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Stroke Prevention In Atrial Fibrillation

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Non Vitamin K Antagonist Oral Anticoagulants

Non Vitamin K Antagonist Oral Anticoagulants Book
Author : Eduard Shantsila,GREGORY LIP
Publisher : Springer
Release : 2015-12-21
ISBN : 331925460X
Language : En, Es, Fr & De

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Book Description :

This book is an essential guide to the medical treatment of thrombosis and presents core principles of anticoagulant therapeutics as well as drug recommendations. Written by recognized experts in the field, this concise, accessible handbook provides a unique and valuable resource in the cardiovascular field, both for those currently in training, and for those already in clinical or research practice.

Prevention of Stroke

Prevention of Stroke Book
Author : John W. Norris,Vladimir C. Hachinski
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 1475742266
Language : En, Es, Fr & De

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Book Description :

Prevention of Stroke sums up and critically analyzes our present knowledge and understanding of all major aspects of stroke prophylaxis, medical and surgical. The book is intended for not only neurologists and neurosurgeons directly involved with stroke patients, but also vascular surgeons, internists, family physicians, and health planners. Topics explored include the cellular basis of atherosclerosis; stroke risk factors; head and neck bruits in stroke prevention; the present status of anticoagulant prophylaxis; hypertension and stroke prevention; and prevention of cardioembolic stroke, as well as the efficacy of aspirin and of ticlopidine in stroke prevention. Surgical prophylaxis is examined through discussions of carotid endarterectomy, prevention of stroke from cerebral vascular malformations, prevention of aneurysmal subarachnoid hemorrhage, balloon transluminal angioplasty of the carotid artery in the head and neck, and prevention of recurrent stroke.

Stroke Prevention in Clinical Practice

Stroke Prevention in Clinical Practice Book
Author : Daryll M. Baker
Publisher : Springer Science & Business Media
Release : 2007-12-10
ISBN : 1852339640
Language : En, Es, Fr & De

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Book Description :

Primary care physicians are the first to diagnose transient ischaemic attacks (TIAs), and are the doctors who can undertake a considerable amount of stroke prevention treatment. This book fills the primary care physician’s need for a short clear text explaining how to accurately diagnose a TIA, determine what investigations are indicated and how and when to intervene to reduce the risk of stroke. Short chapters are written in point form with clear diagrams and figures, each chapter written by an expert in the field. Stroke is a brain attack and a major cause of disability. Active intervention can prevent stroke especially in high risk groups.

Left Atrial Appendage Closure

Left Atrial Appendage Closure Book
Author : Jacqueline Saw,Saibal Kar,Matthew J. Price
Publisher : Springer
Release : 2015-11-09
ISBN : 3319162802
Language : En, Es, Fr & De

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Book Description :

Percutaneous left atrial appendage (LAA) closure is an emerging technology for thromboembolic prevention in patients with atrial fibrillation (AF). The first human implantation of an LAA device occurred in 2001, and since then four devices have received CE mark approval. These devices are being widely used in Europe for LAA closure in patients who are poor candidates for long-term oral anticoagulation. In the US, the WATCHMAN device (Boston Scientific) is anticipated to receive FDA approval imminently for AF patients who are warfarin-eligible. This approval is projected to significantly expand the indications for LAA closures worldwide. Thus, the volume of procedures is anticipated to escalate. This book discusses the epidemiology of AF as a cause of stroke; the use of LAA closure in the reduction of thromboembolism with AF; early surgical approaches and novel surgical devices for LAA closure; and current percutaneous approaches and devices available for LAA closure. The emphasis of this book is on percutaneous technical approaches and contemporary trial results on the leading devices (PLAATO, WATCHMAN, Amplatzer Cardiac Plug, and LARIAT). It also reviews unapproved devices in development, in both clinical and pre-clinical phases.

Large Simple Trials and Knowledge Generation in a Learning Health System

Large Simple Trials and Knowledge Generation in a Learning Health System Book
Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Drug Discovery, Development, and Translation,Roundtable on Value and Science-Driven Health Care
Publisher : National Academies Press
Release : 2013-12-05
ISBN : 0309289149
Language : En, Es, Fr & De

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Book Description :

Randomized clinical trials (RCTs) are often referred to as the "gold standard" of clinical research. However, in its current state, the U.S. clinical trials enterprise faces substantial challenges to the efficient and effective conduct of research. Streamlined approaches to RCTs, such as large simple trials (LSTs), may provide opportunities for progress on these challenges. Clinical trials support the development of new medical products and the evaluation of existing products by generating knowledge about safety and efficacy in pre- and post-marketing settings and serve to inform medical decision making and medical product development. Although well-designed and -implemented clinical trials can provide robust evidence, a gap exists between the evidence needs of a continuously learning health system, in which all medical decisions are based on the best available evidence, and the reality, in which the generation of timely and practical evidence faces significant barriers. Large Simple Trials and Knowledge Generation in a Learning Health System is the summary of a workshop convened by the Institute of Medicine's Roundtable on Value & Science-Driven Health Care and the Forum on Drug Discovery, Development, and Translation. Experts from a wide range of disciplines-including health information technology, research funding, clinical research methods, statistics, patients, product development, medical product regulation, and clinical outcomes research-met to marshal a better understanding of the issues, options, and approaches to accelerating the use of LSTs. This publication summarizes discussions on the potential of LSTs to improve the speed and practicality of knowledge generation for medical decision making and medical product development, including efficacy and effectiveness assessments, in a continuously learning health system. Large Simple Trials and Knowledge Generation in a Learning Health System explores acceleration of the use of LSTs to improve the speed and practicality of knowledge generation for medical decision making and medical product development; considers the concepts of LST design, examples of successful LSTs, the relative advantages of LSTs, and the infrastructure needed to build LST capacity as a routine function of care; identifies structural, cultural, and regulatory barriers hindering the development of an enhanced LST capacity; discusses needs and strategies in building public demand for and participation in LSTs; and considers near-term strategies for accelerating progress in the uptake of LSTs in the United States.

Transient Ischemic Attack and Stroke

Transient Ischemic Attack and Stroke Book
Author : Sarah T. Pendlebury,Matthew F. Giles,Peter M. Rothwell
Publisher : Cambridge University Press
Release : 2009-02-19
ISBN : 0521735122
Language : En, Es, Fr & De

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Book Description :

Accessible handbook covering the investigation, diagnosis and management of transient ischemic attacks and minor strokes.

Stroke Prevention in Atrial Fibrillation

Stroke Prevention in Atrial Fibrillation Book
Author : Greg Flaker
Publisher : Elsevier
Release : 2018-06
ISBN : 9780323554299
Language : En, Es, Fr & De

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Book Description :

Get a quick, expert overview of stroke risks among patients with treated and untreated atrial fibrillation, in addition to best practices for management and treatment of patients with atrial fibrillation to minimize stroke risks. This concise, clinically-focused resource by Dr. Greg Flaker consolidates today's available information on this timely topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee cardiologists as well as general practitioners treating and monitoring these patients. Covers a broad spectrum of management and treatment options for atrial fibrillation including anticoagulants, surgical and implanted devices. Presents information on recent drug trials to keep you up to date with the latest developments. Includes guidance on anticoagulation in special situations, such as cardioversion and ablation, in addition to atrial fibrillation treatment in patients with other medical conditions including cancer, major bleeding disorders, and renal or liver disease. Chapter on Risk Stratification assists in identifying patients with a high risk of stroke and predicting treatment outcomes. Chapter on The New Anticoagulation Clinic overviews best practices for patient education, compliance, follow-up monitoring, and quality assurance to aid in better patient outcomes.

Stroke Prevention in Patients with Atrial Fibrillation

Stroke Prevention in Patients with Atrial Fibrillation Book
Author : Gillian D. Sanders,Duke University Evidence-based Practice Center
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

OBJECTIVE: This review updates previous reviews regarding the optimal risk stratification tools for stroke and bleeding prediction, and treatment options for stroke prevention in patients with atrial fibrillation. DATA SOURCES: We searched PubMed(r), Embase(r), and the Cochrane Database of Systematic Reviews for relevant English-language comparative studies published from January 1, 2000, to February 14, 2018. REVIEW METHODS: Two investigators screened each abstract and full-text article for inclusion, abstracted data, rated quality and applicability, and graded evidence. When possible, random-effects models were used to compute summary estimates of effects. RESULTS: Our review included 320 articles (185 unique studies). This included 61 studies relevant to predicting thromboembolic risk, 38 relevant to predicting bleeding risk, and 117 relevant to interventions for preventing thromboembolic (TE) events. Data suggest that the CHADS2, CHA2DS2-VASc, and ABC risk scores have the best evidence predicting TE risk (moderate strength of evidence [SOE] for limited prediction ability of each score) and that the HAS-BLED score has the best evidence to predict bleeding risk (moderate SOE). We found that a thrombin inhibitor (dabigatran 150 mg) was superior to warfarin in preventing stroke (including hemorrhagic) or systemic embolism (relative risk [RR] 0.66; 95% confidence interval [CI] 0.53 to 0.82), with no statistically significant difference in the occurrence of major bleeding (RR 0.93; 95% CI 0.81 to 1.07) (high SOE for both outcomes). The Xa inhibitor apixaban was superior to warfarin in preventing stroke or systemic embolism (hazard ratio [HR] 0.79; 95% CI 0.66 to 0.95; high SOE), major bleeding (HR 0.69; 95% CI 0.60 to 0.80; high SOE), and all-cause mortality (HR 0.89; 95% CI 0.80 to 0.998; low SOE) Apixaban was also superior to aspirin in preventing stroke or systemic embolism (HR 0.45; 95% CI 0.32 to 0.62), with similar risk for major bleeding (HR 1.13; 95% CI 0.74 to 1.75) in patients who are not suitable for warfarin (moderate SOE for both outcomes). The Xa inhibitor edoxaban reduced hemorrhagic stroke and major bleeding compared to warfarin (moderate SOE for both outcomes) but had no evidence of a difference in stroke or systemic embolism (moderate SOE) or myocardial infarction (moderate SOE). The Xa inhibitor rivaroxaban was similar to warfarin in preventing stroke or systemic embolism (HR 0.88, 95% CI 0.74 to 1.03; moderate SOE), with similar rates of major bleeding (low SOE) and death (moderate SOE). Low SOE for major bleeding was due to a trend toward an increase in risk of major bleeding with rivaroxaban seen in observational studies. Comparative effectiveness findings for stroke prevention were limited by the direct comparisons between individual direct oral anticoagulants. Evidence regarding nonpharmacologic interventions was sparse, but left atrial appendage (LAA) closure devices showed a trend toward benefit over warfarin for strokes, major bleeding, and all-cause mortality that did not reach statistical significance. Higher adverse events (excessive bleeding or procedure-related complications) were observed with LAA (low SOE). CONCLUSIONS: Overall, we found that CHADS2, CHA2DS2-VASc, and ABC scores have similar evidence regarding their ability to predict stroke risk in patients with atrial fibrillation, whereas HAS-BLED has the best evidence to predict bleeding risk. Direct oral anticoagulants (specifically apixaban and dabigatran) demonstrate reductions in stroke events and reductions (apixaban) or similar (dabigatran) rates in bleeding events when compared with warfarin, while rivaroxaban was similar in both benefits and harms to warfarin. Edoxaban reduced hemorrhagic stroke and major bleeding compared to warfarin but had no evidence of a difference in other outcomes. More studies are needed directly comparing oral anticoagulants, including thrombin inhibitors and individual Xa inhibitors.

The Stroke Book

The Stroke Book Book
Author : Michel T. Torbey,Magdy H. Selim
Publisher : Cambridge University Press
Release : 2013-07-18
ISBN : 1107634725
Language : En, Es, Fr & De

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Book Description :

An essential companion for busy professionals seeking to navigate stroke-related clinical situations successfully and make quick informed treatment decisions.

Guidelines for Antithrombotic Therapy

Guidelines for Antithrombotic Therapy Book
Author : Jack Hirsh
Publisher : Pmph USA Limited
Release : 2008-01-01
ISBN : 9781607950097
Language : En, Es, Fr & De

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Book Description :

Includes a new chapter addressing the management of patients who are treated with anti-coagulants or anti-platelet drugs Provides a detail summary to each chapter, documenting the therapeutic recommendations Updates on important clinical trials since last edition

Indications for and implementation of anticoagulant therapy in atrial fibrillation

Indications for and implementation of anticoagulant therapy in atrial fibrillation Book
Author : Sics Editore
Publisher : SICS Editore
Release : 2014-10-01
ISBN : 8869309835
Language : En, Es, Fr & De

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Book Description :

Anticoagulant therapy is the only form of treatment that unquestionably has been shown to improve the prognosis of patients with atrial fibrillation (AF).The most important aspect in clinical practice is to identify and treat patients who will benefit from long-term anticoagulant therapy. The choice between warfarin and the new class of anticoagulants (apixaban, dabigatran, rivaroxaban) should be made individually taking into account the benefits and risks of the drugs as well as the patient’s wishes.

Stroke in Atrial Fibrillation An Issue of Cardiac Electrophysiology Clinics

Stroke in Atrial Fibrillation  An Issue of Cardiac Electrophysiology Clinics  Book
Author : Samuel J. Asirvatham
Publisher : Elsevier Health Sciences
Release : 2014-09-05
ISBN : 032328700X
Language : En, Es, Fr & De

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Book Description :

Because atrial fibrillation promotes the formation of blood clots that can travel to the brain and block an artery, atrial fibrillation independently increases the risk of ischemic stroke four-to-five-fold. In this issue expert authors review drug therapies for stroke prevention, use of the new anticoagulants, ablation strategies for stroke prevention, LAA closure for stroke prevention, stroke in heart rhythm device patients, transesophageal echo in atrial fibrillation, and other topics important to the management of this serious complication.

Epidemiology and Treatment of Atrial Fibrillation

Epidemiology and Treatment of Atrial Fibrillation Book
Author : Gabriel Cismaru,Keith Andrew Chan
Publisher : BoD – Books on Demand
Release : 2020-04-22
ISBN : 1838802479
Language : En, Es, Fr & De

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Book Description :

This book addresses the problem of atrial fibrillation in terms of epidemiology, risk factors, as well as treatment, including medical treatment using drugs, catheter ablation, and cardiac surgery. Most of the authors of the book are arrhythmologists, and chapters on atrial fibrillation are based on their experience in the cardiology clinic or the operating room.

Thrombosis and Stroke Prevention 3rd Edition

Thrombosis and Stroke Prevention 3rd  Edition Book
Author : Mr Hans R Larsen Msc
Publisher : Unknown
Release : 2018-04-27
ISBN : 9780980924213
Language : En, Es, Fr & De

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Book Description :

Do you know your risk of suffering a stroke and what you can do to prevent it? "Hans clearly explains the body's pathways to form blood clots and to dissolve them, the medications in common use to affect these processes, and the natural alternatives that can be used to help prevent stroke. His analysis will also help to prevent heart attack and blood clots in the lungs. Read this book; it may save your life!" Sadja Greenwood MD MPH, CA Thrombosis and Stroke Prevention covers the underlying causes and mechanisms of thrombosis (blood clot formation) and stroke and provides an in-depth review of conventional and alternative approaches to stroke prevention. This new edition adds a chapter on how to live with warfarin and presents new information about stroke risk factors and how to estimate your own risk. It provides an update of the latest research concerning natural and pharmaceutical antithrombotics including the pros and cons of the new oral anticoagulants. A final chapter discusses stroke prevention based on occluding (closing off) the left atrial appendage where the vast majority of clots associated with atrial fibrillation are generated. " Hans Larsen's knowledge on thrombosis and stroke prevention far exceeds that of most conventional medical specialists in this area. This simple to read, cutting edge manual on natural alternatives to stroke prevention is a must read for anyone contemplating anti-coagulation therapy or simply wanting to prevent a stroke." Michael Lam MD MPH, CA " Hans is able to explain the intricate mechanisms involved in the underlying causes of thrombosis leading to strokes, he provides us the clinical tests for each of these entities, and then offers a rational preventive means to alter this process. This book is a rich document replete with abundant references and will have a profound impact on patients attempting to understand and modify their risks for thrombosis and stroke, especially those with lone atrial fibrillation. Highly recommended, and a necessary companion to his Lone Atrial Fibrillation: Towards a Cure." Norman F. Fisher MD, CA

Clinical Guide to Cardiology

Clinical Guide to Cardiology Book
Author : Christian Fielder Camm,A. John Camm
Publisher : John Wiley & Sons
Release : 2016-03-07
ISBN : 1118755332
Language : En, Es, Fr & De

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Book Description :

Clinical Guide to Cardiology is a quick-reference resource, packed full of bullet points, diagrams, tables and algorithms for the key concepts and facts for important presentations and conditions within cardiology. It provides practical, evidence-based information on interventions, investigations, and the management of clinical cardiology. Key features include: A clear evidence-base providing key guidelines and clinical trials in each chapter Coverage of examination techniques, common conditions, imaging modalities (including ECGs, chest X-rays, MRI and CT), interventional therapies, and pharmacology A companion website at www.wiley.com/go/camm/cardiology featuring audio clips, developed for differing levels of knowledge, that explain key concepts or an area in greater detail, as well as numerous additional clinical case studies, audio scripts, and self-assessment material

Anticoagulant Drugs

Anticoagulant Drugs Book
Author : Mojca Božič-Mijovski
Publisher : BoD – Books on Demand
Release : 2018-08-29
ISBN : 1789236223
Language : En, Es, Fr & De

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Book Description :

Anticoagulant drugs are among the most frequently prescribed drugs in everyday clinical practice. In the past decades, several new direct oral anticoagulants were developed that changed the anticoagulant therapy landscape considerably. This book provides an extensive overview of all the known anticoagulants that can be useful for studying different aspects of the haemostatic system or as a starting point for new drug development. It is also a valuable tool for clinicians providing a description of the mode of action and management of therapy for anticoagulant drugs used in everyday clinical practice in different clinical settings, including direct oral anticoagulants dabigatran, rivaroxaban, apixaban and edoxaban.

Atrial Fibrillation

Atrial Fibrillation Book
Author : National Collaborating Centre for Chronic Conditions (Great Britain)
Publisher : Royal College of Physicians
Release : 2006
ISBN : 1860162827
Language : En, Es, Fr & De

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Book Description :

Download Atrial Fibrillation book written by National Collaborating Centre for Chronic Conditions (Great Britain), available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Electrophysiological Disorders of the Heart E Book

Electrophysiological Disorders of the Heart E Book Book
Author : Sanjeev Saksena,A. John Camm
Publisher : Elsevier Health Sciences
Release : 2011-12-12
ISBN : 1437709710
Language : En, Es, Fr & De

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Book Description :

The new edition of Electrophysiological Disorders of the Heart helps you diagnose and treat a full range of heart rhythm disorders using today’s latest technologies and therapies. It provides practical, hands-on coverage of hot topics such as pediatric EP, imaging, echocardiography-guided EP procedures, regenerative therapies, cardiac pacing, and more. Now available in a new full-color format, the title also includes easy online access at www.expertconsult.com. Discover new ways to treat and manage the full range of heart rhythm disorders with content focused on common clinical features, diagnosis, and management. Review expert management strategies to help you handle complex patient problems. Stay current with the latest molecular and technical advances as well as new treatment options implemented over the last few years. Use the latest technologies and devices to accurately diagnose and manage heart rhythm disorders. Consult new and expanded coverage of regenerative therapies, echo-guided procedures, cardiac pacing, and CRT, as well as a new section on pediatric electrophysiology and imaging. Enjoy improved visual guidance with many new full-color images. Log on to www.expertconsult.com to easily search the complete contents online and access a downloadable image library.

Stroke Prevention

Stroke Prevention Book
Author : Wolfgang Dorndorf,Peter Marx
Publisher : S Karger Ag
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Stroke prevention has proved to be effective in hypertensive patients and those with atrial fibrillation and severe symptomatic carotid stenosis. Various interventional studies, based on knowledge about risk factors and improved methods of identifying stroke etiologies in individuals, have demonstrated that stroke can be avoided in a considerable number of patients. This volume brings together the latest developments in this field and considers future directions. The contributions, written by leading scientists, are organized into sections dealing with classification of strokes, risk factors, secondary prevention in vascular disease, surgical and interventional prevention, and cardioembolic stroke. Each article followed by a detailed summary in German. The book will be a valuable source of information for all those interested in this important subject.

Chalk Talks in Internal Medicine

Chalk Talks in Internal Medicine Book
Author : Somnath Mookherjee,Lauren A. Beste,Jared W. Klein,Jennifer Wright
Publisher : Springer Nature
Release : 2020-09-30
ISBN : 3030348148
Language : En, Es, Fr & De

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Book Description :

This book provides teaching scripts for medical educators in internal medicine and coaches them in creating their own teaching scripts. Every year, thousands of attending internists are asked to train the next generation of physicians to master a growing body of knowledge. Formal teaching time has become increasingly limited due to rising clinical workload, medical documentation requirements, duty hour restrictions, and other time pressures. In addition, today’s physicians-in-training expect teaching sessions that deliver focused, evidence-based content that is integrated into clinical workflow. In keeping with both time pressures and trainee expectations, academic internists must be prepared to effectively and efficiently teach important diagnostic and management concepts. A teaching script is a methodical and structured plan that aids in effective teaching. The teaching scripts in this book anticipate learners’ misconceptions, highlight a limited number of teaching points, provide evidence to support the teaching points, use strategies to engage the learners, and provide a cognitive scaffold for teaching the topic that the teacher can refine over time. All divisions of internal medicine (e.g. cardiology, rheumatology, and gastroenterology) are covered and a section on undifferentiated symptom-based presentations (e.g. fatigue, fever, and unintentional weight loss) is included. This book provides well-constructed teaching scripts for commonly encountered clinical scenarios, is authored by experienced academic internists and allows the reader to either implement them directly or modify them for their own use. Each teaching script is designed to be taught in 10-15 minutes, but can be easily adjusted by the reader for longer or shorter talks. Teaching Scripts in Internal Medicine is an ideal tool for internal medicine attending physicians and trainees, as well as physician’s assistants, nurse practitioners, and all others who teach and learn internal medicine.