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Synuclein And The Coelacanth

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Synuclein and the Coelacanth

Synuclein and the Coelacanth Book
Author : James M. Gruschus
Publisher : Academic Press
Release : 2021-01-31
ISBN : 0323899684
Language : En, Es, Fr & De

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Book Description :

Most neurodegenerative diseases have animal parallels such as Alzheimer’s in chimpanzees, multiple sclerosis in macaques, Lou Gehrig’s disease in dogs, but nothing like Parkinson’s has ever been seen in any species but humans. Synuclein and the Coelacanth: The Molecular and Evolutionary Origins of Parkinson's Disease delves into the causes of Parkinson’s disease and how the evolution of the human brain has left us uniquely vulnerable. Genetic risk factors, environmental toxins, and neuroanatomy are woven together in a multidisciplinary discussion that ranges from subatomic physics to socioeconomics. Connections between neurodegenerative disease, neural pathways, and innate immunity are explored. Finally, the author discusses new therapeutic agents are being developed that hope to go beyond just treating the symptoms of Parkinson’s and actually halt the disease. Proposes a new hypothesis on the origins of Parkinson’s disease Examines genetic risk factors, environmental toxins, and neuroanatomy of PD Highlights new therapeutic treatment options in development for patients

Evolution of the Protein Synthesis Machinery and Its Regulation

Evolution of the Protein Synthesis Machinery and Its Regulation Book
Author : Greco Hernández,Rosemary Jagus
Publisher : Springer
Release : 2016-08-10
ISBN : 3319394681
Language : En, Es, Fr & De

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Book Description :

The “omics” era has given a new perspective to the findings on the origin and evolution of the process of translation. This book provides insight into the evolution of the translation process and machinery from a modern perspective. Written by leading experts in molecular biology, this text looks into the origins and evolution of the protein synthetic machinery.

The Networking of Chaperones by Co chaperones

The Networking of Chaperones by Co chaperones Book
Author : Gregory Lloyd Blatch,Adrienne Lesley Edkins
Publisher : Springer
Release : 2014-12-08
ISBN : 3319117319
Language : En, Es, Fr & De

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Book Description :

Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets. The book will be a resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.