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Advanced Handbook of Systemic Lupus Erythematosus

Advanced Handbook of Systemic Lupus Erythematosus Book
Author : Laurent Arnaud,Ronald van Vollenhoven
Publisher : Springer
Release : 2017-09-10
ISBN : 3319430351
Language : En, Es, Fr & De

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Book Description :

This book will provide an introduction to the epidemiology, etiology and pathogenesis of the condition while also exploring the classification, diagnosis, and current and emerging therapies for systemic lupus erythematosus. Systemic lupus erythematosus is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue. It can affect the skin, joints, kidneys, brain, and other organs. The underlying cause of the disease is not fully known, and SLE is much more common in women than in men. It may occur at any age but most often occurs in people between 10 and 50 years of age. This is the second Adis title from Ronald F van Vollenhoven, who previously authored Biologics for the Treatment of Rheumatoid Arthritis.

Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Book
Author : Robert George Lahita
Publisher : Academic Press
Release : 2011
ISBN : 9780123749949
Language : En, Es, Fr & De

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Book Description :

Systemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment is the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, anti-malarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, similar to those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well regarded reference which combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. * Highly illustrated and in full color throughout * Basic science section expanded to allow the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment * Clinical aspects and new drugs will be covered in great detail providing a useful reference to both experienced clinicians and physicians with an interest in lupus in their clinical practice

Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Book
Author : Caroline Gordon,David Isenberg
Publisher : Oxford University Press
Release : 2016-03-10
ISBN : 0191059706
Language : En, Es, Fr & De

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Book Description :

Systemic Lupus Erythematosus (often abbreviated to SLE or lupus) is a systemic autoimmune disease that can affect any part of the body, causing the immune system to attack the body's cells and tissue, and resulting in inflammation and tissue damage. This new addition to the Oxford Rheumatology Library series provides a practical approach to the assessment and management of patients with this complex, multisystem autoimmune disease to improve the diagnosis and treatment of the disease and its complications. It provides comprehensive but easy to assimilate reading for consultant rheumatologists, dermatologists, nephrologists, obstetricians and other specialists and their trainees, interested GPs, specialist nurses, and clinical trial teams both in hospitals and contract research organizations.

Systemic Lupus Erythematosus E Book

Systemic Lupus Erythematosus E Book Book
Author : George Tsokos,Caroline Gordon,Josef S. Smolen
Publisher : Elsevier Health Sciences
Release : 2007-02-23
ISBN : 0323070876
Language : En, Es, Fr & De

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Book Description :

This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find ‘one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.

Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Book
Author : George Tsokos
Publisher : Academic Press
Release : 2020-04
ISBN : 9780128145517
Language : En, Es, Fr & De

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Book Description :

This completely updated and expanded second edition of Systemic Lupus Erythematosus; Basic, Applied and Clinical Aspects includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter will be short and will be presented critically and not in an encyclopedic manner and with selected, up to 50, references which should be valuable to a wider audience. As a seasoned (not old) editor, he worked with practically all the contributors and this enables to achieve the goals of the book. This manual to SLE combines basic science with clinical science to provide a translational treatment of the disease. Systemic Lupus Erythematosus, a Manual, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries. This new edition includes new chapters on: Microbiota and lupus by Dr. Greg Silverman- a pioneer on this topic Innate immune cells and lupus Monogenic lupus And includes also new techniques and ideas that have been developed for the study of the SLE process and related conform all invariant systems like couplings with Gaussian fields and the related "geometries", measures on loops, and new perspectives on CFT. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage Discusses the latest treatment options on disease modifying or disease controlling agents Provides 'one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment

Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Book
Author : Caroline Gordon,David Isenberg
Publisher : Oxford University Press
Release : 2016-03-10
ISBN : 0198739184
Language : En, Es, Fr & De

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Book Description :

Systemic Lupus Erythematosus (often abbreviated to SLE or lupus) is a systemic autoimmune disease that can affect any part of the body, causing the immune system to attack the body's cells and tissue, and resulting in inflammation and tissue damage. This new addition to the Oxford Rheumatology Library series provides a practical approach to the assessment and management of patients with this complex, multisystem autoimmune disease to improve the diagnosis and treatment of the disease and its complications. It provides comprehensive but easy to assimilate reading for consultant rheumatologists, dermatologists, nephrologists, obstetricians and other specialists and their trainees, interested GPs, specialist nurses, and clinical trial teams both in hospitals and contract research organizations.

Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Book
Author : Josef S. Smolen,Christoph C. Zielinski
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642716423
Language : En, Es, Fr & De

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Book Description :

More than 140 years ago, lupus erythematosus (LE) was recognized as a disease entity by clinicians working in the field of dermatology, which had only recently become an independent medical discipline. Soon after cutaneous lupus was first reported, it was realized that, apart from the skin, the disease could involve other organs and thus be systemic in nature. The latter observations were first made by MORITZ KApOSI [1], whose work has attracted renewed attention re cently and who succeeded FERDINAND VON HEBRA to the chair of dermatology at the Medical Faculty in Vienna. The early description of lupus erythematosus in both its cutaneous and systemic manifes tations was thus intimately associated with Vienna and its Medical School. The next phase in the study of lupus was characterized by an in crease in knowledge of the type and extent of organ involvement. The work by OSLER [2], LIBMANN and SACKS [3], and KLEMPERER [4] best represents these advances. The increase in clinical knowledge of LE finally led to DUBOIS' famous monograph [5], which was pub lished at a time of renewed interest in SLE, elicited by the descrip tion by HARGRAVES et al. [6] of the LE-cell phenomenon. A more detailed analysis of this finding revealed that the disease was charac terized by an abnormal immune response, although its pathogenetic implications were still unclear.

Systemic Lupus Erythematosus SLE

Systemic Lupus Erythematosus  SLE  Book
Author : Syuichi Koarada
Publisher : Nova Biomedical
Release : 2013-01-01
ISBN : 9781628089905
Language : En, Es, Fr & De

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Book Description :

Systemic lupus erythematosus (SLE) is one of the prototypical systemic autoimmune diseases characterized by inflammation, immune complex deposition, and vasculitis.?Patients with SLE show various symptoms and clinical images, both constitutional and specific organ symptoms. They include the skin, joints, muscles, kidneys, lungs, nervous system, and blood vessels. Although the etiology of the disease is still unclear, genetic, hormonal, immunologic abnormalities and environmental factors complicatedly play important roles in the pathophysiology in SLE. It is evident that multiple genes show genetic susceptibility to SLE. Environmental factors of SLE and immunologic abnormalities, especially the production of a number of auto-antibody, are important features of the disease. In this book, we present recent knowledge about the prevalence, pathophysiology and prognosis of SLE. The book includes various interesting chapters: Chapter One - an illustrated overview of the prevalence and clinical symptoms of systemic lupus erythematosus; Chapter Two - the pathophysiology of systemic lupus erythematosus; Chapter Three - MBL and MBL genotypes in SLE; Chapter Four - novel biological activities of autoantibodies as the potential markers of systematic lupus erythematosus; Chapter Five - cytokines in systemic lupus erythematosus (sle) with clinical aspects and prognostics; Chapter Six - prognosis in systemic lupus erythematosus; and Chapter Seven - autoantibody-producing RP105-negative B cells in humans and a murine model of lupus erythematosus.

Lahita s Systemic Lupus Erythematosus

Lahita s Systemic Lupus Erythematosus Book
Author : Robert G. Lahita
Publisher : Academic Press
Release : 2021-07-31
ISBN : 0323914888
Language : En, Es, Fr & De

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Book Description :

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries. Completely updated, revised, and expanded with the most comprehensive and accessible reference on SLE for clinicians and scientists Full-color presentation throughout the book Provides the latest information available on diagnosis and treatment Incorporates an international panel of authors who are experts in their fields, with an emphasis on young, cutting-edge scientists and physicians

Systemic Lupus Erythematosus An Issue of Rheumatic Disease Clinics

Systemic Lupus Erythematosus  An Issue of Rheumatic Disease Clinics  Book
Author : Ellen M. Ginzler
Publisher : Elsevier Health Sciences
Release : 2014-08-19
ISBN : 032332388X
Language : En, Es, Fr & De

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Book Description :

In only the last four years, there have been dramatic changes in the understanding of the immunology, genetic/epigenetic associations, and identification of new targets for therapy in Systemic Lupus Erythematosus. The editors have enlisted a superb group of authors to present articles detailing cutting-edge advances in these areas.

Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Book
Author : Jasper Meyer
Publisher : Unknown
Release : 2019-06-20
ISBN : 9781632428523
Language : En, Es, Fr & De

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Book Description :

Systemic lupus erythematosus is a type of autoimmune disease. It is a chronic inflammatory condition in which the immune system mistakenly attacks the healthy tissues and body parts. The symptoms range from mild to severe. Fever, tiredness, painful and swollen joints, red rash on the face, mouth ulcers and swollen lymph nodes are some common symptoms. Genetic and environmental factors are believed to be its causes. Antinuclear antibody (ANA) testing, anti-extractable nuclear antigen (anti-ENA) and lupus band test are used for diagnosing it. Treatment methods include nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying antirheumatic drugs (DMARDs), immunosuppressants and intravenous immunoglobulins (IVIGs). This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of systemic lupus erythematosus. It will also provide interesting topics for research, which interested readers can take up. The extensive content of this book provides the readers with a thorough understanding of this disease.

The Clinical Management of Systemic Lupus Erythematosus

The Clinical Management of Systemic Lupus Erythematosus Book
Author : Peter H. Schur
Publisher : Lippincott Williams & Wilkins
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume is designed to provide clinicians with practical guidance on the diagnosis and management of systemic lupus erythematosus. Revised and updated to reflect diagnostic and therapeutic advances, the book offers advice on the day-to-day care of patients with the varied manifestations of this disease.

The Effect of Lifestyle on Systemic Lupus Erythematosus SLE

The Effect of Lifestyle on Systemic Lupus Erythematosus  SLE  Book
Author : Marissa Brash,Loma Linda University. School of Public Health
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Effect of Lifestyle on Systemic Lupus Erythematosus SLE book written by Marissa Brash,Loma Linda University. School of Public Health, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Systemic Lupus Erythematosus New Insights for the Healthcare Professional 2012 Edition

Systemic Lupus Erythematosus  New Insights for the Healthcare Professional  2012 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-12-10
ISBN : 1464971625
Language : En, Es, Fr & De

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Book Description :

Systemic Lupus Erythematosus: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Systemic Lupus Erythematosus. The editors have built Systemic Lupus Erythematosus: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Systemic Lupus Erythematosus in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Systemic Lupus Erythematosus: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Neuropsychiatric Systemic Lupus Erythematosus

Neuropsychiatric Systemic Lupus Erythematosus Book
Author : Shunsei Hirohata
Publisher : Springer
Release : 2018-04-03
ISBN : 3319764969
Language : En, Es, Fr & De

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Book Description :

Neuropsychiatric manifestation in systemic lupus erythematosus (NPSLE) is one of the most recalcitrant complications of the disease. According to the 1999 ACR nomenclature and case definitions, diffuse psychiatric/neuropsychological syndromes in NPSLE (anxiety disorder, acute confusional state, cognitive dysfunction, mood disorder, psychosis) (diffuse NPSLE) present psychiatric manifestations unlike neurologic syndromes (focal NPSLE) originating from focal CNS lesions, such as cerebrovascular disease, demyelinating syndrome, headache, aseptic meningitis, chorea, seizures and myelopathy. A number of studies have reported that diffuse NPSLE is usually associated with the presence of autoantibodies against neuronal cells in serum as well as in cerebrospinal fluid (CSF). Moreover, IL-6 has been shown to be elevated in CSF of patients with diffuse NPSLE. Recently, it has been demonstrated that the severity of blood-brain barrier damages plays a crucial role in the development of acute confusional state, the severest form of diffuse NPSLE through the accelerated entry of larger amounts of autoantibodies to NMDA receptor subunit NR2 into the CNS. Since the importance of autoantibodies in the NPSLE has been now evident, such an aggressive treatment, especially B cell depleting therapy, would make sense in that it would reduce the levels of pathogenic autoantibodies, leading to a better prognosis of NPSLE. As far as we know, no single book specifically dedicated to NPSLE alone has been published as yet. As mentioned above, NPSLE constitutes a vastly expanding field of research with increasing numbers of papers published annually. Therefore, we believe that an effort to collect and critically review these publications is invaluable. Such an effort will provide an important contribution to basic researchers as well as clinicians working in the field of neurology, rheumatology, psychiatry and internal medicine fields.

Outcome Measures and Metrics in Systemic Lupus Erythematosus

Outcome Measures and Metrics in Systemic Lupus Erythematosus Book
Author : Zahi Touma
Publisher : Springer Nature
Release : 2021-07-22
ISBN : 3030733033
Language : En, Es, Fr & De

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Book Description :

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that manifests with a myriad of clinical and laboratory features. The assessment of SLE is comprehensive and includes different core set domains; disease activity, damage, health-related quality of life, adverse events and economic impact. This comprehensive book is focused on the instruments and outcome measures utilized in the assessment of SLE. It targets different audiences including physicians, scientists/researchers and different health professionals interested in learning about the art of measurement in SLE. The book highlights the importance of measurement in the assessment of SLE in a clinical settings, research and clinical trials. Each of the chapters provide a systematic approach to the instruments utilized in the assessment of a specific construct in SLE (e.g., disease activity, fatigue, etc.) and incorporate a comprehensive coverage of disease specific and disease generic measures. It also discusses different patient-reported outcomes that are crucial to reflect patient perceptions of their health condition and cover constructs such as fatigue, pain, anxiety and depression, cognition, frailty, and many others.

Systemic Lupus Erythematosus

Systemic Lupus Erythematosus Book
Author : Ellen M. Ginzler
Publisher : W B Saunders Company
Release : 2010
ISBN : 9781437718690
Language : En, Es, Fr & De

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Book Description :

This issue brings the rheumatologist on the current thinking on treatment of Systemic Lupus Erythematosus, with an eye to the future. Topics covered include B cell biology and related therapies; glutamate receptor biology and its clinical significance in neuropsychiatric SLE; platelet C4d and vascular complications; biomarkers in lupus nephritis; endothelial function and its implications for cardiovascular and renal disease in SLE; changing worldwide epidemiology of SLE and its relationship to environmental, ethnic, and other sociodemographic factors; work loss, disability, quality of life, and compliance in SLE; pediatric lupus; metabolic syndrome and related endocrine abnormalities; the significance of interferon and the consequences of anti-interferon in SLE; and cutaneous lupus and the CLASI instrument.

Systemic Lupus Erythematosus Advances in Research and Treatment 2011 Edition

Systemic Lupus Erythematosus  Advances in Research and Treatment  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464945551
Language : En, Es, Fr & De

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Book Description :

Systemic Lupus Erythematosus: Advances in Research and Treatment: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Systemic Lupus Erythematosus in a compact format. The editors have built Systemic Lupus Erythematosus: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Systemic Lupus Erythematosus in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Systemic Lupus Erythematosus: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Systemic Lupus Erythematosus Advances in Research and Treatment 2012 Edition

Systemic Lupus Erythematosus   Advances in Research and Treatment  2012 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-12-26
ISBN : 1481622595
Language : En, Es, Fr & De

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Book Description :

Systemic Lupus Erythematosus—Advances in Research and Treatment: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Systemic Lupus Erythematosus in a compact format. The editors have built Systemic Lupus Erythematosus—Advances in Research and Treatment: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Systemic Lupus Erythematosus in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Systemic Lupus Erythematosus—Advances in Research and Treatment: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Systemic Lupus Erythematosus Sle

Systemic Lupus Erythematosus Sle Book
Author : Irvine Turner
Publisher : Unknown
Release : 2017-01-01
ISBN : 9781536106701
Language : En, Es, Fr & De

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Book Description :

Being diagnosed with Systemic Lupus Erythematosus (SLE) can be a severe disappointment, and life after diagnosis can be defined as an existence filled with uncertainty as to the short-and long-term impact of the disease. SLE is a chronic multi-system autoimmune disease that is persistent and recurrent and has the potential of becoming life threatening. The manifestations and severity of the disease varies between individuals. SLE can potentially influence nearly all of the bodys organ systems. In this book, Chapter One reviews, Raynauds phenomenon (RP), one of the nonspecific skin changes that occur in SLE. Chapter Two presents the debate on the causes of fatigue in SLE and factors that increase fatigue. Chapter Three reviews and illustrates the important findings of musculoskeletal diseases in SLE. Chapter Four examines SLE in young adults and reviews information about the pain, social impact, and interventions to improve functioning of these young adults.