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Successes And Challenges Of Nk Immunotherapy

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Successes and Challenges of NK Immunotherapy

Successes and Challenges of NK Immunotherapy Book
Author : Benjamin Bonavida,Anahid Jewett
Publisher : Academic Press
Release : 2021-03-15
ISBN : 9780128243756
Language : En, Es, Fr & De

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Book Description :

Successes and Challenges of NK Immunotherapy: Increasing Anti-tumor Efficacy describes the very novel and unique therapeutic applications of NK cells to fight cancers and, primarily, eliminate both the bulk and the subset of cancer stem cells responsible for metastasis, relapse and recurrences. It provides up to date information on the development, engineering, mechanisms of action, response to various preclinical models, and current applications in various clinical trials. The book covers the state of the art on the development of highly engineered cytotoxic NK cells, their mechanisms of action, preclinical and clinical applications, the development and application of CAR-NK cells, as well as new NK-drug conjugates in order to potentiate their anti-tumor activities. In addition, the book emphasizes that, unlike other immunotherapeutic approaches, the activated NK cells can also target and kill the highly resistant cancer stem cells that are responsible for the relapses and recurrences by all other therapeutic treatments. Written by the leading experts on NK immunotherapy worldwide, this is a valuable resource for researchers, clinicians, and members of biomedical field who are interested in understanding novel and efficient therapies to fight cancers. Discusses the unique developmental application of NK immunotherapy against cancers, which differs greatly from other types of immunotherapies Provides up-to-date and highly relevant information through chapters written by the leading researchers in the field Presents a significant number of schematic diagrams for easy understanding and reproducibility

NK Cells in Cancer Immunotherapy Successes and Challenges

NK Cells in Cancer Immunotherapy  Successes and Challenges Book
Author : Anahid Jewett
Publisher : Academic Press
Release : 2021-03-15
ISBN : 9780128226209
Language : En, Es, Fr & De

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Book Description :

NK cells in cancer immunotherapy: Successes and Challenges explains the latest immunotherapeutic strategies focusing on NK cells to allow the best and precise combination treatment to be offered to cancer patients. It provides existing background knowledge in the field of immunotherapy and discusses the future areas of research required to carry out cutting edge validated therapies for patients. Immunotherapy is fast becoming the method of choice for cancer therapy. Although remarkable advances have been made in the field of immunotherapy, there are significant challenges and difficulties ahead since many of the current immunotherapeutic strategies do not provide long-lasting treatment strategies, and therefore are not very effective. This book provides recent advances in the immunotherapeutic strategies, in particular the use of NK cells with and without T cell therapy in the treatment of cancer and discusses the problems and challenges that are facing the field and the practitioners. The book is a valuable resource for cancer researchers, oncologists, graduate students and several members of biomedical field who are interested in learning more about novel strategies to treat cancer patients. Covers CAR/T and CAR/NK and adoptive NK cell therapy with and without T cell therapies Discusses basic biology of NK cells and mouse models of human cancers, and the role of NK cells in metastatic cancer and in cancer stem cells Encompasses information on combination therapies using check point inhibition, adoptive transfer of cytotoxic effector cells, chemotherapeutic drugs and activating and inhibitory antibodies

HIV and Cancer Immunotherapy Similar Challenges and Converging Approaches

HIV and Cancer Immunotherapy  Similar Challenges and Converging Approaches Book
Author : Mirko Paiardini,Rafi Ahmed,Steven Grant Deeks,Kavita M. Dhodapkar
Publisher : Frontiers Media SA
Release : 2020-05-15
ISBN : 2889637166
Language : En, Es, Fr & De

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Book Description :

Download HIV and Cancer Immunotherapy Similar Challenges and Converging Approaches book written by Mirko Paiardini,Rafi Ahmed,Steven Grant Deeks,Kavita M. Dhodapkar, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Journal of the National Cancer Institute

Journal of the National Cancer Institute Book
Author : Anonim
Publisher : Unknown
Release : 1979
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Journal of the National Cancer Institute book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular Strategies Aimed to Boost NK Cell based Immunotherapy of Cancer

Molecular Strategies Aimed to Boost NK Cell based Immunotherapy of Cancer Book
Author : Loredana Cifaldi,Daniel Olive,James Di Santo
Publisher : Frontiers Media SA
Release : 2020-07-31
ISBN : 2889638766
Language : En, Es, Fr & De

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Book Description :

In this Research Topic, we would like to honor the memory of Prof. Vito Pistoia and pay tribute to his scientific contributions to the field of Cancer Immunity and Immunotherapy. Topic Editor Daniel Olive is the co-founder and shareholder of company Imcheck Therapeutics. All other topic editors declare no competing interests with regards to the Research Topic subject.

Cancer Immunology Immunotherapy

Cancer Immunology  Immunotherapy Book
Author : Anonim
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cancer Immunology Immunotherapy book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Ex Vivo Expansion of Human Natural Killer Cells NK for Adoptive Immunotherapy

Ex Vivo Expansion of Human Natural Killer Cells  NK  for Adoptive Immunotherapy Book
Author : Bryce Andrew Pierson
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Ex Vivo Expansion of Human Natural Killer Cells NK for Adoptive Immunotherapy book written by Bryce Andrew Pierson, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

NK Cell Based Cancer Immunotherapy

NK Cell Based Cancer Immunotherapy Book
Author : Francisco Borrego,Susana Larrucea,Rafael Solana,Raquel Tarazona
Publisher : Frontiers Media SA
Release : 2016-09-08
ISBN : 2889199347
Language : En, Es, Fr & De

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Book Description :

Natural killer (NK) cells are innate lymphoid cells that have a significant role in regulating the defenses against cancer development and certain viral infections. They are equipped with an array of activating and inhibitory receptors that stimulate or diminish NK cell activity, respectively. Inhibitory receptors include, among others, the MHC class I ligands killer cell immunoglobulin-like receptors (KIR) in humans, and members of the Ly49 family of receptors in mice, and CD94/NKG2A. Activating receptors include cytokine and chemokine receptors, and those that interact with ligands expressed on target cells, such as the natural cytotoxicity receptors or NCRs (NKp30, NKp44 and NKp46), NKG2D, CD244 and DNAM-1. In addition, NK cells express Fc?RIIIA or CD16, the receptor that exerts antibody-dependent cell mediated cytotoxicity (ADCC). NK cells also express the death ligands FasL and TRAIL. The killing or sparing of target cells depends on the integration of distinct signals that originate from NK cell receptors. NK cells spare healthy cells that express normal levels of MHC class I molecules and low amounts of stress-induced self-molecules, whereas they kill target cells that down-regulate MHC class I molecules and/or up-regulate stress-induced self-molecules. The latter are common signatures of virus-infected cells and tumors. All the accumulated knowledge on NK cell biology, along with many clinical observations, is driving multiple efforts to improve the arsenal of NK cell-based therapeutic tools in the fight against malignant diseases. Indeed, NK cell-based immunotherapy is becoming a promising approach for the treatment of many cancers. It is well known that NK cells have a significant role in the anti-tumor effect of therapeutic antibodies that use ADCC as a mechanism of action. In addition to this, administration of autologous and allogeneic NK cells after activation and expansion ex vivo is used in the treatment of cancer. Moreover, adoptive transfer of NK cell lines has been tested in humans, and genetically modified NK cells expressing chimeric antigen receptors are being studied in preclinical models for potential use in the clinic.

Tumor Immunology and Immunotherapy

Tumor Immunology and Immunotherapy Book
Author : Robert C. Rees
Publisher : Oxford University Press, USA
Release : 2014-05-20
ISBN : 0199676860
Language : En, Es, Fr & De

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Book Description :

Patients are beginning to benefit from antibody based, cellular and vaccine approaches that are effective against genetically diverse and therapy-resistance cancers. BCG immunotherapy is now being used as a first line treatment for human bladder cancer and the introduction of prophylactic vaccination against Hepatitis B and HPV cancers is starting to show positive results. Following recent FDA approval for a vaccination against prostate cancer, and optimistic results in clinical trials for a vaccine targeting cancer antigens in lung cancer, cancer immunotherapy is now significantly impacting patient clinical management. Tumor Immunology and Immunotherapy provides an up-to-date and comprehensive account of cancer immunity and immunotherapy. It discusses our adaptive and innate immunity to cancer, the mechanisms underpinning our immune response, current approaches to cancer immunotherapy, and how tumour and host responses can circumvent effective anti-cancer immunity. The book examines recent results, publications and current areas of interest including 'immune editing' and the specific issues that are affecting the research and development of vaccines, providing insight into how these problems may be overcome, as viewed by world leaders in the field. Tumor Immunology and Immunotherapy will appeal to clinicians working in oncology and cancer immunotherapy, and research scientists including PhD and masters students, post-doctoral researchers and senior investigators.

Cancer achievements Challenges and Prospects for the 1980s

Cancer  achievements  Challenges  and Prospects for the 1980s Book
Author : Joseph Holland Burchenal,Herbert F. Oettgen
Publisher : Grune & Stratton, Incorporated
Release : 1981
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cancer achievements Challenges and Prospects for the 1980s book written by Joseph Holland Burchenal,Herbert F. Oettgen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Manipulation of T Cell Costimulation in Anti tumor Immunotherapy

The Manipulation of T Cell Costimulation in Anti tumor Immunotherapy Book
Author : Sarah E. Townsend
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Manipulation of T Cell Costimulation in Anti tumor Immunotherapy book written by Sarah E. Townsend, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cellular Molecular and Genetic Approaches to Immunodiagnosis and Immunotherapy

Cellular  Molecular and Genetic Approaches to Immunodiagnosis and Immunotherapy Book
Author : Kyoichi Kano
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cellular Molecular and Genetic Approaches to Immunodiagnosis and Immunotherapy book written by Kyoichi Kano, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Dendritic Cell based Vaccines for Active Immunotherapy of T cell Malignancies

Dendritic Cell based Vaccines for Active Immunotherapy of T cell Malignancies Book
Author : Erin Gatza Janowicz
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Dendritic Cell based Vaccines for Active Immunotherapy of T cell Malignancies book written by Erin Gatza Janowicz, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cellular Therapies in Cancer

Cellular Therapies in Cancer Book
Author : Katy Rezvani,Rohtesh S. Mehta
Publisher : Frontiers Media SA
Release : 2020-01-16
ISBN : 2889633780
Language : En, Es, Fr & De

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Book Description :

Download Cellular Therapies in Cancer book written by Katy Rezvani,Rohtesh S. Mehta, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

International Journal of Immunotherapy

International Journal of Immunotherapy Book
Author : Anonim
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download International Journal of Immunotherapy book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Periodicum Biologorum

Periodicum Biologorum Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Periodicum Biologorum book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Clinical Pediatric Oncology

Clinical Pediatric Oncology Book
Author : Wataru Walter Sutow
Publisher : Unknown
Release : 1984
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Clinical Pediatric Oncology book written by Wataru Walter Sutow, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.