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Structural Biology In Immunology

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Structural Biology in Immunology

Structural Biology in Immunology Book
Author : Chaim Putterman,David Cowburn,Steven Almo
Publisher : Academic Press
Release : 2018-05-14
ISBN : 0128033703
Language : En, Es, Fr & De

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Book Description :

Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease. Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship Features a collaborative editorial effort, involving clinical immunologists and structural biologists Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology Gives interested parties a bridge to learn about computer modeling and structure based design principles

Structural Immunology

Structural Immunology Book
Author : Tengchuan Jin,Qian Yin
Publisher : Springer Nature
Release : 2019-10-18
ISBN : 9811393672
Language : En, Es, Fr & De

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Book Description :

This book presents a comprehensive overview of important immune molecules and their structure-function relationships. The immune system is highly complex, consisting of a network of molecules, cells, tissues and organs, and the immune reaction is involved in various physiological as well as pathological processes, including development, self-tolerance, infection, immunity, and cancer. Numerous molecules participate in immune recognition, inhibition and activation, and these important immune molecules can be roughly divided into cell surface receptors, intracellular receptors and intracellular signaling molecules. The study of how these immune molecules function at molecular level has laid the foundation for understanding the immune system. The book provides researchers and students with the latest research advances concerning the structural biology of key immune molecules/pathways, and offers immunologists essential insights into how these immune molecules function.

Structural Biology in Immunology

Structural Biology in Immunology Book
Author : Chaim Putterman,Steven Almo,David Cowburn
Publisher : Academic Press
Release : 2018-06
ISBN : 9780128033692
Language : En, Es, Fr & De

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Book Description :

Structural Biology in Immunology, Structure and Function of Novel Molecules of Immunologic Importance delivers important new information on structure and function relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. An improved appreciation of central structure function relationships will further enhance our ability to understand what defects in a normal individual can lead to disease. Furthermore, using this knowledge we can also better tailor more targeted and specific therapies, that will have increased efficacy with an improved side effect profile. These insights are currently applied for the development of enhanced antibodies, co-stimulatory molecules and multi-specific reagents. Describes novel/recently discovered immunomodulatory proteins, including antibodies, and co-stimulatory or co-inhibitory molecules Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship Features a collaborative editorial effort, involving clinical immunologists and structural biologists Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology Allows students and others outside of the relevant field a bridge to learn about computer modelling and structure based design principles

Structural Biology of the Complement System

Structural Biology of the Complement System Book
Author : Dimitrios Morikis,John D. Lambris
Publisher : CRC Press
Release : 2005-03-29
ISBN : 0849350360
Language : En, Es, Fr & De

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Book Description :

Of recent, the structure of the complement system has received considerable attention, including the publication of several three-dimensional structures of complement proteins. This has led to the need for an authoritative resource to provide a complete overview of the basics, as well as an explanation of the cutting-edge work being accomplished in

Structural Biology of the Complement System

Structural Biology of the Complement System Book
Author : Dimitrios Morikis,John D. Lambris
Publisher : CRC Press
Release : 2019-12-02
ISBN : 9780367454173
Language : En, Es, Fr & De

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Book Description :

Of recent, the structure of the complement system has received considerable attention, including the publication of several three-dimensional structures of complement proteins. This has led to the need for an authoritative resource to provide a complete overview of the basics, as well as an explanation of the cutting-edge work being accomplished in this emerging science. Structural Biology of the Complement System is devoted to the full exploration of structural aspects of the complement system, with special consideration of the links between molecular structure and function. Containing the work of leading authorities across the disciplines of immunology and structural biology, the book serves both as an introductory volume for newcomers to the field and as a comprehensive reference for established researchers, in particular those whose goal is the discovery of anticomplement drugs. Written in a didactic style, this volume is an appropriate resource for students in the fields of immunology and structural biology. Structural Biology of the Complement System comes with a CD containing color figures, a molecular structure visualization program, and files with three-dimensional coordinates of the structures described in the book. These tools allow readers to perform tailored structural manipulation and analysis, while also serving as a starting point for further research.

Effector Triggered Immunity

Effector Triggered Immunity Book
Author : Thomas A. Kufer
Publisher : Springer Nature
Release : 2022-12-02
ISBN : 1071624490
Language : En, Es, Fr & De

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Book Description :

Download Effector Triggered Immunity book written by Thomas A. Kufer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Immune System

The Immune System Book
Author : Parham, Peter
Publisher : W.W. Norton & Company
Release : 2014-10-01
ISBN : 0815345275
Language : En, Es, Fr & De

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Book Description :

This text emphasizes the human immune system and presents concepts with a balanced level of detail to describe how the immune system works. Written for undergraduate, medical, veterinary, dental, and pharmacy students, it makes generous use of medical examples to illustrate points. This classroom-proven textbook offers clear writing, full-color illustrations, and section and chapter summaries that make the content accessible and easily understandable to students.

Molecular Biology of Assemblies and Machines

Molecular Biology of Assemblies and Machines Book
Author : Wolfgang Baumeister,Baumeister Wolf,Alasdair Steven
Publisher : Garland Science
Release : 2016-03-15
ISBN : 9780815341666
Language : En, Es, Fr & De

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Book Description :

Molecular Biology of Assemblies and Machinespresents a comprehensive narrative describing the structures of macromolecular complexes and how they assemble and interact. Richly illustrated, it is written for advanced undergraduates, graduate students, and researchers in biochemistry, structural biology, molecular biology, biophysics, cell biology, and microbiology, and will also appeal to those in chemistry, immunology, and medicine. Essentially all major biological activities are performed by assemblies of macromolecules (proteins, RNA, and DNA) acting in concert. These assemblies are dynamic and many are endowed with machine-like properties. This unique book explores the molecular mechanisms employed at the critical level between individual macromolecules and cells and organelles.

Encyclopedia of Molecular Biology

Encyclopedia of Molecular Biology Book
Author : John Kendrew
Publisher : Wiley
Release : 1995-10-05
ISBN : 9780865426214
Language : En, Es, Fr & De

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Book Description :

The growth of molecular biology and the spread of its influence in other disciplines has led to a proliferation of terminology which has, as yet, to be effectively defined and housed in one single, accessible reference source. Within one volume this unique reference work contains nearly 6,000 headwords covering all areas of molecular life science including cell biology, immunology, microbiology, neurobiology, structural biology, developmental biology and molecular medicine. The Encyclopedia houses two types of article entry. Short articles of up to 100 words offer a short definition which is fully cross-referenced to article length entries of between 1,000 - 3,000 words. This unique cross-reference system allows the reader to approach their subject at the required level of detail and sophistication

Signalling Networks in Cell Shape and Motility

Signalling Networks in Cell Shape and Motility Book
Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Release : 2005-10-31
ISBN : 0470017651
Language : En, Es, Fr & De

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Book Description :

This book features contributions from experts in cell biology, genetics, neurobiology, immunology and structural biology. The unifying element is that they all study processes of cell shape change and motility. Several key questions in this field of research are discussed: What are the organising principles behind cell shape change? Are there ‘master switches’ present in every cell type? How are extracellular signals interpreted by the cell in order to activate intracellular mechanisms? What is the influence of the extracellular matrix on cell movement and internal signalling pathways? How do pathogens subvert cellular systems in order to stimulate or block their uptake? The book addresses all of these important questions. Data are presented on the key proteins that regulate cell shape: the GTP binding proteins of the Rho family. There are also extensive discussions of the potential applications of the data to clinical problems, particularly that of cell motility in cancer.

Textbook of Structural Biology

Textbook of Structural Biology Book
Author : Anders Liljas,Lars Liljas,Miriam-Rose Ash,Göran Lindblom,Poul Nissen,Morten Kjeldgaard
Publisher : World Scientific
Release : 2022-12-02
ISBN : 9813142499
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive coverage of the basic principles of structural biology, as well as an up-to-date summary of some main directions of research in the field. The relationship between structure and function is described in detail for soluble proteins, membrane proteins, membranes, and nucleic acids. There are several books covering protein structure and function, but none that give a complete picture, including nucleic acids, lipids, membranes and carbohydrates, all being of central importance in structural biology. The book covers state-of-the-art research in various areas. It is unique for its breadth of coverage by experts in the fields. The book is richly illustrated with more than 400 color figures to highlight the wide range of structures.

The Molecular Immunology of Complex Carbohydrates 2

The Molecular Immunology of Complex Carbohydrates    2 Book
Author : Albert M. Wu
Publisher : Springer
Release : 2013-03-03
ISBN : 9781461354697
Language : En, Es, Fr & De

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Book Description :

I organized this symposium, "Molecular Immunology of Complex Carbohydrates-2 (MICC-2)," at the Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan th between August 28-September 2, 1999, as a satellite meeting of the 15 International Glycoconjugate Conference (held August 22-27 in Tokyo, Japan). I also held a Taiwan Canada Glycobiology Workshop after this meeting at the Institutes of Biological Chemistry and Chemistry. To promote glycobiology in Taiwan, I offered a Complexs Carbohydrate & Medicine-2 workshop at the Glyco- Research Laboratory, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan before the MICC-2 symposium. The lecture and poster materials of these three meetings are collected in these proceedings, which are divided into five Sections and two Appendixes. Section I, entitled "Protein-Carbohydrate Interactions of Plant and Animal Lectins," provides current concepts of lectin-carbohydrate interactions; classification of lectins, based on amino acid sequences, molecular structures, and lectin affinity for carbohydrates. However, the relationships between amino acid sequences and carbohydrate affinity of lectins have to be more thoroughly characterized. The reviews on animal lectins in this Section explore new areas of lectins. Section II, "Aspects of Structure and Antigenicity of Glycoconjugates," provides important information on structural concepts of glyco immunology. "Glycotope Expression (Glycosylation), Metabolism and Functions," which play important roles in life processes, are discussed in Section III. Four articles on advances in knowledge on structural roles of glycans and treatment of cancer are discussed in Section IV.

Molecular Biology of Assemblies and Machines

Molecular Biology of Assemblies and Machines Book
Author : Alasdair Steven,Wolfgang Baumeister,Louise N. Johnson,Richard N. Perham
Publisher : Garland Science
Release : 2016-02-18
ISBN : 1000064905
Language : En, Es, Fr & De

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Book Description :

Molecular Biology of Assemblies and Machines presents a comprehensive narrative describing the structures of macromolecular complexes and how they assemble and interact. Richly illustrated, it is written for advanced undergraduates, graduate students, and researchers in biochemistry, structural biology, molecular biology, biophysics, cell biology,

Protein Reviews

Protein Reviews Book
Author : M. Zouhair Atassi
Publisher : Springer Nature
Release : 2021-03-01
ISBN : 3030678148
Language : En, Es, Fr & De

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Book Description :

The Protein Reviews series serves as a publication vehicle for reviews that focus on crucial contemporary and vital aspects of protein structure, function, evolution and genetics. Volumes are published online first, prior to publication in a printed book. Chapters are selected according to their importance to the understanding of biological systems, relevance to the unravelling of issues associated with health and disease, or impact on scientific or technological advances and developments. Volume 21 presents eight review chapters authored by experts in the related fields. The first chapter covers the enzyme squalene monooxygenase and lipid levels and its relevance in health and disease. Chapter two presents a systematic analysis of the structural and functional aspects of heteromeric solute carriers. The third chapter provides a review of the role of CI- in type IV collagen assembly, function, and disease, including future directions for studies. This is followed by a summary in chapter four about the recent progress on defining the roles of the Slit-Robo signaling in bone metabolism and the possible roles of the interaction between Robo and neural epidermal growth factor-like proteins. Chapter five discusses recent data about the evolutionary aspects on structural differences between humans and the nematode in relation to previous knowledge of core proteins and GAG-attachment sites in Chn and CS proteoglycans of C.elegans and humans. The sixth chapter summarizes the immunochemical character of the IGHV1-69-derived RFs and the recognition mechanism of the IGHV1-69-derived RFs. Chapter seven covers regulated alternative translocation and its role as an emerging mechanism to regulate transmembrane proteins. Finally, chapter eight reviews current progress on IL-36 protein and biology and novel investigative tools. This volume is intended for research scientists, clinicians, physicians and graduate students in the fields of biochemistry, cell biology, molecular biology, immunology and genetics.

Advanced Techniques in Soil Microbiology

Advanced Techniques in Soil Microbiology Book
Author : Ajit Varma,Ralf Oelmüller
Publisher : Springer Science & Business Media
Release : 2007-07-25
ISBN : 3540708650
Language : En, Es, Fr & De

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Book Description :

This book presents a wide range of biotechnological methods for application in soil microbiology analysis, including all essential methods involving molecular biology, immunology, microbiology, and structural biology, such as transcriptome analysis, RNAi technology, molecular matchmaking, RAPD, T-RFLP and FT/MS. The techniques and procedures presented here offer practical guides for immediate use in the laboratory. This volume will be of use both to the first-timer and to the experienced scientist.

Molecular Biology of B Cells

Molecular Biology of B Cells Book
Author : Tasuku Honjo,Michael Reth,Andreas Radbruch,Frederick Alt
Publisher : Elsevier
Release : 2014-10-09
ISBN : 0123984904
Language : En, Es, Fr & De

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Book Description :

Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response

The Limits of the Self

The Limits of the Self Book
Author : Thomas Pradeu
Publisher : OUP USA
Release : 2012-02-27
ISBN : 0199775281
Language : En, Es, Fr & De

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Book Description :

Immunology asserts that an individual can be defined through self and nonself. Thomas Pradeu argues that this theory is inadequate, because immune responses to self constituents and immune tolerance of foreign entities are the rule, not the exception.

Biomedical Translational Research

Biomedical Translational Research Book
Author : R. C. Sobti,Aastha Sobti
Publisher : Springer Nature
Release : 2022
ISBN : 9811643458
Language : En, Es, Fr & De

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Book Description :

This book, which is the first volume of Biomedical Translational Research, summarizes emerging technologies in healthcare. The book reviews the advancements in biomedical sciences in genomics, immunology, stem cell, tissue engineering, nanotechnology, computational and structural biology, biomedical engineering, and telemedicine biology. The book highlights the applications of artificial intelligence in the diagnosis of infectious diseases and examines the role of system biology approaches for understanding human complexity, variability, and its influence on health and diseases. It presents the applications of flow cytometry in monitoring the progression and treatment of disease. It covers emerging technologies in cancer research, including CRISPR-Cas9, NGS, and nanotechnology. This book is a useful source of information for clinical researchers, basic scientists, biomedical engineers, and computational biologists.

Advances in Immunology

Advances in Immunology Book
Author : Anonim
Publisher : Academic Press
Release : 2020-11-12
ISBN : 0128207434
Language : En, Es, Fr & De

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Book Description :

Advances in Immunology, Volume 148 offers the latest release in a long-established and highly respected publication, presenting current developments and comprehensive reviews in immunology. Sections in this new volume include chapters on histone deacetylases as targets in autoimmune and autoinflammatory diseases, the role of NK cell as central communicators in cancer immunity, and the mechanism and regulation of class switch recombination by transcriptional control element. Presents current developments and comprehensive reviews in immunology Provides the latest in a longstanding, respected serial on the subject matter Focuses on recent advances in the advancing area of the mechanisms involved in the evolution of HIV-1 neutralizing antibodies

Molecular Biology of the Cell

Molecular Biology of the Cell Book
Author : Bruce Alberts
Publisher : Unknown
Release : 2004
ISBN : 9780815332183
Language : En, Es, Fr & De

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Book Description :

Download Molecular Biology of the Cell book written by Bruce Alberts, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.