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Synthesis of Best Seller Drugs

Synthesis of Best Seller Drugs Book
Author : Ruben Vardanyan,Victor Hruby
Publisher : Academic Press
Release : 2016-01-07
ISBN : 0124115241
Language : En, Es, Fr & De

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Book Description :

Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

Synthesis of Best Seller Drugs

Synthesis of Best Seller Drugs Book
Author : Ruben Vardanyan,Victor Hruby
Publisher : Academic Press
Release : 2016-01-16
ISBN : 9780124114920
Language : En, Es, Fr & De

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Book Description :

Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

The Art of Drug Synthesis

The Art of Drug Synthesis Book
Author : Douglas S. Johnson,Jie Jack Li
Publisher : John Wiley & Sons
Release : 2013-02-26
ISBN : 111867846X
Language : En, Es, Fr & De

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Book Description :

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

Top Drugs

Top Drugs Book
Author : John Saunders
Publisher : Unknown
Release : 2011
ISBN : 9780191848605
Language : En, Es, Fr & De

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Book Description :

Many of today's best selling drugs are first made in the chemical laboratory on a very small scale many years before they enter the market place. During the intervening period, organic chemists investigate alternative methods both to improve the overall yield of the process and to ensure that it operates safely on a manufacturing scale. This book describes how each drug works and then reviews the most efficient routes to their synthesis.

Pharmaceutical Process Chemistry for Synthesis

Pharmaceutical Process Chemistry for Synthesis Book
Author : Peter J. Harrington
Publisher : John Wiley & Sons
Release : 2011-02-23
ISBN : 9780470922866
Language : En, Es, Fr & De

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Book Description :

There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

Piperidine Based Drug Discovery

Piperidine Based Drug Discovery Book
Author : Ruben Vardanyan
Publisher : Elsevier
Release : 2017-06-12
ISBN : 0128134283
Language : En, Es, Fr & De

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Book Description :

Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. Explores this extremely important heterocycle to a high level of detail Describes synthesis methods for 70 current drugs based on Piperidine scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry Book
Author : Anonim
Publisher : Academic Press
Release : 2018-05-21
ISBN : 0128155388
Language : En, Es, Fr & De

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Book Description :

Advances in Heterocyclic Chemistry, Volume 126, is the definitive series in the field, one that is of great importance to organic chemists, polymer chemists and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature is used more frequently in explanations. Updates to this release include sections on The Literature of Heterocyclic Chemistry, Part XVI, 2016, The preparation and properties of heteroarylazulenes and hetero-fused azulenes, Recent developments in pyrazole chemistry, Yne, Ene-Yne Synthetic Approaches to Heterocycles, Appel Salt and Heterocycles: A review of Thirty Years of 4,5-Dichloro-1,2,3-dithiazolium Chloride Chemistry, and more. Written by established authorities in the field, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists Provides timely, comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding on how chemistry drives the preparation and useful properties of heterocyclic compounds

Contemporary Drug Synthesis

Contemporary Drug Synthesis Book
Author : Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth
Publisher : John Wiley & Sons
Release : 2004-12-27
ISBN : 0471686735
Language : En, Es, Fr & De

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Book Description :

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Nanotechnology Applications for Cancer Chemotherapy

Nanotechnology Applications for Cancer Chemotherapy Book
Author : Sanyog Jain,Kaisar Raza,Ashish Kumar Agrawal,Ankur Vaidya
Publisher : Elsevier
Release : 2020-09-30
ISBN : 0128178477
Language : En, Es, Fr & De

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Book Description :

Applications of Nanotechnology in Cancer Chemotherapy offers a complete and concise summary of nanotechnological interventions for cancer management. It highlights the basics of oncology, the cancer microenvironment, targets for active drug delivery, the underlying mechanisms and molecular pathways to enhance the drug delivery to the cancer site. The book discusses the principles of basic and innovative nanocarrier-based therapeutic approaches to modulate the progression of the disease. In addition, this book also explores the evolving targeting approaches specific to the cancer site and type. The scope of the book is not limited to targeted drug delivery for various cancers, but also explores the advancements in cancer imaging and diagnostics employing the nanotechnological tools. Emphasis has been given on the important evaluation techniques like in-vitro cell culture and in-vivo animal models to assess the performance of cancer nanomedicines. The book includes clinical study reports of various drug moieties explored using variety of nanoconstructs in myriad cancer conditions with the input of global market and pharmacoeconomics. Discusses how organic and inorganic nanoplatforms are being used in cancer treatment Shows how nanotechnology is being used to create new and more accurate diagnostic tools Surveys the current generation of cancer nanomedicines, assessing their advantages and challenges

Asymmetric Synthesis of Drugs and Natural Products

Asymmetric Synthesis of Drugs and Natural Products Book
Author : Ahindra Nag
Publisher : CRC Press
Release : 2018-01-12
ISBN : 1315302306
Language : En, Es, Fr & De

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Book Description :

This book focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations. It also emphasizes chiral compounds and design of new catalyst for synthesis of compounds.

An Introduction to Drug Synthesis

An Introduction to Drug Synthesis Book
Author : Graham L. Patrick
Publisher : Oxford University Press, USA
Release : 2015-01
ISBN : 0198708432
Language : En, Es, Fr & De

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Book Description :

'Introduction to Drug Synthesis' explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.

Ethnobotany

Ethnobotany Book
Author : José L. Martinez,Amner Muñoz-Acevedo,Mahendra Rai
Publisher : CRC Press
Release : 2018-12-07
ISBN : 0429841795
Language : En, Es, Fr & De

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Book Description :

Ethnobotany includes the traditional use of plants in different fields like medicine and agriculture. This book incorporates important studies based on ethnobotany of different geographic zones. The book covers medicinaland aromatic plants, ethnopharmacology, bioactive molecules, plants used in cancer, hypertension, disorders of the central nervous system, and also as antipsoriatic, antibacterial, antioxidant, antiurolithiatic. The book will be useful for a diverse group of readers including plant scientists, pharmacologists, clinicians, herbalists, natural therapy experts, chemists, microbiologists, NGOs and those who are interested in traditional therapies.

Synthesis of Heterocycles in Contemporary Medicinal Chemistry

Synthesis of Heterocycles in Contemporary Medicinal Chemistry Book
Author : Zdenko Časar
Publisher : Springer
Release : 2016-07-01
ISBN : 3319399179
Language : En, Es, Fr & De

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Book Description :

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.

Handbook of Chiral Chemicals

Handbook of Chiral Chemicals Book
Author : David Ager
Publisher : CRC Press
Release : 2005-10-21
ISBN : 1420027301
Language : En, Es, Fr & De

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Book Description :

As pharmaceutical companies look to develop single enantiomers as drug candidates, chemists are increasingly faced with the problems associated with this subclass of organic synthesis. "The Handbook of Chiral Chemicals, Second Edition" highlights the problems associated with the production of chiral compounds on a commercial scale. The handbook fir

Modern Strategies for Heterocycle Synthesis

Modern Strategies for Heterocycle Synthesis Book
Author : Gianfranco Favi
Publisher : MDPI
Release : 2021-03-17
ISBN : 3036503404
Language : En, Es, Fr & De

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Book Description :

Heterocycles feature widely in natural products, agrochemicals, pharmaceuticals and dyes, and their synthesis is of great interest to synthetic chemists in both academia and industry. The contributions of recent applications of new methodologies in C–H activation, photoredox chemistry, cross-coupling strategies, borrowing hydrogen catalysis, multicomponent and solvent-free reactions, regio- and stereoselective syntheses, as well as other new, attractive approaches for the construction of heterocyclic scaffolds are of great interest. This Special Issue is dedicated to featuring the latest research that is ongoing in the field of heterocyclic synthesis. It is expected that most submissions will focus on five- and six-membered oxygen and nitrogen-containing heterocycles, but structures incorporating other rings/heteroatoms will also be considered. Original research (communications, full papers and reviews) that discusses innovative methodologies for assembling heterocycles with potential application in materials, catalysis and medicine are therefore welcome.

Transition Metal Catalyzed Carbonylative Synthesis of Heterocycles

Transition Metal Catalyzed Carbonylative Synthesis of Heterocycles Book
Author : Xiao-Feng Wu,Matthias Beller
Publisher : Springer
Release : 2015-12-14
ISBN : 3319249630
Language : En, Es, Fr & De

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Book Description :

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.

Conservation of Plant Genes

Conservation of Plant Genes Book
Author : Gerard Meurant
Publisher : Academic Press
Release : 2012-12-02
ISBN : 0323137938
Language : En, Es, Fr & De

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Book Description :

This is the first report of the DNA Bank-Net, an organization whose goal is to encourage the conservation, collection, and preservation of plant genes. DNA banking and gene retrieval Oligonucleotides from endangered/extinct species Operation of a DNA banking facility The impact of intellectual property rights in developing countries Interim preservation of plants for DNA use Cryopreservation of fruit stocks Critical review of international conservation efforts

Enzyme Catalysis in Organic Synthesis

Enzyme Catalysis in Organic Synthesis Book
Author : Karlheinz Drauz
Publisher : John Wiley & Sons
Release : 2012
ISBN : 3527325476
Language : En, Es, Fr & De

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Book Description :

Download Enzyme Catalysis in Organic Synthesis book written by Karlheinz Drauz, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Enzymatic Reactions in Organic Media

Enzymatic Reactions in Organic Media Book
Author : Ari Koskinen,A. Klibanov
Publisher : Springer Science & Business Media
Release : 1995-12-31
ISBN : 9780751402599
Language : En, Es, Fr & De

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Book Description :

The outlook of organic synthesis has changed many times during its tractable history. The initial focus on the synthesis of substances typical of living matter, exemplified by the first examples of organic chemistry through the synthesis of urea from inorganic substances by Liebig, was accepted as the birth of organic chemistry, and thus also of organic synthesis. Although the early developments in organic synthesis closely followed the pursuit of molecules typical in nature, towards the end of the 19th century, societal pressures placed higher demands on chemical methods appropriate for the emerging age of industrialization. This led to vast amounts of information being generated through the discovery of synthetic reactions, spectroscopic techniques and reaction mechanisms. The basic organic functional group transformations were discovered and improved during the early part of this century. Reaction mechanisms were elucidated at a growing pace, and extremely powerful spectroscopic tools, such as infrared, nuclear magnetic resonance and mass spectrometry were introduced as everyday tools for a practising organic chemist. By the 1950s, many practitioners were ready to agree that almost every molecule could be syn thesized. Some difficult stereochemical problems were exceptions; for example Woodward concluded that erythromycin was a "hopelessly complex target". This frustration led to a hectic phase of development of new and increasingly more ingenious protecting group strategies and functional group transformations, and also saw the emergence of asymmetric synthesis.

Coupling and Decoupling of Diverse Molecular Units in Glycosciences

Coupling and Decoupling of Diverse Molecular Units in Glycosciences Book
Author : Zbigniew J. Witczak,Roman Bielski
Publisher : Springer
Release : 2017-11-20
ISBN : 3319655876
Language : En, Es, Fr & De

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Book Description :

This unique book covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry. Connecting molecules, often referred as bio-conjugation, has become one of the most often performed procedures in modern medicinal chemistry. Sometimes, when the connected molecules are not useful anymore, they must be disconnected. The molecules that must be connected (coupled) may belong to both small and large molecules and include such constructs as glycoproteins, glycopeptides and glycans. In this work, more than 15 experts address a comprehensive range of potential and current uses of in vitro and in vivo bio-conjugation methodologies, leading to a variety of glycoconjugates. The analytical aspects of bio-conjugation are also here discussed. Medicinal and organic chemists from graduate level onwards will understand the appeal of this important book.