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Synuclein And The Coelacanth

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Synuclein and the Coelacanth

Synuclein and the Coelacanth Book
Author : James M. Gruschus
Publisher : Academic Press
Release : 2021-02-18
ISBN : 0323857078
Language : En, Es, Fr & De

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Book Description :

Most neurodegenerative diseases have animal parallels such as Alzheimer's in chimpanzees, multiple sclerosis in macaques, Lou Gehrig's disease in dogs, but nothing like Parkinson's has ever been seen in any species but humans. Synuclein and the Coelacanth: The Molecular and Evolutionary Origins of Parkinson's Disease delves into the causes of Parkinson's disease and how the evolution of the human brain has left us uniquely vulnerable. Genetic risk factors, environmental toxins, and neuroanatomy are woven together in a multidisciplinary discussion that ranges from subatomic physics to socioeconomics. Connections between neurodegenerative disease, neural pathways, and innate immunity are explored. Finally, the author discusses new therapeutic agents are being developed that hope to go beyond just treating the symptoms of Parkinson's and actually halt the disease. Proposes a new hypothesis on the origins of Parkinson's disease Examines genetic risk factors, environmental toxins, and neuroanatomy of PD Highlights new therapeutic treatment options in development for patients

Synuclein and the Coelacanth

Synuclein and the Coelacanth Book
Author : James M. Gruschus
Publisher : Academic Press
Release : 2021-01-31
ISBN : 0323899684
Language : En, Es, Fr & De

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Book Description :

Most neurodegenerative diseases have animal parallels such as Alzheimer’s in chimpanzees, multiple sclerosis in macaques, Lou Gehrig’s disease in dogs, but nothing like Parkinson’s has ever been seen in any species but humans. Synuclein and the Coelacanth: The Molecular and Evolutionary Origins of Parkinson's Disease delves into the causes of Parkinson’s disease and how the evolution of the human brain has left us uniquely vulnerable. Genetic risk factors, environmental toxins, and neuroanatomy are woven together in a multidisciplinary discussion that ranges from subatomic physics to socioeconomics. Connections between neurodegenerative disease, neural pathways, and innate immunity are explored. Finally, the author discusses new therapeutic agents are being developed that hope to go beyond just treating the symptoms of Parkinson’s and actually halt the disease. Proposes a new hypothesis on the origins of Parkinson’s disease Examines genetic risk factors, environmental toxins, and neuroanatomy of PD Highlights new therapeutic treatment options in development for patients

Evolution of the Protein Synthesis Machinery and Its Regulation

Evolution of the Protein Synthesis Machinery and Its Regulation Book
Author : Greco Hernández,Rosemary Jagus
Publisher : Springer
Release : 2016-08-10
ISBN : 3319394681
Language : En, Es, Fr & De

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Book Description :

The “omics” era has given a new perspective to the findings on the origin and evolution of the process of translation. This book provides insight into the evolution of the translation process and machinery from a modern perspective. Written by leading experts in molecular biology, this text looks into the origins and evolution of the protein synthetic machinery.

The Networking of Chaperones by Co chaperones

The Networking of Chaperones by Co chaperones Book
Author : Gregory Lloyd Blatch,Adrienne Lesley Edkins
Publisher : Springer
Release : 2014-12-08
ISBN : 3319117319
Language : En, Es, Fr & De

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Book Description :

Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets. The book will be a resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology.

Cellular Osmolytes

Cellular Osmolytes Book
Author : Laishram Rajendrakumar Singh,Tanveer Ali Dar
Publisher : Springer
Release : 2017-05-16
ISBN : 9811037078
Language : En, Es, Fr & De

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Book Description :

This book provides essential information on improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment. The protein folding solvent environment mainly consists of salts, small molecule compounds, metabolites, molecular chaperones and other chemical species. Therefore, subtle change in the composition of the environment will alter the protein folding process. The importance of the solvent environment in protein folding is precisely due to the fact that various disease-causing proteopathies can be reversed by manipulating the solvent environment of the malfolded proteins. Hostile environmental stresses represent one of the basic causes of such challenges in protein folding or misfolding. Since cells commonly encounter extreme environmental fluctuations, it is crucial that they equip themselves with strategies to circumvent the hostile environmental conditions. Nature has developed many strategies to ensure that the complex and challenging protein folding reaction occurs with adequate efficiency and fidelity for the success of the organism. Among the strategies employed in a wide range of species and cell types is the elaboration of small organic molecules called osmolytes. Additionally, recent advances have also revealed that certain specific osmolytes might be key biomarkers of cancer, infectious diseases and vaccine flocculation. In fact, a large pool of data has been generated regarding their potential for the therapeutic intervention of neurodegenerative diseases and other metabolic disorders caused by protein aggregation or proteostasis failure. Reflecting the multiple applications of these small molecules in the health and other industries, this book combines contributions by respected leaders in the field and will help to inspire college students, basic researchers, and clinicians to translate these biological roles of osmolytes into clinical practice. It will also shed light on some important future prospects of osmolytes like their role as drug excipients and provide a deeper understanding of their mechanism of action in the prevention of neuro-degenerative diseases.

Encyclopedia of Neuroscience

Encyclopedia of Neuroscience Book
Author : Marc D. Binder,Nobutaka Hirokawa,Uwe Windhorst
Publisher : Springer
Release : 2008-10-13
ISBN : 9783540237358
Language : En, Es, Fr & De

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Book Description :

This 5000-page masterwork is literally the last word on the topic and will be an essential resource for many. Unique in its breadth and detail, this encyclopedia offers a comprehensive and highly readable guide to a complex and fast-expanding field. The five-volume reference work gathers more than 10,000 entries, including in-depth essays by internationally known experts, and short keynotes explaining essential terms and phrases. In addition, expert editors contribute detailed introductory chapters to each of 43 topic fields ranging from the fundamentals of neuroscience to fascinating developments in the new, inter-disciplinary fields of Computational Neuroscience and Neurophilosophy. Some 1,000 multi-color illustrations enhance and expand the writings.

Protein Stability

Protein Stability Book
Author : David S. Eisenberg,Christian B. Anfinsen,Frederic Middlebrook Richards
Publisher : Unknown
Release : 1995
ISBN : 9780120342464
Language : En, Es, Fr & De

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Book Description :

The topics covered by this volume include: protein destabilization at low temperatures; engineering the stability and function of Gene V Protein; free energy balance in protein folding; modelling protein stability as a heteropolymer collapse; stability of alpha helices; protein stability with T4 Lysozyme.

El Ascendente

El Ascendente Book
Author : Sam Geppi
Publisher : Unknown
Release : 2020-04-24
ISBN : 9780996848237
Language : En, Es, Fr & De

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Book Description :

Vedic Astrology book on The Ascendant in Spanish

Sensory Evolution on the Threshold

Sensory Evolution on the Threshold Book
Author : J. G. M. Thewissen,Sirpa Nummela
Publisher : Univ of California Press
Release : 2008-02-04
ISBN : 0520252780
Language : En, Es, Fr & De

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Book Description :

Ranging from crocodiles and penguins to seals and whales, this synthesis explores the function and evolution of sensory systems in animals whose ancestors lived on land. It explores the dramatic transformation of smell, taste, sight, hearing, and balance that occurred as lineages of reptiles, birds, and mammals returned to aquatic environments.

Dendritic Spines

Dendritic Spines Book
Author : Rafael Yuste
Publisher : MIT Press
Release : 2010-09-24
ISBN : 0262013509
Language : En, Es, Fr & De

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Book Description :

A leading neurobiologist explores the fundamental function of dendritic spines in neural circuits by analyzing different aspects of their biology, including structure, development, motility, and plasticity. Most neurons in the brain are covered by dendritic spines, small protrusions that arise from dendrites, covering them like leaves on a tree. But a hundred and twenty years after spines were first described by Ramón y Cajal, their function is still unclear. Dozens of different functions have been proposed, from Cajal's idea that they enhance neuronal interconnectivity to hypotheses that spines serve as plasticity machines, neuroprotective devices, or even digital logic elements. In Dendritic Spines, leading neurobiologist Rafael Yuste attempts to solve the “spine problem,” searching for the fundamental function of spines. He does this by examining many aspects of spine biology that have fascinated him over the years, including their structure, development, motility, plasticity, biophysical properties, and calcium compartmentalization. Yuste argues that we may never understand how the brain works without understanding the specific function of spines. In this book, he offers a synthesis of the information that has been gathered on spines (much of which comes from his own studies of the mammalian cortex), linking their function with the computational logic of the neuronal circuits that use them. He argues that once viewed from the circuit perspective, all the pieces of the spine puzzle fit together nicely into a single, overarching function. Yuste connects these two topics, integrating current knowledge of spines with that of key features of the circuits in which they operate. He concludes with a speculative chapter on the computational function of spines, searching for the ultimate logic of their existence in the brain and offering a proposal that is sure to stimulate discussions and drive future research.

Genetics Neurology Behavior and Diet in Parkinson s Disease

Genetics  Neurology  Behavior  and Diet in Parkinson s Disease Book
Author : Colin R. Martin,Victor R Preedy
Publisher : Academic Press
Release : 2020-08-13
ISBN : 0128159510
Language : En, Es, Fr & De

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Book Description :

Genetics, Neurology, Behavior, and Diet in Parkinson's Disease: The Neuroscience of Parkinson’s Disease, Volume 2 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about Parkinson’s disease

Genetics Neurology Behavior and Diet in Dementia

Genetics  Neurology  Behavior  and Diet in Dementia Book
Author : Colin R. Martin,Victor R Preedy
Publisher : Academic Press
Release : 2020-08-11
ISBN : 0128158697
Language : En, Es, Fr & De

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Book Description :

Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers comprehensive coverage of a broad range of topics related to dementia Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about dementia

Protein Folding in the Cell

Protein Folding in the Cell Book
Author : Anonim
Publisher : Elsevier
Release : 2002-02-20
ISBN : 0080522408
Language : En, Es, Fr & De

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Book Description :

This volume of Advances in Protein Chemistry provides a broad, yet deep look at the cellular components that assist protein folding in the cell. This area of research is relatively new--10 years ago these components were barely recognized, so this book is a particularly timely compilation of current information. Topics covered include a review of the structure and mechanism of the major chaperone components, prion formation in yeast, and the use of microarrays in studying stress response. Outlines preceding each chapter allow the reader to quickly access the subjects of greatest interest. The information presented in this book should appeal to biochemists, cell biologists, and structural biologists.

Neurotransmitter Release

Neurotransmitter Release Book
Author : Hugo J. Bellen
Publisher : Oxford University Press, USA
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Begins by providing a comprehensive introduction to the features and properties of synapses. It then describes key techniques used to study neurotransmitter release, from calcium entry to exocytosis. This is followed by chapters covering the identification and function of proteins involved in neurotransmitter release, the role of phospholipids in neurosecretion, and neurotransmitter transporter proteins. Subsequent chapters concentrate on approaches to unravel the function of specific proteins in vivo using toxins that affect neurotransmitter release, giant squit axons, C. elegans, Drosophila, and mice.

The Zebrafish in Biomedical Research

The Zebrafish in Biomedical Research Book
Author : Samuel Cartner,Judith S. Eisen,Susan F. Farmer,Karen J. Guillemin,Michael L. Kent,George E. Sanders
Publisher : Academic Press
Release : 2019-11-22
ISBN : 0128124326
Language : En, Es, Fr & De

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Book Description :

The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series

Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology Part C

Dancing Protein Clouds  Intrinsically Disordered Proteins in the Norm and Pathology  Part C Book
Author : Anonim
Publisher : Academic Press
Release : 2021-10-14
ISBN : 0323853005
Language : En, Es, Fr & De

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Book Description :

Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C, Volume 183 represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussions on the evolution of disorder, consideration of the peculiarities of phase separation of the prion protein, a general discussion of the relationships between intrinsic disorder and protein functions, coverage of the structural and functional characterization of several important intrinsically disordered proteins, such as transcription factors, outer membrane porins, trans-membrane and membrane associated proteins with ID regions, discussion of molecular simulations of IDPs, and much more. Provides recent studies on the intrinsically disordered proteins and their functions, along with the involvement of intrinsically disordered proteins in the pathogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams and tables) to help readers delve into the information provided Includes contributions from recognized experts in the field

Why Fish Don t Exist

Why Fish Don t Exist Book
Author : Lulu Miller
Publisher : Simon and Schuster
Release : 2020-04-14
ISBN : 1501160370
Language : En, Es, Fr & De

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Book Description :

A Best Book of 2020: The Washington Post * NPR * Chicago Tribune * Smithsonian A “remarkable” (Los Angeles Times), “seductive” (The Wall Street Journal) debut from the new cohost of Radiolab, Why Fish Don’t Exist is a dark and astonishing tale of love, chaos, scientific obsession, and—possibly—even murder.​ “At one point, Miller dives into the ocean into a school of fish…comes up for air, and realizes she’s in love. That’s how I felt: Her book took me to strange depths I never imagined, and I was smitten.” —The New York Times Book Review David Starr Jordan was a taxonomist, a man possessed with bringing order to the natural world. In time, he would be credited with discovering nearly a fifth of the fish known to humans in his day. But the more of the hidden blueprint of life he uncovered, the harder the universe seemed to try to thwart him. His specimen collections were demolished by lightning, by fire, and eventually by the 1906 San Francisco earthquake—which sent more than a thousand discoveries, housed in fragile glass jars, plummeting to the floor. In an instant, his life’s work was shattered. Many might have given up, given in to despair. But Jordan? He surveyed the wreckage at his feet, found the first fish that he recognized, and confidently began to rebuild his collection. And this time, he introduced one clever innovation that he believed would at last protect his work against the chaos of the world. When NPR reporter Lulu Miller first heard this anecdote in passing, she took Jordan for a fool—a cautionary tale in hubris, or denial. But as her own life slowly unraveled, she began to wonder about him. Perhaps instead he was a model for how to go on when all seemed lost. What she would unearth about his life would transform her understanding of history, morality, and the world beneath her feet. Part biography, part memoir, part scientific adventure, Why Fish Don’t Exist is a wondrous fable about how to persevere in a world where chaos will always prevail.

Lehninger Principles of Biochemistry

Lehninger Principles of Biochemistry Book
Author : Nelson David L.,Albert L. Lehninger,David L. Nelson,Michael M. Cox,Institute for Molecular Genetics David L Nelson,University Michael M Cox
Publisher : Macmillan
Release : 2005
ISBN : 9780716743392
Language : En, Es, Fr & De

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Book Description :

CD-ROM includes animations, living graphs, biochemistry in 3D structure tutorials.

Dancing protein clouds Intrinsically disordered proteins in health and disease Part A

Dancing protein clouds  Intrinsically disordered proteins in health and disease  Part A Book
Author : Anonim
Publisher : Academic Press
Release : 2019-09-11
ISBN : 0128168528
Language : En, Es, Fr & De

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Book Description :

"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field

Mechanisms of Cell Death and Approaches to Neuroprotection Disease Modification in Parkinson s Disease

Mechanisms of Cell Death and Approaches to Neuroprotection Disease Modification in Parkinson   s Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2021-11-10
ISBN : 0323899447
Language : En, Es, Fr & De

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Book Description :

Mechanisms of Cell Death and Approaches to Neuroprotection/Disease Modification in Parkinson’s Disease explores the results of numerous studies surrounding in vitro and animal model evidence that looks at the impact of a-synucleinopathy on neuronal dysfunction and behavioral impairments, (ii) how research in animal models supports the development of therapeutic strategies, and (iii) how findings in animal models might relate to the disease process in humans. In this book, the author's shed light upon the complex scenario of the mechanisms of cell death and approaches to neuroprotection/disease modification in PD, both in vitro to in vivo. Along with degeneration, the pathological hallmark of PD is the presence of intraneuronal proteinaceous cytoplasmic inclusions, named Lewy Bodies (LB) that invade the whole nervous system as the disease progresses. Several fundamental discoveries have shed light upon the implication of the a-syn protein in the pathogenesis of familial and sporadic forms of PD. Other proteins also accumulate in LB, but a-syn is a major protein component of the pathological landmarks. Updates on the latest research surrounding Mechanisms of Cell Death in Parkinson’s Disease Includes In vitro and In vivo models of synucleinopathy Presents therapeutic strategies in Parkinson’s Disease