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Synaptic Transmission

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Synaptic Transmission

Synaptic Transmission Book
Author : Stephen D. Meriney,Erika Fanselow
Publisher : Academic Press
Release : 2019-06-12
ISBN : 0128153210
Language : En, Es, Fr & De

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Book Description :

Synaptic Transmission is a comprehensive guide to the topic of neurotransmission that provides an in-depth discussion on many aspects of synapse structure and function—a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winning researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders. Provides a comprehensive reference on synaptic structure, physiology, function and neurotransmission Discusses many landmark experiments in the field of synaptic transmission to emphasize core principles Includes references to primary scientific literature, relevant review articles and books, many of which could be assigned as discussion material for courses focused on this topic

Cellular and Molecular Basis of Synaptic Transmission

Cellular and Molecular Basis of Synaptic Transmission Book
Author : Herbert Zimmermann
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 3642731724
Language : En, Es, Fr & De

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Book Description :

Major progresses in the study of the cellular and molecular basis of synaptic transmission of nerve cells are highlighted. Each individual contribution gives an overview of the subject, presenting a description of the technical approach and considering future perspectives of the developments in the field. Topics range from historical aspects of the development of biochemical studies on synaptic transmission to the most advanced techniques applicable in morphological and functional studies of the nerve terminal. Studies on synaptic vesicles, the regulation of presynaptic transmitter synthesis, transmitter-release and especially the molecular structure and function of presynaptic ion channels and of transmitter receptors offer a detailed insight into synaptic events.

Modulation of Synaptic Transmission and Plasticity in Nervous Systems

Modulation of Synaptic Transmission and Plasticity in Nervous Systems Book
Author : Georg Hertting,Hanns-Christof Spatz
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 3642731600
Language : En, Es, Fr & De

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Book Description :

This volume is based on a workshop "Modulation of Synaptic Transmission and Plasticity in Nervous Systems" held in n Ciocco, Castelvecchio, Pascoli, Italy, from September 8th to 13th, 1987. The purpose of the meeting was to bring together scientists working on plasticity in nervous systems on different levels. The contributions can be subgrouped into six fields of research: 1) Presynaptic Modulation of Chemical Neurotransmission 2) Postsynaptic Signal Transduction 3) Modulation of Synaptic Transmission and Plasticity in the Hippocampus 4) Modulation of Neuromuscular Transmission 5) Molecular and Cellular Analysis of Conditioning in Marine Snails 6) Analysis of Learning and Memory in Insects Understanding how nervous systems and in particular our brain processes and stores information has been a major challenge in science for centuries and will remain for some time to come. Not until recently neurobiologists agreed to seek plasticity of behavior primarily in the modulation of the properties of synapses between nerve cells. This is to be understood within the context provided by a neural circuitry. An important stimulus came from the work on the marine snail Aplysia, where learning processes can be described as a modulation of transmitter release, traced back to a complete chain of molecular events in an identified neuron. Learning became a topic of molecular biology. Three systems appear particularly promising for this approach: insects, in particular Drosophila, marine snails and the mammalian hippocampal tissue. Our views on neurotransmission have rapidly changed.

Regulatory Mechanisms of Synaptic Transmission

Regulatory Mechanisms of Synaptic Transmission Book
Author : R. Tapia
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1468439685
Language : En, Es, Fr & De

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Book Description :

This book, which originated in the presentations of a symposium sponsored by the Universidad Nacional Autonoma de Mexico, held in Mexico City on April 14-16, 1980, represents an attempt to analyze some of the most relevant aspects of synaptic transmission. This topic was chosen on the strong belief that the progress of the neurosciences depends to a great extent on the understanding of the basic mechanisms of synaptic function. Rather than selecting only a specific approach or speciality, the book intends to cover this field in a multi disciplinary way. This means that neurochemical, neurophysiological and morphological studies are mingled throughout the book, which hopefully will help the reader to integrate the different faces of the same problem. Across the book the presynaptic component of synaptic transmission and its regulation is stressed much more than the postsynaptic phenomena. Although this might be a limitation, it has the advantage of increasing the focus of the book on a series of events which are gaining importance and interest every day.

Central Cholinergic Synaptic Transmission

Central Cholinergic Synaptic Transmission Book
Author : Frotscher,Misgeld
Publisher : Birkhäuser
Release : 2011-09-27
ISBN : 9783034899222
Language : En, Es, Fr & De

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Book Description :

Our knowledge of cholinergic synaptic transmission in the peripheral nervous system (PNS) has expanded enormously since the early 1930's, at which time O. Loewi discovered chemical neurotransmission through acetylcholine (ACh) and the pharmacological actions of ACh were described by H. Dale and his colleagues. Description of ACh's actions and receptors in various parts of the brain was followed by a detailed analysis of ACh's synthesis, release mechanism, removal from the synaptic cleft, modes of agonist-receptor interactions, properties of regulated conductances and of the pre-and postsynaptic modulation of cholinergic synapses. Our knowledge has been increasingly consolidat ing, leading us to the recent clarification of the structure of the periph eral nicotinic receptor-ion channel and its functional properties. It is appropriate to maintain the claim that the fundamentals of our under standing of synaptic transmission come from studies on cholinergic synapses in the PNS. Contrastingly, views held on the role of cholinergic synapses in the mammalian central nervous system (CNS) are extremely controversial, although it has been clear for some time that ACh is present in the brain. Illustrating this, no unanimous view is held on the role of nicotinic receptors in the CNS. There is one notable exception to this confusion: Studies begun by J. C. Eccles and associates in the 1960's and completed by D. R. Curtis and R. W.

Central Cholinergic Synaptic Transmission

Central Cholinergic Synaptic Transmission Book
Author : Frotscher,Misgeld
Publisher : Birkhäuser
Release : 2013-03-07
ISBN : 3034891385
Language : En, Es, Fr & De

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Book Description :

Our knowledge of cholinergic synaptic transmission in the peripheral nervous system (PNS) has expanded enormously since the early 1930's, at which time O. Loewi discovered chemical neurotransmission through acetylcholine (ACh) and the pharmacological actions of ACh were described by H. Dale and his colleagues. Description of ACh's actions and receptors in various parts of the brain was followed by a detailed analysis of ACh's synthesis, release mechanism, removal from the synaptic cleft, modes of agonist-receptor interactions, properties of regulated conductances and of the pre-and postsynaptic modulation of cholinergic synapses. Our knowledge has been increasingly consolidat ing, leading us to the recent clarification of the structure of the periph eral nicotinic receptor-ion channel and its functional properties. It is appropriate to maintain the claim that the fundamentals of our under standing of synaptic transmission come from studies on cholinergic synapses in the PNS. Contrastingly, views held on the role of cholinergic synapses in the mammalian central nervous system (CNS) are extremely controversial, although it has been clear for some time that ACh is present in the brain. Illustrating this, no unanimous view is held on the role of nicotinic receptors in the CNS. There is one notable exception to this confusion: Studies begun by J. C. Eccles and associates in the 1960's and completed by D. R. Curtis and R. W.

Aspects of Synaptic Transmission

Aspects of Synaptic Transmission Book
Author : T. W. Stone
Publisher : Taylor & Francis
Release : 1991
ISBN : 9780850668285
Language : En, Es, Fr & De

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Book Description :

A collection of reviews on selected areas of synaptic transmission from neuroscientists in a number of areas of work in the nervous system and related disciplines. Five areas are covered - long-term potentiation, galanin, autonomic, opioids and 5-hydroxytryptamine.

Electrophysiological Analysis of Synaptic Transmission

Electrophysiological Analysis of Synaptic Transmission Book
Author : John I. Hubbard,Rodolfo Riascos Llinás,David M. J. Quastel
Publisher : Hodder Education
Release : 1969
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Electrophysiological Analysis of Synaptic Transmission book written by John I. Hubbard,Rodolfo Riascos Llinás,David M. J. Quastel, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Sensory Hair Cells

Sensory Hair Cells Book
Author : Georgij N. Akoev,Yurij N. Andrianov
Publisher : Springer
Release : 2011-11-22
ISBN : 9783642779213
Language : En, Es, Fr & De

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Book Description :

This monograph summarizes the results of the authors' own in vestigations as well as relevant literature data about the mechanism of synaptic transmission in sensory hair cells of the acousticolater al system. It deals mainly with primary processes in hair cells. Ad ditionally, data on the properties and selectivity of various ionic channels are presented, with data concerning the mechanism of release of the neurotransmitter from the hair cell and the proper ties of postsynaptic responses of afferent fibres. The role of ex citatory amino acids in synaptic transmission is analyzed. This book gives a comprehensive overview of current research on synaptic transmission in sensory hair cells, which should be valuable to both those in the field and neuroscientists of various disciplines. St. Petersburg, January 1993 G.N. Akoev G. N. Andrianov Table of Contents Introduction ...................................... . Chapter 1 Anatomy of the Mecha- and Electroreceptors of the Acousticolateral System 3 1.1 The Organ of Corti ............................ 3 1.2 Semicircular Canals ............................ 8 1.3 The Otolith Organs ............................ 11 1.4 Lateral-Line Organs ............................ 15 1.5 Electroreceptors ............................... 20 1.5.1 Ampullary Receptors ........................... 21 1.5.2 Tuberous Receptors ............................ 26 Chapter 2 Electrophysiological Analysis of Synaptic lhlnsmission in Hair Cells ................ 33 2.1 Electrical Characteristics of Hair Cells.

Drugs and Central Synaptic Transmission

Drugs and Central Synaptic Transmission Book
Author : Anonim
Publisher : Macmillan International Higher Education
Release : 1976-06-18
ISBN : 1349012475
Language : En, Es, Fr & De

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Book Description :

Download Drugs and Central Synaptic Transmission book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Dynamics and Modulation of Synaptic Transmission in the Mammalian CNS

Dynamics and Modulation of Synaptic Transmission in the Mammalian CNS Book
Author : Maria Elisa Calcagnotto,Alberto A. Rasia-Filho,Idan Segev
Publisher : Frontiers Media SA
Release : 2019-06-21
ISBN : 2889458911
Language : En, Es, Fr & De

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Book Description :

Download Dynamics and Modulation of Synaptic Transmission in the Mammalian CNS book written by Maria Elisa Calcagnotto,Alberto A. Rasia-Filho,Idan Segev, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Electrophysiological Analysis of Synaptic Transmission

Electrophysiological Analysis of Synaptic Transmission Book
Author : John I. Hubbard,Rodolfo Riascos Llinás,David M. J. Quastel
Publisher : Unknown
Release : 1969
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Electrophysiological Analysis of Synaptic Transmission book written by John I. Hubbard,Rodolfo Riascos Llinás,David M. J. Quastel, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

An Integrated Model for Calcium Dynamics During Synaptic Transmission

An Integrated Model for Calcium Dynamics During Synaptic Transmission Book
Author : Gabriel Ruben Soto
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download An Integrated Model for Calcium Dynamics During Synaptic Transmission book written by Gabriel Ruben Soto, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Diabetes induced Depression of Synaptic Transmission in Autonomic Ganglia and in Adrenal Medulla

Diabetes induced Depression of Synaptic Transmission in Autonomic Ganglia and in Adrenal Medulla Book
Author : Alona Rudchenko
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Synapses in the autonomic ganglia form a vital link between the activity of the central nervous system and the peripheral tissues. The fast neurotransmission in these autonomic synapses is mediated by the postsynaptic nicotinic acetylcholine receptors (nAChRs) and is remarkably robust, producing suprathreshold excitatory postsynaptic potentials. However, in diabetes, the sympathetic synaptic transmission becomes depressed when hyperglycemia elevates reactive oxygen species (ROS) and ROS inactivate the postsynaptic nAChRs containing the [alpha]3 subunit. Because dysautonomias result from such synaptic depression, the important questions are whether the synaptic depression happens in all 3 branches of the autonomic nervous system - the sympathetic, the parasympathetic, and the adrenal medulla, and whether it is possible to reverse this autonomic synaptic depression, or prevent it in diabetes. To address these questions, I studied sympathetic and parasympathetic ganglia and the adrenal medulla using intracellular recordings of synaptic transmission and whole-cell patch clamp combined with imaging of ROS in primary neuronal cultures and in the intact ganglia. I hypothesized the following. 1) Autonomic ganglia will develop depressed synaptic transmission in diabetes provided that postsynaptic nAChRs are [alpha]3-containing and intracellular ROS become elevated. 2) If ROS are lowered in diabetes in vivo by reversing hyperglycemia with insulin, the nAChR function would recover in the neurons and synaptic transmission would recover in vivo. 3) If ROS in autonomic neurons are decreased in a mutant mouse strain with improved ROS detoxification, synaptic depression will not develop. To find out whether [alpha]3 subunit-containing nAChRs mediate synaptic transmission in different autonomic ganglia and the adrenal medulla, I used mice with a deletion in the [alpha]3 gene. To study the effects of diabetes, I induced hyperglycemia by destroying pancreatic [beta] cells in mice with streptozotocin injections, as well as a genetic mouse model of diabetes, Akita mouse, which has a mutation in the insulin 2 gene. To reverse hyperglycemia, I implanted insulin pellets in diabetic mice. To test the effects of lowered ROS levels, I used the mutant mouse strain WLDs, the strain which previously showed improved detoxification of intracellular ROS in peripheral neurons. My results demonstrated that in all autonomic ganglia studied and in the adrenal medulla, EPSPs were mediated almost entirely by [alpha]3-containing nAChRs. Only in the parasympathetic ganglion, about 10% of the postsynaptic response on average was mediated by [alpha]7-containing nAChRs. During hyperglycemia, ROS became elevated and the postsynaptic nAChRs were inactivated in the sympathetic neurons and the adrenal gland, depressing the synaptic transmission. However, parasympathetic synaptic transmission remained normal in diabetes and the neurons were resistant to elevation in ROS. The studies on the nAChR recovery after inactivation in cultured neurons showed that the function of the receptor returns within 24-48 hours, and may not require new protein synthesis. In vivo, reversing hyperglycemia with insulin restored the synaptic transmission fully after short diabetes duration (2 weeks), but only partially after longer diabetes durations. When the effects of lowered ROS in diabetes were explored in WLDs mouse strain, remarkably, normal synaptic transmission was maintained despite 2 months of hyperglycemia in these mice. Together, these results reveal that 1) although [alpha]3-containing nAChRs underlie most of the sympathetic and parasympathetic synaptic transmission, the 2 autonomic branches differ in vulnerability to diabetes; 2) reversing the synaptic depression is possible by correcting hyperglycemia with insulin, although a critical period exists for the full recovery to happen, and 3) if ROS detoxification can be improved, as may happen in the WLDs mouse strain, the synaptic depression can be prevented in diabetes." --

The Molecular Mechanism Behind Synaptic Transmission

The Molecular Mechanism Behind Synaptic Transmission Book
Author : Jiajie Diao,Cong Ma
Publisher : Frontiers Media SA
Release : 2020-05-05
ISBN : 2889636925
Language : En, Es, Fr & De

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Book Description :

Download The Molecular Mechanism Behind Synaptic Transmission book written by Jiajie Diao,Cong Ma, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Stress and Steroid regulation of synaptic transmission from physiology to pathophysiology

Stress and Steroid regulation of synaptic transmission  from physiology to pathophysiology Book
Author : Menahem Segal,Harmen J. Krugers,Nicola Maggio
Publisher : Frontiers E-books
Release : 2021-09-25
ISBN : 9782889191031
Language : En, Es, Fr & De

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Book Description :

Recently, several pioneering discoveries have identified new roles of stress and steroid hormones in modulating CNS functions. Specifically, glucocorticoids, mineralocorticoids, sex hormones and neurosteroids have been shown to affect synaptic receptors and ion channels and therefore regulate in a complex manner physiological processes ranging from homeostatic to cognitive functions. Likewise, in some disorders of the nervous system, steroid hormones have been shown to play different roles: either favoring or combating the disease process. In this Frontier Research Topic, we have put together leaders in the field to provide novel opinions on the effects of steroid hormones on synaptic transmission and plasticity from ion channels to pathophysiological processes. We expect critical reviews of the work that has been conducted recently in this area and enrich these discussions with the novel, exciting new findings.

An Interplay Between Glutamate Uptake and Release Controls the Synaptic Transmission at the Photoreceptor Terminal

An Interplay Between Glutamate Uptake and Release Controls the Synaptic Transmission at the Photoreceptor Terminal Book
Author : Lubor Gaal
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download An Interplay Between Glutamate Uptake and Release Controls the Synaptic Transmission at the Photoreceptor Terminal book written by Lubor Gaal, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Synaptic Transmission and Neuronal Interaction

Synaptic Transmission and Neuronal Interaction Book
Author : Michael Vander Laan Bennett
Publisher : Unknown
Release : 1974
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Synaptic Transmission and Neuronal Interaction book written by Michael Vander Laan Bennett, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Developmental Ortho substituted Polychlorinated Biphenyls Exposure Alters Synaptic Transmission and Seizure Susceptibility

Developmental Ortho substituted Polychlorinated Biphenyls Exposure Alters Synaptic Transmission and Seizure Susceptibility Book
Author : Kyung Ho Kim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Developmental Ortho substituted Polychlorinated Biphenyls Exposure Alters Synaptic Transmission and Seizure Susceptibility book written by Kyung Ho Kim, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.