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Systems Biology

Systems Biology Book
Author : Edda Klipp,Wolfram Liebermeister,Christoph Wierling,Axel Kowald,Ralf Herwig
Publisher : John Wiley & Sons
Release : 2016-06-27
ISBN : 3527336362
Language : En, Es, Fr & De

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Book Description :

This advanced textbook is tailored for an introductory course in Systems Biology and is well-suited for biologists as well as engineers and computer scientists. It comes with student-friendly reading lists and a companion website featuring a short exam prep version of the book and educational modeling programs. The text is written in an easily accessible style and includes numerous worked examples and study questions in each chapter. For this edition, a section on medical systems biology has been included.

Systems Biology

Systems Biology Book
Author : Bernhard Ø. Palsson
Publisher : Cambridge University Press
Release : 2015-01-26
ISBN : 1316239942
Language : En, Es, Fr & De

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Book Description :

Recent technological advances have enabled comprehensive determination of the molecular composition of living cells. The chemical interactions between many of these molecules are known, giving rise to genome-scale reconstructed biochemical reaction networks underlying cellular functions. Mathematical descriptions of the totality of these chemical interactions lead to genome-scale models that allow the computation of physiological functions. Reflecting these recent developments, this textbook explains how such quantitative and computable genotype-phenotype relationships are built using a genome-wide basis of information about the gene portfolio of a target organism. It describes how biological knowledge is assembled to reconstruct biochemical reaction networks, the formulation of computational models of biological functions, and how these models can be used to address key biological questions and enable predictive biology. Developed through extensive classroom use, the book is designed to provide students with a solid conceptual framework and an invaluable set of modeling tools and computational approaches.

Systems Biology

Systems Biology Book
Author : P. Bringmann,E. Butcher,G. Parry,B. Weiss
Publisher : Springer Science & Business Media
Release : 2007-05-26
ISBN : 3540313397
Language : En, Es, Fr & De

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Book Description :

This volume features contributions from participants of an ESRF Workshop on "Systems Biology" held in Berkeley, USA, in November 2005. Significant progress has been made in developing technologies that enable systems interrogations at a molecular level. Recent successes and challenges of applying systems level measurements to the different steps of drug discovery and development in the pharmaceutical industry are summarized.

Systems Biology

Systems Biology Book
Author : Robert A. Meyers
Publisher : John Wiley & Sons
Release : 2012-07-02
ISBN : 3527326073
Language : En, Es, Fr & De

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Book Description :

Systems biology is a relatively new biological study field that focuses on the systematic study of complex interactions in biological systems, thus using a new perspective (integration instead of reduction) to study them. Particularly from year 2000 onwards, the term is used widely in the biosciences, and in a variety of contexts. Systems biology is the study of the interconnected aspect of molecular, cellular, tissue, whole animal and ecological processes, and comprises mathematical and mechanistic studies of dynamical, mesoscopic, open, spatiotemporally defined, nonlinear, complex systems that are far from thermodynamic equilibrium.

An Introduction to Systems Biology

An Introduction to Systems Biology Book
Author : Uri Alon
Publisher : CRC Press
Release : 2006-07-07
ISBN : 1584886420
Language : En, Es, Fr & De

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Book Description :

Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.

Systems Biology

Systems Biology Book
Author : Mohamed Al-Rubeai,Martin Fussenegger
Publisher : Springer Science & Business Media
Release : 2007-05-15
ISBN : 1402052529
Language : En, Es, Fr & De

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Book Description :

This book is a comprehensive guide to the revolutionary area of systems biology and its application in cell culture engineering. It is designed to offer a state-of-the-art review with in depth assessments and perspectives of post-genomic biology through understanding the molecular and cellular basis of integrated biological systems. The chapters describe the necessary methodologies for performing systems biology research.

Systems Biology

Systems Biology Book
Author : Shigetada Nakanishi,Ryoichiro Kageyama,Dai Watanabe
Publisher : Springer Science & Business Media
Release : 2009-03-18
ISBN : 4431877045
Language : En, Es, Fr & De

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Book Description :

Biological signaling pathways dynamically interact with one another to form complex information networks intracellularly, intercellularly, and eventually at the level of the organism. Biology and medicine have conventionally focused on identification and characterization of functional elements in biological signaling pathways. Recently, research in this field has pursued a new approach, systems biology, to understand the dynamics, complexity, and physiological functions of the biological signaling networks. Instead of reductionistic analyses or large-scale studies of biomolecules piece by piece, systems biology emphasizes the need for interdisciplinary methods and analysis of the regulation and operation of information networks at the systems level. The contributors to this book are leading researchers in the rising field of systems biology. Readers will find not only the most recent advances in research, but also the latest information about interdisciplinary methods and related topics.

Systems Biology a Very Short Introduction

Systems Biology  a Very Short Introduction Book
Author : Eberhard O. Voit
Publisher : Oxford University Press, USA
Release : 2020-03-26
ISBN : 0198828373
Language : En, Es, Fr & De

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Book Description :

Systems biology came about as growing numbers of engineers and scientists from other fields created algorithms which supported the analysis of biological data in incredible quantities. Whereas biologists of the past had been forced to study one item or aspect at a time, due to technical and biological limitations, it suddenly became possible to study biological phenomena within their natural contexts. This interdisciplinary field offers a holistic approach to interpreting these processes, and has been responsible for some of the most important developments in the science of human health and environmental sustainability. This Very Short Introduction outlines the exciting processes and possibilities in the new field of systems biology. Eberhard O. Voit describes how it enabled us to learn how intricately the expression of every gene is controlled, how signaling systems keep organisms running smoothly, and how complicated even the simplest cells are. He explores what this field is about, why it is needed, and how it will affect our understanding of life, particularly in the areas of personalized medicine, drug development, food and energy production, and sustainable stewardship of our environments. Throughout he considers how new tools are being provided from the fields of mathematics, computer science, engineering, physics, and chemistry to grasp the complexity of the countless interacting processes in cells which would overwhelm the cognitive and analytical capabilities of the human mind. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Systems Biology in Practice

Systems Biology in Practice Book
Author : Edda Klipp,Ralf Herwig,Axel Kowald,Christoph Wierling,Hans Lehrach
Publisher : John Wiley & Sons
Release : 2008-07-15
ISBN : 352760488X
Language : En, Es, Fr & De

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Book Description :

Presenting the main concepts, this book leads students as well as advanced researchers from different disciplines to an understanding of current ideas in the complex field of comprehensive experimental investigation of biological objects, analysis of data, development of models, simulation, and hypothesis generation. It provides readers with guidance on how a specific complex biological question may be tackled: - How to formulate questions that can be answered - Which experiments to perform - Where to find information in databases and on the Internet - What kinds of models are appropriate - How to use simulation tools - What can be learned from the comparison of experimental data and modeling results - How to make testable predictions. The authors demonstrate how mathematical concepts can illuminate the principles underlying biology at a genetic, molecular, cellular and even organism level, and how to use mathematical tools for analysis and prediction.

Systems Biology

Systems Biology Book
Author : Fred Boogerd,Frank J. Bruggeman,Jan-Hendrik S. Hofmeyr,H.V. Westerhoff
Publisher : Elsevier
Release : 2007-03-20
ISBN : 9780080475271
Language : En, Es, Fr & De

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Book Description :

Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, and from philosophy to chemistry. Studying the philosophical foundations of systems biology may resolve a longer standing issue, i.e., the extent to which Biology is entitled to its own scientific foundations rather than being dominated by existing philosophies. * Answers the question of what distinguishes the living from the non-living * An in-depth look to a vigorous and expanding discipline, from molecule to system * Explores the region between individual components and the system

Systems Biology

Systems Biology Book
Author : Isidore Rigoutsos,Gregory Stephanopoulos
Publisher : Oxford University Press on Demand
Release : 2007
ISBN : 0195300815
Language : En, Es, Fr & De

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Book Description :

The genome is seen as a network of interacting components, explored in new ways by sub-discipline specialists. Systems biology is a powerful new computational approach to studying such complex living systems, made possible through technological breakthroughs such as the human genome project, and explosive interest in genetics and molecular biology. At once groundbreaking and synthetic, each chapter in this book treats systems and related technologies as seen by world renowned, trail-blazing experts in their respective fields. It will be useful for researchers in biology, genetics, bioinformatics, molecular biology, biochemical engineering, mathematics, computer science, physics, and chemistry who, using high throughput methods, seek ways to organize vast data sets at the molecular and sub-molecular levels.

Bioinformatics for Systems Biology

Bioinformatics for Systems Biology Book
Author : Stephen Krawetz
Publisher : Springer Science & Business Media
Release : 2008-12-11
ISBN : 9781597454407
Language : En, Es, Fr & De

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Book Description :

Bioinformatics for Systems Biology bridges and unifies many disciplines. It presents the life scientist, computational biologist, and mathematician with a common framework. Only by linking the groups together may the true life sciences revolution move forward.

Introduction to Systems Biology

Introduction to Systems Biology Book
Author : Sangdun Choi
Publisher : Springer Science & Business Media
Release : 2008-05-17
ISBN : 1597455318
Language : En, Es, Fr & De

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Book Description :

This book provides an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems. The authors offer a broad overview of the field using key examples and typical approaches to experimental design. The volume begins with an introduction to systems biology and then details experimental omics tools. Other sections introduce the reader to challenging computational approaches. The final sections provide ideas for theoretical and modeling optimization in systemic biological researches. The book is an indispensable resource, providing a first glimpse into the state-of-the-art in systems biology.

Computational Systems Biology

Computational Systems Biology Book
Author : Andres Kriete,Roland Eils
Publisher : Academic Press
Release : 2013-11-26
ISBN : 0124059384
Language : En, Es, Fr & De

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Book Description :

This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

Systems Biology

Systems Biology Book
Author : Aleš Prokop,Béla Csukás
Publisher : Springer Science & Business Media
Release : 2013-08-28
ISBN : 9400768036
Language : En, Es, Fr & De

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Book Description :

Growth in the pharmaceutical market has slowed down – almost to a standstill. One reason is that governments and other payers are cutting costs in a faltering world economy. But a more fundamental problem is the failure of major companies to discover, develop and market new drugs. Major drugs losing patent protection or being withdrawn from the market are simply not being replaced by new therapies – the pharmaceutical market model is no longer functioning effectively and most pharmaceutical companies are failing to produce the innovation needed for success. This multi-authored new book looks at a vital strategy which can bring innovation to a market in need of new ideas and new products: Systems Biology (SB). Modeling is a significant task of systems biology. SB aims to develop and use efficient algorithms, data structures, visualization and communication tools to orchestrate the integration of large quantities of biological data with the goal of computer modeling. It involves the use of computer simulations of biological systems, such as the networks of metabolites comprise signal transduction pathways and gene regulatory networks to both analyze and visualize the complex connections of these cellular processes. SB involves a series of operational protocols used for performing research, namely a cycle composed of theoretical, analytic or computational modeling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory.

Systems Biology

Systems Biology Book
Author : Lilia Alberghina,Hans V. Westerhoff
Publisher : Springer Science & Business Media
Release : 2007-10-04
ISBN : 9783540742692
Language : En, Es, Fr & De

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Book Description :

For life to be understood and disease to become manageable, the wealth of postgenomic data now needs to be made dynamic. This development requires systems biology, integrating computational models for cells and organisms in health and disease; quantitative experiments (high-throughput, genome-wide, living cell, in silico); and new concepts and principles concerning interactions. This book defines the new field of systems biology and discusses the most efficient experimental and computational strategies. The benefits for industry, such as the new network-based drug-target design validation, and testing, are also presented.

Fundamentals of Systems Biology

Fundamentals of Systems Biology Book
Author : Markus W. Covert
Publisher : CRC Press
Release : 2017-10-19
ISBN : 1498728472
Language : En, Es, Fr & De

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Book Description :

For decades biology has focused on decoding cellular processes one gene at a time, but many of the most pressing biological questions, as well as diseases such as cancer and heart disease, are related to complex systems involving the interaction of hundreds, or even thousands, of gene products and other factors. How do we begin to understand this complexity? Fundamentals of Systems Biology: From Synthetic Circuits to Whole-cell Models introduces students to methods they can use to tackle complex systems head-on, carefully walking them through studies that comprise the foundation and frontier of systems biology. The first section of the book focuses on bringing students quickly up to speed with a variety of modeling methods in the context of a synthetic biological circuit. This innovative approach builds intuition about the strengths and weaknesses of each method and becomes critical in the book’s second half, where much more complicated network models are addressed—including transcriptional, signaling, metabolic, and even integrated multi-network models. The approach makes the work much more accessible to novices (undergraduates, medical students, and biologists new to mathematical modeling) while still having much to offer experienced modelers--whether their interests are microbes, organs, whole organisms, diseases, synthetic biology, or just about any field that investigates living systems.

Systems Biology

Systems Biology Book
Author : Marvin Cassman,Adam Arkin,Frank Doyle,Fumiaki Katagiri,Douglas Lauffenburger,Cynthia Stokes
Publisher : Springer Science & Business Media
Release : 2007-05-16
ISBN : 1402054688
Language : En, Es, Fr & De

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Book Description :

This book explores Systems Biology as the understanding of biological network behaviors, and in particular their dynamic aspects, which requires the utilization of mathematical modeling tightly linked to experiment. A variety of approaches are discussed here: the identification and validation of networks, the creation of appropriate datasets, the development of tools for data acquisition and software development, and the use of modeling and simulation software in close concert with experiment.

Systems Biology

Systems Biology Book
Author : Bernhard Palsson
Publisher : Unknown
Release : 2006-01-16
ISBN : 9780521859035
Language : En, Es, Fr & De

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Book Description :

The new discipline of systems biology examines how biological components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook, the first devoted to systems biology, describes how to model networks, how to determine their properties, and how to relate these to phenotypic functions. The prerequisites are some knowledge of linear algebra and biochemistry. Though the links between the mathematical ideas and biological processes are made clear, the book reflects the irreversible trend of increasing mathematical content in biology education. Therefore to assist both teacher and student, in an associated web site Palsson provides problems set, projects and powerpoint slides, and keeps the presentation in the bookconcrete with illustrative material and experimental results.

Systems Biology for Signaling Networks

Systems Biology for Signaling Networks Book
Author : Sangdun Choi
Publisher : Springer Science & Business Media
Release : 2010-08-09
ISBN : 9781441957979
Language : En, Es, Fr & De

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Book Description :

System Biology encompasses the knowledge from diverse fields such as Molecular Biology, Immunology, Genetics, Computational Biology, Mathematical Biology, etc. not only to address key questions that are not answerable by individual fields alone, but also to help in our understanding of the complexities of biological systems. Whole genome expression studies have provided us the means of studying the expression of thousands of genes under a particular condition and this technique had been widely used to find out the role of key macromolecules that are involved in biological signaling pathways. However, making sense of the underlying complexity is only possible if we interconnect various signaling pathways into human and computer readable network maps. These maps can then be used to classify and study individual components involved in a particular phenomenon. Apart from transcriptomics, several individual gene studies have resulted in adding to our knowledge of key components that are involved in a signaling pathway. It therefore becomes imperative to take into account of these studies also, while constructing our network maps to highlight the interconnectedness of the entire signaling pathways and the role of that particular individual protein in the pathway. This collection of articles will contain a collection of pioneering work done by scientists working in regulatory signaling networks and the use of large scale gene expression and omics data. The distinctive features of this book would be: Act a single source of information to understand the various components of different signaling network (roadmap of biochemical pathways, the nature of a molecule of interest in a particular pathway, etc.), Serve as a platform to highlight the key findings in this highly volatile and evolving field, and Provide answers to various techniques both related to microarray and cell signaling to the readers.