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STRUCTURAL BIOLOGY IN IMMUNOLOGY

STRUCTURAL BIOLOGY IN IMMUNOLOGY Book
Author : Isaac Mills
Publisher : Unknown
Release : 2018
ISBN : 9781684696260
Language : En, Es, Fr & De

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Book Description :

Download STRUCTURAL BIOLOGY IN IMMUNOLOGY book written by Isaac Mills, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Structural Biology in Immunology

Structural Biology in Immunology Book
Author : Chaim Putterman,David Cowburn,Steven Almo
Publisher : Academic Press
Release : 2018-05-14
ISBN : 0128033703
Language : En, Es, Fr & De

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Book Description :

Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease. Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship Features a collaborative editorial effort, involving clinical immunologists and structural biologists Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology Gives interested parties a bridge to learn about computer modeling and structure based design principles

Structural Biology of the Complement System

Structural Biology of the Complement System Book
Author : Dimitrios Morikis,John D. Lambris
Publisher : CRC Press
Release : 2005-03-29
ISBN : 0849350360
Language : En, Es, Fr & De

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Book Description :

Of recent, the structure of the complement system has received considerable attention, including the publication of several three-dimensional structures of complement proteins. This has led to the need for an authoritative resource to provide a complete overview of the basics, as well as an explanation of the cutting-edge work being accomplished in

Structural Immunology

Structural Immunology Book
Author : Tengchuan Jin,Qian Yin
Publisher : Springer Nature
Release : 2019-10-18
ISBN : 9811393672
Language : En, Es, Fr & De

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Book Description :

This book presents a comprehensive overview of important immune molecules and their structure-function relationships. The immune system is highly complex, consisting of a network of molecules, cells, tissues and organs, and the immune reaction is involved in various physiological as well as pathological processes, including development, self-tolerance, infection, immunity, and cancer. Numerous molecules participate in immune recognition, inhibition and activation, and these important immune molecules can be roughly divided into cell surface receptors, intracellular receptors and intracellular signaling molecules. The study of how these immune molecules function at molecular level has laid the foundation for understanding the immune system. The book provides researchers and students with the latest research advances concerning the structural biology of key immune molecules/pathways, and offers immunologists essential insights into how these immune molecules function.

The B7 CD28 Family Molecules

The B7 CD28 Family Molecules Book
Author : Lieping Chen
Publisher : Springer Science & Business Media
Release : 2003-10-31
ISBN : 9780306478420
Language : En, Es, Fr & De

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Book Description :

The B7-CD28 family molecules are probably the most intensively studied receptor-ligand systems in the field of immunology. This is evident from the explosive accumulation of literature, particularly in the last ten years. Recent years have witnessed rapid discoveries and characterization of new receptors and ligands in the family. These new pathways, although still in their infancy, have already brought much excitement to the field. However, until now, there has been no single volume to cover this entire area. This book was created to bring together state-of-the-art information and critical thinking from the leading investigators. This book covers significant territory of this rapidly moving field from structural biology and biochemical signalling to immunological functions and their potential applications in the treatment of human diseases. This is an excellent handbook and reference for immunologists, health professionals as well as medical students and graduate students in life science field.

Encyclopedia of Molecular Biology

Encyclopedia of Molecular Biology Book
Author : John Kendrew
Publisher : Wiley
Release : 1995-10-05
ISBN : 9780865426214
Language : En, Es, Fr & De

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Book Description :

The growth of molecular biology and the spread of its influence in other disciplines has led to a proliferation of terminology which has, as yet, to be effectively defined and housed in one single, accessible reference source. Within one volume this unique reference work contains nearly 6,000 headwords covering all areas of molecular life science including cell biology, immunology, microbiology, neurobiology, structural biology, developmental biology and molecular medicine. The Encyclopedia houses two types of article entry. Short articles of up to 100 words offer a short definition which is fully cross-referenced to article length entries of between 1,000 - 3,000 words. This unique cross-reference system allows the reader to approach their subject at the required level of detail and sophistication

Signalling Networks in Cell Shape and Motility

Signalling Networks in Cell Shape and Motility Book
Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Release : 2005-10-31
ISBN : 0470017651
Language : En, Es, Fr & De

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Book Description :

This book features contributions from experts in cell biology, genetics, neurobiology, immunology and structural biology. The unifying element is that they all study processes of cell shape change and motility. Several key questions in this field of research are discussed: What are the organising principles behind cell shape change? Are there ‘master switches’ present in every cell type? How are extracellular signals interpreted by the cell in order to activate intracellular mechanisms? What is the influence of the extracellular matrix on cell movement and internal signalling pathways? How do pathogens subvert cellular systems in order to stimulate or block their uptake? The book addresses all of these important questions. Data are presented on the key proteins that regulate cell shape: the GTP binding proteins of the Rho family. There are also extensive discussions of the potential applications of the data to clinical problems, particularly that of cell motility in cancer.

The Molecular Immunology of Complex Carbohydrates 2

The Molecular Immunology of Complex Carbohydrates    2 Book
Author : Albert M. Wu
Publisher : Springer
Release : 2013-03-03
ISBN : 9781461354697
Language : En, Es, Fr & De

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Book Description :

I organized this symposium, "Molecular Immunology of Complex Carbohydrates-2 (MICC-2)," at the Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan th between August 28-September 2, 1999, as a satellite meeting of the 15 International Glycoconjugate Conference (held August 22-27 in Tokyo, Japan). I also held a Taiwan Canada Glycobiology Workshop after this meeting at the Institutes of Biological Chemistry and Chemistry. To promote glycobiology in Taiwan, I offered a Complexs Carbohydrate & Medicine-2 workshop at the Glyco- Research Laboratory, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan before the MICC-2 symposium. The lecture and poster materials of these three meetings are collected in these proceedings, which are divided into five Sections and two Appendixes. Section I, entitled "Protein-Carbohydrate Interactions of Plant and Animal Lectins," provides current concepts of lectin-carbohydrate interactions; classification of lectins, based on amino acid sequences, molecular structures, and lectin affinity for carbohydrates. However, the relationships between amino acid sequences and carbohydrate affinity of lectins have to be more thoroughly characterized. The reviews on animal lectins in this Section explore new areas of lectins. Section II, "Aspects of Structure and Antigenicity of Glycoconjugates," provides important information on structural concepts of glyco immunology. "Glycotope Expression (Glycosylation), Metabolism and Functions," which play important roles in life processes, are discussed in Section III. Four articles on advances in knowledge on structural roles of glycans and treatment of cancer are discussed in Section IV.

Structural Proteomics and Its Impact on the Life Sciences

Structural Proteomics and Its Impact on the Life Sciences Book
Author : Joel Sussman,Israel Silman
Publisher : World Scientific
Release : 2008
ISBN : 9812772057
Language : En, Es, Fr & De

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Book Description :

The role played by structural proteomics in the first decade of the 21st century is equivalent to that played by the Human Genome Project in the last decade of the 20th century. The development of high-throughput technologies that permit the solution of hundreds of 3D structures of individual proteins, proteinOCoprotein complexes and proteinOCodrug complexes, just by one laboratory in a single year, will provide a knowledge base which will change the face of structural biology. This will have an immediate influence on medicinal chemistry and molecular pharmacology, as well as an increasing impact on such disciplines as neurobiology, developmental biology, immunology and molecular medicine.This book presents a state-of-the-art overview of the structural proteomics field, ranging from policy issues related to funding and goals, through the high-throughput procedures for protein production, to the solution of the structures of proteins and higher-order entities, via a multidisciplinary approach involving molecular biology, X-ray crystallography, NMR and electron microscopy, as well as bioinformatics analysis. This is the first book to provide such a comprehensive coverage of a rapidly evolving field.

Advanced Techniques in Soil Microbiology

Advanced Techniques in Soil Microbiology Book
Author : Ajit Varma,Ralf Oelmüller
Publisher : Springer Science & Business Media
Release : 2007-07-25
ISBN : 3540708650
Language : En, Es, Fr & De

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Book Description :

This book presents a wide range of biotechnological methods for application in soil microbiology analysis, including all essential methods involving molecular biology, immunology, microbiology, and structural biology, such as transcriptome analysis, RNAi technology, molecular matchmaking, RAPD, T-RFLP and FT/MS. The techniques and procedures presented here offer practical guides for immediate use in the laboratory. This volume will be of use both to the first-timer and to the experienced scientist.

Structural Proteomics and Its Impact on the Life Sciences

Structural Proteomics and Its Impact on the Life Sciences Book
Author : Anonim
Publisher : Unknown
Release : 2021-12-08
ISBN : 9814474061
Language : En, Es, Fr & De

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Book Description :

Download Structural Proteomics and Its Impact on the Life Sciences book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chromatin Remodelling and Immunity

Chromatin Remodelling and Immunity Book
Author : Anonim
Publisher : Academic Press
Release : 2017-01-02
ISBN : 0128123931
Language : En, Es, Fr & De

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Book Description :

Chromatin Remodelling and Immunity, Volume 106, the latest release in the Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Written by authorities in the field Targeted to a wide audience of researchers, specialists, and students

Advances in HIV 1 Assembly and Release

Advances in HIV 1 Assembly and Release Book
Author : Eric O. Freed
Publisher : Springer Science & Business Media
Release : 2013-07-12
ISBN : 1461477298
Language : En, Es, Fr & De

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Book Description :

​Over the past decade, enormous progress has been made in understanding the late events in the HIV replication cycle. This has been made possible by major advances in cell biology, virology, and structural biology. The field continues to move forward rapidly, with important new discoveries being reported on a regular basis. The impact of this progress across a broad spectrum of biomedical research has been substantial. The increase in basic knowledge in the areas of HIV assembly, release, and maturation has been accompanied by new possibilities for therapeutic intervention.The work includes topics relating to basic molecular biology, cell biology, and structural biology of HIV assembly, coupled with more applied ideas of how this basic information can inform the field of antiretroviral research. The book covers all major topics pertaining to the late stages of HIV replication, with leaders in each area recruited to contribute chapters in their areas of expertise . The topics will be sufficiently focused to allow authors the opportunity to cover the latest developments in detail.​

Mucosal Immune Defense Immunoglobulin A

Mucosal Immune Defense  Immunoglobulin A Book
Author : Charlotte S. Kaetzel
Publisher : Springer Science & Business Media
Release : 2007-10-04
ISBN : 0387722319
Language : En, Es, Fr & De

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Book Description :

Immune responses at mucosal surfaces play a major role in host mucosal defense against microbial pathogens and in the pathogenesis of acute and chronic mucosal inflammatory diseases. This volume draws on a broad spectrum of molecular biologic, biochemical, and immunogenetic approaches in combination with human and murine in vitro cell culture and in vivo model systems to address questions in mucosal immunity. Humans produce more immunoglobulin A (IgA) than all other antibody isotypes combined, most of which is rapidly transported into the external secretions bathing mucous membranes. It has been estimated that more than 3 grams of IgA are transported daily into mucosal secretions, carrying out a wide range of antimicrobial and anti-inflammatory functions. IgA is the second most abundant class of antibody in the bloodstream, contributing to systemic as well as secretory immunity. Recent advances in human genomics, gene regulation, structural biology, cell signaling, and immunobiology have greatly enhanced our understanding of this important class of antibody. This book is designed to serve as a concise reference of the present knowledge of the biology of IgA, including structure of IgA and its interaction with Fc receptors; epithelial transport of IgA; regulation of the mucosal IgA system; biological roles of IgA, including newly discovered functions; IgA-associated diseases, and therapeutic applications for IgA. Chapters have been contributed by internationally recognized leaders in the field of IgA research, representing 8 countries on 3 continents.

Anticarbohydrate Antibodies

Anticarbohydrate Antibodies Book
Author : Paul Kosma,Sven Müller-Loennies
Publisher : Springer Science & Business Media
Release : 2011-11-27
ISBN : 9783709108703
Language : En, Es, Fr & De

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Book Description :

Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite specificity are important factors for their successful use. “Anticarbohydrate Antibodies – from molecular basis to clinical application” compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.

The Immune System

The Immune System Book
Author : Parham, Peter
Publisher : W.W. Norton & Company
Release : 2014-10-01
ISBN : 0815345275
Language : En, Es, Fr & De

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Book Description :

This text emphasizes the human immune system and presents concepts with a balanced level of detail to describe how the immune system works. Written for undergraduate, medical, veterinary, dental, and pharmacy students, it makes generous use of medical examples to illustrate points. This classroom-proven textbook offers clear writing, full-color illustrations, and section and chapter summaries that make the content accessible and easily understandable to students.

Signalling Networks in Cell Shape and Motility

Signalling Networks in Cell Shape and Motility Book
Author : Gregory R. Bock,Jamie A. Goode
Publisher : Wiley
Release : 2005-10-14
ISBN : 9780470011904
Language : En, Es, Fr & De

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Book Description :

This book features contributions from experts in cell biology, genetics, neurobiology, immunology and structural biology. The unifying element is that they all study processes of cell shape change and motility. Several key questions in this field of research are discussed: What are the organising principles behind cell shape change? Are there ‘master switches’ present in every cell type? How are extracellular signals interpreted by the cell in order to activate intracellular mechanisms? What is the influence of the extracellular matrix on cell movement and internal signalling pathways? How do pathogens subvert cellular systems in order to stimulate or block their uptake? The book addresses all of these important questions. Data are presented on the key proteins that regulate cell shape: the GTP binding proteins of the Rho family. There are also extensive discussions of the potential applications of the data to clinical problems, particularly that of cell motility in cancer.

Anticarbohydrate Antibodies

Anticarbohydrate Antibodies Book
Author : Paul Kosma,Sven Müller-Loennies
Publisher : Springer
Release : 2012-03-10
ISBN : 9783709108710
Language : En, Es, Fr & De

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Book Description :

Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite specificity are important factors for their successful use. “Anticarbohydrate Antibodies – from molecular basis to clinical application” compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.

Encyclopedia of Life Sciences

Encyclopedia of Life Sciences Book
Author : Wiley
Publisher : Wiley
Release : 2007-04-02
ISBN : 9780470061411
Language : En, Es, Fr & De

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Book Description :

Spanning the entire spectrum of life science research, the Encyclopedia features more than 4,000 specially commissioned and peer-reviewed articles. These concentrate primarily on the molecular and cellular life sciences, including biochemical topics, methods and techniques. Applied areas of science are also included on a selective basis, as are biographies and general interest articles on ethics and the history of science. Since the acquisition of ELS from NPG in 2004, Wiley has been adding both new and updated articles to keep readers up-to-date with the relentlessly evolving nature of life sciences, carefully commissioning in areas that have been particularly dynamic on the advice of a specialist board of scientific editors. Accordingly, in this six-volume work, we have published an additional 650 new and updated peer-reviewed articles that compliment the original print volume set. By completing the original set with these new articles, the reader is kept up-to-date with research across the life sciences in one complete print product. Aimed at researchers, students and teachers, articles provide comprehensive and authoritative coverage, written by leaders in the field. Colour illustrations and tables accompany articles, with appendix and glossary material providing essential information for the non-specialist, including biochemical and taxonomic information, acronyms, synonyms, units and other technical data. Importantly, all articles have been peer-reviewed to ensure a balanced representation of the literature. Articles are divided into three different categories indicating their level of complexity: Introductory, Advanced and Keynote. Introductory articles have been written primarily for undergraduate and non-specialists requiring the basic concepts of a particular subject. Advanced articles provide a more detailed discussion of specialist subjects, equivalent to that found in graduate level texts. Keynote articles provide a platform for debate where controversial issues and 'hot topics' can be discussed. Coverage includes: Biochemistry Cell Biology Developmental Biology Ecology Evolution and Diversity of Life Functional and Comparative Morphology Genetics and Disease Genetics and Molecular Biology Immunology Microbiology Neuroscience Plant Science Science and Society Structural Biology Virology Don't miss this great opportunity to own the leading resource in the life sciences.

Encyclopedia of Life Sciences 32 Volume Set

Encyclopedia of Life Sciences  32 Volume Set Book
Author : John Wiley & Sons Ltd
Publisher : Wiley
Release : 2010-10-25
ISBN : 9780470664780
Language : En, Es, Fr & De

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Book Description :

The Encyclopedia of Life Sciences (ELS) Volumes 1-32 comprises the original 20 volumes of ELS (published in 2002), the supplementary Volumes 21-26 published in 2007, and Volumes 27-32 published in 2010. Volumes 21-32 bring together all the information that has been added to the online version of ELS on WileyInterscience® since publication of the first 20-volume set. Together, they provide readers with the most comprehensive and up-to-date information in Life Sciences. Spanning the entire spectrum of the life sciences, ELS features more than 4,300 specially commissioned and peer-reviewed articles, making it an essential read for life scientists and a valuable resource for teaching. Aimed at researchers, students and teachers, articles provide comprehensive and authoritative coverage, written by leaders in the field. Colour illustrations and tables accompany articles, with appendix and glossary material providing essential information for the non-specialist, including biochemical and taxonomic information, acronyms, synonyms, units and other technical data. All articles have been peer-reviewed to ensure a balanced representation of the literature. Articles are divided into three categories - Introductory, Advanced and Keynote. Introductory articles have been written primarily for undergraduate and non-specialists requiring the basic concepts of a particular subject. Advanced articles provide a more detailed discussion of specialist subjects, equivalent to that found in graduate level texts. Keynote articles provide a platform for debate where controversial issues and 'hot topics' can be discussed. Coverage includes: Biochemistry Cell Biology Developmental Biology Ecology Evolution and Diversity of Life Genetics and Disease Genetics and Molecular Biology Immunology Microbiology Neuroscience Plant Science Science and Society Structural Biology Virology