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Systemic Drug Delivery Strategies

Systemic Drug Delivery Strategies Book
Author : Mansoor M. Amiji,Lara Scheherazade Milane
Publisher : Elsevier
Release : 2021-09-17
ISBN : 0323857817
Language : En, Es, Fr & De

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Book Description :

Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 examines the challenges of delivering immuno-oncology therapies, focusing specifically on the multiple technologies of affective drug delivery strategies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses methods of targeting tumors, CRISPR technology, and vaccine delivery among many other delivery strategies. Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Systemic Drug Delivery Strategies

Systemic Drug Delivery Strategies Book
Author : Mansoor M. Amiji,Lara Scheherazade Milane
Publisher : Academic Press
Release : 2021-08-21
ISBN : 0323909256
Language : En, Es, Fr & De

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Book Description :

Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 examines the challenges of delivering immuno-oncology therapies, focusing specifically on the multiple technologies of affective drug delivery strategies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses methods of targeting tumors, CRISPR technology, and vaccine delivery among many other delivery strategies. Systemic Drug Delivery Strategies: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, Volume 2 creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Biomaterials Based Drug Delivery Systems for Treating Spinal Cord Injury

Biomaterials Based Drug Delivery Systems for Treating Spinal Cord Injury Book
Author : Robert Shultz
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Spinal cord injury occurs when the cord is subjected to physical trauma. Because spinal cord tissue exhibits limited regenerative capacity, injuries result in significant loss of motor, sensory, and autonomic function. In the hours to weeks following initial trauma, secondary injury mechanisms are triggered, exacerbating tissue damage. Because these mechanisms occur at delayed timepoints, they can theoretically can be targeted by therapeutic interventions. Although a wide range of molecules have been shown to attenuate secondary injury mechanisms in animal models of SCI, clinical translation of these strategies has been slow, in part due to difficulty in safely and effectively achieving therapeutic concentrations of the indicated molecules in injured spinal cord tissue. Biomaterials-based drug delivery systems offer unique opportunities to safely administer drugs to the injured spinal cord while avoiding any deleterious side effects associated with systemic drug administration. In the first part of this thesis, a novel drug delivery system was developed, characterized, and optimized to target endogenous progenitor differentiation with the goal of replacing oligodendrocytes lost during SCI progression. The drug delivery system was shown to safely provide local delivery of the thyroid hormone T3, a known inducer of oligodendrocyte differentiation that cannot be safely administered systemically at therapeutic doses. Local delivery of T3 stimulated oligodendrocyte differentiation, resulting in increased numbers of newly generated oligodendrocytes and improved myelination following SCI. In the second part of this thesis, drug delivery systems were developed to target the inflammatory response following SCI. Delivery systems were based on novel drug-loaded microparticles, which were extensively characterized to reveal mechanisms of formation and drug release, and shown to provide sustained release of a synthetic PEGylated peptide as well as a small molecule drug. These strategies highlight the promise of biomaterials-based drug delivery to expand the researcher's toolkit, allowing for the use of previously infeasible drugs, and to facilitate the translation of therapeutic strategies from neuroscience laboratories to viable clinical treatments.

Targeted Delivery of Small and Macromolecular Drugs

Targeted Delivery of Small and Macromolecular Drugs Book
Author : Ajit S. Narang,Ram I. Mahato
Publisher : CRC Press
Release : 2010-05-12
ISBN : 1420087738
Language : En, Es, Fr & De

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Book Description :

Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Focusing on the delivery technologies that utilize both systemic and local rou

Focal Controlled Drug Delivery

Focal Controlled Drug Delivery Book
Author : Abraham J. Domb,Wahid Khan
Publisher : Springer Science & Business Media
Release : 2014-02-17
ISBN : 1461494346
Language : En, Es, Fr & De

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Book Description :

The concept of focal controlled drug delivery has been applied for treating illnesses that are localized to a certain tissue or organ. These delivery systems are applied directly to the diseased site and deliver a desired dose for an extended time period while minimizing systemic distribution of toxic drug. Controlled drug delivery systems have been focused on oral extended release formulations and on systemic delivery of small drugs and peptides. Despite the upsurge of interest in focal targeted drug delivery, there is currently no single reference text on the subject. By comparison, there are numerous authored and edited books on oral, systemic and transdermal drug delivery or books on biodegradable polymers as drug carriers. Thus, the aim of Focal Drug Delivery is to bring together leading experts and researchers in the field to provide an authoritative account of the essential pharmaceutical, technological, physiological and biological sciences underpinning the topic. In addition, the book will review advances in treatment options for diseases localized at a certain tissue or organ.

Drug Delivery to the Brain

Drug Delivery to the Brain Book
Author : Margareta Hammarlund-Udenaes,Elizabeth C.M. de Lange,Robert G. Thorne
Publisher : Springer Science & Business Media
Release : 2013-12-03
ISBN : 1461491053
Language : En, Es, Fr & De

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Book Description :

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. ​

Advanced Drug Delivery Systems in the Management of Cancer

Advanced Drug Delivery Systems in the Management of Cancer Book
Author : Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone
Publisher : Elsevier
Release : 2021-06-24
ISBN : 0323900798
Language : En, Es, Fr & De

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Book Description :

Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Nano and Microscale Drug Delivery Systems

Nano  and Microscale Drug Delivery Systems Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2017-03-27
ISBN : 0323527280
Language : En, Es, Fr & De

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Book Description :

Nano- and Microscale Drug Delivery Systems: Design and Fabrication presents the developments that have taken place in recent years in the field of micro- and nanoscale drug delivery systems. Particular attention is assigned to the fabrication and design of drug delivery systems in order to i) reduce the side effects of therapeutic agents, ii) increase their pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. This book is designed to offer a cogent, concise overview of current scholarship in this important area of research through its focus on the characterization and fabrication of a variety of nanomaterials for drug delivery applications. It is an invaluable reference source for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems. Shows how micro- and nanomaterials can be engineered to create more effective drug delivery systems Summarizes current nanotechnology research in the field of drug delivery systems Explores the pros and cons of using particular nanomaterials as therapeutic agents Serves as a valuable reference for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems

Novel Approaches for the Delivery of Anti HIV Drugs

Novel Approaches for the Delivery of Anti HIV Drugs Book
Author : José das Neves
Publisher : MDPI
Release : 2020-05-20
ISBN : 3039219006
Language : En, Es, Fr & De

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Book Description :

HIV/AIDS continues to be one of the most challenging individual and public health concerns of the present day. According to the UNAIDS, nearly 38 million individuals were living with the infection by the end of 2018, while 1.7 million new cases occurred during that same year. In spite of the numerous advances in the development and delivery of antiretroviral agents, both for treatment and prevention, several challenges remain. This book includes original research and review articles on innovative strategies and approaches for the formulation and delivery of anti-HIV drugs, including genetic material and other biopharmaceuticals. Different local and systemic delivery strategies are addressed based on different technologies intended for oral, transdermal, subcutaneous, vaginal, or rectal administration. Authored by eminent scientists in academia and nonprofit organizations involved in the development of antiretroviral drug products, this collection provides useful information for all those involved in HIV/AIDS treatment and prevention.

Nano Drug Delivery Strategies for the Treatment of Cancers

Nano Drug Delivery Strategies for the Treatment of Cancers Book
Author : Awesh K. Yadav,Umesh Gupta,Rajeev Sharma
Publisher : Academic Press
Release : 2020-09-03
ISBN : 0128197943
Language : En, Es, Fr & De

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Book Description :

Nano Drug Delivery Strategies for the Treatment of Cancers discusses several current and promising approaches for the diagnosis and treatment of cancer by using the most recent developments in nanomedical technologies. The book presents introductory information about the biology of different types of cancer in order to provide the reader with knowledge on their specificities. In addition, it discusses various novel drug delivery systems, detailing their functionalities, expected outcomes and future developments in the field, focusing on brain, mouth and throat, breast, lung, liver, pancreas, stomach, colon, bool, skin and prostate cancers. The book is a valuable source for cancer researchers, oncologists, pharmacologists and nanotechnologists who are interested in novel drug delivery systems and devices for treatment of various types of cancer that take advantage of recent advances in this exciting field. Discusses a wide range of promising approaches for the diagnosis and treatment of cancer using the latest advancement in cutting-edge nanomedical technologies Provides foundational information on different types of cancer and their biology to help the reader choose the best nano drug delivery system for patients Presents novel drug delivery systems based on nanoparticles, microparticles, liposomes, self-assembling Micelles and block copolymer micelles

Basic Physical Pharmacy

Basic Physical Pharmacy Book
Author : Joseph K. H. Ma,Boka Hadzija
Publisher : Jones & Bartlett Publishers
Release : 2013
ISBN : 0763757349
Language : En, Es, Fr & De

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Book Description :

Basic Physical Pharmacy provides a thorough yet accessible overview of the principles of physical pharmacy and their application in drug formulation and administration. This definitive guide to physical pharmacy covers all types of pharmaceuticals, from traditional forms and dosages to nanotechnology-based novel dosage design. Authored by two nationally recognized pharmaceutical scientists and active pharmacy faculty, Basic Physical Pharmacy is clearly organized into four sections: Physical Pharmacy in Solutions; Solid Dosage Forms; Polyphasic Systems; and Drug Delivery and Novel Drug Delivery Systems. Students can build upon their chemistry education to learn the physicochemical properties of drugs and their therapeutic effects on the body. With a highly accessible approach, Basic Physical Pharmacy will help students comprehend and apply the principles of physical pharmacy in clinical practice. Covers major drug products and delivery systems Features current trends in pharmaceutical research and development, including nanotechnology-based dosage design Includes many examples of useful equations and formulation methods Contains over 200 illustrations, photos, and tables Topics Include: Solutions Ionization of Drugs in Solutions Buffers and Buffered Solutions Drug Solubility Diffusion and Dissolution Distribution Phenomena Complexation and Protein Binding Interfacial Phenomena Rheology Colloids Suspensions and Emulsions Semisolid Dosage Forms Dermatologicals Suppositories Powders Capsules Tablets Aerosols Sterile Dosage Forms Ophthalmic Formulations Radiopharmaceuticals Modified Release Drug Delivery Systems Biotechnology Products Drug Product Stability Each new print textbook includes an access code for the online Companion Website. Ebooks do not include access to the Companion Website. Access to the Companion Website may also be purchased separately under the RESOURCES tab, FOR STUDENTS. Student Companion Website includes: Cross Words, Flash Cards, Interactive Glossary, Matching Questions Instructor Resources Answers to End of Chapter Questions Image Bank Power Point Presentations Test Bank Topics Include: Solutions Ionization of Drugs in Solutions Buffers and Buffered Solutions Drug Solubility Diffusion and Dissolution Distribution Phenomena Complexation and Protein Binding Interfacial Phenomena Rheology Colloids Suspensions and Emulsions Semisolid Dosage Forms Dermatologicals Suppositories Powders Capsules Tablets Aerosols Sterile Dosage Forms Ophthalmic Formulations Radiopharmaceuticals Modified Release Drug Delivery Systems Biotechnol

Systemic Delivery Technologies in Anti Aging Medicine Methods and Applications

Systemic Delivery Technologies in Anti Aging Medicine  Methods and Applications Book
Author : Wing-Fu Lai
Publisher : Springer Nature
Release : 2020-10-19
ISBN : 3030544907
Language : En, Es, Fr & De

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Book Description :

This book presents a multidisciplinary assessment of the state of science in the use of systemic delivery technologies to deliver anti-aging therapeutics now under development. There is a gap between basic aging research and the development of intervention technologies. This major obstacle must be overcome before biogerontological interventions can be put into clinical practice. As biogerontology comes to understand aging as a systemic degenerative process, it is clear that there is a pressing need for technologies that enable cells and tissues in a fully developed adult body to be manipulated systemically to combat aging. The authors review advances in the chemistry and engineering of systemic delivery methods and analyze the strengths and limitations of each. The book is organized into six sections. The first offers an overview of the need for systemic delivery technologies alongside the development of anti-aging therapies and describes approaches that will be required for studying the properties and efficiency of carriers for systemic delivery. Sections II, III and IV describe recent advances in a range of strategies that may enable systemic delivery to help combat aging conditions ranging from cell senescence to decline in immune function and hormonal secretion. Section V discusses practical strategies to engineer and optimize the performance of delivery technologies for applications in systemic delivery, along with their working principles. The final section discusses technical and biological barriers that must be overcome as systemic delivery technologies move from research laboratory to clinical applications aimed at tackling aging and age-associated diseases. Benefiting scholars, students and a broader audience of interested readers, the book includes helpful glossary sections in each chapter, as well as sidebars that highlight important notes, and questions for future research.

Drug Delivery to the Brain

Drug Delivery to the Brain Book
Author : Margareta Hammarlund-Udenaes,Elizabeth de Lange,Robert G. Thorne
Publisher : Springer
Release : 2013-12-17
ISBN : 9781461491040
Language : En, Es, Fr & De

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Book Description :

The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood –brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, and drug industry perspectives. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications. ​

Temperature Responsive Hydrogels and Nanoparticles for Advanced Drug Delivery

Temperature Responsive Hydrogels and Nanoparticles for Advanced Drug Delivery Book
Author : Brandon Vaughn Slaughter
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Many important therapeutic agents are associated with significant undesired side effects which often limit treatment duration and dosing. Specifically, most major classes of antitumor chemotherapeutics have deleterious effects on cell division and DNA synthesis throughout the body due to systemic biodistribution. Engineering systems for controlled drug delivery allows for improved quality of life during treatment; as well as higher localized therapeutic concentrations by isolating toxic drugs used in many diseases to specific physiological compartments. An important drug delivery strategy for controlled release of therapeutics is based on responsive polymer matrices, which undergo swelling transitions in response to environmental stimuli. Biologically relevant factors which may trigger the release of therapeutics from responsive polymers include pH, ionic strength, and temperature. Temperature responsive polymers integrated into a composite system with metal nanoparticles allow for on demand drug release via an externally-applied optical or magnetic energy source. The intent of this work was to develop a temperature-responsive drug delivery platform for controlled therapeutic release, as well to expand the toolbox for rational design of responsive hydrogel nanoparticles intended for therapeutic delivery. Temperature-responsive hydrogels were synthesized and examined in the form of nanoparticles and bulk polymer networks. These materials are based on interpenetrating polymer networks (IPNs) of polyacrylamide (PAAm) and poly(acrylic acid) (PAA), which exhibit a positive volume swelling response with respect to temperature. Since this system responds to pH, ionic strength, and temperature, these IPNs were characterized over a wide range of solution conditions. Critical synthesis parameters needed to optimize thermal responses for specific solution conditions were identified, as were the specific effects of pH and ionic strength on network swelling and stability. The reverse emulsion process used to synthesize IPN nanoparticles was characterized to determine how particle growth proceeds during preparation. To enhance biocompatibility, IPN nanoparticles were surface-modified with a corona of poly(ethylene glycol) to reduce protein adsorption, a common strategy to improve in vivo performance. Due to the large amounts of surfactants employed in the preparation of IPN nanoparticles, purification methods needed to improve safety of IPN nanoparticles were optimized, and studied in vitro to ensure cellular compatibility.

Nanoarchitectonics in Biomedicine

Nanoarchitectonics in Biomedicine Book
Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Release : 2019-03-20
ISBN : 0128172614
Language : En, Es, Fr & De

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Book Description :

Nanoarchitectonics in Biomedicine describes this new area of nanoscience that has emerged as a major branch of nanoscience. The book brings together recent applications and discusses the advantages and disadvantages of each process, offering international perspectives on the technologies based on these findings. It offers new insights for nanoarchitectonics, starting with the currently used methods of synthesis and characterization of such materials, along with their biomedical applications. Authored by a wide range of international scientists, this volume shows how nanoarchitectonics is being used to create more efficient medical treatment solutions. Users will find this to be an important research resource for those wanting to learn more on the emerging topic of nanoarchitectonics in biomedical science. Explores how design aspects, smart materials and personalized materials are used in biomedicine today Offers global perspectives on how nanoarchitectonics is used in different regions Presents an important research resource for those wanting to learn more on the emerging topic of nanoarchitectonics in biomedical science

Drug Delivery Strategies for Poorly Water Soluble Drugs

Drug Delivery Strategies for Poorly Water Soluble Drugs Book
Author : Dionysios Douroumis,Alfred Fahr
Publisher : John Wiley & Sons
Release : 2012-12-19
ISBN : 1118444671
Language : En, Es, Fr & De

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Book Description :

Many newly proposed drugs suffer from poor water solubility,thus presenting major hurdles in the design of suitableformulations for administration to patients. Consequently, thedevelopment of techniques and materials to overcome these hurdles is a major areaof research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs providesa comprehensive overview of currently used formulation strategiesfor hydrophobic drugs, including liposome formulation, cyclodextrindrug carriers, solid lipid nanoparticles, polymeric drugencapsulation delivery systems, self–microemulsifying drugdelivery systems, nanocrystals, hydrosol colloidal dispersions,microemulsions, solid dispersions, cosolvent use, dendrimers,polymer- drug conjugates, polymeric micelles, and mesoporous silicananoparticles. For each approach the book discusses the maininstrumentation, operation principles and theoretical background,with a focus on critical formulation features and clinical studies. Finally, the bookincludes some recent and novel applications, scale-upconsiderations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is anessential multidisciplinary guide to this important area of drugformulation for researchers in industry and academia working indrug delivery, polymers and biomaterials.

Brain Targeted Drug Delivery Systems

Brain Targeted Drug Delivery Systems Book
Author : Huile Gao,Xiaoling Gao
Publisher : Academic Press
Release : 2018-09-20
ISBN : 012814002X
Language : En, Es, Fr & De

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Book Description :

Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain. Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers Discusses key points in developing brain targeting drug delivery systems Summarizes and presents currently available strategies for brain targeting drug delivery Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research

Novel Trans dermal Drug Delivery Strategies

Novel  Trans dermal Drug Delivery Strategies Book
Author : Garvie-Cook Hazel
Publisher : Springer
Release : 2016-01-23
ISBN : 3319289012
Language : En, Es, Fr & De

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Book Description :

This work represents an inventive attempt to apply recent advances in nanotechnology to identify and characterise novel polymer systems for drug delivery through the skin. Atomic force microscopy (AFM) measurements of the nanoscale mechanical properties of topical, drug-containing polymeric films enabled the author to identify optimal compositions, in terms of flexibility and substantivity, for application to the skin. To elucidate the enhanced drug release from polyacrylate films incorporating medium chain triglycerides, the author combined AFM studies with the complementary technique of Raman micro-spectroscopy. This experimental strategy revealed that the significant increase in the drug released from these films is the result of a nanoscale two-phase structure. Finally, in experiments examining the microporation of skin using femtosecond laser ablation, the author demonstrated that the threshold at which the skin's barrier function is undermined can be dramatically reduced by the pre-application of ink. The approach allows thermal damage at the pore edge to be minimised, suggesting a very real potential for substantially increasing drug delivery in a minimally invasive fashion.

Pharmaceutical Dosage Forms and Drug Delivery Third Edition

Pharmaceutical Dosage Forms and Drug Delivery  Third Edition Book
Author : Ram I. Mahato,Ajit S. Narang
Publisher : CRC Press
Release : 2017-11-22
ISBN : 1482253690
Language : En, Es, Fr & De

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Book Description :

Completely revised and updated, this third edition of Pharmaceutical Dosage Forms and Drug Delivery elucidates the basic principles of pharmaceutics, biopharmaceutics, dosage form design, and drug delivery – including emerging new biotechnology-based treatment modalities. The authors integrate aspects of physical pharmacy, chemistry, biology, and biopharmaceutics into drug delivery.? This book highlights the increased attention that the recent spectacular advances in gene therapy and nanotechnology have brought to dosage form design and drug delivery. With the expiration of older patents and generic competition, the biopharmaceutical industry is evolving faster than ever. Apart from revising and updating existing chapters on the basic principles, this edition highlights the emerging emphasis on drug discovery, antibodies and antibody-drug conjugates as therapeutic moieties, individualized medicine including patient stratification strategies, targeted drug delivery, and the increasing role of modeling and simulation. Although there are numerous books on pharmaceutics and dosage forms, most cover different areas of the discipline and do not provide an integrated approach. The integrated approach of this book not only provides a singular perspective of the overall field, but also supplies a unified source of information for students, instructors and professionals, saving their time and money.

Drug Delivery Systems in Cancer Therapy

Drug Delivery Systems in Cancer Therapy Book
Author : Dennis M. Brown
Publisher : Springer Science & Business Media
Release : 2003-09-08
ISBN : 1592594271
Language : En, Es, Fr & De

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Book Description :

Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.