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Structure And Function Of The Extracellular Matrix

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The Extracellular Matrix an Overview

The Extracellular Matrix  an Overview Book
Author : Robert Mecham
Publisher : Springer Science & Business Media
Release : 2011-02-16
ISBN : 9783642165559
Language : En, Es, Fr & De

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Book Description :

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Structure and function of Collagen types

Structure and function of Collagen types Book
Author : Richard Maynes
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0323155715
Language : En, Es, Fr & De

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Book Description :

Structure and Function of Collagen Types is a collection of articles that reviews the different types of collagens (Type I to XI). Each article focuses on a particular type of collagen and written by leading investigators in the collagen field. The book begins with a review of the fibril forming collagens (types I, II, and III) and traces the early work on the structure of these collagens to our knowledge of the structure of the collagen genes. This chapter is followed by a detailed description of type IV (basement membrane) collagen. Chapter 3 addresses the biosynthesis and chain assembly of type V collagen. The evidence that type VI collagen is assembled to form tetramers is presented in chapter 4. The subsequent article shows that type VII collagens are assembled to form partially overlapping dimers. Chapter 6 presents the structure of type VIII collagen. Chapters 7, 8, and 9 discuss the structure and characteristics of collagens that are synthesized by cartilaginous tissues and these are designated as type IX, type X, and type XI. The final chapter reviews the recombinant DNA techniques used to investigate collagen structure and the possibility to recognize new collagen types from a cDNA library. Physiologists, cell biologists, and researchers in the field of collagen will find the text very insightful.

Extracellular Matrix

Extracellular Matrix Book
Author : A. H. Reddi
Publisher : Unknown
Release : 1985-12
ISBN : 9780471847687
Language : En, Es, Fr & De

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Book Description :

Download Extracellular Matrix book written by A. H. Reddi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Extracellular Matrix

Extracellular Matrix Book
Author : Anonim
Publisher : Unknown
Release : 1985
ISBN : 9780845126233
Language : En, Es, Fr & De

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Book Description :

Download Extracellular Matrix book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Structure and Function of Fibulin 1

Structure and Function of Fibulin 1 Book
Author : Huan Trung Tran
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Structure and Function of Fibulin 1 book written by Huan Trung Tran, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Structure and Function of the Extracellular Matrix

Structure and Function of the Extracellular Matrix Book
Author : Bela Suki
Publisher : Academic Press
Release : 2020-10
ISBN : 9780128197165
Language : En, Es, Fr & De

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Book Description :

Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces the basic concepts of biomechanics and biophysics with applications, to better understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behaviour from the scale of single molecules, through fibrils and fibers to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. It provides an introduction to the properties and organization of the extracellular matrix components, to quantitative models of the matrix and guides the reader through predicting the functional properties. This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into the normal functioning as well as the pathological alterations of the extracellular matrix. Prof Suki's book is written to be useful to upper class undergraduates, graduate students and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin and bone may also be interested in this book.

Cell Surface and Extracellular Glycoconjugates

Cell Surface and Extracellular Glycoconjugates Book
Author : Anonim
Publisher : Academic Press
Release : 2012-12-02
ISBN : 0323138098
Language : En, Es, Fr & De

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Book Description :

This book serves as a much-needed guide for new investigators in the field of glycobiology as well as researchers in other disciplines attempting to define the role of glycoconjugates in their biological systems. Cell Surface and Extracellular Glycoconjugates: Structure and Function describes the determination of structure and function of glycoconjugates that occur on the cell surface and in molecules involved in cell-matrix interactions. The broad scope of thebook covers basic background and technical information in this rapidly expanding field. The text is specifically designed to inform researchers in diverse disciplines of the approaches and resources that can be employed to address problems in glycoconjugate biology. Includes coverage of the: * Structure of cell surface carbohydrates * Biosynthesis of glycoproteins * Biological signals associated with glycoproteins * Diversity of glycoprotein structure

Composition and Function of the Extracellular Matrix in the Human Body

Composition and Function of the Extracellular Matrix in the Human Body Book
Author : Francesco Travascio
Publisher : BoD – Books on Demand
Release : 2016-06-15
ISBN : 9535124153
Language : En, Es, Fr & De

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Book Description :

The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.

Evolution of Extracellular Matrix

Evolution of Extracellular Matrix Book
Author : Fred W. Keeley,Robert Mecham
Publisher : Springer Science & Business Media
Release : 2013-03-15
ISBN : 3642360025
Language : En, Es, Fr & De

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Book Description :

The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.

The Structure Function and Evolution of the Extracellular Matrix

The Structure  Function and Evolution of the Extracellular Matrix Book
Author : Lawrence Graham Cromar
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Structure Function and Evolution of the Extracellular Matrix book written by Lawrence Graham Cromar, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cell Biology of Extracellular Matrix

Cell Biology of Extracellular Matrix Book
Author : Elizabeth D. Hay
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 146130881X
Language : En, Es, Fr & De

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Book Description :

At a recent meeting to discuss the domains of cell biology, I put forth a case for the extracellular matrix, even though my argument ran the risk of falling on deaf ears. After all, the matrix is EXTRAcellular, outside the cells. In this book, however, the authors make a compelling case for the relevance of the matrix to cellular concerns. Not only are numerous cell types, including many epithelia, quite caught up in the business of manufacturing matrix components, but also most of them contain matrix molecules in exoskeletons that are attached to the plasmalemma and that organize or otherwise influence the affairs of the cyto plasm. The idea of this book is to present the extracellular matrix to cell biolo gists of all levels. The authors are active and busy investigators, recognized experts in their fields, but all were enthusiastic about the prospect of writing for this audience. The chapters are not "review" articles in the usual sense, nor are they rehashes of symposium talks; they were written specifically for this book and they present the "state of the art" in engaging style, with ample references to more technical or historical reviews. The book is rich in electron micro graphs and diagrams and for many of the latter, as well as for the design of the cover, we are indebted to Sylvia J. Keene, medical illustrator for the Department of Anatomy at Harvard Medical Scrool. We also owe special thanks to Susan G.

The Extracellular Matrix

The Extracellular Matrix Book
Author : Kristian Wejse Sanggaard
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Extracellular Matrix book written by Kristian Wejse Sanggaard, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Collagen XII Splice Variants

Collagen XII Splice Variants Book
Author : Manuel Koch
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Collagen XII Splice Variants book written by Manuel Koch, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biochemistry of Collagens Laminins and Elastin

Biochemistry of Collagens  Laminins and Elastin Book
Author : Morten Karsdal
Publisher : Academic Press
Release : 2019-05-28
ISBN : 0128170697
Language : En, Es, Fr & De

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Book Description :

There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides an updated comprehensive introduction to collagen and structural proteins Gives insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes seven new chapters, including one on how collagen biomarkers are used in clinical research to support drug development and in precision medicine Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states Proves the importance of proteins for collagen assembly, function, and durability