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Systems Biology In Toxicology And Environmental Health

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Systems Biology in Toxicology and Environmental Health

Systems Biology in Toxicology and Environmental Health Book
Author : Rebecca Fry
Publisher : Academic Press
Release : 2015-06-11
ISBN : 0128015683
Language : En, Es, Fr & De

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Book Description :

Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease, providing an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing environmental agent-induced diseases, and the development of computational methods to predict susceptibility to environmental agents. Introductory chapters on molecular and cellular biology, toxicology and computational biology are included as well as an assessment of systems-based tools used to evaluate environmental health risks. Further topics include research on environmental toxicants relevant to human health and disease, various high-throughput technologies and computational methods, along with descriptions of the biological pathways associated with disease and the developmental origins of disease as they relate to environmental contaminants. Systems Biology in Toxicology and Environmental Health is an essential reference for undergraduate students, graduate students, and researchers looking for an introduction in the use of systems biology approaches to assess environmental exposures and their impacts on human health. Provides the first reference of its kind, demonstrating the application of systems biology in environmental health and toxicology Includes introductions to the diverse fields of molecular and cellular biology, toxicology, and computational biology Presents a foundation that helps users understand the connections between the environment and health effects, and the biological mechanisms that link them

Environmental Toxicology

Environmental Toxicology Book
Author : Ming-Ho Yu,Humio Tsunoda,Masashi Tsunoda
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1439840393
Language : En, Es, Fr & De

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Book Description :

Human survival depends on the availability of clean air, water, and food and on the welfare of plants and animals. However, anthropogenic and naturally occurring chemicals can cause adverse effects on living organisms and ecological processes. Environmental Toxicology: Biological and Health Effects of Pollutants, Third Edition presents fundamental information on the effects of environmental toxicants on living systems. It focuses on the chemical and biological characteristics of major pollutants found in the air, water, and soil and relates them to the health and well being of humans, animals, and plants. An Indispensable Reference on Air, Soil, & Water Pollutants and Their Impact on Living Systems Surveying the environmental and health changes that have occurred in recent decades, the book discusses the sources, metabolism, and damage process of toxicants, and the environmental, biological, and nutritional factors that may influence toxicity. It looks at natural defense systems, including the mechanisms for detoxification—such as endogenous antioxidants and free radical scavenging enzymes—on a cellular level. The text examines the major toxicants: EPA criteria air pollutants, environmental fluoride, volatile organic compounds (VOCs), environmental metals and metalloids involved in soil and water pollution, and pesticides and related material such as PCBs and dioxins. It then addresses their relationship with endocrine disruption and environmental cancer. This comprehensive approach offers insight into the interaction of various chemical agents with DNA. Fully revised and expanded, the third edition of this popular book includes new and updated material as well as a new chapter on occupational toxicology. Appendices cover the process of ecological risk assessment, carcinogens, and PCB nomenclature. Based on research from more than 35 years of teaching environmental toxicology and related courses, this textbook is a useful resource for students, professionals, and researchers interested in the effects of pollutants on living systems. What’s New in This Edition A new chapter on occupational toxicology, covering indoor air quality, chemicals in the workplace, nanoparticle exposure, and more An updated chapter on environmental changes and health, including significant environmental changes that have occurred since the last edition An updated chapter on environmental cancer, including changes in death rates of respiratory cancers New material on the importance of nitrous oxide (N2O) in stratospheric ozone layer depletion An expanded discussion of environmental disasters

The Exposome

The Exposome Book
Author : Gary W Miller
Publisher : Elsevier
Release : 2013-11-16
ISBN : 0124172180
Language : En, Es, Fr & De

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Book Description :

The Exposome: A Primer is the first book dedicated to exposomics, detailing the purpose and scope of this emerging field of study, its practical applications and how it complements a broad range of disciplines. Genetic causes account for up to a third of all complex diseases. (As genomic approaches improve, this is likely to rise.) Environmental factors also influence human disease but, unlike with genetics, there is no standard or systematic way to measure the influence of environmental exposures. The exposome is an emerging concept that hopes to address this, measuring the effects of life-long environmental exposures on health and how these exposures can influence disease. This systematic introduction considers topics of managing and integrating exposome data (including maps, models, computation, and systems biology), "-omics"-based technologies, and more. Both students and scientists in disciplines including toxicology, environmental health, epidemiology, and public health will benefit from this rigorous yet readable overview.

Molecular Biological Markers for Toxicology and Risk Assessment

Molecular Biological Markers for Toxicology and Risk Assessment Book
Author : Bruce A. Fowler
Publisher : Academic Press
Release : 2016-06-10
ISBN : 0128019018
Language : En, Es, Fr & De

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Book Description :

Molecular Biological Markers for Toxicology and Risk Assessment provides an introduction to the exciting field of biomarkers and their use in toxicology and risk assessment. In recent years, new classes of molecular biomarkers capable of detecting early manifestations of ongoing chemical-induced cell injury and cell death have been developed as a result of advances in analytical chemistry, molecular biology, and computational modeling. The interplay between these emergent tools of science has resulted in new insights into initial mechanisms of chemical-induced toxicity and carcinogenicity. Molecular Biological Markers for Toxicology and Risk Assessment guides the reader through a broad range of molecular biological markers, including the "omic" biomarkers, and provides an examination of the various elements in the evolution of these modern tools. It then explores possible ways in which these markers may be applied to advance the field of chemical risk assessment. Since molecular biomarkers and related technologies are inherently complex, the book concludes with a section on risk communication in order that readers may appreciate both the strengths and limitations of molecular biological marker approaches to risk assessment practice. Introduces the use of molecular biomarkers to detect toxic effects of chemicals as early as possible Provides an accessible overview of this emerging, interdisciplinary field, to best inform decision making in chemical and pharmaceutical safety Includes a section on risk communication of these complex concepts, essential for effective risk assessment Provides new insights into the initial mechanisms of chemical-induced toxicity and carcinogenicity

Environmental Health Perspectives

Environmental Health Perspectives Book
Author : Anonim
Publisher : Unknown
Release : 2003-05
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Environmental Health Perspectives book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment

A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment Book
Author : Natàlia Garcia-Reyero,Cheryl A. Murphy
Publisher : Springer
Release : 2018-02-24
ISBN : 3319660845
Language : En, Es, Fr & De

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Book Description :

Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.

The Bah a Blanca Estuary

The Bah  a Blanca Estuary Book
Author : Sandra M. Fiori,Paula D. Pratolongo
Publisher : Springer Nature
Release : 2021-08-03
ISBN : 3030664864
Language : En, Es, Fr & De

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Book Description :

The Bahía Blanca Estuary is one of the largest coastal systems in Atlantic South America. This mesotidal estuary, situated in a sharp transition between humid subtropical and semiarid climates, has a unique combination of large interannual climatic variations. The estuarine area encompasses roughly 2300 square kilometers and is composed of wide expanses of intertidal flats, salt marshes, and emerged islands, which create intricate landscape patterns. Natural environments in the estuary sustain a high concentration of marine and terrestrial species, including endemic, threatened, and endangered fish and shorebirds. Puerto Cuatreros, in the inner zone of the estuary, hosts a permanent marine research station, whose records span more than 30 years of biophysical variables, and represent one of the largest time series of ecological data in South America. Beyond its ecological relevance, the Bahía Blanca Estuary is under increasing anthropogenic pressure from large urban settlements, industrial developments and harbors, raising the question of how to balance conservation and development. The Bahía Blanca Estuary: Ecology and Biodiversity offers a comprehensive review of life in the ecosystems of the estuary. The book is divided into five major sections, the first of which provides a description of the regional setting and covers key aspects of estuarine dynamics. The three following sections are dedicated to different habitat types and, within each section, the chapters are organized around major functional groups from pelagic and benthic environments. The fifth and final section covers issues related to management and conservation. Overall, the book provides essential and up-to-date reference material on the biodiversity and ecosystem processes of the Bahía Blanca Estuary, and will appeal to a broad international audience.

The rights and wrongs of zebrafish Behavioral phenotyping of zebrafish

The rights and wrongs of zebrafish  Behavioral phenotyping of zebrafish Book
Author : Allan V. Kalueff
Publisher : Springer
Release : 2017-02-06
ISBN : 3319337742
Language : En, Es, Fr & De

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Book Description :

Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans (~75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally). Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book “The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling” explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes. The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.

Principles of Nutrigenetics and Nutrigenomics

Principles of Nutrigenetics and Nutrigenomics Book
Author : Raffaele De Caterina,J. Alfredo Martinez,Martin Kohlmeier
Publisher : Academic Press
Release : 2019-09-22
ISBN : 0128045876
Language : En, Es, Fr & De

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Book Description :

Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields. Uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics Includes a valuable guide to ethics for genetic testing for nutritional advice Chapters include definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts Companion website includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book

Computational Toxicology

Computational Toxicology Book
Author : Bruce A. Fowler
Publisher : Academic Press
Release : 2013-06-04
ISBN : 012396508X
Language : En, Es, Fr & De

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Book Description :

Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided in this book are based on cutting-edge technologies and set out to stimulate the further development of this promising field to offer rapid, better and more cost-effective answers to major public health concerns. Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared

Understanding Toxicology

Understanding Toxicology Book
Author : Mercurio
Publisher : Jones & Bartlett Publishers
Release : 2016-08-30
ISBN : 0763771163
Language : En, Es, Fr & De

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Book Description :

While the historic view is that toxicology is the study of poisons, in fact it is just as appropriate to consider modern toxicology as a way of determining new chemotherapies for cancer, microbial diseases, parasites or fungal infections.Biological Toxicology will thoroughly prepare your students for participation in toxicology research. Through a presentation of experimental evidence, students will understand the process for designing and collecting data in biological toxicology research.In five sections, the book examines the foundations of the field, toxic reactions of cells, toxic reactions of tissues/organs, toxic reactions of ecosystems, and biological toxicants.

Electronic Waste

Electronic Waste Book
Author : Bruce A. Fowler
Publisher : Academic Press
Release : 2017-04-13
ISBN : 0128030844
Language : En, Es, Fr & De

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Book Description :

Electronic Waste: Toxicology and Public Health Issues discusses the major public health concerns due to the presence of toxic chemicals that are generated from improper recycling and disposal practices of electronic waste (e-waste). This book highlights hazardous inorganic chemicals found in e-waste, including arsenic, cadmium, lead, mercury, gallium, iridium, and nanomaterials, also focusing on health issues related to the presence of BPA, styrene, and other plastic components and combustion products, while also identifying populations at special risk. To provide readers with potential solutions to this global problem, Dr. Fowler presents risk assessment approaches using chemicals, mixtures, biomarkers, susceptibility factors, and computational toxicology. He discusses how to translate the information gathered through risk assessment into safe and effective international policies. The final chapter is devoted to future research directions. This is a timely and useful resource for all those concerned with the health issues surrounding e-waste management and proper disposal, including toxicologists, public health and policy officials, environmental scientists, and risk assessors. Offers a well-researched, single authored book and draws attention to the need for better and more informed risk assessment and policymaking in this area Emphasizes the transference of electronic waste (e-waste) to developing countries where populations of concern include children working in recycling activities and impoverished groups with poor nutritional status and limited access to medical resources Reviews, in detail, the issue of exposure to chemical mixtures as a central feature of e-waste due to the presence of a number of organic and inorganic chemicals in modern electronic devices

The Exposome

The Exposome Book
Author : Gary W. Miller
Publisher : Academic Press
Release : 2020-07-03
ISBN : 0128140798
Language : En, Es, Fr & De

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Book Description :

The Exposome: A New Paradigm for the Environment and Health, Second Edition, is a thoroughly expanded and updated edition of The Exposome: A Primer, the first book dedicated to the topic. This new release outlines the purpose and scope of this emerging field of study, its practical applications, and how it complements a broad range of disciplines. The book contains sections on -omics-based technologies, newer detection methods, managing and integrating exposome data (including maps, models, computation and systems biology), and more. Both students and scientists in toxicology, environmental health, epidemiology and public health will benefit from this rigorous, yet readable, overview. This updated edition includes a more in-depth examination of the exposome, including full references, further reading and thought questions. Addresses an emerging field that connects with other exciting disciplines Written by a single author who is a leader in the field Includes new content that widely expands on the first edition

Toxicology and Human Environments

Toxicology and Human Environments Book
Author : Ernest Hodgson
Publisher : Academic Press
Release : 2012
ISBN : 0124158137
Language : En, Es, Fr & De

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Book Description :

Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments. The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis. Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them

Proteomics and Systems Biology

Proteomics and Systems Biology Book
Author : Anonim
Publisher : Academic Press
Release : 2021-08-01
ISBN : 032385320X
Language : En, Es, Fr & De

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Book Description :

Proteomics and Systems Biology, Volume 127 in the Advances in Protein Chemistry and Structural Biology series, outlines current proteomic methodologies and discuss the challenges in future applications of systems biology in a number of biomedical/bioscience subjects. In last few decades, advances in genomics, proteomics, metabolomics, glycomics, venomics, etc., have produced vast large-scale datasets that need to be analyzed with a single main objective of understanding biological systems as a whole. Such understanding will allow us to predict and characterize the dynamic properties of biological systems. Integrates experimental and computational methods for understanding biological systems as a whole Contains timely chapters written by well-renowned authorities in their field Includes well supported content that is accompanied by a number of high-quality illustrations, figures and tables, hence it targets a wide audience of specialists, researchers and students

Sustainability Midwifery and Birth

Sustainability  Midwifery and Birth Book
Author : Lorna Davies,Rea Daellenbach,Mary Kensington
Publisher : Routledge
Release : 2020-07-29
ISBN : 1000091244
Language : En, Es, Fr & De

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Book Description :

This new edition outlines how sustainability can be incorporated into midwifery practice, education and research. It has been thoroughly revised to include new models of sustainable midwifery practice and new chapters on rural midwives and rural communities, social justice, and compassion. Environmental awareness and sustainability are vitally important concepts and, as a low environmental impact healthcare profession, midwifery has the potential to stand as a model of excellence. This international collection of experts explores the challenges, inviting readers to critically reflect on the issues and consider how they could move to effect changes within their own working environments. Divided into three parts, the book discusses: The politics of midwifery and sustainability Midwifery as a sustainable healthcare practice Supporting an ecological approach to parenting. Sustainability, Midwifery and Birth is a vital read for all midwives and midwifery students interested in sustainable practice.

Risk Assessment for Environmental Health

Risk Assessment for Environmental Health Book
Author : Mark G. Robson,William A. Toscano
Publisher : John Wiley & Sons
Release : 2007-03-22
ISBN : 9780787988593
Language : En, Es, Fr & De

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Book Description :

Written by experts in the field, this important book provides an introduction to current risk assessment practices and procedures and explores the intrinsic complexities, challenges, and controversies associated with analysis of environmental health risks. Environmental Health Risk Assessment for Public Health offers 27 substantial chapters on risk-related topics that include: What Is Risk and Why Study Risk Assessment The Risk Assessment–Risk Management Paradigm Risk Assessment and Regulatory Decision-Making in Environmental Health Toxicological Basis of Risk Assessment The Application of PBPK Modeling to Risk Assessment Probabilistic Models to Characterize Aggregate and Cumulative Risk Molecular Basis of Risk Assessment Comparative Risk Assessment Occupational Risk Radiological Risk Assessment Microbial Risk Assessment Children’s Risk Assessment Life Cycle Risk Environmental Laws and Regulations Precautionary Principles Risk Communication

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

A Comprehensive Guide to Toxicology in Nonclinical Drug Development Book
Author : Ali S. Faqi
Publisher : Academic Press
Release : 2016-11-03
ISBN : 0128036214
Language : En, Es, Fr & De

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Book Description :

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology

Artificial Intelligence Methods and Tools for Systems Biology

Artificial Intelligence Methods and Tools for Systems Biology Book
Author : W. Dubitzky,Francisco Azuaje
Publisher : Springer
Release : 2006-08-02
ISBN : 1402028652
Language : En, Es, Fr & De

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Book Description :

This book provides simultaneously a design blueprint, user guide, research agenda, and communication platform for current and future developments in artificial intelligence (AI) approaches to systems biology. It places an emphasis on the molecular dimension of life phenomena and in one chapter on anatomical and functional modeling of the brain. As design blueprint, the book is intended for scientists and other professionals tasked with developing and using AI technologies in the context of life sciences research. As a user guide, this volume addresses the requirements of researchers to gain a basic understanding of key AI methodologies for life sciences research. Its emphasis is not on an intricate mathematical treatment of the presented AI methodologies. Instead, it aims at providing the users with a clear understanding and practical know-how of the methods. As a research agenda, the book is intended for computer and life science students, teachers, researchers, and managers who want to understand the state of the art of the presented methodologies and the areas in which gaps in our knowledge demand further research and development. Our aim was to maintain the readability and accessibility of a textbook throughout the chapters, rather than compiling a mere reference manual. The book is also intended as a communication platform seeking to bride the cultural and technological gap among key systems biology disciplines. To support this function, contributors have adopted a terminology and approach that appeal to audiences from different backgrounds.

A Comprehensive Guide to Toxicology in Preclinical Drug Development

A Comprehensive Guide to Toxicology in Preclinical Drug Development Book
Author : Ali S. Faqi
Publisher : Academic Press
Release : 2012-10-18
ISBN : 0123878160
Language : En, Es, Fr & De

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Book Description :

A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide that outlines day-to-day activities and experiences in preclinical toxicology. This multi-contributed reference provides a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. The book discusses discovery toxicology and the international guidelines for safety evaluation, and presents traditional and nontraditional toxicology models. Chapters cover development of vaccines, oncology drugs, botanic drugs, monoclonal antibodies, and more, as well as study development and personnel, the role of imaging in preclinical evaluation, and supporting materials for IND applications. By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing. Chapters written by world-renowned contributors who are experts in their fields Includes the latest research in preclinical drug testing and international guidelines Covers preclinical toxicology in small molecules and biologics in one single source