biomedicine

Complex Systems Science in Biomedicine Book
Author : Thomas Deisboeck,J. Yasha Kresh
Publisher : Springer Science & Business Media
Release : 2007-06-13
ISBN : 0387335323
Language : En, Es, Fr & De

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Book Description :

Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.

Metadata driven Software Systems in Biomedicine

Metadata driven Software Systems in Biomedicine Book
Author : Prakash M. Nadkarni
Publisher : Springer Science & Business Media
Release : 2011-05-27
ISBN : 0857295101
Language : En, Es, Fr & De

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Book Description :

While the use of database technology is ubiquitous throughout IT (and health IT in particular), it is not generally appreciated that, as a database increases in scope, certain designs are far superior to others. In biomedical domains, new knowledge is being generated continually, and the databases that must support areas such as clinical care and research must also be able to evolve while requiring minimal or no logical / physical redesign. Appropriately designed metadata, and software designed to utilize it effectively, can provide significant insulation against change. Many of the larger EMR or clinical research database vendors have realized this, but their designs are proprietary and not described in the literature. Consequently, numerous misconceptions abound among individuals who have not had to work with large-scale biomedical systems, and graduates of a health or bioinformatics program may find that they need to unlearn what they were taught in database and software design classes in order to work productively with such systems. A working knowledge of such systems is also important for individuals who are not primarily software developers, such as health informaticians, medical information officers and data analysts. This book is, in a sense, intended to prepare all of the above individuals for the real world.

Systems biomedicine concepts and perspectives

Systems biomedicine   concepts and perspectives Book
Author : Edison T. Liu,Douglas A. Lauffenburger
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Systems biomedicine concepts and perspectives book written by Edison T. Liu,Douglas A. Lauffenburger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Highly Mutable Animal RNA Viruses Adaptation and Evolution

Highly Mutable Animal RNA Viruses  Adaptation and Evolution Book
Author : Akio Adachi,Masako Nomaguchi
Publisher : Frontiers Media SA
Release : 2017-11-30
ISBN : 2889453480
Language : En, Es, Fr & De

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Book Description :

Viruses are widely present in nature, and numerous viral species with a variety of unique characteristics have been identified so far. Even now, new emerging or re-emerging viruses are being found or re-found as novel viral classes or as quasi-species. Indeed, viruses are everywhere. Of note, viruses are pivotal as targets and tools of basic and applied sciences. On one hand, portions of the viruses are infectious for animals including humans, and cause various diseases in infected hosts by distinct mechanisms and at a different level of severity. While many of viruses are known to co-exist quietly with their hosts, pathogenic viruses certainly affect and threaten our society as well as individuals to provoke serious medical or economic attention. We should act against certain dreadful and highly infectious viruses as a global problem. Animal RNA viruses can readily mutate to adapt themselves in their hostile environments for their survival. Resultant viruses may sometimes show essentially altered phenotypes from the original parental strains. This fundamental and general property of animal RNA viruses represents major extensive issues of scientific, medical, and/or economic importance. In this Research Topic, we have focused on the high mutability of animal RNA viruses, and selected relevant articles on animal viruses of broad-ranges such as primate lentiviruses, influenza viruses, paramyxoviruses, flaviviruses, rabies virus, norovirus, picornaviruses, and picobirnavirus. Each article has taken up intriguing aspects of the subject viruses. We are sure that readers acquire important information on virus mutation, adaptation, diversification, and evolution, and hope that researchers in the field related to virology gain some solid hints from the reported articles for further virological and /or medical studies. Finally, we thank all the contributing researchers in this Research Topic, entitled “Highly Mutable Animal RNA Viruses: Adaptation and Evolution”, for their elegant and interesting works.

Bioinformatics for Diagnosis Prognosis and Treatment of Complex Diseases

Bioinformatics for Diagnosis  Prognosis and Treatment of Complex Diseases Book
Author : Bairong Shen
Publisher : Springer Science & Business Media
Release : 2013-11-25
ISBN : 9400779755
Language : En, Es, Fr & De

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Book Description :

The book introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases. The book covers both state of the art of bioinformatics methodologies and the examples for the identification of simple or network biomarkers. In addition, bioinformatics software tools and scripts are provided to the practical application in the study of complex diseases. The present state, the future challenges and perspectives were discussed. The book is written for biologists, biomedical informatics scientists and clinicians, etc. Dr. Bairong Shen is Professor and Director of Center for Systems Biology, Soochow University; he is also Director of Taicang Center for Translational Bioinformatics.

Research Awards Index

Research Awards Index Book
Author : Anonim
Publisher : Unknown
Release : 1978
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Research Awards Index book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Adaptive Health Management Information Systems Concepts Cases Practical Applications

Adaptive Health Management Information Systems  Concepts  Cases    Practical Applications Book
Author : Joseph Tan,Fay Cobb Payton
Publisher : Jones & Bartlett Publishers
Release : 2010-03-09
ISBN : 1449658210
Language : En, Es, Fr & De

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Book Description :

This book covers all the fundamental concepts of Health Management Information Systems (HMIS), provides relevant and current HMIS cases throughout, and touches on emerging technologies. Topics include: information systems from a managerial perspective; roles of cio/cto for healthcare services organizations; HMIS hardware/software concepts; HMIS database concepts.Important Notice: The digital edition of this book is missing some of the images or content found in the physical edition.

Generic

Generic Book
Author : Jeremy A. Greene
Publisher : Johns Hopkins University Press
Release : 2016-09-01
ISBN : 142142164X
Language : En, Es, Fr & De

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Book Description :

Greene’s history sheds light on the controversies shadowing the success of generics: problems with the generalizability of medical knowledge, the fragile role of science in public policy, and the increasing role of industry, marketing, and consumer logics in late-twentieth-century and early twenty-first century health care.

The African Transformation of Western Medicine and the Dynamics of Global Cultural Exchange

The African Transformation of Western Medicine and the Dynamics of Global Cultural Exchange Book
Author : David Baronov
Publisher : Temple University Press
Release : 2010-05-14
ISBN : 1592139167
Language : En, Es, Fr & De

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Book Description :

Beginning with the colonial era, Western biomedicine has radically transformed African medical beliefs and practices. Conversely, in using Western biomedicine, Africans have also transformed it. The African Transformation of Western Medicine and the Dynamics of Global Cultural Exchange contends that contemporary African medical systems—no less “biomedical” than Western medicine—in fact greatly enrich and expand the notion of biomedicine, reframing it as a global cultural form deployed across global networks of cultural exchange. The book analyzes biomedicine as a complex and dynamic sociocultural form, the conceptual premises of which make it necessarily subject to ongoing change and development as it travels the globe. David Baronov captures the complexities of this cultural exchange by using world-systems analysis in a way that places global cultural processes on equal footing with political and economic processes. In doing so, he both allows the story of Africa’s transformation of “Western” biomedicine to be told and offers new insights into the capitalist world system.

A Handbook of Practicing Anthropology

A Handbook of Practicing Anthropology Book
Author : Riall Nolan
Publisher : John Wiley & Sons
Release : 2013-01-16
ISBN : 1118484347
Language : En, Es, Fr & De

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Book Description :

An essential career-planning resource, A Handbook ofPracticing Anthropology presents a comprehensive account ofcontemporary anthropological practice written primarily byanthropological practitioners Engagingly written and instructive accounts ofpractice by anthropological professionals working in corporations,governmental, entrepreneurial, and educational settings Provides essential guidance on applying anthropologicalprinciples on the job: what works well and what must belearned Emphasizes the value of collaboration, teamwork, and continuouslearning as key elements to success in non-academic careers Highlights the range of successful career options forpractitioners , describes significant sectors of professionalactivity, and discusses key issues, concerns, and controversies inthe field Chapters examine key practice sectors such as freelancing,managing a consulting firm, working for government, non-profits,and corporations, and the domains of health, industry, education,international development, and the military

Knowledge Based Systems in Biomedicine and Computational Life Science

Knowledge Based Systems in Biomedicine and Computational Life Science Book
Author : Tuan D. Pham,Lakhmi C. Jain
Publisher : Springer
Release : 2012-12-14
ISBN : 3642330150
Language : En, Es, Fr & De

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Book Description :

This book presents a sample of research on knowledge-based systems in biomedicine and computational life science. The contributions include: personalized stress diagnosis system, image analysis system for breast cancer diagnosis, analysis of neuronal cell images, structure prediction of protein, relationship between two mental disorders, detection of cardiac abnormalities, holistic medicine based treatment and analysis of life-science data.

Immune Rebalancing

Immune Rebalancing Book
Author : Diana Boraschi,Giselle Penton-Rol
Publisher : Academic Press
Release : 2016-01-25
ISBN : 0128033363
Language : En, Es, Fr & De

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Book Description :

Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc. Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposes Encourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infections Examines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approaches Provides information on the new strategies for drug development in this field Considers the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader’s strategy for addressing therapeutic immune modulations

Poisonous Plants and Phytochemicals in Drug Discovery

Poisonous Plants and Phytochemicals in Drug Discovery Book
Author : Andrew G. Mtewa,Chukwuebuka Egbuna,G. M. Narasimha Rao
Publisher : John Wiley & Sons
Release : 2020-12-04
ISBN : 1119650275
Language : En, Es, Fr & De

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Book Description :

Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery - Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery - Written and edited by leading researchers in phytochemistry, medicinal chemistry, analytical chemistry, toxicology, and more - Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career

A Systems Approach to Biomedicine

A Systems Approach to Biomedicine Book
Author : William B. Blesser
Publisher : Unknown
Release : 1969
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download A Systems Approach to Biomedicine book written by William B. Blesser, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Purchasing To Improve Health Systems Performance

Purchasing To Improve Health Systems Performance Book
Author : Figueras, Josep,Robinson, Ray,Jakubowski, Elke
Publisher : McGraw-Hill Education (UK)
Release : 2005-03-01
ISBN : 0335213677
Language : En, Es, Fr & De

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Book Description :

Purchasing is championed as key to improving health systems performance. However, despite the central role the purchasing function plays in many health system reforms, there is very little evidence about its development or its real impact on societal objectives. This book addresses this gap and provides: ·A comprehensive account of the theory and practice of purchasing for health services across Europe ·An up-to-date analysis of the evidence on different approaches to purchasing ·Support for policy-makers and practitioners as they formulate purchasing strategies so that they can increase effectiveness and improve performance in their own national context ·An assessment of the intersecting roles of citizens, the government and the providers Written by leading health policy analysts, this book is essential reading for health policy makers, planners and managers as well as researchers and students in the field of health studies. Contributors: Toni Ashton, Philip Berman, Michael Borowitz, Helmut Brand, Reinhard Busse, Andrea Donatini, Martin Dlouhy, Antonio Duran, Tamás Evetovits, André P. van den Exter, Josep Figueras, Nick Freemantle, Julian Forder, Péter Gaál, Chris Ham, Brian Hardy, Petr Hava, David Hunter, Danguole Jankauskiene, Maris Jesse, Ninel Kadyrova, Joe Kutzin, John Langenbrunner, Donald W. Light, Hans Maarse, Nicholas Mays, Martin McKee, Eva Orosz, John Øvretveit, Dominique Polton, Alexander S. Preker, Thomas A. Rathwell, Sabine Richard, Ray Robinson, Andrei Rys, Constantino Sakellarides, Sergey Shishkin, Peter C. Smith, Markus Schneider, Francesco Taroni, Marcial Velasco-Garrido, Miriam Wiley

Knowledge Based Intelligent Information and Engineering Systems

Knowledge Based Intelligent Information and Engineering Systems Book
Author : Rajiv Khosla,Robert J. Howlett
Publisher : Springer Science & Business Media
Release : 2005-08-30
ISBN : 354028897X
Language : En, Es, Fr & De

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Book Description :

The four volume set LNAI 3681, LNAI 3682, LNAI 3683, and LNAI 3684 constitute the refereed proceedings of the 9th International Conference on Knowledge-Based Intelligent Information and Engineering Systems, KES 2005, held in Melbourne, Australia in September 2005. The 716 revised papers presented were carefully reviewed and selected from nearly 1400 submissions. The papers present a wealth of original research results from the field of intelligent information processing in the broadest sense; topics covered in the fourth volume are innovations in intelligent systems and their applications, data mining and soft computing applications, skill acquisition and ubiquitous human computer interaction, soft computing and their applications, agent-based workflows, knowledge sharing and reuse, multi-media authentication and watermarking applications, knowledge and engineering techniques for spatio-temporal applications, intelligent data analysis and applications, creativitiy support environment and its social applications, collective intelligence, computational methods for intelligent neuro-fuzzy applications, evolutionary and self-organizing sensors, actuators and processing hardware, knowledge based systems for e-business and e-learning, multi-agent systems and evolutionary computing, ubiquitous pattern recognition, neural networks for data mining, and knowledge-based technology in crime matching, modelling and prediction.