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Stress And Epigenetics In Suicide

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Stress and Epigenetics in Suicide

Stress and Epigenetics in Suicide Book
Author : Vsevolod Rozanov
Publisher : Academic Press
Release : 2017-02-13
ISBN : 0128052864
Language : En, Es, Fr & De

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Book Description :

Stress and Epigenetics in Suicidediscusses the central role of epigenetic modifications in suicidal behavior. As early-life stress and an individual's ability to cope with such stressors, combined with psychological factors, social factors, and existential and cognitive factors can predispose young people to suicidal behavior and put them at added risk of suicidal behavior later in life, this book provides readers with an overview of the neurobiology of stress, an introduction to the epigenetic changes induced by stress, and an understanding of how vulnerability and resilience to stress are built. It integrates these mechanisms into a biobehavioral model of suicide based on epigenetic marks, gene-environment interactions, and other stressors. More importantly, it provides future direction for research and discusses potential interventions. This book is an ideal and trusted resource for researchers and clinicians who are interested in learning how the environment can affect behavior through genetics, and for those seeking the development of new methods for suicide prevention. Explores the neurobiology of stress and stress-related epigenetics, including discussion of the role of stress-induced epigenetic changes in behavioral, emotional, and cognitive mechanisms and whether these epigenetic marks are transgenerational Provides compelling biobehavioral models of suicide based on genetics, epigenetics, and behavioral adjustment Integrates social, psychological, and existential influences, giving readers a better understanding of the interdisciplinary nature of suicide risk factors Presents future directions for suicide-prevention strategies that incorporate recent research on genomics and stress resilience

The Epigenetics of Suicide

The Epigenetics of Suicide Book
Author : Benoit Labonté
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Suicide is a problem resulting from the interaction between several factors. Among these factors, early-life adversity, characterized by child sexual and physical abuse as well as parental neglect, is one of the strongest risk factors for depression and suicidal behaviors. While it is clear that child abuse increases the risk for depression and suicide, the mechanisms mediating these effects are still unknown. Recent evidences suggest that epigenetic mechanisms may be involved in mediating the effects of early-life adversity on behavior. Early-life stress in animals has been shown to alter DNA methylation in genes regulatory regions what, in turn, has been associated with changes in gene expression and behavioral modifications. Importantly, similar changes have been reported in several genes in the human brain. However, although epigenetic modifications have been found in several genes, the extent of epigenetic changes induced by early-life adversity is still unknown and their impacts on increasing suicide risk are unclear. This thesis aims at expanding our understanding of suicide by investigating one potential mechanism by which early-life adversity may increase vulnerability to mood disorders and suicide, namely epigenetic regulation of gene expression. We first expanded our characterization of DNA methylation alterations induced by early and adult-life stress in the regulatory regions of the glucocorticoid receptor gene which is one of the most consistent alterations associated with stress, depression and suicidal behaviors. We then opted for a genome-wide characterization of DNA methylation alterations found in the brains of suicide completers with and without a history of child abuse using microarray analyses focusing on gene promoters throughout the genome. Our findings revealed several DNA methylation alterations in genes with known roles on behavioral regulation and identified several new genes and networks which may be specifically altered by early-life adversity. We also characterized the functional impact of these alterations on gene expression and promoter transcriptional activity. Overall, this work identifies and characterizes the molecular mechanisms by which environment induces behavioral changes conferring vulnerability toward mood disorders and suicidal behaviors. " --

Biological Aspects of Suicidal Behavior

Biological Aspects of Suicidal Behavior Book
Author : W. P. Kaschka,D. Rujescu
Publisher : Karger Medical and Scientific Publishers
Release : 2016
ISBN : 3318055832
Language : En, Es, Fr & De

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Book Description :

Suicide is one of the most important causes of death in modern societies. To develop more effective preventive measures, we have to be aware of and learn more about its neurobiological foundations. In recent years, the tools of modern neurosciences have increasingly been utilized to characterize the pathophysiology of complex human behaviors such as suicide. To improve suicide risk assessment and suicide prevention, a better understanding of its pathophysiology is crucial. This includes research from a variety of disciplines such as neuropsychological, psychosocial and cultural studies but also findings from biochemistry, neuropathology, electrophysiology, immunology, neuroimaging, genetics, and epigenetics. Important results have, for example, been obtained in the field of gene-environment interaction and suicidal behavior. We have just begun to understand how early-life adversity may increase suicide risk by epigenetic mechanisms. Based on such insights, novel therapeutic interventions and preventive measures can be developed. Furthermore, a better understanding of the pathophysiological mechanisms involved in suicidal behavior could reveal the mechanism of compounds like lithium salts. In this book, suicidal behavior and its prevention is discussed by international experts in the light of the most recent results from a broad spectrum of neurosciences.

DNA Methylation and the Stress Response in the Anterior Cingulate Cortex of Abused Suicide Completers

DNA Methylation  and the Stress Response in the Anterior Cingulate Cortex of Abused Suicide Completers Book
Author : Adel Farah
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Suicide is a major health problem in Canada and around the globe. Studies have shown that individuals with a history of childhood abuse are more likely to commit suicide and neurobiological correlates have been identified in these individuals. Some of these biological changes have included over-activity of stress response pathways in the brain such as the neuroendocrine, hypothalamic pituitary adrenal axis (HPA) and connected networks in the prefrontal cortex like the anterior cingulate cortex (ACC), which affect behaviour. Prior investigations have also shown that epigenetic changes in genes that regulate the HPA can be observed in subjects with a history of child abuse. We investigated DNA methylation in regulatory sites of HPA and related genes, including the corticotrophin releasing hormone (CRH) and its receptors 1 and 2 (CRHR1 and CRHR2), arginine vasopressin (AVP), proopiomelanocortin (POMC), and an intergenic region between AVP and oxytocin, in individuals who died by suicide and had histories of child abuse as compared with controls without histories of abuse. Our findings within the ACC have shown no DNA methylation changes in the areas of the genes we examined; however there was an increase in the expression of CRH and a down regulation of its receptor, CRHR1. These results suggest possible HPA perturbations in our cases, but not through methylation changes in the sequences investigated. These results point to the complexity of epigenetic regulation of genes as an interface with the environment and behaviour and further studies are necessary to explore the role of these genes in the prefrontal cortex and how the environment might affect their molecular regulation. " --

Stress Genetics Epigenetics and Genomics

Stress  Genetics  Epigenetics and Genomics Book
Author : George Fink
Publisher : Academic Press
Release : 2020-10-24
ISBN : 0128131578
Language : En, Es, Fr & De

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Book Description :

This fourth volume in the Handbook of Stress series, Stress: Genetics, Epigenetics and Genomics, deals with the influence that genetics, epigenetics, and genomics have on the effects of and responses to stress. Chapters refer to epigenetic mechanisms that involve DNA methylation, histone modification, and/or noncoding RNA-associated gene activation or silencing. There is also coverage of epigenetic mechanisms in stress-related transgenerational transmission of characteristics, and how these may help explain heritability in some complex human diseases. The Handbook of Stress series, comprised of self-contained volumes that each focus on a specific stress area, covers the significant advances made since the publication of Elsevier’s Encyclopedia of Stress (2000 and 2007). Volume 4 is ideal for graduate students, post-doctoral fellows, faculty and clinicians interested in stress genetics, epigenetics and genomics involved in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry and the social sciences. Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge Richly illustrated with explanatory figures and tables Each chapter includes a boxed “Key points call out section Affordably priced, self-contained volume for readers specifically interested in stress genetics and epigenetics, removing the need to purchase the whole Handbook series

Epigenetics and Psychiatric Disease

Epigenetics and Psychiatric Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2018-06-22
ISBN : 0128135662
Language : En, Es, Fr & De

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Book Description :

Epigenetics and Psychiatric Disease, Volume 157, the latest volume in the Progress in Molecular Biology and Translational Science series, includes recent developments on a variety of topics, including the Epigenetic landscapes of the adversity-exposed brain, Chromosomal conformations and epigenomic regulation in schizophrenia, Progress in the epigenetics of depression, the epigenetics of circadian rhythms in imprinted neurodevelopmental disorders, DNA methylation mediating substance abuse, mechanisms and therapeutic opportunities, DNA methylation in animals model of psychosis, Epigenetics of early life stress, Epigenetic drugs for mood disorders, and more. Accessible to students and researchers alike, with content that appeals to a variety of readers Written by leading authorities in their respective fields of molecular biology

Stress and Brain Health In Clinical Conditions

Stress and Brain Health  In Clinical Conditions Book
Author : Anonim
Publisher : Academic Press
Release : 2020-05-22
ISBN : 0128211172
Language : En, Es, Fr & De

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Book Description :

Stress and Brain Health: In Clinical Conditions, Volume 152, examines up-to-date knowledge on how stress effects brain health. The book's wide-ranging topics include the effects of pre-natal and childhood stress on neurodevelopment and aging. Chapters cover Stress and neuropsychiatric disorders, Stress and schizophrenia, Stress and addictive behaviors, Stress and suicide, Stress as a factor in the progression of PD, Social prescribing for stress-related disorder, and more. Comprises diverse evidence from world-leading researchers in each area Provides a readily accessible introduction to the topics covered, including basic guidance on stress theory and measurement Essential reading for those in the fields of neuroscience, psychophysiology, psychoneuroendocrinology, health psychology, developmental psychology, neuro-rehabilitation and clinical research

Epigenetic Modulation of Glucocorticoid Receptors in Posttraumatic Stress Disorder

Epigenetic Modulation of Glucocorticoid Receptors in Posttraumatic Stress Disorder Book
Author : Nelson Azoulay
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

PTSD is a devastating disorder that affects 7-12% of individuals who experience a traumatic event in their lives. Individuals suffering from the disorder show a dysfunctional HPA axis with decreased basal cortisol release and increased glucocorticoid receptor sensitivity. Recently, epigenetic studies have shown associations between trauma and the subsequent effects on the HPA axis in abused participants who committed suicide. Importantly, findings also showed child trauma as being a significant factor in DNA methylation levels in promoter region 1F in the hippocampus. This thesis shows the possible role of epigenetic programming of glucocorticoid receptors in PTSD while examining the effects of different timing of trauma. Methods included the measurements of salivary basal cortisol levels, the expression of glucocorticoid receptors in whole blood and the DNA methylation levels in two promoter regions of the glucocorticoid receptors by sequenome epityper. Results ...

Handbook of Epigenetics

Handbook of Epigenetics Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2017-07-10
ISBN : 0128054778
Language : En, Es, Fr & De

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Book Description :

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

Suicide by Self Immolation

Suicide by Self Immolation Book
Author : César A. Alfonso
Publisher : Springer Nature
Release : 2021-07-29
ISBN : 303062613X
Language : En, Es, Fr & De

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Book Description :

Download Suicide by Self Immolation book written by César A. Alfonso, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Understanding Suicide

Understanding Suicide Book
Author : Philippe Courtet
Publisher : Springer
Release : 2016-03-05
ISBN : 3319262823
Language : En, Es, Fr & De

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Book Description :

In this book international experts address a range of key current issues relating to suicide. The opening chapters discuss nosology, definitions, clinical determinants, and conceptual models of the suicide process and consider the evidence regarding potential biomarkers of suicide risk based on neuroscientific research. Adopting a neo-Durkheimian perspective, the role of various social factors in the genesis of suicidal behavior is then explored in depth. Practical user-friendly tools that facilitate risk assessment by clinicians are provided, and detailed consideration is given to efficient and innovative strategies for the prevention of suicide and the treatment of suicidal behavior, such as psychotherapy, psychopharmacological approaches, and effective organization of care, including surveillance and the use of online tools. The final part of the book focuses on the need for and development of a personalized approach within the field of suicide prevention.

Alternatives to Suicide

Alternatives to Suicide Book
Author : Andrew Page,Werner Stritzke
Publisher : Academic Press
Release : 2020-01-26
ISBN : 0128142987
Language : En, Es, Fr & De

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Book Description :

Alternatives to Suicide: Beyond Risk and Toward a Life Worth Living demonstrates how fostering resilience and a desire for life can broaden and advance an understanding of suicide. The book summarizes the existing literature and outlines a new focus on the dynamic interplay of risk and resilience that leads to a life-focus approach to suicide prevention. It calls for a treatment approach that enhances the opportunity to collaboratively engage clients in discussion about their lives. Providing a new perspective on how to approach suicide prevention, the book also lays out key theories on resilience and the interplay of risk and protective factors. Finally, the book outlines how emerging technologies and advances in data-analytic sophistication using real-time monitoring of suicide dynamics are ushering the field of suicide research and prevention into a new and exciting era. Focuses on what attenuates the transition from thinking about suicide to attempting it Calls for a life-focus treatment approach as opposed to risk-aversion intervention techniques Demonstrates how fostering resilience can advance our understanding of pathways to suicide Discusses emerging technologies being used in current suicide research and prevention Outlines the differences between risk factors and risk correlates Covers real-time assessment of dynamic suicide risk

Phenomenology of Suicide

Phenomenology of Suicide Book
Author : Maurizio Pompili
Publisher : Springer
Release : 2017-10-10
ISBN : 3319479768
Language : En, Es, Fr & De

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Book Description :

This book will help the reader to understand the suicidal mind from a phenomenological point of view, shedding light on the feelings of suicidal individuals and also those of clinicians. In accordance with the importance that the phenomenological approach attaches to subjectivity and sense of self as the starting points for knowledge, emphasis is placed on the need for the clinician to focus on the subjective experiences of the at-risk individual, to set aside prior assumptions, judgments, or interpretations, and to identify ways of bridging gaps in communication associated with negative emotions. The vital importance of empathy is stressed, drawing attention to the insights offered by neuroimaging studies and the role of mirror neurons in social cognition. It is widely acknowledged that when a clinician meets a person who wants to die by suicide, the clinician does not fully understand what is going on inside the mind of that individual. This book recognizes that any approach to suicide prevention must promote understanding of suicidal thoughts and feelings. The awareness that it fosters and the innovative perspectives that it presents will appeal to a wide readership.

Epigenetics

Epigenetics Book
Author : Benedikt Hallgrímsson,Brian K. Hall
Publisher : Univ of California Press
Release : 2011-04-11
ISBN : 0520267095
Language : En, Es, Fr & De

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Book Description :

“If you want to understand evolution, you need to understand the murky world of epigenetics. A hearty congratulations should be paid to Hallgrimsson and Hall, who provide reliable and steady illumination.”-Bernard Wood, Center for the Advanced Study of Hominid Paleobiology, George Washington University

Behavioral Neurobiology of Suicide and Self Harm

Behavioral Neurobiology of Suicide and Self Harm Book
Author : Enrique Baca-Garcia
Publisher : Springer Nature
Release : 2021-01-22
ISBN : 3030575748
Language : En, Es, Fr & De

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Book Description :

This book reviews the recent research into biological aspects of suicide behavior and outlines each of the varied, recent approaches to prevent suicide. Suicidal behavior, perhaps, is the most complex behavior that combines biological, social, and psychological factors. A new frontier and new opportunities are opening with the technologies of data acquisition and data analysis. Personalized models based on digital phenotype could provide promising strategies for preventing suicide.

Handbook of Stress Coping and Health

Handbook of Stress  Coping  and Health Book
Author : Virginia Hill Rice
Publisher : SAGE
Release : 2012
ISBN : 1412999294
Language : En, Es, Fr & De

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Book Description :

This unique and comprehensive handbook examines the various models of stress, coping, and health and their relevance for nursing and related health fields. Building on the first edition that has been highly-praised for its analysis and critique of existing models and its discussion of new research surrounding self-regulation and stress, this Second Edition continues to provide a critical analysis of the field while providing up to date cutting-edge research. Under the expert editorship of Dr. Virginia Hill Rice, experienced scholars and practitioners present a broad range of issues and research that relate to stress and health, such as response-oriented stress; stimulus-oriented stress; and transactional stress, coping, and health in children, adolescents, attitudes, and much, much more.

The Neuroscience of Suicidal Behavior

The Neuroscience of Suicidal Behavior Book
Author : Kees van Heeringen
Publisher : Cambridge University Press
Release : 2018-08-31
ISBN : 1108609031
Language : En, Es, Fr & De

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Book Description :

Nearly one million people take their own lives each year world-wide - however, contrary to popular belief, suicide can be prevented. While suicide is commonly thought to be an understandable reaction to severe stress, it is actually an abnormal reaction to regular situations. Something more than unbearable stress is needed to explain suicide, and neuroscience shows what this is, how it is caused and how it can be treated. Professor Kees van Heeringen describes findings from neuroscientific research on suicide, using various approaches from population genetics to brain imaging. Compelling evidence is reviewed that shows how and why genetic characteristics or early traumatic experiences may lead to a specific predisposition that makes people vulnerable to triggering life events. Neuroscientific studies are yielding results that provide insight into how the risk of suicide may develop; ultimately demonstrating how suicide can be prevented.

Suicidal Behavior New Insights for the Healthcare Professional 2012 Edition

Suicidal Behavior  New Insights for the Healthcare Professional  2012 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-12-10
ISBN : 1464978166
Language : En, Es, Fr & De

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Book Description :

Suicidal Behavior: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Suicidal Behavior in a compact format. The editors have built Suicidal Behavior: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Suicidal Behavior in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Suicidal Behavior: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

A Concise Guide to Understanding Suicide

A Concise Guide to Understanding Suicide Book
Author : Stephen H. Koslow,Pedro Ruiz,Charles B. Nemeroff
Publisher : Cambridge University Press
Release : 2014-09-18
ISBN : 1139992422
Language : En, Es, Fr & De

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Book Description :

Suicide rates continue to increase globally. The volume of research in this field has also expanded rapidly. In A Concise Guide to Understanding Suicide, leading researchers and clinicians provide a concise review of recent literature, report solutions achieved and give practical guidance for patient care to aid understanding and help prevent suicide. Each chapter is highly focused to provide pertinent information covering all major aspects of the field, from epidemiology and theories of causation through to treatment and prevention. This text will educate practising clinicians (psychologists, psychiatrists, nurses, counsellors, and emergency room personnel) and other health care workers and researchers, as well as providing a pathway for undergraduate and graduate students interested in furthering their understanding of the complexities surrounding suicide. Further, mental health professionals and those in the social sciences will be extremely interested in this monograph, as will the University community, armed forces and interested lay public.