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Stress Genetics Epigenetics And Genomics

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Stress Genetics Epigenetics and Genomics

Stress  Genetics  Epigenetics and Genomics Book
Author : George Fink
Publisher : Academic Press
Release : 2020-10-24
ISBN : 0128131578
Language : En, Es, Fr & De

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Book Description :

This fourth volume in the Handbook of Stress series, Stress: Genetics, Epigenetics and Genomics, deals with the influence that genetics, epigenetics, and genomics have on the effects of and responses to stress. Chapters refer to epigenetic mechanisms that involve DNA methylation, histone modification, and/or noncoding RNA-associated gene activation or silencing. There is also coverage of epigenetic mechanisms in stress-related transgenerational transmission of characteristics, and how these may help explain heritability in some complex human diseases. The Handbook of Stress series, comprised of self-contained volumes that each focus on a specific stress area, covers the significant advances made since the publication of Elsevier’s Encyclopedia of Stress (2000 and 2007). Volume 4 is ideal for graduate students, post-doctoral fellows, faculty and clinicians interested in stress genetics, epigenetics and genomics involved in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry and the social sciences. Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge Richly illustrated with explanatory figures and tables Each chapter includes a boxed “Key points call out section Affordably priced, self-contained volume for readers specifically interested in stress genetics and epigenetics, removing the need to purchase the whole Handbook series

Epigenetics of Stress and Stress Disorders

Epigenetics of Stress and Stress Disorders Book
Author : Nagy Youssef
Publisher : Academic Press
Release : 2022-02-25
ISBN : 0128230622
Language : En, Es, Fr & De

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Book Description :

Epigenetics of Stress and Stress Disorders, Volume 31 in the Translational Epigenetics series, examines the epigenetic mechanisms involved in modifying DNA or gene expression following prolonged stress and/or trauma. Sections introduce both genetic and psychiatric foundations, including modes of epigenetic modification and gene expression that result from stress, as well as the medical knowledge required to understand stress related disorders and resilience. From here, chapters discuss epigenetic research techniques applied in recent studies, including epigenome-wide association studies (EWAS) of PTSD and resilience, the possible effects of prolonged stress on telomere shortening, and the long-term physical effects of PSTD. The book concludes by examining the possible effects of transgenerational stress-induced epigenetic alterations on the resilience of future offspring, the potential for epigenetic therapeutics, and public health implications. Examines the epigenetics of stress, trauma and related stress disorders Includes methods (e.g. EWAS), protocols and directions for further studies Connects new research to clinical practice and highlights implications for patient care, drug discovery and public health

Stress and Epigenetics in Suicide

Stress and Epigenetics in Suicide Book
Author : Vsevolod Rozanov
Publisher : Academic Press
Release : 2017-02-13
ISBN : 0128052864
Language : En, Es, Fr & De

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Book Description :

Stress and Epigenetics in Suicidediscusses the central role of epigenetic modifications in suicidal behavior. As early-life stress and an individual's ability to cope with such stressors, combined with psychological factors, social factors, and existential and cognitive factors can predispose young people to suicidal behavior and put them at added risk of suicidal behavior later in life, this book provides readers with an overview of the neurobiology of stress, an introduction to the epigenetic changes induced by stress, and an understanding of how vulnerability and resilience to stress are built. It integrates these mechanisms into a biobehavioral model of suicide based on epigenetic marks, gene-environment interactions, and other stressors. More importantly, it provides future direction for research and discusses potential interventions. This book is an ideal and trusted resource for researchers and clinicians who are interested in learning how the environment can affect behavior through genetics, and for those seeking the development of new methods for suicide prevention. Explores the neurobiology of stress and stress-related epigenetics, including discussion of the role of stress-induced epigenetic changes in behavioral, emotional, and cognitive mechanisms and whether these epigenetic marks are transgenerational Provides compelling biobehavioral models of suicide based on genetics, epigenetics, and behavioral adjustment Integrates social, psychological, and existential influences, giving readers a better understanding of the interdisciplinary nature of suicide risk factors Presents future directions for suicide-prevention strategies that incorporate recent research on genomics and stress resilience

Epigenetics in Psychiatry

Epigenetics in Psychiatry Book
Author : Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Publisher : Academic Press
Release : 2021-08-16
ISBN : 0128235780
Language : En, Es, Fr & De

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Book Description :

Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

Advances in the Understanding of Biological Sciences Using Next Generation Sequencing NGS Approaches

Advances in the Understanding of Biological Sciences Using Next Generation Sequencing  NGS  Approaches Book
Author : Gaurav Sablok,Sunil Kumar,Saneyoshi Ueno,Jimmy Kuo,Claudio Varotto
Publisher : Springer
Release : 2015-07-16
ISBN : 3319171577
Language : En, Es, Fr & De

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Book Description :

Provides a global view of the recent advances in the biological sciences and the adaption of the pathogen to the host plants revealed using NGS. Molecular Omic’s is now a major driving force to learn the adaption genetics and a great challenge to the scientific community, which can be resolved through the application of the NGS technologies. The availability of complete genome sequences, the respective model species for dicot and monocot plant groups, presents a global opportunity to delineate the identification, function and the expression of the genes, to develop new tools for the identification of the new genes and pathway identification. Genome-wide research tools, resources and approaches such as data mining for structural similarities, gene expression profiling at the DNA and RNA level with rapid increase in available genome sequencing efforts, expressed sequence tags (ESTs), RNA-seq, gene expression profiling, induced deletion mutants and insertional mutants, and gene expression knock-down (gene silencing) studies with RNAi and microRNAs have become integral parts of plant molecular omic’s. Molecular diversity and mutational approaches present the first line of approach to unravel the genetic and molecular basis for several traits, QTL related to disease resistance, which includes host approaches to combat the pathogens and to understand the adaptation of the pathogen to the plant host. Using NGS technologies, understanding of adaptation genetics towards stress tolerance has been correlated to the epigenetics. Naturally occurring allelic variations, genome shuffling and variations induced by chemical or radiation mutagenesis are also being used in functional genomics to elucidate the pathway for the pathogen and stress tolerance and is widely illustrated in demonstrating the identification of the genes responsible for tolerance in plants, bacterial and fungal species.

Epigenetics of Lifestyle

Epigenetics of Lifestyle Book
Author : Marcelina Párrizas,Rosa Gasa,Perla Kaliman
Publisher : Bentham Science Publishers
Release : 2012-09-07
ISBN : 1608052990
Language : En, Es, Fr & De

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Book Description :

Recent advances in the fields of genomics and bioinformatics have made it increasingly clear that genetic sequence alone cannot explain how the genome regulates the development and function of complex multicellular organisms both in health and disease. This inference has led to the expansion of epigenetics as a discipline. Epigenetics refers to the way in which the environment in the wide sense participates in the regulation of gene expression. Several studies show that the well-known beneficial role of a healthy lifestyle over a number of pathologies or as a pre-emptive therapy is at least in part exerted through epigenetic mechanisms, thus giving rise to a new paradigm of preventive medicine based on the concept of genetic plasticity. In Epigenetics of Lifestyle, several contributors provide a comprehensive view of how various facets of lifestyle, including nutrition, exercise, stress, addiction or social interactions, affect chromatin (the combination of DNA and proteins that make up the contents of a cell nucleus) - resulting in profound and long-lasting changes in gene function. In summary, Epigenetics of Lifestyle is a fresh approach towards epigenetics and presents the reader with significant research findings in epigenetics and lifestyle studies. This volume is a simplified source of information for both undergraduate and working professionals interested in lifestyle medicine and life sciences in general.

Epigenetics Brain and Behavior

Epigenetics  Brain and Behavior Book
Author : Paolo Sassone Corsi,Yves Christen
Publisher : Springer Science & Business Media
Release : 2012-08-28
ISBN : 3642279120
Language : En, Es, Fr & De

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Book Description :

What lies at the heart of neuronal plasticity? Accumulating evidence points to epigenetics. This word originally indicated potentially heritable modifications in gene expression that do not involve changes in DNA sequence. Today this definition is much less strict, and epigenetic control is thought to include DNA methylation, histone modifications, histone variants, microRNA metabolic pathways and non-histone proteins modifications. Thus, while neuronal plasticity is rightly thought to be intimately associated to genomic control, it is critical to appreciate that there is much more to the genome than DNA sequence. Recent years have seen spectacular advances in the field of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigenetic regulation to brain functions has been accumulating. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molecular mechanisms implicated in epigenetic control and how these may operate in concert. It will be critical to unravel how specificity is achieved. Importantly, specific modifications seem to mediate both developmental processes and adult brain functions, such as synaptic plasticity and memory. Many aspects of the research in neurosciences and endocrinology during the upcoming decade will be dominated by the deciphering of epigenetic control. This book constitutes a compendium of the most updated views in the field.

Rice Genomics Genetics and Breeding

Rice Genomics  Genetics and Breeding Book
Author : Takuji Sasaki,Motoyuki Ashikari
Publisher : Springer
Release : 2018-02-14
ISBN : 9811074615
Language : En, Es, Fr & De

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Book Description :

This book presents the latest advances in rice genomics, genetics and breeding, with a special focus on their importance for rice biology and how they are breathing new life into traditional genetics. Rice is the main staple food for more than half of the world’s population. Accordingly, sustainable rice production is a crucial issue, particularly in Asia and Africa, where the population continues to grow at an alarming rate. The book’s respective chapters offer new and timely perspectives on the synergistic effects of genomics and genetics in novel rice breeding approaches, which can help address the urgent issue of providing enough food for a global population that is expected to reach 9 billion by 2050.

Epigenetic Modifications Associated with Abiotic and Biotic Stresses in Plants An Implication for Understanding Plant Evolution

Epigenetic Modifications Associated with Abiotic and Biotic Stresses in Plants  An Implication for Understanding Plant Evolution Book
Author : Mahmoud W. Yaish,Heribert Hirt,Barbara Hohn
Publisher : Frontiers Media SA
Release : 2018-01-16
ISBN : 2889453812
Language : En, Es, Fr & De

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Book Description :

Alterations in gene expression are essential during growth and development phases and when plants are exposed to environmental challenges. Stress conditions induce gene expression modifications, which are associated with changes in the biochemical and physiological processes that help plants to avoid or reduce potential damage resulting from these stresses. After exposure to stress, surviving plants tend to flower earlier than normal and therefore transfer the accumulated epigenetic information to their progenies, given that seeds, where this information is stored, are formed at a later stage of plant development. DNA methylation is correlated with expression repression. Likewise, miRNA produced in the cell can reduce the transcript abundance or even prevent translation of mRNA. However, histone modulation, such as histone acetylation, methylation, and ubiquitination, can show distinct effects on gene expression. These alterations can be inherited, especially if the plants are consistently exposed to a particular environmental stress. Retrotransposons and retroviruses are foreign movable DNA elements that play an important role in plant evolution. Recent studies have shown that epigenetic alterations control the movement and the expression of genes harbored within these elements. These epigenetic modifications have an impact on the morphology, and biotic and abiotic tolerance in the subsequent generations because they can be inherited through the transgenerational memory in plants. Therefore, epigenetic modifications, including DNA methylation, histone modifications, and small RNA interference, serve not only to alter gene expression but also may enhance the evolutionary process in eukaryotes. In this E-book, original research and review articles that cover issues related to the role of DNA methylation, histone modifications, and small RNA in plant transgenerational epigenetic memory were published. The knowledge published on this topic may add new insight on the involvement of epigenetic factors in natural selection and environmental adaptation. This information may also help to generate a modeling system to study the epigenetic role in evolution.

Early Life Stress Induced Epigenetic Changes Involved in Mental Disorders

Early Life Stress Induced Epigenetic Changes Involved in Mental Disorders Book
Author : Fushun Wang,Jason H. Huang,Fang Pan,Yi-Yuan Tang
Publisher : Frontiers Media SA
Release : 2021-08-09
ISBN : 2889711536
Language : En, Es, Fr & De

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Book Description :

Download Early Life Stress Induced Epigenetic Changes Involved in Mental Disorders book written by Fushun Wang,Jason H. Huang,Fang Pan,Yi-Yuan Tang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Genomic and Personalized Medicine

Genomic and Personalized Medicine Book
Author : Anonim
Publisher : Academic Press
Release : 2012-10-30
ISBN : 0123822289
Language : En, Es, Fr & De

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Book Description :

Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Plant Root Interaction With Associated Microbiomes to Improve Plant Resiliency and Crop Biodiversity

Plant Root Interaction With Associated Microbiomes to Improve Plant Resiliency and Crop Biodiversity Book
Author : Nikolay Vassilev,Eligio Malusà,Davide Neri,Xiangming Xu
Publisher : Frontiers Media SA
Release : 2021-09-10
ISBN : 2889712788
Language : En, Es, Fr & De

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Book Description :

Download Plant Root Interaction With Associated Microbiomes to Improve Plant Resiliency and Crop Biodiversity book written by Nikolay Vassilev,Eligio Malusà,Davide Neri,Xiangming Xu, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Sports Exercise and Nutritional Genomics

Sports  Exercise  and Nutritional Genomics Book
Author : Debmalya Barh,Ildus I. Ahmetov
Publisher : Academic Press
Release : 2019-08-25
ISBN : 0128163402
Language : En, Es, Fr & De

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Book Description :

Sports, Exercise, and Nutritional Genomics: Current Status and Future Directions is the first reference volume to offer a holistic examination of omics-driven advances across different aspects of exercise and sports physiology, biochemistry, sports medicine, psychology, anthropology, and sports nutrition; and highlighting the opportunities towards advance personalized training and athlete health management. More than 70 international experts from 14 countries have discussed key exercise and sport-related themes through the prism of genomics, epigenomics, transcriptomics, proteomics, metabolomics, telomere biology, talent in sport, individual differences in response to regular physical activity, that in the future may empower coaches, sports physicians, fitness experts, genetic counselors, and translational scientists to employ various omics data and approaches in improving health and physical performance of people participating in sports and exercise activities. Contributors address current knowledge of genetic influence on athletic performance, individual responses to exercise training, as well as the genetics of musculoskeletal phenotypes, exercise-related injuries, flexibility, and neurodegenerative disorders in athletes. Finally, performance-related and psychological traits associated with epigenetic, transcriptomic and metagenomic biomarkers are also considered, along with nutritional and pharmacogenomic aids in sports medicine and personalized nutrition. Effectively synthesizes key themes across molecular aspects of exercise and sports sciences Provides a knowledge base for future translation of omics solutions to talent identification, individualized training, and nutrition Features contributions from international experts (researchers and clinicians) in the subject area

Epigenetics

Epigenetics Book
Author : Rosaria Meccariello
Publisher : BoD – Books on Demand
Release : 2019-09-11
ISBN : 1789840872
Language : En, Es, Fr & De

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Book Description :

Epigenetic changes are heritable and reversible modifications that significantly affect gene expression without any change in DNA sequence. The epigenetic signature is remodelled during the lifespan as a direct consequence of both environment and lifestyle. Therefore, health or disease status strongly depends on epigenetic marks. This book summarizes the current knowledge in the field and includes chapters on epigenetics in plants and epigenetics in health and disease. It is written for a wide audience of basic and clinical scientists, teachers and students interested in gaining a better understanding of epigenetics.

Behavioral Neurogenomics

Behavioral Neurogenomics Book
Author : Elisabeth B. Binder,Torsten Klengel
Publisher : Springer Nature
Release : 2019-12-12
ISBN : 3030312658
Language : En, Es, Fr & De

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Book Description :

This book provides a unique overview on the most recent developments in initially diverse areas of behavioral genomic research that now start to intertwine to provide more detailed insights into the complex nature of behavior in health and disease. It focuses on our current understanding of genetic and epigenetic mechanisms of brain function and how they contribute to the complex formation of behavioral traits and psychiatric disorders. Readers experience diverse perspectives of the contributing authors starting from the genetic viewpoint and the effort to establish functional connection between genetic variants and behavioral phenotypes. Particular attention is given to the broad spectrum of epigenetic mechanisms and behavior. The chapter 'Role of MicoRNAs in Anxiety and Anxiety-Related Disorders' is available open access under a CC BY 4.0 license at link.springer.com

Transgenerational Epigenetics

Transgenerational Epigenetics Book
Author : Anonim
Publisher : Academic Press
Release : 2019-05-18
ISBN : 0128167335
Language : En, Es, Fr & De

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Book Description :

Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research. Presents a fully-updated and expanded release addressing transgenerational epigenetics, epigenetic mechanisms of gene regulation, and the role of epigenetics in human longevity and cancer Examines the field from "bench-to-bedside", discussing basic science, disease management, current debates, and next steps in epigenetic research and drug discovery Features chapter contributions from international experts

Advances in Plant Breeding Strategies Breeding Biotechnology and Molecular Tools

Advances in Plant Breeding Strategies  Breeding  Biotechnology and Molecular Tools Book
Author : Jameel M. Al-Khayri,Shri Mohan Jain,Dennis V. Johnson
Publisher : Springer
Release : 2016-02-02
ISBN : 3319225219
Language : En, Es, Fr & De

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Book Description :

The basic concept of this book is to examine the use of innovative methods augmenting traditional plant breeding towards the development of new crop varieties under different environmental conditions to achieve sustainable food production. This book consists of two volumes: Volume 1 subtitled Breeding, Biotechnology and Molecular Tools and Volume 2 subtitled Agronomic, Abiotic and Biotic Stress Traits. This is Volume 1 which consists of 21 chapters covering domestication and germplasm utilization, conventional breeding techniques and the role of biotechnology. In addition to various biotechnological applications in plant breeding, it includes functional genomics, mutations and methods of detection, and molecular markers. In vitro techniques and their applications in plant breeding are discussed with an emphasis on embryo rescue, somatic cell hybridization and somaclonal variation. Other chapters cover haploid breeding, transgenics, cryogenics and bioinformatics.

Applied Genomics and Public Health

Applied Genomics and Public Health Book
Author : George P. Patrinos
Publisher : Academic Press
Release : 2019-11-13
ISBN : 0128136960
Language : En, Es, Fr & De

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Book Description :

Applied Genomics and Public Health examines the interdisciplinary and growing area of how evidence-based genomic knowledge can be applied to public health, population health, healthcare and health policies. The book gathers experts from a variety of disciplines, including life sciences, social sciences, and health care to develop a comprehensive overview of the field. In addition, the book delves into subjects such as pharmacogenomics, genethics, big data, data translation and analysis, economic evaluation, genomic awareness and education, sociology, pricing and reimbursement, policy measures and economic evaluation in genomic medicine. This book is essential reading for researchers and students exploring applications of genomics to population and public health. In addition, it is ideal for those in the biomedical sciences, medical sociologists, healthcare professionals, nurses, regulatory bodies and health economists interested in learning more about this growing field. Explores the growing application of genomics to population and public health Features internationally renowned contributors from a variety of related fields Contains chapters on important topics such as genomic data sharing, genethics and public health genomics, genomics and sociology, and regulatory aspects of genomic medicine and pharmacogenomics

Unravelling Complexities in Genetics and Genomics

Unravelling Complexities in Genetics and Genomics Book
Author : Moyra Smith
Publisher : World Scientific
Release : 2016-10-11
ISBN : 9814759481
Language : En, Es, Fr & De

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Book Description :

Unravelling Complexities in Genetics and Genomics: Impact on Diagnosis Counseling and Management reviews recent advances in defining genetic and genomic factors that play important roles in diseases in humans. It includes discussions on new technologies in DNA and RNA sequencing, genome analysis, and bioinformatics applied to the study of patients with specific disorders and to normal populations, and illustrates how modern molecular techniques can improve diagnoses and enable the design of specific targeted therapies and methods of prevention. Additional emphasis is placed on the genetic variants and genomic risk factors related to the development of complex common disorders, including neurobehavioral and neurocognitive disorders in children and adults and late onset disorders in adults, including atherosclerosis, type 2 diabetes, cancer, and neurodegenerative disorders. Physicians, nurses, genetic counselors, graduate students in genetics and genomics will find this book a valuable read. Contents:Expanding Insights into Genes and ExpressionGenomic Integrity and Relevance to DiseaseEpigenetics and EpigenomicsProteins, Proteomics, Protein Folding and ProteostasisGenotype–Phenotype Correlations and ComplexitiesImmune SystemLipids, Atherosclerosis, Metabolic Syndromes and DiabetesEarly-Onset Neurocognitive and Neurobehavioral DisordersIntegrating Advances in Neurobiology and Genetics into PsychiatryNeurodegenerative DiseasesCancerEpilogue Readership: Physicians, nurses, genetic counselors, graduate students in genetics and genomics.

Quantitative Genetics Genomics and Plant Breeding 2nd Edition

Quantitative Genetics  Genomics and Plant Breeding  2nd Edition Book
Author : Manjit S. Kang
Publisher : CABI
Release : 2020-04-01
ISBN : 1789240212
Language : En, Es, Fr & De

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Book Description :

This book presents state-of-the-art, authoritative chapters on contemporary issues in the broad areas of quantitative genetics, genomics and plant breeding. Section 1 (Chapters 2 to 12) emphasizes the application of genomics, and genome and epigenome editing techniques, in plant breeding; bioinformatics; quantitative trait loci mapping; and the latest approaches of examining and exploiting genotype-environment interactions. Section 2 (Chapters 13 to 20) represents the intersection of breeding, genetics and genomics. This section describes the use of cutting-edge molecular breeding and quantitative genetics techniques in wheat, rice, maize, root and tuber crops and pearl millet. Overall, the book focuses on using genomic information to help evaluate traits that can combat biotic/abiotic stresses, genome-wide association mapping, high-throughput genotyping/phenotyping, biofortification, use of big data, orphan crops, and gene editing techniques. The examples featured are taken from across crop science research and cover a wide geographical base.