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Studies On Hepatitis Viruses

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Studies on Hepatitis Viruses

Studies on Hepatitis Viruses Book
Author : Satya Prakash Gupta
Publisher : Academic Press
Release : 2018-06-20
ISBN : 0128133317
Language : En, Es, Fr & De

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Book Description :

Studies on Hepatitis Viruses: Life Cycle, Structure, Functions, and Inhibition presents the latest on this systemic infection that predominantly affects the liver with inflammation that can be acute or chronic. Hepatitis viruses have been the subject of intense study in the last twenty years, with a wealth of information related to their lifecycle, structure, functions and inhibition being presented. This book compiles the most important developments and research, giving users a very useful guide on this evolving area of virology and medicinal chemistry. Provides comprehensive, state-of-the-art coverage of hepatitis virus infections, the virus' lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of viral hepatitis Presents an in-depth view of the structure and function of viral hepatitis Discusses classification, epidemiology, pathogenesis, natural history, clinical manifestations, diagnosis, complications, associated disorders and animal models

Viral Hepatitis Chronic Hepatitis C

Viral Hepatitis  Chronic Hepatitis C Book
Author : Resat Ozaras,Dominique Salmon-Ceron
Publisher : Springer
Release : 2019-06-21
ISBN : 3030037576
Language : En, Es, Fr & De

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Book Description :

This book presents up-to-date, practically oriented information on major topics in chronic hepatitis C. The coverage encompasses epidemiology; diagnosis, including molecular methods; treatment and challenges; and the management of co-infections. Readers will find guidance on pretherapeutic evaluation with respect to disease severity and extrahepatic manifestations. Resistance to antiviral treatment and its management are discussed, and the nature of optimal follow-up is addressed in detail. Treatment of HCV/HIV co-infection is considered separately, and the approach in special patient populations is thoroughly examined. Chronic Hepatitis C will be of high value for general practitioners and specialists in gastroenterology, infectious diseases, and internal medicine. It will be international in scope in terms of both authorship and appeal.

Enteric Hepatitis Viruses

Enteric Hepatitis Viruses Book
Author : Stanley M. Lemon,Christopher M. Walker
Publisher : Perspectives Cshl
Release : 2018
ISBN : 9781621821625
Language : En, Es, Fr & De

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Book Description :

"A subject collection from Cold Spring Harbor Perspectives in Medicine"--title page.

Guidelines on Hepatitis B and C Testing

Guidelines on Hepatitis B and C Testing Book
Author : World Health Organization
Publisher : Unknown
Release : 2018-02-06
ISBN : 9789241549981
Language : En, Es, Fr & De

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Book Description :

Testing and diagnosis of hepatitis B (HBV) and C (HCV) infection is the gateway for access to both prevention and treatment services, and is a crucial component of an effective response to the hepatitis epidemic. Early identification of persons with chronic HBV or HCV infection enables them to receive the necessary care and treatment to prevent or delay progression of liver disease. Testing also provides an opportunity to link people to interventions to reduce transmission, through counselling on risk behaviors and provision of prevention commodities (such as sterile needles and syringes) and hepatitis B vaccination. These are the first WHO guidelines on testing for chronic HBV and HCV infection and complement published guidance by WHO on the prevention, care and treatment of chronic hepatitis C and hepatitis B infection. These guidelines outline the public health approach to strengthening and expanding current testing practices for HBV and HCV, and are intended for use across age groups and populations.

Eliminating the Public Health Problem of Hepatitis B and C in the United States

Eliminating the Public Health Problem of Hepatitis B and C in the United States Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on a National Strategy for the Elimination of Hepatitis B and C
Publisher : National Academies Press
Release : 2016-06-01
ISBN : 0309438020
Language : En, Es, Fr & De

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Book Description :

Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the first of two, examines the feasibility of hepatitis B and C elimination in the United States and identifies critical success factors. The phase two report will outline a strategy for meeting the elimination goals discussed in this report.

Hepatitis and Liver Cancer

Hepatitis and Liver Cancer Book
Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee on the Prevention and Control of Viral Hepatitis Infections
Publisher : National Academies Press
Release : 2010-05-23
ISBN : 0309146283
Language : En, Es, Fr & De

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Book Description :

The global epidemic of hepatitis B and C is a serious public health problem. Hepatitis B and C are the major causes of chronic liver disease and liver cancer in the world. In the next 10 years, 150,000 people in the United States will die from liver disease or liver cancer associated with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections. Today, between 800,000 and 1.4 million people in the United States have chronic hepatitis B and between 2.7 and 3.9 million have chronic hepatitis C. People most at risk for hepatitis B and C often are the least likely to have access to medical services. Reducing the rates of illness and death associated with these diseases will require greater awareness and knowledge among health care workers, improved identification of at-risk people, and improved access to medical care. Hepatitis B is a vaccine-preventable disease. Although federal public health officials recommend that all newborns, children, and at-risk adults receive the vaccine, about 46,000 new acute cases of the HBV infection emerge each year, including 1,000 in infants who acquire the infection during birth from their HBV-positive mothers. Unfortunately, there is no vaccine for hepatitis C, which is transmitted by direct exposure to infectious blood. Hepatitis and Liver Cancer identifies missed opportunities related to the prevention and control of HBV and HCV infections. The book presents ways to reduce the numbers of new HBV and HCV infections and the morbidity and mortality related to chronic viral hepatitis. It identifies priorities for research, policy, and action geared toward federal, state, and local public health officials, stakeholder, and advocacy groups and professional organizations.

A National Strategy for the Elimination of Hepatitis B and C

A National Strategy for the Elimination of Hepatitis B and C Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on a National Strategy for the Elimination of Hepatitis B and C
Publisher : National Academies Press
Release : 2017-07-30
ISBN : 0309457297
Language : En, Es, Fr & De

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Book Description :

Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the second of two, builds off the conclusions of the first report and outlines a strategy for hepatitis reduction over time and specific actions to achieve them.

Hepatitis B

Hepatitis B Book
Author : Baruch S. Blumberg
Publisher : Princeton University Press
Release : 2003-11-16
ISBN : 9780691116235
Language : En, Es, Fr & De

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Book Description :

The Hepatitis B virus comes under the microscope as a renowned doctor discusses this killer virus and the vaccine that is reducing its mortality around the globe.

Clinical Dilemmas in Viral Liver Disease

Clinical Dilemmas in Viral Liver Disease Book
Author : Graham R. Foster,K. Rajender Reddy
Publisher : John Wiley & Sons
Release : 2020-03-20
ISBN : 1119533430
Language : En, Es, Fr & De

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Book Description :

The only evidence-based book to approach viral liver disease by focusing exclusively on the clinical dilemmas encountered by hepatologists and their medical teams Although viral hepatitis is a growing public health risk around the world, the World Health Organization (WHO) views the elimination of hepatitis infection over the next several as an achievable goal. Effective pharmaceutical therapies are now available, yet medical teams caring for patients with viral hepatitis are challenged when looking for answers to specific questions in the current medical literature. The second edition of Clinical Dilemmas in Viral Liver Disease provides evidence-based guidance for medical teams involved in diagnosing, treating, and managing patients with viral liver disease. This fully updated book explores developments in new treatments and new diagnostic approaches that are contributing to WHO goals of viral elimination. Brief, easily referenced chapters examine clearly defined topics, addressing the clinical questions and difficulties encountered by medical teams in day-to-day practice. Contributions by an international team of investigators and clinicians address clinical questions and issues which are seldom found in standard textbooks and online repositories. Offering practical guidance on the specific challenges and dilemmas of treating viral liver disease, this unique volume: Provides practical, evidence-based guidance on topical and controversial issues Addresses understudied questions that arise in day-to-day clinical practice Discusses the challenges surrounding global elimination programs Presents focused approach that is supported by current literature and expert opinion The second edition of Clinical Dilemmas in Viral Liver Disease is required reading for practicing and trainee hepatologists, gastroenterologists, transplant surgeons, virologists, and other practitioners involved in caring for patients with liver disease.

Research in Chronic Viral Hepatitis

Research in Chronic Viral Hepatitis Book
Author : Wolfram Gerlich
Publisher : Springer
Release : 1993-12-21
ISBN : 9783211824979
Language : En, Es, Fr & De

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Book Description :

Chronic viral hepatitis remains one of the major medical problems worldwide. Neither a cure nor eradication of this disease is in sight. The chronic disease caused by hepatitis viruses type B, C and D is a much greater problem than the acute disease caused by the same viruses or by hepatitis viruses type A and E. Chronic viral hepatitis often remains unrecognized until the patient develops decompensated liver cirrhosis or hepatocellular carcinoma. Furthermore, unrecognized chronic virus carriers are a persistent source of infection by sexual and other close contacts as well as during many medical procedures. The viruses of chronic hepatitis are very different from each other from a taxonomical point of view, but they share many common pathogenic properties and they often coinfect individuals. Six years ago Carlo De Bac, Gloria Taliani (Rome) and I undertook an effort to bring together, under the auspices of the European Society against Virus Diseases, clinicians, laboratory physicians, epidemiologists, pathologists and molecular biologists whose primary research interest is chronic viral hepatitis. The contributions from these quite divergent participants to a meeting devoted solely to chronic viral hepatitis were most stimulating and valuable. As a result of the success of the first meeting in Fiuggi (Italy), a second followed in Siena (Italy) 1990 and the recent third meeting was held in Pisa (Italy). Most of the speakers expressed interest in publishing their contributions in the form of a proceedings volume, as was done in the case of the Siena meeting.

Dangerous Medicine

Dangerous Medicine Book
Author : Sydney A. Halpern
Publisher : Yale University Press
Release : 2021-11-23
ISBN : 0300262450
Language : En, Es, Fr & De

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Book Description :

The untold history of America’s mid-twentieth-century program of hepatitis infection research, its scientists’ aspirations, and the damage the project caused human subjects From 1942 through 1972, American biomedical researchers deliberately infected people with hepatitis. Government-sponsored researchers were attempting to discover the basic features of the disease and the viruses causing it, and to develop interventions that would quell recurring outbreaks. Drawing from extensive archival research and in-person interviews, Sydney Halpern traces the hepatitis program from its origins in World War II through its expansion during the initial Cold War years, to its demise in the early 1970s amid an outcry over research abuse. The subjects in hepatitis studies were members of stigmatized groups—conscientious objectors, prison inmates, the mentally ill, and developmentally disabled adults and children. The book reveals how researchers invoked military and scientific imperatives and the rhetoric of a common good to win support for the experiments and access to recruits. Halpern examines the participants’ long-term health consequences and raises troubling questions about hazardous human experiments aimed at controlling today’s epidemic diseases.

Chronic Viral Hepatitis

Chronic Viral Hepatitis Book
Author : Kirti Shetty,George Y. Wu
Publisher : Springer Science & Business Media
Release : 2009-06-13
ISBN : 9781597455657
Language : En, Es, Fr & De

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Book Description :

Chronic viral hepatitis affect hundreds of millions of people worldwide, and each year millions more people become infected. In Chronic Viral Hepatitis, Second Edition, a panel of distinguished clinicians and clinical investigators build upon the first edition by comprehensively reviewing all the relevant new information regarding resistance, side effects, and therapies for chronic viral hepatitis. The text covers recent advances in the understanding of pathogenesis of viral hepatitis while discussing promising agents in development for its treatment. The authors devote special attention to reactivation of hepatitis B with chemotherapy and immunosuppression, herbal and non-traditional therapies, chronic viral hepatitis in the pediatric population, and immunology and immunotherapy of HCV and provide relative costs for all diagnostic and therapeutic options. Authoritative and up-to-date, Chronic Viral Hepatitis, Second Edition offers today's gastroenterologists, internists, hepatologists, and infectious disease specialists a practical guide to the recognition, diagnosis and treatment of chronic viral hepatitis from a multidisciplinary approach.

Liver Disease in Children

Liver Disease in Children Book
Author : Frederick J. Suchy,Ronald J. Sokol,William F. Balistreri
Publisher : Cambridge University Press
Release : 2014-02-20
ISBN : 1107729092
Language : En, Es, Fr & De

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Book Description :

The fourth edition of this authoritative text covers every aspect of liver disease affecting infants, children and adolescents. As in the previous editions, it offers an integrative approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. All of the chapters are written by international experts and address the unique pathophysiology, manifestations and management of these disorders. This edition of the landmark text features extended coverage of viral hepatitis, metabolic liver disease, fatty liver disease and liver transplantation, including a new chapter on post-transplant care and outcomes. All of the chapters have been updated to reflect changing epidemiology and recent advances in molecular medicine and genomics. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.

Handbook of Hepatitis C

Handbook of Hepatitis C Book
Author : Nicolas Goossens,Sophie Clément,Francesco Negro
Publisher : Springer
Release : 2016-05-25
ISBN : 3319280538
Language : En, Es, Fr & De

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Book Description :

This book is a concise and up-to-date review of the clinical features, pathophysiology, diagnosis, and treatment of patients with hepatitis C. Busy health care professionals who want a quick review of hepatitis C and new developments in treatment for hepatitis C will benefit from this succinct guide. Hepatitis C virus primarily infects liver cells and can lead to chronic damage to the liver. Patients with hepatitis C infection often develop liver sequelae such as fibrosis, cirrhosis, and hepatocellular carcinoma if left untreated. It is estimated that 150 million people worldwide are infected with hepatitis C virus, and if eradication is to be achieved it is imperative to diagnose and treat such individuals.

Hepatitis C

Hepatitis C Book
Author : Imran Shahid
Publisher : BoD – Books on Demand
Release : 2018-10-10
ISBN : 1789842077
Language : En, Es, Fr & De

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Book Description :

The propagation of hepatitis C from acute to chronic infection and afterward to end-stage liver diseases (hepatic fibrosis, cirrhosis, and hepatocellular carcinoma) involves a highly orchestrated series of molecular and cellular events, including a plethora of genes and cell signaling cascades. The treatment paradigms was revolutionized after the development and approval of all oral interferon-free direct-acting antivirals achieving higher sustained virologic response rates in treated individuals. This book pragmatically overviews the intricate interplay between viral and host factors during hepatitis C virus infection progression, as well as other hepatitis C-associated clinical implications. Hepatitis C - From Infection to Cure also provides up-to-date information about hepatitis C cures for clinicians, physicians, and healthcare providers with an ample understanding of the current treatment horizon, as well as other investigational and emerging treatment strategies. The authors with their valuable scientific contributions belong to many eminent institutes around the world and are much experienced in hepatitis C virology, pathology, and therapeutics.

Hepatitis B Virus and Liver Disease

Hepatitis B Virus and Liver Disease Book
Author : Jia-Horng Kao,Ding-Shinn Chen
Publisher : Springer
Release : 2019-02-11
ISBN : 9789811352454
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive, state-of-the art review of HBV infection and liver disease. It discusses new data on basic and translational medicine, including the viral life cycle, the immunopathogenesis of virus-induced chronic hepatitis, viral and host genetic factors affecting disease progression, and the mechanism of virus-induced hepatocarcinogenesis, as well as their potential applications in daily clinical practice. The clinical aspects of chronic HBV infection are examined in chapters on the global epidemiology, efficacy of HBV vaccination, natural history, co-infections with HCV, HDV or HIV, and management of special populations including children, pregnant women and patients undergoing immunosuppressive therapy. Further, it describes the advances and perspectives in the development of novel antiviral treatments as possible cures for HBV infection. The book is a valuable resource for medical students, physicians, and researchers who are interested in managem ent of patients with chronic HBV infection and investigation of HBV infection.

Guidelines for the Screening Care and Treatment of Persons with Chronic Hepatitis C Infection Updated Version April 2016

Guidelines for the Screening Care and Treatment of Persons with Chronic Hepatitis C Infection Updated Version April 2016 Book
Author : World Health Organization
Publisher : World Health Organization
Release : 2016-04-30
ISBN : 9241549610
Language : En, Es, Fr & De

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Book Description :

The field of HCV therapeutics continues to evolve rapidly and since the World Health Organization (WHO) issued its first Guidelines for the screening care and treatment of persons with hepatitis C infection in 2014 several new medicines have been approved by at least one stringent regulatory authority. These medicines called direct-acting antivirals (DAAs) are transforming the treatment of HCV enabling regimens that can be administered orally are of shorter duration (as short as eight weeks) result in cure rates higher than 90% and are associated with fewer serious adverse events than the previous interfere on containing regimens. WHO is updating its hepatitis C treatment guidelines to provide recommendations for the use of these new medicines. The objectives of these WHO guidelines are to provide updated evidence-based recommendations for the treatment of persons with hepatitis C infection using where possible all DAA-only combinations. The guidelines also provide recommendations on the preferred regimens based on a patient?s HCV genotype and clinical history and assess the appropriateness of continued use of certain medicines. This document also includes existing recommendations on screening for HCV infection and care of persons infected with HCV that were first issued in 2014. The key audience for these guidelines are policy-makers in low- and middle-income countries who formulate country-specific treatment guidelines and who plan infectious disease treatment programmes and services in addition to those people responsible for delivering treatment. The guidelines are appropriate for all countries including high-income countries.

Primary Care Management of Hepatitis B

Primary Care Management of Hepatitis B Book
Author : Public Health Agency of Canada
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Primary Care Management of Hepatitis B book written by Public Health Agency of Canada, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pathology of Viral Hepatitis

Pathology of Viral Hepatitis Book
Author : R. D. Goldin,Herbert Thomas,Michael A. Gerber
Publisher : CRC Press
Release : 1998-08-28
ISBN : 9780340596647
Language : En, Es, Fr & De

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Book Description :

A number of viruses cause inflammation of the liver and some forms of the disease can be life-threatening. This book addresses the need for a definitive, up-to-date text on the pathology of viral hepatitis, and provides a summary of modern understanding of these diseases. An international team of contributors has produced a comprehensive, highly illustrated account for pathologists, virologists and clinical hepatologists. It covers not only the hepatotrophic viruses but also other viruses which damage the liver. Special attention is given to viral hepatitis in immunosuppressed individuals. The mechanisms whereby viruses damage the liver and the role in carcinogenesis are discussed in detail.

Viral Hepatitis

Viral Hepatitis Book
Author : Howard C. Thomas,Anna S. F. Lok,Stephen A. Locarnini,Arie J. Zuckerman
Publisher : John Wiley & Sons
Release : 2013-07-22
ISBN : 111863733X
Language : En, Es, Fr & De

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Book Description :

The 4th edition of Viral Hepatitis coverscomprehensively the entire complex field of infections caused byall of the different hepatitis viruses, which affect many millionsof people throughout the world with considerable morbidity andmortality. Howard Thomas and Arie Zuckerman are joined by Anna Lok from theUSA and Stephen Locarnini from Australia as Editors. Theyhave recruited leading researchers and physicians from manycountries, who have produced an authoritative account of currentknowledge and research on this important infection, including newinsights into immune response to HBV and HCV. The result is a comprehensive account on all aspects of viralhepatitis, including rapid advances in the diagnosis, management,treatment and prevention of a complex infection, which in the caseof hepatitis B, C and D may lead to severe complications includingchronic hepatitis, cirrhosis and hepatocellular carcinoma. The latest edition of Viral Hepatitis offers an essentialresource of current information for hepatologists,gastroenterologists, infectious diseases specialists and otherclinicians, researchers, public health physicians and National andInternational Health Authorities.