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Stem Cells And Cancer In Hepatology

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Stem Cells and Cancer in Hepatology

Stem Cells and Cancer in Hepatology Book
Author : Yun-Wen Zheng
Publisher : Academic Press
Release : 2018-05-18
ISBN : 0128123028
Language : En, Es, Fr & De

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Book Description :

Stem Cells and Cancer in Hepatology: From the Essentials to Application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. It discusses how the liver performs regeneration and repair, the role stem cells play in these processes, and the mechanisms by which liver cancers are initiated and developed. As the field of stem cells and cancer stem cells in hepatology is new and dynamic, thus making it difficult for researchers and clinicians to understand the most relevant historic and novel studies, this volume addresses that challenge. Addresses both the basic and clinical perspectives of the topic, including sections on normal and cancer stem cells of the liver Provides coverage of the molecular mechanisms of liver development, the proliferation of hepatic progenitor cells during development, epithelial cell plasticity, generation of hepatocytes by transdifferentiation, liver tissue engineering, and more Presents a study of hepatic stem cells that will help readers understand critical events during development, stem cell differentiation towards functional liver cell fate, and tumor initiation

Stem Cells for Cancer and Genetic Disease Treatment

Stem Cells for Cancer and Genetic Disease Treatment Book
Author : Phuc Van Pham,Ahmed El-Hashash
Publisher : Springer
Release : 2018-11-07
ISBN : 3319980653
Language : En, Es, Fr & De

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Book Description :

This invaluable resource discusses insights ranging from basic biological mechanisms of various types of stem cells through the potential applications in the treatment of human diseases, including cancer and genetic disorders. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in understanding different types of stem cell biology and their potential applications in tissue repair and regeneration and in the treatment different types of human cancer and genetic diseases or disorders. Stem Cells for Cancer and Genetic Disease Treatment and the other books in the Stem Cells in Clinical Applicationsseries will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering as well as cancer or genetics research.

Advances in Cancer Stem Cell Biology

Advances in Cancer Stem Cell Biology Book
Author : Roberto Scatena,Alvaro Mordente,Bruno Giardina
Publisher : Springer Science & Business Media
Release : 2011-10-06
ISBN : 9781461408093
Language : En, Es, Fr & De

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Book Description :

In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.

Cancer Stem Cells in Solid Tumors

Cancer Stem Cells in Solid Tumors Book
Author : Alison L. Allan
Publisher : Springer Science & Business Media
Release : 2011-08-12
ISBN : 1617792462
Language : En, Es, Fr & De

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Book Description :

The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.

Molecular Genetics of Liver Neoplasia

Molecular Genetics of Liver Neoplasia Book
Author : Xin Wei Wang,Joe W. Grisham,Snorri S. Thorgeirsson
Publisher : Springer Science & Business Media
Release : 2010-11-08
ISBN : 9781441960825
Language : En, Es, Fr & De

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Book Description :

Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500,000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking. Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumor’s aggressiveness at the time of diagnosis and the lack of effective therapy.

Stem Cells and Cancer

Stem Cells and Cancer Book
Author : Sadhan Majumder
Publisher : Springer Science & Business Media
Release : 2009-06-07
ISBN : 9780387896113
Language : En, Es, Fr & De

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Book Description :

Cancer is a primary cause of human mortality worldwide. Despite decades of basic and clinical research, the outcome for most cancer patients is still dismal. Some stumbling blocks to developing effective therapy include the heterogeneity of cancer tissues, the lack of knowledge about the critical molecular mechanisms in cancer tissues (which are typically aberrant compared with mechanisms in normal tissue), and the lack of good mechanism-based therapeutic approaches. The recent findings that most cancers contain a small fraction of self-renewing, differentiation-blocked stem cell-like cells (cancer stem cells) and that it is these cells—and not the major bulk of the tissue—that are the root cause for cancer initiation and metastasis have also highlighted the need to change our approach to cancer therapy. The objectives of this book, therefore, would be to impart up-to-date information about the role of stem cells in the development of normal and cancerous tissue, the mechanisms that differentiate normal from cancerous functions, and the use of these findings in developing mechanism-based therapies.

State of the Art of Hepatology

State of the Art of Hepatology Book
Author : Hans Popper
Publisher : Springer Science & Business Media
Release : 2004-06-30
ISBN : 9780792387954
Language : En, Es, Fr & De

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Book Description :

In honour of Hans Popper's 100th birthday

Hepatic Cancer New Insights for the Healthcare Professional 2012 Edition

Hepatic Cancer  New Insights for the Healthcare Professional  2012 Edition Book
Author : N.A
Publisher : ScholarlyEditions
Release : 2012-12-10
ISBN : 1464989354
Language : En, Es, Fr & De

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Book Description :

Hepatic Cancer: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Hepatic Cancer in a compact format. The editors have built Hepatic Cancer: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hepatic Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hepatic Cancer: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Hepatology

Hepatology Book
Author : N.A
Publisher :
Release : 1997-07
ISBN :
Language : En, Es, Fr & De

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Book Description :

Stem Cells and Cancer

Stem Cells and Cancer Book
Author : Devon W. Parsons
Publisher : Nova Science Pub Incorporated
Release : 2007
ISBN :
Language : En, Es, Fr & De

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Book Description :

Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, autoimmune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This book brings together leading research from throughout the world with particular focus on stem cells and cancer research.

MacSween s Pathology of the Liver E Book

MacSween s Pathology of the Liver E Book Book
Author : Alastair D. Burt,Linda D. Ferrell,Stefan G Hubscher,Bernard C. Portmann
Publisher : Elsevier Health Sciences
Release : 2011-08-30
ISBN : 0702047546
Language : En, Es, Fr & De

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Book Description :

MacSween’s Pathology of the Liver delivers the expert know-how you need to diagnose all forms of liver pathology using the latest methods. Updated with all the most current knowledge and techniques, this medical reference book will help you more effectively evaluate and interpret both the difficult and routine cases you see in practice. Compare the specimens you encounter in practice to thousands of high-quality images that capture the appearance of every type of liver disease. Efficiently review all the key diagnostic criteria and differential diagnoses for each lesion.

Disease Progression and Carcinogenesis in the Gastrointestinal Tract

Disease Progression and Carcinogenesis in the Gastrointestinal Tract Book
Author : P.R. Galle,G. Gerken,W.E. Schmidt,B. Wiedenmann
Publisher : Springer Science & Business Media
Release : 2003-09-30
ISBN : 9780792387855
Language : En, Es, Fr & De

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Book Description :

Development and progression of gastrointestinal disease involves inflammatory, vascular, fibrogenetic and immune reactions accompanied by deregulation of cellular growth and death often resulting in cancer of the organs affected. This book, the proceedings of Falk Symposium 132 on `Disease Progression and Carcinogenesis in the Gastrointestinal Tract', held in Freiburg, Germany, October 9-10, 2002, addresses these various cellular processes in five sections in order to build up a broad pathogenic concept of gastrointestinal disease, purposely going beyond organ-specific research. Each section combines experts in the various fields of molecular medicine together with clinical scientists in order to stimulate interdisciplinary discussion. In addition, clinical chapters focus on new findings in both diagnostics and therapeutics.

Practical Gastroenterology and Hepatology

Practical Gastroenterology and Hepatology Book
Author : N.A
Publisher : John Wiley & Sons
Release : 2011-07-11
ISBN : 1444347861
Language : En, Es, Fr & De

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Book Description :

This comprehensive resource for fellows/trainees and candidates for recertification in gastroenterology summarizes the field in a modern, fresh format. Prominent experts from around the globe write on their areas of expertise, and each chapter follows a uniform structure. The focus is on key knowledge, with the most important clinical facts highlighted in boxes. Color illustrations reinforce the text.

Principles of Stem Cell Biology and Cancer

Principles of Stem Cell Biology and Cancer Book
Author : Tarik Regad,Thomas Sayers,Robert Rees
Publisher : John Wiley & Sons
Release : 2015-05-06
ISBN : 1118670620
Language : En, Es, Fr & De

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Book Description :

Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK The field of cancer stem cells is expanding rapidly, with many groups focusing on isolating and identifying cancer stem cell populations. Although some progress has been made developing efficient cancer therapies, targeting cancer stem cells remains one of the important challenges facing the growing stem cell research community. Principles of Stem Cell Biology and Cancer brings together original contributions from international experts in the field to present the very latest information linking stem cell biology and cancer. Divided into two parts, the book begins with a detailed introduction to stem cell biology with a focus on the characterization of these cells, progress that has been made in their identification, as well as future therapeutic applications of stem cells. The second part focuses on cancer stem cells and their role in cancer development, progression and chemo-resistance. This section of the book includes an overview of recent progress concerning therapies targeting cancer stem cells. Features: An authoritative introduction to the link between stem cell biology and cancer. Includes contributions from leading international experts in the field. Well-illustrated with full colour figures throughout. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current progress and exciting future possibilities for stem cell research.

Biotechnology and Biopharmaceuticals

Biotechnology and Biopharmaceuticals Book
Author : N.A
Publisher : John Wiley & Sons
Release : 2013-09-19
ISBN : 1118659988
Language : En, Es, Fr & De

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Book Description :

Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.

Stem Cell Research Advances

Stem Cell Research Advances Book
Author : Lydia P. Davenport
Publisher : Nova Biomedical
Release : 2007
ISBN :
Language : En, Es, Fr & De

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Book Description :

Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, autoimmune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This book presents leading-edge research in this rapidly-growing field.

Stem Cell Research Trends

Stem Cell Research Trends Book
Author : Josse R. Braggina
Publisher : Nova Science Pub Incorporated
Release : 2007
ISBN :
Language : En, Es, Fr & De

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Book Description :

Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, auto-immune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This book presents important research from around the globe.

Blumgart s Surgery of the Liver Pancreas and Biliary Tract E Book

Blumgart s Surgery of the Liver  Pancreas and Biliary Tract E Book Book
Author : William R. Jarnagin
Publisher : Elsevier Health Sciences
Release : 2012-03-09
ISBN : 1455746061
Language : En, Es, Fr & De

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Book Description :

Comprehensive and complete, Blumgart’s Surgery of the Liver, Pancreas and Biliary Tract – edited by Dr. William R. Jarnagin and a team of experts- delivers the comprehensive, cutting-edge guidance you need to achieve optimal outcomes in surgery of the liver, biliary tract, and pancreas. Edited by a panel of experts and featuring contributions by many leading authorities, this 2-volume reference brings you the latest information on pathology, diagnostics, surgery, and non-operative intervention all in one source. At www.expertconsult.com you can not only access the complete contents online, but also an abundance of detailed illustrations and step-by-step procedural video clips from the Memorial Sloan Kettering video library that show you how to perform key procedures step by step. Glean all essential, up-to-date, need-to-know information in one comprehensive reference that provides extensive coverage of pathology, diagnostics, surgery, and non-operative intervention as well as hepatobiliary and pancreatic surgery. Deepen your understanding of surgical anatomy to help with diagnosis, surgical operation, interventional radiology, and endoscopy. See how to perform key procedures by watching operative videos from the Memorial Sloan Kettering video library. Apply the most advanced diagnostic and management options for each disease, including interventional techniques. Stay current with the latest knowledge and advancements including minimally invasive techniques in hepatic resection; surgical considerations for congenital disorders of the pancreas; non-surgical therapies for pancreatic cancer; microwave ablation and other emerging technologies; the most recent developments in the rapidly changing area of transplantation; and the newest best practices in pre- and post-operative care and blood transfusion. Get in-depth coverage of the pancreas from the only fully comprehensive text on both hepatobiliary and pancreatic surgery. Learn from the very best. Rely on the trusted guidance of experts, with a fresh perspective from senior editor, Dr. William Jarnigan, who has earned a national and international reputation in the surgical management of diseases of the biliary tract. Access the full text online at www.expertconsult.com, along with image and video libraries, tables, figures, and more! Over 200 additional contributing experts. A single, comprehensive reference that covers pathology, diagnostics, surgery, and non-operative intervention all in one text!