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Structure And Function Of The Extracellular Matrix

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Structure and Function of the Extracellular Matrix

Structure and Function of the Extracellular Matrix Book
Author : Bela Suki
Publisher : Academic Press
Release : 2021-12-06
ISBN : 0128226056
Language : En, Es, Fr & De

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Book Description :

Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties. This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki’s book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book. Examines the evolutionary origins and consequences of the extracellular matrix Delivers the first book to quantitatively treat the extracellular matrix as a multiscale system Presents problems and a set of computational laboratory projects in various chapters to aid teaching and learning Provides an introduction to the properties and organization of the extracellular matrix components

The Extracellular Matrix an Overview

The Extracellular Matrix  an Overview Book
Author : Robert Mecham
Publisher : Springer Science & Business Media
Release : 2011-02-16
ISBN : 3642165559
Language : En, Es, Fr & De

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Book Description :

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Composition and Function of the Extracellular Matrix in the Human Body

Composition and Function of the Extracellular Matrix in the Human Body Book
Author : Francesco Travascio
Publisher : BoD – Books on Demand
Release : 2016-06-15
ISBN : 9535124153
Language : En, Es, Fr & De

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Book Description :

The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.

Calcific Aortic Valve Disease

Calcific Aortic Valve Disease Book
Author : Elena Aikawa
Publisher : BoD – Books on Demand
Release : 2013-06-12
ISBN : 9535111507
Language : En, Es, Fr & De

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Book Description :

Due to population aging, calcific aortic valve disease (CAVD) has become the most common heart valve disease in Western countries. No therapies exist to slow this disease progression, and surgical valve replacement is the only effective treatment. Calcific Aortic Valve Disease covers the contemporary understanding of basic valve biology and the mechanisms of CAVD, provides novel insights into the genetics, proteomics, and metabolomics of CAVD, depicts new strategies in heart valve tissue engineering and regenerative medicine, and explores current treatment approaches. As we are on the verge of understanding the mechanisms of CAVD, we hope that this book will enable readers to comprehend our current knowledge and focus on the possibility of preventing disease progression in the future.

Molecular Biology of the Cell

Molecular Biology of the Cell Book
Author : Bruce Alberts
Publisher : Unknown
Release : 2004
ISBN : 9780815332183
Language : En, Es, Fr & De

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Book Description :

Download Molecular Biology of the Cell book written by Bruce Alberts, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Tissue Regeneration

Tissue Regeneration Book
Author : Hussein Abdelhay Essayed Kaoud
Publisher : BoD – Books on Demand
Release : 2018-06-06
ISBN : 1789232600
Language : En, Es, Fr & De

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Book Description :

Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different surgical fields and operations. This book includes 7 sections and 11 chapters that provide an overview of the essentials in tissue regeneration science and their potential applications in surgery. The authors of each chapter have given consolidated information on ground realities and attempted to provide a comprehensive knowledge of tissue engineering and regeneration. This book will be useful to researchers and students of biological and biomedical sciences (medical and veterinarian researchers).

Extracellular Matrix in Development

Extracellular Matrix in Development Book
Author : Douglas W. DeSimone,Robert Mecham
Publisher : Springer Science & Business Media
Release : 2013-03-15
ISBN : 3642359353
Language : En, Es, Fr & De

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Book Description :

Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

Structure and function of Collagen types

Structure and function of Collagen types Book
Author : Richard Maynes
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0323155715
Language : En, Es, Fr & De

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Book Description :

Structure and Function of Collagen Types is a collection of articles that reviews the different types of collagens (Type I to XI). Each article focuses on a particular type of collagen and written by leading investigators in the collagen field. The book begins with a review of the fibril forming collagens (types I, II, and III) and traces the early work on the structure of these collagens to our knowledge of the structure of the collagen genes. This chapter is followed by a detailed description of type IV (basement membrane) collagen. Chapter 3 addresses the biosynthesis and chain assembly of type V collagen. The evidence that type VI collagen is assembled to form tetramers is presented in chapter 4. The subsequent article shows that type VII collagens are assembled to form partially overlapping dimers. Chapter 6 presents the structure of type VIII collagen. Chapters 7, 8, and 9 discuss the structure and characteristics of collagens that are synthesized by cartilaginous tissues and these are designated as type IX, type X, and type XI. The final chapter reviews the recombinant DNA techniques used to investigate collagen structure and the possibility to recognize new collagen types from a cDNA library. Physiologists, cell biologists, and researchers in the field of collagen will find the text very insightful.

Extracellular Matrix Biology

Extracellular Matrix Biology Book
Author : Richard O. Hynes,Kenneth M. Yamada
Publisher : Unknown
Release : 2012
ISBN : 9781936113385
Language : En, Es, Fr & De

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Book Description :

In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in the regulation of cell function. ECM proteins bind to cell surface receptors such as integrins, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis. This book covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during tumorigenesis and other disease states. The editors are both giants in the field (Dr. Hynes discovered fibronectin), who are highly respected through the cell, molecular, and cancer biology communities.

Extracellular Matrix Biomineralization of Dental Tissue Structures

Extracellular Matrix Biomineralization of Dental Tissue Structures Book
Author : Michel Goldberg,Pamela Den Besten
Publisher : Springer Nature
Release : 2021-09-30
ISBN : 3030762831
Language : En, Es, Fr & De

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Book Description :

This book addresses the structural and biological properties of dental and peridental tissue structures and covers their mineralization process. The book contains a description of dentines, cementum, enamel and bone, including collagens, as well as non-collagenous proteins (SIBLINGs, SLRPs, GAGs, PGs, lipids, and MMPs). The mechanisms of mineralization are described in detail and the book is focused on matrix vesicles, collagen mineralization and the role of non-collagenous extracellular matrix components either as promoters or inhibitors of mineralization. In addition, the matrix components (non-collagenous) of enamel (amelogenin, ameloblastin, enamelin, MMP4, MMP20 and other proteases) are reviewed and their respective roles in dental tissues biomineralizations and tissue turnover are discussed. Additionally, environmental factors involved in enamel / dentin defects are adressed. With state-of-the-art contributions from experts in the respective domains, the book is a useful introduction to the field for junior scientists, interested in dental and peridental tissue biomineralization. It is also an interesting read for advanced scientists and clinicians working in dental research, giving them a broader view of the topic beyond their area of specialization. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

Mimicking the Extracellular Matrix

Mimicking the Extracellular Matrix Book
Author : Gregory H. Hudalla,William L. Murphy
Publisher : Royal Society of Chemistry
Release : 2015-11-18
ISBN : 1849738335
Language : En, Es, Fr & De

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Book Description :

The extracellular matrix (ECM) is the focus of much interest in biology and bioengineering. Increasing understanding of the influence of the ECM on cell behaviour has led to the exciting possibilities of tissue engineering. Aside from new therapeutic tools, understanding the ECM is of course fundamental to basic cell biology research. Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Seven topics are approached each in a pair of chapters, one with a biological approach and its partner with a bioengineering approach. Topics include the mechanical properties of the ECM, which outlines current knowledge of the ECM physical structure and reviewing state-of-the-art strategies to mimic its native microenvironments. The organisational characteristics of the ECM form the focus of another pair of chapters, where the collagen triple helix is discussed, followed by a review of advances in artificial reproduction of well-ordered systems using self-assembling peptides, or peptide amphiphiles. The balanced approach of this text gives it a broad appeal to those interested in the ECM from a range of backgrounds and disciplines. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.

Extracellular Matrix

Extracellular Matrix Book
Author : A. H. Reddi
Publisher : Unknown
Release : 1985-12
ISBN : 9780471847687
Language : En, Es, Fr & De

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Book Description :

Download Extracellular Matrix book written by A. H. Reddi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Extracellular Matrix Degradation

Extracellular Matrix Degradation Book
Author : William C. Parks,Robert Mecham
Publisher : Springer Science & Business Media
Release : 2011-04-07
ISBN : 3642168612
Language : En, Es, Fr & De

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Book Description :

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

Biochemistry of Collagens Laminins and Elastin

Biochemistry of Collagens  Laminins and Elastin Book
Author : Morten Karsdal
Publisher : Academic Press
Release : 2016-07-29
ISBN : 0128098996
Language : En, Es, Fr & De

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Book Description :

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteins Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes a chapter dedicated to the biomarkers of structural proteins Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states

Matrix Metalloproteinase Biology

Matrix Metalloproteinase Biology Book
Author : Irit Sagi,Jean Gaffney
Publisher : John Wiley & Sons
Release : 2015-08-03
ISBN : 1118772326
Language : En, Es, Fr & De

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Book Description :

Discussing recent advances in the field of matrix metalloproteinase (MMP) research from a multidisciplinary perspective, "Matrix Metalloproteinase Biology" is a collection of chapters written by leaders in the field of MMPs. The book focuses on the challenges of understanding the mechanisms of substrate degradation by MMPs, as well as on how these enzymes are able to degrade large, highly ordered substrates such as collagen. All topics addressed are considered in relation to disease progression including the role of MMPs in cancer metastasis, rheumatoid arthritis, and other inflammatory diseases.The first section provides an overview of MMPs, focusing on the history, the development and failures of small molecule inhibitors in clinical trials, and work with TIMPS, endogenous inhibitors of MMPs. These introductory chapters establish the foundation for later discussion of the recent progress in the design of different types of inhibitors, including novel antibody-based therapeutics. The second section emphasizes on research using novel methods to further the study of the MMPs. The third and final section focuses on in vivo research, particularly with respect to cancer models, degradation of the extracellular matrix, and MMP involvement in other disease states.Written and edited by leaders in the field, "Matrix Metalloproteinase Biology" addresses the rapid growth in MMP research and will be an invaluable resource to advanced students and researchers studying cell and molecular biology.. Discusses recent advances in the field of matrix metalloproteinase research from a multidisciplinary perspective. . Chapters authored by leaders in the field of matrix metalloproteinase research. . Covers past research and places emphasis on future directions. . Topics considered in relation to disease progression including the role of MMPs in cancer metastasis, rheumatoid arthritis, and other inflammatory diseases.

Extracellular Matrix

Extracellular Matrix Book
Author : Anonim
Publisher : Unknown
Release : 1985
ISBN : 9780845126233
Language : En, Es, Fr & De

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Book Description :

Download Extracellular Matrix book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Extracellular Matrix Genes

Extracellular Matrix Genes Book
Author : Charles Boyd
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0323157661
Language : En, Es, Fr & De

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Book Description :

Extracellular Matrix Genes provides some of the interesting complexities of the structure of the entire family of extracellular matrix genes. This book illustrates the permanent role that molecular biology and molecular genetics play in the detailed understanding of the normal biology of extracellular matrix. Organized into 10 chapters, this book begins with an overview of the structural and sequence aspects of the entire family of genomic sequences with a view to establishing common functional domains among collagens and their genes. This text then examines the status of the literature concerning human types. III and V. Other chapters consider the FACIT collagen gene family. This book discusses as well the development in understanding the structure of small proteoglycan core proteins and their role in proteoglycan biosynthesis and function as a result of their molecular cloning and expression. The final chapter deals with mutations in collagen genes. This book is a valuable resource for biochemists.

Etiology and Morphogenesis of Congenital Heart Disease

Etiology and Morphogenesis of Congenital Heart Disease Book
Author : Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi
Publisher : Springer
Release : 2016-06-24
ISBN : 4431546286
Language : En, Es, Fr & De

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Book Description :

This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.

Cell Biology of Extracellular Matrix

Cell Biology of Extracellular Matrix Book
Author : E.D. Hay
Publisher : Springer Science & Business Media
Release : 2013-11-11
ISBN : 1461537703
Language : En, Es, Fr & De

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Book Description :

In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Postgraduate Orthopaedics

Postgraduate Orthopaedics Book
Author : Paul A. Banaszkiewicz,Deiary F. Kader
Publisher : Cambridge University Press
Release : 2012-08-16
ISBN : 1139561332
Language : En, Es, Fr & De

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Book Description :

This book has been written specifically for candidates sitting the oral part of the FRCS (Tr & Orth) examination. It presents a selection of questions arising from common clinical scenarios along with detailed model answers. The emphasis is on current concepts, evidence-based medicine and major exam topics. Edited by the team behind the successful Candidate's Guide to the FRCS (Tr & Orth) Examination, the book is structured according to the four major sections of the examination; adult elective orthopaedics, trauma, children's/hands and upper limb and applied basic science. An introductory section gives general exam guidance and end section covers common diagrams that you may be asked to draw out. Each chapter is written by a recent (successful) examination candidate and the style of each reflects the author's experience and their opinions on the best tactics for first-time success. If you are facing the FRCS (Tr & Orth) you need this book.