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Strategies To Modify The Drug Release From Pharmaceutical Systems

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Strategies to Modify the Drug Release from Pharmaceutical Systems

Strategies to Modify the Drug Release from Pharmaceutical Systems Book
Author : Marcos Luciano Bruschi
Publisher : Woodhead Publishing
Release : 2015-06-16
ISBN : 0081001126
Language : En, Es, Fr & De

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Book Description :

Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. Addresses the principles, systems, applications and advances in the field of drug delivery Highlights the mathematical and physicochemical principles related to strategies Discusses drug release and its possible modifications

3D Printing of Pharmaceuticals and Drug Delivery Devices

3D Printing of Pharmaceuticals and Drug Delivery Devices Book
Author : Dimitrios A. Lamprou
Publisher : MDPI
Release : 2020-07-01
ISBN : 3039364235
Language : En, Es, Fr & De

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Book Description :

The 3D printing (3DP) process was patented in 1986; however, only in the last decade has it begun to be used for medical applications, as well as in the fields of prosthetics, bio-fabrication, and pharmaceutical printing. 3DP or additive manufacturing (AM) is a family of technologies that implement layer-by-layer processes in order to fabricate physical models based on a computer aided design (CAD) model. 3D printing permits the fabrication of high degrees of complexity with great reproducibility in a fast and cost-effective fashion. 3DP technology offers a new paradigm for the direct manufacture of individual dosage forms and has the potential to allow for variations in size and geometry as well as control dose and release behavior. Furthermore, the low cost and ease of use of 3DP systems means that the possibility of manufacturing medicines and medical devices at the point of dispensing or at the point of use could become a reality. 3DP thus offers the perfect innovative manufacturing route to address the critical capability gap that hinders the widespread exploitation of personalized medicines for molecules that are currently not easy to deliver. This Special Issue will address new developments in the area of 3D printing and bioprinting for drug delivery applications, covering the recent advantages and future directions of additive manufacturing for pharmaceutical products.

Release and Bioavailability of Nanoencapsulated Food Ingredients

Release and Bioavailability of Nanoencapsulated Food Ingredients Book
Author : Anonim
Publisher : Academic Press
Release : 2020-06-02
ISBN : 012815666X
Language : En, Es, Fr & De

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Book Description :

Release and Bioavailability of Nanoencapsulated Food Ingredients, volume five in the Nanoencapsulation in the Food Industry series, reviews different release mechanisms of nanoencapsulated food ingredients. The book discusses mathematical and intelligent modeling of the release of bioactive agents from nano-vehicles to better understand their release mechanisms, while also covering different approaches for studying the release profile of these ingredients (such as in-vitro and in-vivo assays). Authored by a team of global experts in the fields of nano and microencapsulation of food, nutraceutical and pharmaceutical ingredients, this title will be of great value to those engaged in various fields of nanoencapsulation. Thoroughly explores the different release mechanisms of nanoencapsulated food ingredients Examines the release of bioactive ingredients by in vitro and in vivo systems Discusses different approaches for modeling the release data of nanoencapsulated ingredients

Nanotechnology for Oral Drug Delivery

Nanotechnology for Oral Drug Delivery Book
Author : João Pedro Martins,Hélder A. Santos
Publisher : Academic Press
Release : 2020-07-30
ISBN : 0128180390
Language : En, Es, Fr & De

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Book Description :

Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies. Highlights the relevance of oral drug delivery in the clinical setting Covers the most recent advances in the field of nanotechnology for oral drug delivery Provides the scientific community with data that can facilitate and guide their research

Basic Fundamentals of Drug Delivery

Basic Fundamentals of Drug Delivery Book
Author : Anonim
Publisher : Academic Press
Release : 2018-11-30
ISBN : 0128179104
Language : En, Es, Fr & De

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Book Description :

Basic Fundamentals of Drug Delivery covers the fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to transform a drug candidate or new chemical entity into a final administrable drug delivery system. The book also covers various approaches involved in optimizing the therapeutic performance of a biomolecule while designing its appropriate advanced formulation. Provides up-to-date information on translating the physicochemical properties of drugs into drug delivery systems Explores how drugs are administered via various routes, such as orally, parenterally, transdermally or through inhalation Contains extensive references and further reading for course and self-study

Biomaterials and Implant Biocompatibility

Biomaterials and Implant Biocompatibility Book
Author : Anişoara Cîmpean,Florin Miculescu
Publisher : MDPI
Release : 2020-03-10
ISBN : 3039282166
Language : En, Es, Fr & De

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Book Description :

The scientific advances in life sciences and engineering are constantly challenging, expanding, and redefining concepts related to the biocompatibility and safety of medical devices. New biomaterials, new products, and new testing regimes are being introduced to scientific research practices. In order to provide clinically predictive results and to ensure a high benefit–risk ratio for patients, we need to optimize material and implant characteristics, and to adapt performance and safety evaluation practices for these innovative medical devices. Various characteristics related to materials and implant development such as raw materials composition, implant surface morphology, design, geometry, porosity, and mechanical properties need to be thoroughly characterized before evaluating the biological performance of implants. Furthermore, with the increase of regulatory demands, biological evaluation needs to ensure appropriate models and methods for each implant development stage. This book is a result of the Special Issue of Materials on "Biomaterials and Implant Biocompatibility”, which focused on the recent progress in development, material testing, and the biocompatibility and bioactivity evaluation of various materials including, but not limited to, bioceramics, biopolymers, biometals, composite materials, biomimetic materials, hybrid biomaterials, and drug/device combinations for implants and prostheses with medical applications spanning from soft to hard tissue regeneration. The book covers aspects ranging from investigations into material characterization to in vitro and in vivo testing for the assessment of biological performance of advanced, novel biomaterials and implants.

Food Medical and Environmental Applications of Polysaccharides

Food  Medical  and Environmental Applications of Polysaccharides Book
Author : Kunal Pal,Indranil Banerjee,Preetam Sarkar,Dr. Arindam Bit,Doman Kim,Arfat Anis,Samarendra Maji
Publisher : Elsevier
Release : 2020-12-03
ISBN : 0128193131
Language : En, Es, Fr & De

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Book Description :

Food, Medical, and Environmental Applications of Polysaccharides provides a detailed resource for those interested in the design and preparation of polysaccharides for state-of-the-art applications. The book begins with an introductory section covering sources, chemistry, architectures, bioactivity, and chemical modifications of polysaccharides. Subsequent parts of the book are organized by field, with chapters focusing on specific applications across food, medicine, and the environment. This is an extremely valuable book for researchers, scientists, and advanced students in biopolymers, polymer science, polymer chemistry, biomaterials, materials science, biotechnology, biomedical engineering, cosmetics, medicine, food science, and environmental science. This important class of biopolymer can offer attractive properties and modification potential, enabling its use in groundbreaking areas across food, medical, and environmental fields. The book will be of interest to scientists, R&D professionals, designers, and engineers who utilize polysaccharide-based materials. Presents comprehensive information of the polymeric structures and properties that can be developed from polysaccharides Offers systematic coverage of classification, synthesis, and characterization, enabling targeted design and preparation of polysaccharides for specific applications Explores advanced methods, for novel applications across food, medicine, and the environment

Soft Matter for Biomedical Applications

Soft Matter for Biomedical Applications Book
Author : Dr Helena S Azevedo,Dr João F Mano,Dr João Borges
Publisher : Royal Society of Chemistry
Release : 2021-06-11
ISBN : 1788017579
Language : En, Es, Fr & De

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Book Description :

Dynamic soft materials that have the ability to expand and contract, change stiffness, self-heal or dissolve in response to environmental changes, are of great interest in applications ranging from biosensing and drug delivery to soft robotics and tissue engineering. This book covers the state-of-the-art and current trends in the very active and exciting field of bioinspired soft matter, its fundamentals and comprehension from the structural-property point of view, as well as materials and cutting-edge technologies that enable their design, fabrication, advanced characterization and underpin their biomedical applications. The book contents are supported by illustrated examples, schemes, and figures, offering a comprehensive and thorough overview of key aspects of soft matter. The book will provide a trusted resource for undergraduate and graduate students and will extensively benefit researchers and professionals working across the fields of chemistry, biochemistry, polymer chemistry, materials science and engineering, nanosciences, nanotechnologies, nanomedicine, biomedical engineering and medical sciences.

Polymers Coatings

Polymers Coatings Book
Author : Inamuddin,Rajender Boddula,Mohd Imran Ahamed,Abdullah M. Asiri
Publisher : John Wiley & Sons
Release : 2020-05-27
ISBN : 1119654998
Language : En, Es, Fr & De

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Book Description :

The explores the cutting-edge technology of polymer coatings. It discusses fundamentals, fabrication strategies, characterization techniques, and allied applications in fields such as corrosion, food, pharmaceutical, biomedical systems and electronics. It also discusses a few new innovative self-healing, antimicrobial and superhydrophobic polymer coatings. Current industrial applications and possible potential activities are also discussed.

7th International Conference on the Development of Biomedical Engineering in Vietnam BME7

7th International Conference on the Development of Biomedical Engineering in Vietnam  BME7  Book
Author : Vo Van Toi,Trung Quoc Le,Hoan Thanh Ngo,Thi-Hiep Nguyen
Publisher : Springer
Release : 2019-06-05
ISBN : 9811358591
Language : En, Es, Fr & De

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Book Description :

This volume presents the proceedings of the 7th International Conference on the Development of Biomedical Engineering in Vietnam which was held from June 27-29, 2018 in Ho Chi Minh City. The volume reflects the progress of Biomedical Engineering and discusses problems and solutions. It aims to identify new challenges, and shaping future directions for research in biomedical engineering fields including medical instrumentation, bioinformatics, biomechanics, medical imaging, drug delivery therapy, regenerative medicine and entrepreneurship in medical devices.

Medical Application of Polymer Based Composites

Medical Application of Polymer Based Composites Book
Author : Haw-Ming Huang
Publisher : MDPI
Release : 2021-04-21
ISBN : 3036502602
Language : En, Es, Fr & De

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Book Description :

Polymer-based compounds play an important role in modern medical applications. Among them, high-molecular-weight polymers modified by biomolecules can increase biological activity and improve their biocompatibility. The composite material formed by the biopolymers combined with other materials can improve the mechanical strength. These materials that can complement polymers include micron, sub-micron, and nano-scale materials. Their application covers the entire field of biomedicine.

Antibiotic Materials in Healthcare

Antibiotic Materials in Healthcare Book
Author : Varaprasad Kokkarachedu,Vimala Kanikireddy,Rotimi Sadiku
Publisher : Academic Press
Release : 2020-05-22
ISBN : 012822536X
Language : En, Es, Fr & De

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Book Description :

Antibiotic Materials in Healthcare provides significant information on antibiotic related issues, accurate solutions, and recent investigative information for health-related applications. In addition, the book addresses the design and development of antibiotics with advanced (physical, chemical and biological) properties, an analysis of materials, in vivo and in vitro applications, and their biomedical applications for healthcare. Provides information on all aspects of antibiotic related issues Offers a balanced synthesis of basic and clinical science for each individual case, presenting clinical courses and detailed microbiological information for each infection Describes the prevalence and incidence of global issues and current therapeutic approaches

Advanced Materials in Drug Release and Drug Delivery Systems

Advanced Materials in Drug Release and Drug Delivery Systems Book
Author : Katarzyna Winnicka
Publisher : MDPI
Release : 2021-09-03
ISBN : 3036510583
Language : En, Es, Fr & De

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Book Description :

Development of new drug molecules is costly and requires longitudinal, wide-ranging studies; therefore, designing advanced pharmaceutical formulations for existing and well-known drugs seems to be an attractive device for the pharmaceutical industry. Properly formulated drug delivery systems can improve pharmacological activity, efficacy and safety of the active substances. Advanced materials applied as pharmaceutical excipients in designing drug delivery systems can help solve problems concerning the required drug release—with the defined dissolution rate and at the determined site. Novel drug carriers enable more effective drug delivery, with improved safety and with fewer side effects. Investigations concerning advanced materials represent a rapidly growing research field in material/polymer science, chemical engineering and pharmaceutical technology. Exploring novel materials or modifying and combining existing ones is now a crucial trend in pharmaceutical technology. Eleven articles included in the the Special Issue “Advanced Materials in Drug Release and Drug Delivery Systems” present the most recent insights into the utilization of different materials with promising potential in drug delivery and into different formulation approaches that can be used in the design of pharmaceutical formulations.

Systems Biology in Biotech Pharma

Systems Biology in Biotech   Pharma Book
Author : Ales Prokop,Seth Michelson
Publisher : Springer Science & Business Media
Release : 2012-01-05
ISBN : 9400728484
Language : En, Es, Fr & De

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Book Description :

The US is currently well ahead of the rest of the world in the development and application of SB and its principles especially as they pertain to basic medical research and development. This lead is largely due to its earlier start in the academic arena. However, there is evidence of rapid development in both the UK/EU and Japan, and the gap is narrowing, particularly in the UK. From an industrial point of view, the Pharmaceutical Industry based in the US and UK can capitalize on these opportunities and gain the benefits of this technology. Many educational institutions (particularly their medical divisions) at present are heavily business-oriented, realize that in this particular industrial environment, that every dollar counts.

Functional Polymers for Controlled Drug Release

Functional Polymers for Controlled Drug Release Book
Author : Umile Gianfranco Spizzirri
Publisher : MDPI
Release : 2020-03-19
ISBN : 3039284908
Language : En, Es, Fr & De

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Book Description :

This Special Issue focuses on the synthesis and characterization of hydrogels specifically used as carriers of biological molecules for pharmaceutical and biomedical employments. Pharmaceutical applications of hydrophilic materials has emerged as one of the most significant trends in the area of nanotechnology. To propose some of the latest findings in this field, each contribution involves an in-depth analysis including different starting materials and their physico-chemical and biological properties with the aim of synthetizing high-performing devices for specific use. In this context, intelligent polymeric devices able to be morphologically modified in response to an internal or external stimulus, such as pH or temperature, have been actively pursued. In general, hydrophilic polymeric materials lead to high in vitro and/or in vivo therapeutic efficacy, with programmed site-specific feature showing remarkable potential for targeted therapy. This Special Issue serves to highlight and capture the contemporary progress in this field. Relevant resources and people to approach - American Association Pharmaceutical Scientists (AAPS): web: www.aaps.org; email: (marketing division): [email protected]; (mmeting division): [email protected] - International Association for Pharmaceutical Technology (APV): web: apv-mainz.de; email (managing director): [email protected]; (congresses and trade fairs): [email protected] - International Society of Drug Delivery Sciences and Technology (APGI): web: http://www.apgi.org; email: [email protected]; - The Society of Chemical Industry (SCI): web: www.soci.org; email: [email protected] - Italian society of researchers in pharmaceutical technology (A.D.R.I.T.E.L.F.): web: www-3.unipv.it/adritelf/; email (head): [email protected]; - Italian Chemical Society (SCI): web: www.soc.chim.it; email: [email protected] - Associazione Farmaceutici Industria (AFI): web: http://www.afiweb.it; email:: [email protected] - Società Italiana di Chimica e Scienze Cosmetologiche (SICC): web: www.sicc.tv; mail: [email protected] - Society for biomaterials: web: www.biomaterials.org; email: [email protected] - European Society for Biomaterials (ESB): web: www.esbiomaterials.eu; email: - Società Italiana Biomateriali (SIB): web: www.biomateriali.org; email: [email protected] - Medical Device Manufactures Association (MDMA): web: www.medicaldevices.org; - European Polymer Federaton (EPF): web: www.europolyfed.org; email: [email protected] - Society of Plastics Engineers (SPE): web: www.4spe.org; email: [email protected] - Polymer Processing Society (PPS): web: www.poly-eng.uakron.edu/pps/; email: [email protected]; - American Chinese Pharmaceutical Association; web: www.acpa-rx.org; - Chinese Pharmaceutical Association: web: www.pharmachinaonline.com - Society of Polymer Science, Japan: web: www.spsj.or.jp; email: [email protected]

Recent Development of Electrospinning for Drug Delivery

Recent Development of Electrospinning for Drug Delivery Book
Author : Romána Zelkó,Dimitrios A. Lamprou,István Sebe
Publisher : MDPI
Release : 2020-03-27
ISBN : 3039281402
Language : En, Es, Fr & De

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Book Description :

Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (i.e., high specific surface area, porosity, and the possibility of controlling the crystalline–amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is also responsible for their physical–chemical instability. This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery and wound healing applications, covering recent advantages and future directions in electrospun fiber formulations and scalability. Moreover, it serves to highlight and capture the contemporary progress in electrospinning techniques, with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. All aspects of small molecule or biologics-loaded fibrous dosage forms, focusing on the processability, structures and functions, and stability issues, are included.

Nanomaterials for Clinical Applications

Nanomaterials for Clinical Applications Book
Author : Costas Demetzos,Natassa Pippa
Publisher : Elsevier
Release : 2020-02-14
ISBN : 0128168765
Language : En, Es, Fr & De

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Book Description :

Nanomaterials in Clinical Medicine: Case Studies in Nanomedicines focuses on the nanomaterials that can be formulated as drug delivery vehicles, such as liposomes, micelles, nanoemulsions and nanogels. Their physicochemical, morphological, thermo-dynamical and nanotoxicological properties are analyzed with respect to the design and development of drug delivery nanosystems for the encapsulation of an active pharmaceutical ingredient and its controlled release. Each chapter covers basic properties, the nanosystem (e.g., liposomes), the added value in drug delivery and targeting, and future perspectives. Case studies and examples of how nanomaterials are being used in clinical medicine, including marketed liposomal medicines and medical utility and regimens are also included. Particular attention is given to new nanocarriers, such as elastic liposomes, lipid polymeric hybrid nanoparticles, organogel, nanofibers carbon nanomaterials, quantum dots and inorganic nanoparticles. This book is an important information source for those wanting to increase their understanding of what major nanomaterials are being used to create more effective drug delivery systems. Summarizes the major nanomaterials used in clinical medicine, explaining how their properties make them suitable for this purpose Explains how nanomaterials are used to create increasingly efficient drug delivery vehicles Includes real-life examples, demonstrating how nanomaterials are being used in medical practice

Nanostructured Biomaterials for Regenerative Medicine

Nanostructured Biomaterials for Regenerative Medicine Book
Author : Vincenzo Guarino,Michele Iafisco,Silvia Spriano
Publisher : Woodhead Publishing
Release : 2019-10-05
ISBN : 0081025955
Language : En, Es, Fr & De

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Book Description :

Nanostructured Biomaterials for Regenerative Medicine focuses on the definition of new trends for the design of biomaterials for biomedical applications. It includes the ex novo synthesis as well as technological strategies to manipulate them into appropriate two-dimensional (2D) and three-dimensional (3D) forms, in order to impart all the main physical, chemical, structural and biological properties requested to achieve desired clinical efficacy. This book aims at offering a concise overview of innovative platforms based on nanostructured biomaterials as a function of their chemical nature - established by a consolidated material classification i.e., polymer, ceramics and metals. For each class, emerging bioinspired systems with rapid expansion in the biomedical research area and fabricated via new enabling technologies will be proposed for the use in tissue repair/regeneration and nanomedicine. This book is an essential resource for researchers, academics and professionals interested in the potential of nanostructured biomaterials for regenerative medicine. Classifies materials into three classes for comprehensive discussion Discusses design techniques to create innovative nanostructured biomaterials Looks at enabling technologies and strategies for emerging applications

Pharmaceutical Applications of Polymers for Drug Delivery

Pharmaceutical Applications of Polymers for Drug Delivery Book
Author : David Jones
Publisher : iSmithers Rapra Publishing
Release : 2004
ISBN : 9781859574799
Language : En, Es, Fr & De

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Book Description :

Annotation The review focuses on the use of pharmaceutical polymer for controlled drug delivery applications. Examples of pharmaceutical polymers and the principles of controlled drug delivery are outlined and applications of polymers for controlled drug delivery are described. The field of controlled drug delivery is vast therefore this review aims to provide an overview of the applications of pharmaceutical polymers. The review is accompanied by approximately 250 abstracts taken from papers and books in the Rapra Polymer Library database, to facilitate further reading on this subject.

Transport Processes in Pharmaceutical Systems

Transport Processes in Pharmaceutical Systems Book
Author : Gordon L. Amidon,Ping I. Lee,Elizabeth M. Topp
Publisher : CRC Press
Release : 1999-11-24
ISBN : 9780824766108
Language : En, Es, Fr & De

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Book Description :

This cutting-edge reference clearly explains pharmaceutical transport phenomena, demonstrating applications ranging from drug or nutrient uptake into vesicle or cell suspensions, drug dissolution and absorption across biological membranes, whole body kinetics, and drug release from polymer reservoirs and matrices to heat and mass transport in freeze-drying and hygroscopicity. Focuses on practical applications of drug delivery from a physical and mechanistic perspective, highlighting biological systems. Written by more than 30 international authorities in the field, Transport Processes in Pharmaceutical Systems discusses the crucial relationship between the transport process and thermodynamic factors analyzes the dynamics of diffusion at liquid-liquid, liquid-solid, and liquid-cultured cell interfaces covers prodrug design for improving membrane transport addresses the effects of external stimuli in altering some natural and synthetic polymer matrices examines properties of hydrogels, including synthesis, swelling degree, swelling kinetics, permeability, biocompatibility, and biodegradability presents mass transfer of drugs and pharmacokinetics based on mass balance descriptions and more! Containing over 1000 references and more than 1100 equations, drawings, photographs, micrographs, and tables, Transport Processes in Pharmaceutical Systems is a must-read resource for research pharmacists, pharmaceutical scientists and chemists, chemical engineers, physical chemists, and upper-level undergraduate and graduate students in these disciplines.