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Stress Immunology And Inflammation

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The immunology of cellular stress proteins

The immunology of cellular stress proteins Book
Author : Willem Van Eden,Ruurd Van Der Zee,Cristina Bonorino
Publisher : Frontiers E-books
Release : 2014-10-05
ISBN : 288919325X
Language : En, Es, Fr & De

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Book Description :

Stress proteins or heat-shock proteins (HSP) are evolutionary conserved proteins present in every prokaryotic and eukaryotic cell. Their main function is to protect cells and proteins from damage under stressful circumstances. The latter circumstances do include the cell and protein damaging effects of inflammation. The discovery of mycobacterial HSP60 being a critical antigen in the model of adjuvant arthritis, has led to studies that showed the immuno-dominance of microbial HSP60 and the potential of the microbial HSP induced repertoire of antibodies and T cells to cross-recognize the self-HSP homologues of stressed cells. Since then, the research in the immunology of stress proteins started to comprise a widening spectrum of topics with potential medical relevance. Interestingly, since stress proteins have their activities in both innate and adaptive immunity, they are key elements in the cross-roads between both arms of the immune system. Stress proteins or HSP can be considered as functional 'biomarkers' of inflammation. They are up-regulated locally during inflammation and interestingly, they seem to function as targets for anti-inflammatory regulatory T cells. In experimental models of autoimmunity, mainly arthritis, administration of HSP peptides have been shown to suppress disease. First clinical trials have shown the anti-inflammatory nature of T cell responses to Hsp. In type I diabetes and in rheumatoid arthritis, parenteral and oral administration of Hsp peptides were shown to induce a bias in pro-inflammatory T cells, switching them in the direction of regulatory cytokine production (IL4, IL5 and IL10). In addition a raised level of a marker of natural T regulatory cells, the transcription factor FoxP3, was noted in the RA trial. Other inflammatory diseases or diseases with inflammatory components which feature the immune imprint of the up-regulated Hsp are atherosclerosis, inflammatory bowel diseases, multiple sclerosis and atopic diseases such atopic dermatitis and allergic asthma.

Heat Shock Proteins Potent Mediators of Inflammation and Immunity

Heat Shock Proteins  Potent Mediators of Inflammation and Immunity Book
Author : Alexzander A.A. Asea,Antonio De Maio
Publisher : Springer Science & Business Media
Release : 2007-09-05
ISBN : 1402055854
Language : En, Es, Fr & De

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Book Description :

This book provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulate the hosts’ immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step-wise fashion take the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provide answers as to its biological significance to the host.

Stress Consequences

Stress Consequences Book
Author : George Fink
Publisher : Academic Press
Release : 2010-04-06
ISBN : 9780123751751
Language : En, Es, Fr & De

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Book Description :

Stress is a universal phenomenon that impacts adversely on most people. This volume provides a readily accessible compendium that focuses on the physical and psychological consequences of stress for individuals and society. Clinical attention focuses on disorders of the stress control system (e.g. Cushing’s Syndrome: Addison’s Disease) and the adverse impact of stress on human physical and mental health. Detailed reviews address disorders such as PTSD, anxiety, major depression, psychoses and related disorders such as combat fatigue and burnout. The work covers interactions between stress and neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease, as well as stress-immune-inflammatory interactions in relation to cancer and autoimmune and viral diseases. Emphasis is also placed on the role of stress in obesity, hypertension, diabetes type II and other features of the metabolic syndrome which has now reached epidemic proportions in the USA and other countries. Chapters offer impressive scope with topics addressing animal studies, disaster, diurnal rhythms, drug effects and treatments, cognition and emotion, physical illness, psychopathology, immunology and inflammation, lab studies and tests, and psychological / biochemical / genetic aspects Richly illustrated in full color with over 200 figures Articles carefully selected by one of the world’s most preeminent stress researchers and contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge

Stress Depression Inflammation and Personalized Medicine

Stress  Depression  Inflammation  and Personalized Medicine Book
Author : Pharm Tao
Publisher : Lulu Press, Inc
Release : 2016-08-31
ISBN : 1329905768
Language : En, Es, Fr & De

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Book Description :

Psychological stress has been associated with higher levels of inflammation and the risks of many physical disorders including heart diseases. Inflammatory processes are the common complications of a wide range of diseases including diabetes and cancer. Inflammation can be enhanced by stress and depression, such as in the condition of troubled relationships. The emerging field of psychoneuroimmunology (PNI) focuses on the interactions among the immune system, the central nervous system (CNS), and behavior. Both genetic and environmental factors can influence human personality and various mental problems including autism, bipolar disorder, schizophrenia, and post-traumatic stress disorder (PTSD). Gene-environment interactions may affect neural processing and play a critical role in individual differences in disease susceptibility. The identification of these factors can help with the development of strategies for more targeted care in personalized medicine.

Immunity and Inflammation in Health and Disease

Immunity and Inflammation in Health and Disease Book
Author : Shampa Chatterjee,Wolfgang Jungraithmayr,Debasis Bagchi
Publisher : Academic Press
Release : 2017-08-31
ISBN : 0128054026
Language : En, Es, Fr & De

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Book Description :

Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here. Conceptualizes the key features in natural products which can boost immune function and immune health Explains the intricate mechanistic aspects and balance behind immune health Presents the pathophysiology of several diseases associated with immune system disruption

Stress Science

Stress Science Book
Author : George Fink
Publisher : Unknown
Release : 2010
ISBN : 9780123750662
Language : En, Es, Fr & De

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Book Description :

Stress is a universal phenomenon that impacts adversely on most people. This volume provides a readily accessible compendium that explains the phenomenon of stress, the neural, endocrine and molecular mechanisms involved, the clinical effects, and the impact on individuals and society. Clinical attention focuses on disorders of the stress control system (e.g. Cushing's Syndrome: Addison's Disease) and the adverse impact of stress on human physical and mental health . Detailed reviews address disorders such as PTSD, anxiety, major depression, psychoses and related disorders such as combat fatigue and burnout. The work covers interactions between stress and neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, as well as stress-immune-inflammatory interactions in relation to cancer and autoimmune and viral diseases. Emphasis is also placed on the role of stress in obesity, hypertension, diabetes type II and other features of the metabolic syndrome which has now reached epidemic proportions in the USA and other countries. Chapters offer impressive scope with topics addressing animal studies, disaster, diurnal rhythms, drug effects and treatments, cognition and emotion, physical illness, psychopathology, immunology and inflammation, lab studies and tests, and psychological / biochemical / genetic aspects Richly illustrated with over 200 figures, 75 in color Priced affordably, this compendium of articles appeals to the end user interested in stress research who would not otherwise purchase the larger Encyclopedia of Stress Articles carefully selected by one of the world's most preeminent stress researchers and contributors represent the most outstanding scholarship in the field, with each chapter providing fully vetted and reliable expert knowledge

The Psychoneuroimmunology of Chronic Disease

The Psychoneuroimmunology of Chronic Disease Book
Author : Kathleen Kendall-Tackett,Kathleen A. Kendall-Tackett
Publisher : Amer Psychological Assn
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Recent years have witnessed considerable growth in the field of psychoneuroimmunology (PNI), which describes how psychological factors, such as stress and depression, impact the neurological and immune systems. Research increasingly indicates that psychological states play a key role in the development and exacerbation of inflammatory diseases such as heart disease, diabetes, multiple sclerosis, Alzheimers, and autoimmune disorders. In this book, editor Kathleen Kendall-Tackett and an elite group of researchers explore the ways physical and psychological stressors such as poor sleep, PTSD, and depression, trigger the inflammatory response and increase the risk of disease. They approach this material from a variety of perspectives. Chapters in Part I describe the biological processes involved in inflammation, focusing on both the typical bodily response to threat as well as on the long-term deleterious effects of stress upon the immune system; while chapters in Part II examine the role of psychosocial stress in disease etiology. Throughout, chapter authors present evidence of connections between mind and body, and emphasize the need for improved communication between physicians and mental health care providers. This book will be a valuable resource for researchers as well as practitioners who hope to share the benefits of these findings with their clients.

Cytokines Stress and Depression

Cytokines  Stress  and Depression Book
Author : Robert Dantzer,Emmanuelle E. Wollmann,Raz Yirmiya
Publisher : Springer
Release : 2013-03-23
ISBN : 9781475786101
Language : En, Es, Fr & De

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Book Description :

Cytokines had been characterized in the early eighties as communication mole cules between immune cells, and between immunocytes and other peripheral cells, such as fibroblasts and endothelial cells. They play a key role in the regulation of the immune response and the coordination of the host response to infection. Based on these biological properties, nobody would have predicted that one decade later cytokines would burst upon neurosciences and permeate into several avenues of current research. In neurology, the connection between cytokines and inflammation, and the demonstration of a pivotal role of some of these molecules in cell death by apoptosis, prompted the investigation of their involvement in several neurological diseases involving an inflammatory component, including multiple sclerosis, brain trauma, stroke, and Alzheimer's disease. This movement started in the late eighties, and the corresponding field of research, known as neuroimmunology, is presently booming. In psychiatry, however, the relationship between cytokines and mental disorders was much less evident and took longer to materialize. The first indication that cytokines might be involved in psychopathology came from cancerology and internal medicine.

Psychoneuroimmunology

Psychoneuroimmunology Book
Author : Qing Yan
Publisher : Humana Press
Release : 2018-04-29
ISBN : 9781493978274
Language : En, Es, Fr & De

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Book Description :

This fully-updated book provides systems-based methodologies and innovative technologies that can be used for solving complicated problems of complex systems. A wide range of theoretical and experimental approaches are introduced for practical applications, as the content explores the basic and novel concepts in psychoneuroimmunology (PNI), especially the relationships among stress, inflammation, and psychophysiological disorders, as well as various cutting-edge technologies and methods for PNI studies, including the utilizations of mouse models and vaccine models. In addition, this book focuses on translational medicine by applying PNI methods in clinical practice. As part of the Methods in Molecular Biology series, the chapters seek to provide a practical, state-of-the-art, and holistic view for the translation of PNI into better preventive and personalized medical practice. Authoritative and hands-on, Psychoneuroimmunology: Methods and Protocols, Second Edition will be of use to biomedical students and professionals at all levels who are interested in integrative studies in psychology, psychiatry, neuroscience, immunology, molecular biology, genetics, bioengineering, physiology, pathology, microbiology, systems biology, and clinical medicine.

Mind over Matter Regulation of Peripheral Inflammation by the CNS

Mind over Matter   Regulation of Peripheral Inflammation by the CNS Book
Author : Michael Schäfer,Christoph Stein
Publisher : Springer
Release : 2012-12-06
ISBN : 3034880391
Language : En, Es, Fr & De

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Book Description :

Several new developments in the field of neuroimmunology with focus on the brain-to-immune system communication have been the incentive for this PIR volume. It covers topics such as brain-immune interactions, the impact of stress on the immune response, pain and immunosuppression, the modulation of inflammation and pain by the sympathetic nervous system, consequences of nerve injury for the immune system, neuronal mechanisms of immune cell recruitment, and the modulation of the immune response by corticotropin-releasing hormone or adenosine. The authors are a unique group of scientists who are all interested in brain-to-immune interactions; however, each from a different perspective. The volume will serve both neurobiologists and immunologists to understand the influence of the central nervous system on peripheral inflammation. Many aspects of this book will also be stimulating for researchers in the pain field.

Inflammation and Immunity in Depression

Inflammation and Immunity in Depression Book
Author : Bernhard Baune
Publisher : Academic Press
Release : 2018-05-23
ISBN : 0128110740
Language : En, Es, Fr & De

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Book Description :

Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression. Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system Explores translational potential of targeting immune dysfunction for clinical interventions

Exercise Immunology

Exercise Immunology Book
Author : Michael Gleeson,Nicolette Bishop,Neil Walsh
Publisher : Routledge
Release : 2013-06-26
ISBN : 1136455868
Language : En, Es, Fr & De

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Book Description :

Exercise immunology is an important, emerging sub-discipline within exercise physiology, concerned with the relationship between exercise, immune function and infection risk. This book offers a comprehensive, up-to-date and evidence-based introduction to exercise immunology, including the physiological and molecular mechanisms that determine immune function and the implications for health and performance in sport and everyday life. Written by a team of leading exercise physiologists, the book describes the characteristics of the immune system and how its components are organised to form an immune response. It explains the physiological basis of the relationship between stress, physical activity, immune function and infection risk, and identifies the ways in which exercise and nutrition interact with immune function in athletes and non-athletes. The book shows students how to evaluate the strengths and limitations of the evidence linking physical activity, immune system integrity and health, and explains why exercise is associated with anti-inflammatory effects that are potentially beneficial to long-term health. Every chapter includes useful features, such as clear summaries, definitions of key terms, discussions of seminal research studies and practical guidelines for athletes on ways to minimise infection risk, with additional learning resources available on a companion website. This is an essential textbook for any course on exercise immunology or advanced exercise physiology.

Stress and Skin Disorders

Stress and Skin Disorders Book
Author : Katlein França,Mohammad Jafferany
Publisher : Springer
Release : 2016-12-16
ISBN : 3319463527
Language : En, Es, Fr & De

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Book Description :

Dermatological conditions are intimately related to stress. Stress can affect, reveal or even exacerbate a number of skin disorders, including alopecia, seborrheic dermatitis, psoriasis, atopic dermatitis, pruritus, herpes, lichen planus, rosacea and urticarial. On the other hand, the skin disease itself could induce a secondary stress for the patient, influencing his or her quality of life. There is increasing evidence that stress influences disease processes and contributes to inflammation through the modulating hypothalamicpituitary- adrenal axis – releasing neuropeptides, neurotrophins, lymphokines and other chemical mediators from nerve endings to dermal cells. This is one of the first books published on this topic, focusing more on the basic science aspects of stress in dermatopathology (oxidants, antioxidants, and oxidative injury in dermatopathology, dermatopharmacology, and dermatotoxicology.) Most Psychodermatology texts adopt a practical approach to identify all types of Psychodermatology disorders, focusing on clinical treatment. This concise title offers a comprehensive and didactic approach to skin diseases caused or exacerbated by stress, as well as covers the immunology, role and effect of stress on skin disease, and quality of life in dermatology. In the current programs of medical residency in dermatology, little is taught about the relationship between stress and skin diseases and this book is an important tool for young dermatologists and psychodermatologists in training.

Cytokines

Cytokines Book
Author : Robert E. Faith,Anthony J. Murgo,Robert A. Good,Nicholas P. Plotnikoff
Publisher : CRC Press
Release : 2006-10-10
ISBN : 1420003801
Language : En, Es, Fr & De

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Book Description :

Cytokine involvement in the immune system's response to stress is now very well documented. Cytokine activity has been implicated in a variety of mental and physical diseases, and has been shown to have a significant role in fueling the vicious circle of depression and illness. The first edition of Cytokines: Stress and Immunity pointed out

The Effects of Telephone Delivered Cognitive Behavioral Stress Management on Inflammation and Symptoms in Myalgic Enchephalomyelitis Chronic Fatigue Syndrome

The Effects of Telephone Delivered Cognitive Behavioral Stress Management on Inflammation and Symptoms in Myalgic Enchephalomyelitis Chronic Fatigue Syndrome Book
Author : Emily G Lattie
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multi-systemic and unpredictable medical illness for which effective treatments are lacking. A number of studies have documented immune dysregulation in this patient population, and past research has demonstrated the benefits of stress management training on immune functioning. Due to unpredictable and often severe symptoms, patients with ME/CFS have reported difficulties in attending appointments outside of the home. In consideration of these difficulties, this patient population may particularly benefit from therapeutic services available from one's own home. This study aimed to examine the impact of telephone-delivered CBSM on inflammation and symptoms in individuals with ME/CFS. In order to determine the relationships between cytokine network coexpression patterns and CFS symptoms, the first study examined the presence of cytokine network coexpression patterns and symptom patterns in 215 women diagnosed with ME/CFS. Principal component analyses of 16 cytokines demonstrated a two-component solution in which the first component was characterized primarily by the presence of pro-inflammatory and Th1 cytokines, while the second component was primarily characterized by absence of pro-inflammatory and Th1 cytokines and presence of anti-inflammatory IL-13. Examination of 20 common ME/CFS symptoms revealed three distinct clusters of ME/CFS symptoms: Fatigue/Sleep Impairments, Pain/Neurological Impairments and Immune/Gastrointestinal Impairments. Attempts to model cytokine components and symptom clusters together revealed that while cytokines shared a substantial amount of variability with one another and the variables within each symptom cluster were highly correlated with one another, there were few direct pathways, or "links" between the cytokines and symptoms. Direct relationships were observed between IL-1[alpha] and the symptoms chills and sinus or nasal symptoms, IL-6 and the symptom of severe headaches, IL-17 and the symptom problems getting to sleep or problems waking up early in the morning, and IFN-[gamma] and the symptom eyes extremely sensitive to light. In a second study, longitudinal differences in cytokines and symptoms were examined between participants who received telephone-delivered CBSM (N = 53) and participants who received a telephone-delivered health promotion program (N = 40) as part of a randomized controlled trial. No group by time effects were detected in changes in cytokines or symptoms over a 9-month follow-up, which may have been due to both the use of a stronger control condition and a weaker intervention, as group CBSM participants may have had difficulty engaging with the intervention material over the telephone. However, there were significant changes across time in both groups in the cytokine components (the first described the presence of pro-inflammatory and Th1 cytokines, while the second component was primarily characterized by absence of pro-inflammatory and Th1 cytokines and presence of anti-inflammatory IL-13) and in the Fatigue/Sleep Impairments symptom cluster. Mechanisms for change over this period may include increased self-efficacy to solve one's problems, resulting in reduced stress and enhanced self-care. Given the barriers to treatment faced by many individuals with ME/CFS, future therapeutic interventions for this population should examine the effects of alternate modes of intervention delivery such as home-based video-conferencing or module-based websites.

MIF Family Cytokines in Innate Immunity and Homeostasis

MIF Family Cytokines in Innate Immunity and Homeostasis Book
Author : Richard Bucala,Jürgen Bernhagen
Publisher : Springer
Release : 2017-06-12
ISBN : 3319523546
Language : En, Es, Fr & De

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Book Description :

The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.

Psychoneuroimmunology

Psychoneuroimmunology Book
Author : Qing Yan
Publisher : Springer
Release : 2016-10-03
ISBN : 3319451111
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of the cutting-edge discoveries and the systems approaches related to the multi-disciplinary field of psychoneuroimmunology (PNI), which may provide the scientific basis for mind-body relationships, and aid in the development of personalized medicine. Specifically, the book focuses on the systems biology studies of complex mechanisms, such as stress and inflammation. There is strong evidence supporting the close relationship between stress, inflammation, and disorders including obesity, cardiovascular disease, diabetes, skin diseases, and sleep disorders. As inflammation is a critical connection among different diseases, further elucidating this connection may contribute to the findings of systemic therapeutic targets. Translational medicine is also addressed, by applying PNI approaches in clinical practice. A major challenge in current bioscience is the translation of basic scientific discoveries into better clinical outcomes. With the understanding of the translational implications of PNI, integrative interventions can be applied to modulate stress responses and to promote healthier behaviors. As an important feature of this book, a broad overview of the PNI-associated integrative interventions is provided. These interventions include nutritional supplements, meditation, and other mind-body strategies. From basic concepts to systems methodologies, from theoretical sources to clinical applications, Psychoneuroimmunology contributes to the understanding and development of PNI toward the establishment of personalized and mind-body medicine.

Immuno Psychiatry

Immuno Psychiatry Book
Author : Michael Berk,Marion Leboyer,Iris E. Sommer
Publisher : Springer Nature
Release : 2021-08-14
ISBN : 303071229X
Language : En, Es, Fr & De

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Book Description :

This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.

Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging

Autophagy  Cancer  Other Pathologies  Inflammation  Immunity  Infection  and Aging Book
Author : M. A. Hayat
Publisher : Academic Press
Release : 2013-07-29
ISBN : 0124055354
Language : En, Es, Fr & De

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Book Description :

Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, these books offer a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections. Considering that autophagy is associated with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases, there is a great need to understanding its role. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological situations (conditions) mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. Volumes in the Series

Environmental Influences on the Immune System

Environmental Influences on the Immune System Book
Author : Charlotte Esser
Publisher : Springer
Release : 2016-02-04
ISBN : 3709118905
Language : En, Es, Fr & De

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Book Description :

This book brings together articles on the overarching theme of how the environment shapes the immune system. The immune system is commonly assumed to respond to harmful pathogens such as bacteria and viruses. However, harmless bacteria, chemicals, stress, normal food and other factors can also trigger, shape or interfere with the immune system, often producing adverse effects. Yet, it is also becoming increasingly accepted that some of these interactions are physiological and necessary for a healthy immune system. Examples of negative effects include the immunosuppressive effects of UV irradiation, or the immunotoxic effects of man-made chemicals such as polycyclic aromatic hydrocarbons. Autoimmunity or allergies can be the adverse consequences of interaction between the immune system and chemical compounds such as drugs. Positive effects can come from natural exposure levels to bacteria, healthy life-style or the diet. There is a great need to understand how communication between the environment and the immune system works. This book addresses this need. It covers environmental factors (such as bacteria, sun exposure), human factors (such as age, exercise or stress), and important man-made factors (such as air pollution). A chapter on human rights complements the scientific chapters. The book is intended for immunologists, toxicologists and researchers who want to know how the immune system works and is triggered, as well as for medical doctors in environmental medicine and the general public interested in immunology.