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Introduction to Molecular Vaccinology

Introduction to Molecular Vaccinology Book
Author : Matthias Giese
Publisher : Springer
Release : 2016-03-11
ISBN : 331925832X
Language : En, Es, Fr & De

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Book Description :

This textbook provides an easy-to-understand introduction to the complex topic of vaccine research and development. It gives a comprehensive though clearly arranged insight to the most important aspects of molecular vaccinology, leading from the basics in immunology, to design of vaccines and mode of action of vaccines to the actual formulation, manufacturing and registration of vaccines. The volume is therefore a valuable text about modern vaccinology for graduate students and a basic introduction for newcomers in vaccine design and development.

Computational Systems Biology

Computational Systems Biology Book
Author : Andres Kriete,Roland Eils
Publisher : Academic Press
Release : 2013-11-26
ISBN : 0124059384
Language : En, Es, Fr & De

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Book Description :

This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

ADME and Translational Pharmacokinetics Pharmacodynamics of Therapeutic Proteins

ADME and Translational Pharmacokinetics   Pharmacodynamics of Therapeutic Proteins Book
Author : Honghui Zhou,Frank-Peter Theil
Publisher : John Wiley & Sons
Release : 2015-10-26
ISBN : 111889880X
Language : En, Es, Fr & De

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Book Description :

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

Systems Biology

Systems Biology Book
Author : Michael G. Katze
Publisher : Springer Science & Business Media
Release : 2013-01-04
ISBN : 3642330991
Language : En, Es, Fr & De

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Book Description :

First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies—oligonucleotide microarrays, mass spectrometry, and next-generation sequencing—and the analysis of this data through sophisticated mathematical algorithms. It is perhaps the use of mathematics, to integrate abundant and diverse types of data and to generate models of interconnected molecular networks, that best characterizes systems biology.

Proceedings

Proceedings Book
Author : National Breeders' Roundtable
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Proceedings book written by National Breeders' Roundtable, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Vaccinology

Vaccinology Book
Author : W. John W. Morrow,Nadeem A. Sheikh,Clint S. Schmidt,D. Huw Davies
Publisher : John Wiley & Sons
Release : 2012-06-12
ISBN : 1118345347
Language : En, Es, Fr & De

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Book Description :

Covering all aspects of vaccine research and development in one volume, this authoritative resource takes a comprehensive and systematic approach to the science of vaccinology focusing not only on basic science, but also on the many stages required to commercialize and navigate the regulatory requirements for human application, both in the United States and Europe. Reviews in detail the process of designing a vaccine, from the initial stages of antigen discovery to human application Includes evaluation of vaccine efficacy and safety Details clinical trial design, including regulatory requirements Discusses the emerging field of active cellular immunotherapy Vaccinology: Principles and Practice provides an invaluable resource for clinicians, scientific and medical researchers, lecturers and postdoctoral fellows working in the field of vaccines.

Vaccines for Humans

Vaccines for Humans Book
Author : European Commission. Directorate-General for Health and Consumer Protection
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Recoge : Basic vaccinology - Diseases specific vaccine research - Clinical research and capacity building.

Polish Journal of Microbiology

Polish Journal of Microbiology Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Polish Journal of Microbiology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines

Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines Book
Author : Darren R. Flower,Yvonne Perrie
Publisher : Springer Science & Business Media
Release : 2012-12-09
ISBN : 1461450705
Language : En, Es, Fr & De

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Book Description :

This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.

Progress in Fish Vaccinology

Progress in Fish Vaccinology Book
Author : Paul J. Midtlyng
Publisher : S Karger Ag
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume gives a comprehensive update on recent developments in fish vaccinology and the potential and current use of vaccines in modern fish farming. Among the topics presented in 25 overview articles and original contributions are: new findings on immune mechanisms in fish and crustaceans update on bacterial and viral vaccines for farmed fish overview of adjuvant technology and mechanisms causing adverse effects bath immunisation using ultrasound, and oral vaccination methods development of recombinant, live and DNA vaccines for fish critical assessment of regulatory standards and tests immunological control of reproduction The book will be an indispensable aid and source of up-to-date information for fish health professionals, managers in the aquaculture industry, and industrial researchers working in the field of fish immunology, vaccine development and disease control worldwide.

Fish Vaccinology

Fish Vaccinology Book
Author : Roar Gudding,A. Lillehaug
Publisher : S Karger Ag
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This is the first book to give complete coverage of the field of fish vaccinology. Written by acknowledged experts from 15 different countries, the reviews in this volume not only provide the theoretical basis for the vaccination of fish, but also present a wealth of practical aspects. The main topics covered include - the immune system of fish -methods of vaccine delivery - immunization with bacterial, viral and parasite antigens - antigen production - methods of vaccine evaluation - regulatory aspects; licensing of fish vaccines in Europe and America - environmental effects - vaccination strategies Compiling the most up-to-date and comprehensive information on how to protect fish from infectious diseases, this book will become the 'Bible' of fish vaccinology. It will be of great value to veterinarians, fish biologists, fish pathologists, manufacturers of fish vaccines and anyone concerned with fish health.

Vaccinology

Vaccinology Book
Author : Alan D. T. Barrett
Publisher : John Wiley & Sons
Release : 2015-02-16
ISBN : 0470656166
Language : En, Es, Fr & De

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Book Description :

Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines. With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes. Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.

Supplement to the Official Journal of the European Communities

Supplement to the Official Journal of the European Communities Book
Author : Anonim
Publisher : Unknown
Release : 1995-12-15
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Supplement to the Official Journal of the European Communities book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Current Challenges in Vaccinology

Current Challenges in Vaccinology Book
Author : Ursula Wiedermann,Rita Carsetti,Ed C. Lavelle,Winfried F. Pickl
Publisher : Frontiers Media SA
Release : 2021-02-22
ISBN : 2889664538
Language : En, Es, Fr & De

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Book Description :

We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS).

Official Journal of the European Communities

Official Journal of the European Communities Book
Author : Anonim
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Official Journal of the European Communities book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Vaccine Adjuvants and Delivery Systems

Vaccine Adjuvants and Delivery Systems Book
Author : Manmohan Singh
Publisher : John Wiley & Sons
Release : 2007-08-03
ISBN : 9780470134924
Language : En, Es, Fr & De

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Book Description :

The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: * Provides a comprehensive overview of the rapidly evolving field and developing formulation methods * Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage * Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more * Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions * Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.

Modulation of HIV 1 Infection by Immune System Lectins

Modulation of HIV 1 Infection by Immune System Lectins Book
Author : Patrick Won-Pyo Hong
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Modulation of HIV 1 Infection by Immune System Lectins book written by Patrick Won-Pyo Hong, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biotechnological Innovations in Animal Productivity

Biotechnological Innovations in Animal Productivity Book
Author : Anonim
Publisher : Unknown
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This work is concerned with biotechnical innovations in animal productivity. It is part of a series of biotechnology texts suitable for self-study or as the basis for in-house training schemes. It includes reference questions for students, key phrases, and a summary of objectives for each chapter.

Bioinformatics for Vaccinology

Bioinformatics for Vaccinology Book
Author : Darren R. Flower
Publisher : John Wiley & Sons
Release : 2008-10-13
ISBN : 0470699825
Language : En, Es, Fr & De

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Book Description :

“... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once...” Human Vaccines, 2010 "... This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..." –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.

Innovation in Vaccinology

Innovation in Vaccinology Book
Author : Selene Baschieri
Publisher : Springer Science & Business Media
Release : 2012-07-20
ISBN : 9400745435
Language : En, Es, Fr & De

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Book Description :

Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology platforms that have been realized or are currently under development to try to address unsolved and new issues in the field of vaccine development. Common denominator of all thematic areas described herein is the multidisciplinary teamwork. Most of the enabling technologies have been established by putting in the “melting pot” expertise in fields that, at first glance, may appear very far apart. I hope that this collection of articles will make the readers aware that vaccinology is rapidly taking a new direction, ceasing to be an empirical science.