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Synaptic Transmission

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Synaptic Transmission

Synaptic Transmission Book
Author : Stephen D. Meriney,Erika Fanselow
Publisher : Academic Press
Release : 2019-06-12
ISBN : 0128153210
Language : En, Es, Fr & De

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Book Description :

Synaptic Transmission is a comprehensive guide to the topic of neurotransmission that provides an in-depth discussion on many aspects of synapse structure and function—a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winning researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders. Provides a comprehensive reference on synaptic structure, physiology, function and neurotransmission Discusses many landmark experiments in the field of synaptic transmission to emphasize core principles Includes references to primary scientific literature, relevant review articles and books, many of which could be assigned as discussion material for courses focused on this topic

Mechanisms of Synaptic Transmission

Mechanisms of Synaptic Transmission Book
Author : Joseph D. Robinson
Publisher : Oxford University Press
Release : 2001-05-17
ISBN : 0198031459
Language : En, Es, Fr & De

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Book Description :

Synaptic transmission plays a central role in the nervous system as the mechanism that allows for chemical and electrical communication between cells and thus connects discrete elements into the functioning whole. This is a broad account of anatomical, biochemical, embryological, medical, pathological, pharmacological, and physiological studies on synaptic transmission during the hundred years beginning in 1890. During this century, the process of synaptic transmission came to be recognized not only as the most fundamental neurophysiological process, but also as a seat of pathological changes, and as the predominant site of action for drugs used to treat a wide range of psychiatric and neurological disorders. At the same time, research from these various disciplines was transformed into a new and unifying field, neuroscience. The course of these investigations reveals ingenious experiments, powerful new techniques, and imaginative insights. The author describes broadly who did what, when, where, and how (and, in cases where it is apparent, why) and uses experimental results and interpretations to display the evolutionary course to our current understanding of how nerve cells communicate: the basic principle of neural functioning. The book will be of interest to basic and clinical neuroscientists, pharmacologists, and physiologists, to historians and philosophers of the life sciences and medicine, and to their respective students.

Electrophysiological Analysis of Synaptic Transmission

Electrophysiological Analysis of Synaptic Transmission Book
Author : Nicholas Graziane,Yan Dong
Publisher : Unknown
Release : 2016
ISBN : 9781493932740
Language : En, Es, Fr & De

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Book Description :

Electrophysiology is one of the finest approaches capable of detecting and analyzing electrical events in the brain. However, like all other experimental approaches, it has its limitations. This book was created to serve as a guide for those endeavoring to understand the function of electrophysiology and its underlying components: neurons, neural systems, and the brain. It introduces and highlights important topics in the field of electrophysiology, while also extending these topics to practical electrophysiological approaches through the perspective of the two authors. This book is ideal for graduate students or junior postdoctoral fellows interested in starting a journey in synaptic neuroscience.

The Synapse

The Synapse Book
Author : Virginia M. Pickel,Menahem Segal
Publisher : Elsevier
Release : 2013-11-16
ISBN : 0124186823
Language : En, Es, Fr & De

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Book Description :

The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases. Part 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses. Part 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis. Part 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations. Part 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function. Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings. A comprehensive reference focused on the structure and function of the synapse Covers the links between the synapse and neural plasticity and the cellular basis of neurologic disease Detailed coverage of dendritic spines and associated perisynaptic glia—the tripartite synapse Includes in-depth coverage of synapse degeneration due to aging or hormonal decline related to severe cognitive impairment

Aspects of Synaptic Transmission

Aspects of Synaptic Transmission Book
Author : T. W. Stone
Publisher : Taylor & Francis
Release : 1991
ISBN : 9780850668285
Language : En, Es, Fr & De

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Book Description :

A collection of reviews on selected areas of synaptic transmission from neuroscientists in a number of areas of work in the nervous system and related disciplines. Five areas are covered - long-term potentiation, galanin, autonomic, opioids and 5-hydroxytryptamine.

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System Book
Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2011-07-05
ISBN : 0309212243
Language : En, Es, Fr & De

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Book Description :

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Central Cholinergic Synaptic Transmission

Central Cholinergic Synaptic Transmission Book
Author : Frotscher,Misgeld
Publisher : Birkhäuser
Release : 2013-03-07
ISBN : 3034891385
Language : En, Es, Fr & De

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Book Description :

Our knowledge of cholinergic synaptic transmission in the peripheral nervous system (PNS) has expanded enormously since the early 1930's, at which time O. Loewi discovered chemical neurotransmission through acetylcholine (ACh) and the pharmacological actions of ACh were described by H. Dale and his colleagues. Description of ACh's actions and receptors in various parts of the brain was followed by a detailed analysis of ACh's synthesis, release mechanism, removal from the synaptic cleft, modes of agonist-receptor interactions, properties of regulated conductances and of the pre-and postsynaptic modulation of cholinergic synapses. Our knowledge has been increasingly consolidat ing, leading us to the recent clarification of the structure of the periph eral nicotinic receptor-ion channel and its functional properties. It is appropriate to maintain the claim that the fundamentals of our under standing of synaptic transmission come from studies on cholinergic synapses in the PNS. Contrastingly, views held on the role of cholinergic synapses in the mammalian central nervous system (CNS) are extremely controversial, although it has been clear for some time that ACh is present in the brain. Illustrating this, no unanimous view is held on the role of nicotinic receptors in the CNS. There is one notable exception to this confusion: Studies begun by J. C. Eccles and associates in the 1960's and completed by D. R. Curtis and R. W.

Electrophysiological Analysis of Synaptic Transmission

Electrophysiological Analysis of Synaptic Transmission Book
Author : Nicholas Graziane,Yan Dong
Publisher : Springer Nature
Release : 2022-09-04
ISBN : 1071625896
Language : En, Es, Fr & De

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Book Description :

This second edition volume expands on the previous edition with discussions on the latest techniques used to study synaptic transmissions. The chapters in this book are organized into six parts. Part One looks at the basic concepts, such as extracellular and intracellular recordings, and spatiotemporal effects of synaptic currents. Part Two describes the recording of synaptic currents, such as measuring kinetics of synaptic current and measuring reversal potentials. Part Three discusses basic experimentations of synaptic transmission and covers run-up and run-down, and amplitude. Parts Four and Five cover experimentations with computational components and molecular and visual components, such as measurement of a single synapse and electrophysiological and visual tags. Part Six explores in vivo recordings and talks about general considerations for in vivo exploration of synaptic plasticity. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Authoritative and thorough, Electrophysiological Analysis of Synaptic Transmission, Second Edition is a valuable resource that introduces graduate students and postdoctoral fellows to important topics in this field and also expands these topics to practical electrophysiological approaches.

The Molecular Mechanism Behind Synaptic Transmission

The Molecular Mechanism Behind Synaptic Transmission Book
Author : Jiajie Diao,Cong Ma
Publisher : Frontiers Media SA
Release : 2020-05-05
ISBN : 2889636925
Language : En, Es, Fr & De

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Book Description :

Download The Molecular Mechanism Behind Synaptic Transmission book written by Jiajie Diao,Cong Ma, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Dynamics and Modulation of Synaptic Transmission in the Mammalian CNS

Dynamics and Modulation of Synaptic Transmission in the Mammalian CNS Book
Author : Maria Elisa Calcagnotto,Alberto A. Rasia-Filho,Idan Segev
Publisher : Frontiers Media SA
Release : 2019-06-21
ISBN : 2889458911
Language : En, Es, Fr & De

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Book Description :

Download Dynamics and Modulation of Synaptic Transmission in the Mammalian CNS book written by Maria Elisa Calcagnotto,Alberto A. Rasia-Filho,Idan Segev, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Hormones and Synapse

Hormones and Synapse Book
Author : Gerald Litwack
Publisher : Academic Press
Release : 2020-07-26
ISBN : 0128220260
Language : En, Es, Fr & De

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Book Description :

Hormones and Synapse, Volume 114 in the Vitamins and Hormones series, highlights advances in the field, with this new volume presenting timely topics, including how growth hormone promotes synaptogenesis, sex hormones and proteins involved in brain plasticity, corticotropin releasing factor modulates excitatory synaptic transmission, bisphenol a and memory: a role for dendritic spines, brain insulin resistance impairs hippocampal synaptic plasticity, estradiol induces synaptic rearrangements, stress and remodeling of hippocampal spine synapses, neurotrophin-3 modulates synaptic transmission, nongenomic neurosteroid modulation of hippocampal dendritic spines, neural sex steroids and hippocampal synaptic plasticity, origin of chemical synapses, neural sex steroids and hippocampal synaptic plasticity, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Vitamins and Hormones series Includes the latest information on Hormones and Synapse

Regulatory Mechanisms of Synaptic Transmission

Regulatory Mechanisms of Synaptic Transmission Book
Author : R. Tapia
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1468439685
Language : En, Es, Fr & De

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Book Description :

This book, which originated in the presentations of a symposium sponsored by the Universidad Nacional Autonoma de Mexico, held in Mexico City on April 14-16, 1980, represents an attempt to analyze some of the most relevant aspects of synaptic transmission. This topic was chosen on the strong belief that the progress of the neurosciences depends to a great extent on the understanding of the basic mechanisms of synaptic function. Rather than selecting only a specific approach or speciality, the book intends to cover this field in a multi disciplinary way. This means that neurochemical, neurophysiological and morphological studies are mingled throughout the book, which hopefully will help the reader to integrate the different faces of the same problem. Across the book the presynaptic component of synaptic transmission and its regulation is stressed much more than the postsynaptic phenomena. Although this might be a limitation, it has the advantage of increasing the focus of the book on a series of events which are gaining importance and interest every day.

Stress and Steroid regulation of synaptic transmission from physiology to pathophysiology

Stress and Steroid regulation of synaptic transmission  from physiology to pathophysiology Book
Author : Menahem Segal,Harmen J. Krugers,Nicola Maggio
Publisher : Frontiers E-books
Release : 2022-08-10
ISBN : 9782889191031
Language : En, Es, Fr & De

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Book Description :

Recently, several pioneering discoveries have identified new roles of stress and steroid hormones in modulating CNS functions. Specifically, glucocorticoids, mineralocorticoids, sex hormones and neurosteroids have been shown to affect synaptic receptors and ion channels and therefore regulate in a complex manner physiological processes ranging from homeostatic to cognitive functions. Likewise, in some disorders of the nervous system, steroid hormones have been shown to play different roles: either favoring or combating the disease process. In this Frontier Research Topic, we have put together leaders in the field to provide novel opinions on the effects of steroid hormones on synaptic transmission and plasticity from ion channels to pathophysiological processes. We expect critical reviews of the work that has been conducted recently in this area and enrich these discussions with the novel, exciting new findings.

Protein Dynamics and Membrane Traffic in Synaptic Transmission and Synaptic Plasticity

Protein Dynamics and Membrane Traffic in Synaptic Transmission and Synaptic Plasticity Book
Author : Cong Ma,Zhitao Hu,Wei Liu
Publisher : Frontiers Media SA
Release : 2022-02-14
ISBN : 2889743659
Language : En, Es, Fr & De

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Book Description :

Download Protein Dynamics and Membrane Traffic in Synaptic Transmission and Synaptic Plasticity book written by Cong Ma,Zhitao Hu,Wei Liu, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Jasper s Basic Mechanisms of the Epilepsies

Jasper s Basic Mechanisms of the Epilepsies Book
Author : Jeffrey Noebels,Massimo Avoli,Michael Rogawski,Richard Olsen,Antonio Delgado-Escueta
Publisher : Oxford University Press
Release : 2012-06-01
ISBN : 0199842590
Language : En, Es, Fr & De

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Book Description :

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

Neurotransmitter Release

Neurotransmitter Release Book
Author : Hugo J. Bellen
Publisher : Oxford University Press, USA
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Begins by providing a comprehensive introduction to the features and properties of synapses. It then describes key techniques used to study neurotransmitter release, from calcium entry to exocytosis. This is followed by chapters covering the identification and function of proteins involved in neurotransmitter release, the role of phospholipids in neurosecretion, and neurotransmitter transporter proteins. Subsequent chapters concentrate on approaches to unravel the function of specific proteins in vivo using toxins that affect neurotransmitter release, giant squit axons, C. elegans, Drosophila, and mice.

Basic Neurochemistry

Basic Neurochemistry Book
Author : Scott Brady,George Siegel,R. Wayne Albers,Donald Price
Publisher : Academic Press
Release : 2011-11-02
ISBN : 0080959016
Language : En, Es, Fr & De

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Book Description :

Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, the outstanding and comprehensive classic text on neurochemistry, is now newly updated and revised in its Eighth Edition. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. It is also an excellent source of current information on basic biochemical and cellular processes in brain function and neurological diseases for continuing medical education and qualifying examinations. This text continues to be the standard reference and textbook for exploring the translational nature of neuroscience, bringing basic and clinical neuroscience together in one authoritative volume. Our book title reflects the expanded attention to these links between neurochemistry and neurologic disease. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from: Intracellular trafficking; Stem cells, adult neurogenesis, regeneration; Lipid messengers; Expanded coverage of all major neurodegenerative and psychiatric disorders; Neurochemistry of addiction; Neurochemistry of pain; Neurochemistry of hearing and balance; Neurobiology of learning and memory; Sleep; Myelin structure, development, and disease; Autism; and Neuroimmunology. Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475

The Physiology of Synapses

The Physiology of Synapses Book
Author : John C. Eccles
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642649505
Language : En, Es, Fr & De

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Book Description :

I must thank my friend, Professor HANS WEBER, for being, as it were, the prime mover in causing this book to be written. He persuaded me in 1960 to contribute a review to the Ergebnisse der Physiologie. As originally planned, it was to be relatively short. However, the interest and scope of the whole subject of synapses stimulated me to write a much more comprehensive and extensive account. I was not even then satisfied, particularly as so many new and attractive investigations and ideas were being evolved during and after the writing of this review; and during the writing of this book most interesting developments are occurring in so many centres of research. Through the kind cooperation of my friends I have been given the opportunity to quote and even to illustrate from these new and fascinating developments before their final publication. There would be some justification if the author were to make the claim that this book is the fruit of a life-time of enquiry into the physiology of synapses. In 1927 the subject of Excitatory and Inhibitory Synapses was chosen for investigation in the course leading to the Oxford D. Phil. But there have been such remarkable developments during the last 12 years that in this book very little reference will be made to work earlier than 1951 except in the historical introductions.

Introduction to Cellular Biophysics Volume 2

Introduction to Cellular Biophysics  Volume 2 Book
Author : Armin Kargol
Publisher : Morgan & Claypool Publishers
Release : 2019-12-13
ISBN : 1643277561
Language : En, Es, Fr & De

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Book Description :

All living matter is comprised of cells, small compartments isolated from the environment by a cell membrane and filled with concentrated solutions of various organic and inorganic compounds. Some organisms are single-cell, where all life functions are performed by that cell. Others have groups of cells, or organs, specializing in one particular function. The survival of the entire organism depends on all of its cells and organs fulfilling their roles. While the cells are studied by different sciences, they are seen differently by biologists, chemists, or physicists. Biologists concentrate their attention on cell structure and function. What the cells consists of? Where are its organelles? What function each organelle fulfils? From a chemists’ point of view, a cell is a complex chemical reaction chamber where various molecules are synthesized or degraded. The main question is how these, sometimes very complicated chains of reactions are controlled. Finally, from a physics standpoint, some of the fundamental questions are about the physical movement of all these molecules between organelles within the cell, their exchange with the extracellular medium, as well as electrical phenomena resulting from such transport. The aim of this book is to look into the basic physical phenomena occurring in cells. These physical transport processes facilitate chemical reactions in the cell and various electrical effects, and that in turn leads to biological functions necessary for the cell to satisfy its role in the mother organism. Ultimately, the goals of every cell are to stay alive and to fulfill its function as a part of a larger organ or organism. The first volume of this book is an inventory of physical transport processes occurring in cells while this second volume provides a closer look at how complex biological and physiological cell phenomena result from these very basic physical processes.