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Systems Vaccinology

Systems Vaccinology Book
Author : Anonim
Publisher : Unknown
Release : 2016
ISBN : 9789082196863
Language : En, Es, Fr & De

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Book Description :

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Vaccinology

Vaccinology Book
Author : Gregg N. Milligan,Alan D. T. Barrett
Publisher : John Wiley & Sons
Release : 2014-12-04
ISBN : 111863652X
Language : En, Es, Fr & De

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Book Description :

Vaccinology: An Essential Guide outlines in a clear,practical format the entire vaccine development process, fromconceptualization and basic immunological principles through toclinical testing and licensing of vaccines. With anoutstanding introduction to the history and practice ofvaccinology, it also guides the reader through the basic sciencerelating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economicand geographical issues that drive vaccine development and trials,it also presents vaccine delivery strategies, novel vaccineplatforms (including experimental vaccines and pathogens), antigendevelopment and selection, vaccine modelling, and the developmentof vaccines against emerging pathogens and agents of bioterror.There are also sections devoted to veterinary vaccines andassociated regulatory processes. Vaccinology: An Essential Guide is a perfect tool fordesigned for undergraduate and graduate microbiologists andimmunologists, as well as residents, fellows and trainees ofinfectious disease and vaccinology. It is also suitable for allthose involved in designing and conducting clinical vaccine trials,and is the ideal companion to the larger reference bookVaccinology: Principles and Practice.

Computational Systems Biology

Computational Systems Biology Book
Author : Helder I Nakaya
Publisher : Elsevier Inc. Chapters
Release : 2013-11-26
ISBN : 0128070161
Language : En, Es, Fr & De

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Book Description :

Download Computational Systems Biology book written by Helder I Nakaya, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Modern Vaccinology

Modern Vaccinology Book
Author : Edouard Kurstak
Publisher : Springer Science & Business Media
Release : 2013-11-11
ISBN : 1489914501
Language : En, Es, Fr & De

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Book Description :

The recent developments in modern vaccinology are mainly based on: (i) cloning of microbial genes into recombinant vectors containing genetic information for expression of desired neutralizing immunogens; (ii) alternatives of attenuated vectors with deleted genes permitting the insertion of several foreign genes expressing antigens exposed to the host immune system during the abortive replication of such vectors; (iii) combined vaccines with the aim to protect against many diseases with a limited number of administrations; (iv) evidence demonstrating the ability of animals to respond serologically to DNA injections considered as a potential method of vaccination; (v) the possibility to manipulate the immune system with new and improved immunomodulators enhancing the immune response; and (vi) new microcarrier systems for particular immunogens or immunomodulators delivery, either in a single dose or sustained release, and presentation to the immune system for a relevant response. New vaccines being developed are mainly based on viral, bacterial or other vectors modified with genetic engineering technology, to possess and express desired antigens for vaccination against single or multiple infections. Existing combined vaccines like diphtheria, tetanus, pertussis (DTP) are also experimented with new additional components like recombinant hepatitis B virus surface antigen, inactivated poliovirus, and Haemophilus inJluenzae type b immunogens, in order to produce multivalent vaccines. Such types of vaccines permitting the reduction of multiple medical visits is of particular interest to pediatric immuni zation programs, and would benefit especially the developing countries assuring better vaccine compliance with immunization schedules.

Application of Systems Vaccinology to the Veterinary Field Using a Toll like Receptor Ligand Adjuvanted Liposomal Vaccine Targeting Antigen Presenting Cells

Application of Systems Vaccinology to the Veterinary Field Using a Toll like Receptor Ligand Adjuvanted Liposomal Vaccine Targeting Antigen Presenting Cells Book
Author : Roman Othmar Braun
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Application of Systems Vaccinology to the Veterinary Field Using a Toll like Receptor Ligand Adjuvanted Liposomal Vaccine Targeting Antigen Presenting Cells book written by Roman Othmar Braun, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

What to know about VACCINOLOGY The Basic Principles New Developments An Introductory Review

What to know about VACCINOLOGY  The Basic Principles   New Developments  An Introductory Review  Book
Author : 5.70
Publisher : Dr.Hakim Saboowala
Release : 2021-12-03
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

What to know about VACCINOLOGY: The Basic Principles & New Developments. An Introductory Review. Vaccines have transformed public health, particularly since national programmes for immunization first became properly established and coordinated in the 1960s Immunization is a cornerstone of public health policy and is demonstrably highly cost-effective when used to protect child health. Although it could be argued that immunology has not thus far contributed much to vaccine development, in that most of the vaccines used today were developed and tested empirically, it is clear that there are major challenges ahead to develop new vaccines for difficult-to-target pathogens, for which scientific people urgently need a better understanding of protective immunity. Moreover, recognition of the huge potential and challenges for vaccines to control disease outbreaks and protect the older population, together with the availability of an array of new technologies, make it the perfect time for immunologists to be involved in designing the next generation of powerful immunogens. An attempt has been made in this Booklet to provide an Introductory overview of Vaccines, Immunization and related issues and thereby aiming to inform a broad Scientific audience about the underlying Immunological concepts along with plenty of relevant ILLUSTRATIONS & Tables for better understanding. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Current Challenges in Vaccinology

Current Challenges in Vaccinology Book
Author : Ursula Wiedermann,Rita Carsetti,Ed C. Lavelle,Winfried F. Pickl
Publisher : Frontiers Media SA
Release : 2021-02-22
ISBN : 2889664538
Language : En, Es, Fr & De

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Book Description :

We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS).

Avian Immunology

Avian Immunology Book
Author : Karel A. Schat,Bernd Kaspers,Pete Kaiser
Publisher : Academic Press
Release : 2012-12-02
ISBN : 0123972728
Language : En, Es, Fr & De

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Book Description :

The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research

Introduction to Molecular Vaccinology

Introduction to Molecular Vaccinology Book
Author : Matthias Giese
Publisher : Springer
Release : 2016-03-11
ISBN : 331925832X
Language : En, Es, Fr & De

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Book Description :

This textbook provides an easy-to-understand introduction to the complex topic of vaccine research and development. It gives a comprehensive though clearly arranged insight to the most important aspects of molecular vaccinology, leading from the basics in immunology, to design of vaccines and mode of action of vaccines to the actual formulation, manufacturing and registration of vaccines. The volume is therefore a valuable text about modern vaccinology for graduate students and a basic introduction for newcomers in vaccine design and development.

Handbook of Vertebrate Immunology

Handbook of Vertebrate Immunology Book
Author : Paul-Pierre Pastoret
Publisher : Academic Press
Release : 1998
ISBN : 0125464010
Language : En, Es, Fr & De

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Book Description :

This unique book provides a comprehensive and comparative guide to the immune systems of major vertebrate species, including domestic and wild animals of veterinary or medical interest, fish and amphibia. Data in this essential reference work has been compiled by world-renowned editors and an international group of authors. For each species, the information is presented in a structured 'user-friendly' format allowing easy cross reference and comparison between the various species. This book will be considered the definitive reference work on vertebrate immunology and will be essential for scientists and professionals working in Immunology, Vaccinology or with Animal Models, for students of Veterinary or Human Medicine, Biology and researchers in Comparative Medicine and Physiology. Each section, devoted to a major animal group covers: Lymphoid organs and their anatomical disposition Leukocytes and their markers Leukocyte traffic and associated molecules Cytokines T cell receptors Immunoglobulins MHC antigens Ontogeny of the immune system Passive transfer of immunity Neonatal immune responses Non-specific immunity Complement system Mucosal immunity Immunodeficiencies Tumours of the immune system Autoimmunity

Innovation in Vaccinology

Innovation in Vaccinology Book
Author : Selene Baschieri
Publisher : Springer Science & Business Media
Release : 2012-07-20
ISBN : 9400745435
Language : En, Es, Fr & De

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Book Description :

Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may raise safety concerns. The aim of this book is to provide an overview of some of the technology platforms that have been realized or are currently under development to try to address unsolved and new issues in the field of vaccine development. Common denominator of all thematic areas described herein is the multidisciplinary teamwork. Most of the enabling technologies have been established by putting in the “melting pot” expertise in fields that, at first glance, may appear very far apart. I hope that this collection of articles will make the readers aware that vaccinology is rapidly taking a new direction, ceasing to be an empirical science.

Computational Systems Biology

Computational Systems Biology Book
Author : Andres Kriete,Roland Eils
Publisher : Academic Press
Release : 2013-11-26
ISBN : 0124059384
Language : En, Es, Fr & De

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Book Description :

This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. Logical information flow aids understanding of basic building blocks of life through disease phenotypes Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

Vaccine Adjuvants and Delivery Systems

Vaccine Adjuvants and Delivery Systems Book
Author : Manmohan Singh
Publisher : John Wiley & Sons
Release : 2007-08-03
ISBN : 9780470134924
Language : En, Es, Fr & De

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Book Description :

The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: * Provides a comprehensive overview of the rapidly evolving field and developing formulation methods * Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage * Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more * Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions * Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.

Recent Advances in Precision Vaccine Discovery Development

Recent Advances in Precision Vaccine Discovery   Development Book
Author : Ofer Levy,Simon Daniel Van Haren,Scott James Tebbutt,Francesco Borriello,Jay Evans
Publisher : Frontiers Media SA
Release : 2021-11-23
ISBN : 2889716589
Language : En, Es, Fr & De

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Book Description :

Topic Editor Jay Evans is the co-founder, President and CEO of Inimmune Corporation. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

Identification of Markers and Mechanisms in Infection and Immunity

Identification of Markers and Mechanisms in Infection and Immunity Book
Author : Thomas Hagan
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Successful immune response to infection involves coordinated interactions among a myriad of cell types located across multiple tissues in the body. As a result of the highly complex nature of this biological system, many of the mechanisms involved in generating immune responses, particularly at a molecular level, remain unknown. Recent advances in high-throughput technologies, along with the development of computational tools to integrate diverse data types and build comprehensive models of biological responses, are enabling insight into these molecular mechanisms at greater depth than ever before. This dissertation details a systems biology approach to identifying reliable molecular signatures of immune response to vaccination and infection and utilizing these signatures to predict responsiveness to vaccination and improve understanding of the molecular processes underlying the immune system. Chapter 1 provides an overview of the field of systems vaccinology, which employs systems biology approaches to study vaccine response. Chapter 2 describes the development of a predictive classifier of influenza vaccine response, capable of discriminating between responders and nonresponders to vaccination through identification of distinguishing transcriptional signatures post-vaccination. In Chapter 3, the analysis of immune response to influenza vaccine is extended to examine age-associated changes in response, signatures of response longevity, and miRNA regulation of transcription post-vaccination. Chapter 4 presents an integrated transcriptional and metabolic analysis of dendritic cells, an important innate immune cell, stimulated in vitro with LPS, a bacterial endotoxin that stimulates immune responses to infection. Lastly, Chapter 5 discusses the potential impact of systems biology and predictive analysis on vaccine use and development, as well as future directions and challenges for this field.

Bioinformatics for Vaccinology

Bioinformatics for Vaccinology Book
Author : Darren R. Flower
Publisher : John Wiley & Sons
Release : 2008-10-13
ISBN : 0470699825
Language : En, Es, Fr & De

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Book Description :

“... this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once...” Human Vaccines, 2010 "... This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..." –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.

Biological DNA Sensor

Biological DNA Sensor Book
Author : Ken Ishii,Choon Kit Tang
Publisher : Academic Press
Release : 2013-10-30
ISBN : 0124051685
Language : En, Es, Fr & De

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Book Description :

Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class experts Ideal source of information for those wanting to learn about DNA sensing Provides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them

ADME and Translational Pharmacokinetics Pharmacodynamics of Therapeutic Proteins

ADME and Translational Pharmacokinetics   Pharmacodynamics of Therapeutic Proteins Book
Author : Honghui Zhou,Frank-Peter Theil
Publisher : John Wiley & Sons
Release : 2015-10-26
ISBN : 111889880X
Language : En, Es, Fr & De

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Book Description :

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs • Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines • Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan • Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

Systems Biology

Systems Biology Book
Author : Michael G. Katze
Publisher : Springer Science & Business Media
Release : 2013-01-04
ISBN : 3642330991
Language : En, Es, Fr & De

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Book Description :

First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies—oligonucleotide microarrays, mass spectrometry, and next-generation sequencing—and the analysis of this data through sophisticated mathematical algorithms. It is perhaps the use of mathematics, to integrate abundant and diverse types of data and to generate models of interconnected molecular networks, that best characterizes systems biology.

Veterinary Vaccines

Veterinary Vaccines Book
Author : Laurel J. Gershwin
Publisher : Unknown
Release : 2020
ISBN : 9781913652609
Language : En, Es, Fr & De

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Book Description :

This concise book captures the essence of current and future shifts in vaccine development research that will likely transform our understanding of methods to stimulate specific and protective immune responses to infectious diseases, and to offer improved therapeutic applications for oncology patients. The book opens with a chapter on reverse vaccinology and systems vaccinology approaches that should lead to more effective vaccines with fewer side effects. This is followed by a chapter describing recent developments in cancer immunotherapy and vaccination. Additional chapters provide updates o.