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Stem Cells And Aging

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Adult Stem Cells in Aging Diseases and Cancer

Adult Stem Cells in Aging  Diseases and Cancer Book
Author : K.L. Rudolph
Publisher : Karger Medical and Scientific Publishers
Release : 2014-12-22
ISBN : 3318027324
Language : En, Es, Fr & De

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Book Description :

The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.

Stem Cells and Aging

Stem Cells and Aging Book
Author : Surajit Pathak,Antara Banerjee
Publisher : Academic Press
Release : 2021-03-26
ISBN : 0128204133
Language : En, Es, Fr & De

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Book Description :

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Stem Cells and Aging

Stem Cells and Aging Book
Author : Kursad Turksen
Publisher : Humana
Release : 2020-09-19
ISBN : 9781493997152
Language : En, Es, Fr & De

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Book Description :

This fully updated book collects protocols that reflect current investigations into how stem cell populations change during organismal aging. These methodologies are well-established and described in easy to follow fashion so as to be valuable for not only experts but novices in the ever-developing stem cell field. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Stem Cells and Aging: Methods and Protocols, Second Edition serves as an ideal guide for all researchers working in this very active area of study.

Stem Cell Aging Mechanisms Consequences Rejuvenation

Stem Cell Aging  Mechanisms  Consequences  Rejuvenation Book
Author : Hartmut Geiger,Heinrich Jasper,Maria Carolina Florian
Publisher : Springer
Release : 2015-07-06
ISBN : 370911232X
Language : En, Es, Fr & De

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Book Description :

Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.

Antiaging Effect of Stem Cells on Aging and Stem Cell Aging

Antiaging   Effect of Stem Cells on Aging and Stem Cell Aging Book
Author : Jisook Moon
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Aging is defined broadly as the normal progressive process, consequently leading to growing vulnerability to disease and death. A major challenge lies in dissecting the underlying mechanisms of aging with conventional experiments due to the complexity of and multicontributions to the aging process, reflecting a need for investigation into it in various aspects. For this reason, the age process has currently been subjected to OMICS technologies including genomics, transcriptomics, proteomics, and metabolomics, allowing the exploration of age-related changes in a multifactorial manner. In addition, since age-dependent decline in stem cell function is almost identical to the biological age, stem cells have used to understand "aging" and to investigate key reverse factors for "antiaging". This suggests that a range of new approaches are needed to reveal the unknown biological basis for aging at a variety of different molecular levels using stem cells as a tool of normal aging process and can further apply fundamental aspects in biological aging and longevity.

Stem Cells and Aging

Stem Cells and Aging Book
Author : Cesar V. Borlongan,Gary K. Steinberg
Publisher : Frontiers Media SA
Release : 2021-07-14
ISBN : 2889710343
Language : En, Es, Fr & De

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Book Description :

Dr. Borlongan and Dr. Steinberg serve as consultants to stem cell-based companies, hold patents and patent applications, and have funded grants related to stem cell biologics and applications.

Stem Cells and Aging

Stem Cells and Aging Book
Author : Kursad Turksen
Publisher : Humana
Release : 2019-10-07
ISBN : 9781493997121
Language : En, Es, Fr & De

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Book Description :

This fully updated book collects protocols that reflect current investigations into how stem cell populations change during organismal aging. These methodologies are well-established and described in easy to follow fashion so as to be valuable for not only experts but novices in the ever-developing stem cell field. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Stem Cells and Aging: Methods and Protocols, Second Edition serves as an ideal guide for all researchers working in this very active area of study.

Advances in Stem Cell Aging

Advances in Stem Cell Aging Book
Author : K. Lenhard Rudolph
Publisher : Karger Medical and Scientific Publishers
Release : 2012
ISBN : 3318021709
Language : En, Es, Fr & De

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Book Description :

Up-to-date meeting report of the Else Kr ner-Fresenius Symposium on Adult Stem Cell Aging Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells. This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kr ner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.

Telomeres and Telomerase in Aging Disease and Cancer

Telomeres and Telomerase in Aging  Disease  and Cancer Book
Author : K. Lenhard Rudolph
Publisher : Springer Science & Business Media
Release : 2007-11-07
ISBN : 354073709X
Language : En, Es, Fr & De

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Book Description :

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Mammalian Development

Mammalian Development Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Mammalian Development book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mesenchymal Stem Cell Aging

Mesenchymal Stem Cell Aging Book
Author : Faizal Asumda
Publisher : LAP Lambert Academic Publishing
Release : 2012-07
ISBN : 9783659186714
Language : En, Es, Fr & De

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Book Description :

Cell-based therapy geared at the replacement of lost myocardial cells, and subsequent regeneration of damaged myocardial tissue is a viable and attractive therapeutic option. Bone Marrow derived Mesenchymal stem cells (BM-MSCs) have emerged in recent years as a practical and clinically relevant stem cell for the technique of cellular cardiomyoplasty. Enthusiasm for BM-MSCs is however tempered by evidence that cells from older donors show measurable and qualitative changes in their efficacy. This work provides a theoretical exposition on why BM-MSCs are a preferred cell source for cardiac regeneration, outlines aspects of their appeal that is diminished by natural aging, and discusses approaches to their in vitro cardiomyogenic differentiation. Also presented is a theoretical discussion of the physiological significance of nuclear cardiac troponins and tropomyosin with regard to BM-MSC specific cardiomyogenesis, the importance of the stem cell niche environment, and its potential contribution to diminished BM-MSC plasticity with advancing age.

Molecular Mechanisms of Adult Stem Cell Aging

Molecular Mechanisms of Adult Stem Cell Aging Book
Author : K.L. Rudolph
Publisher : Karger Medical and Scientific Publishers
Release : 2010-04-22
ISBN : 3805592442
Language : En, Es, Fr & De

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Book Description :

There is growing evidence that adult stem cells age. This process can result in alterations in the number and function of stem cells, leading to distinct phenotypic outcomes in different organ systems. This publication provides an outstanding overview of this emerging field.The molecular causes of stem cell aging remain to be defined. Stem cell aging can involve cell-intrinsic as well as cell-extrinsic alterations affecting the stem cell niche or the macroenvironment. Stem cells have a longer life span than other cell populations and retain a capacity to proliferate and differentiate in adult organs. The aging of adult stem cells plays a key role in the decline of organ maintenance and regenerative potential during aging and during the end stage of chronic diseases. In addition, it can contribute to stem cell transformation and carcinogenesis.Molecular Mechanisms of Adult Stem Cell Aging will appeal to scientists working in the fields such as stem cells, aging, regeneration and cancer. This subject matter should be of interest to physicians and scientists specializing in geriatric medicine, internal medicine, and surgery. It is also likely to be an invaluable resource for medical students and biologists who wish to enhance their understanding of molecular and stem cell biology.

Centrosomal Sas 6 in Regulation of Stem Cells and Aging

Centrosomal Sas 6 in Regulation of Stem Cells and Aging Book
Author : Li Ming Gooi
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Centrosomal Sas 6 in Regulation of Stem Cells and Aging book written by Li Ming Gooi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Anti Aging Triad

The Anti Aging Triad Book
Author : Stephen Holt
Publisher : AuthorHouse
Release : 2011-04-01
ISBN : 1456755757
Language : En, Es, Fr & De

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Book Description :

Th is book is a ground breaking review of the three most important scientifi c areas of anti-aging medicine. Stephen Holt MD has navigated areas of conventional and integrative medicine to produce a book that is valuable for both a layperson and biomedical experts.

Role of Septins in Hematopoietic Stem Cells and Aging

Role of Septins in Hematopoietic Stem Cells and Aging Book
Author : Katharina Senger
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Role of Septins in Hematopoietic Stem Cells and Aging book written by Katharina Senger, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Aging Stem Cells and the Cancer Stem Cell Hypothesis

Aging  Stem Cells and the Cancer Stem Cell Hypothesis Book
Author : Dave Comstock,City University of New York. City College
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Aging Stem Cells and the Cancer Stem Cell Hypothesis book written by Dave Comstock,City University of New York. City College, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Effects of the Local Organ and Systemic Environments on Stem Cell Aging

Effects of the Local Organ and Systemic Environments on Stem Cell Aging Book
Author : Morgan Erik Carlson
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This work uncovers mechanisms of aging within stem cell niches that are evolutionarily conserved between mice and humans, and affect both embryonic and adult stem cells. Specifically, the effects of aged muscle and systemic niches on key molecular identifiers of regenerative potential of human embryonic stem cells (hESCs) and postnatal muscle stem cells (satellite cells) were examined. Results reveal that aged differentiated niches dominantly inhibit the expression of Oct4 in hESC and Myf-5 in activated satellite cells, and reduce proliferation and myogenic differentiation of both embryonic and tissue specific adult stem cells (ASCs). Therefore, the ability of hESCs, and the more differentiated myogenic ASCs to contribute to tissue repair in the old will be restricted, due to the conserved inhibitory influence of aged differentiated niches. Additionally, this work establishes that hESC-derived factors enhance the regenerative potential of both young and importantly, aged muscle stem cells in vitro and in vivo; thus, suggesting that the regenerative outcome of stem cell-based replacement therapies will be determined by a balance between negative influences of aged tissues on transplanted cells and positive effects of embryonic cells on the endogenous regenerative capacity.

Stem Cell Aging

Stem Cell Aging Book
Author : Primož Rožman
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Stem cells persist throughout life, replacing cells lost to homeostatic turnover, injury, and disease. However, their functions decline with age, which contributes to degeneration and dysfunction. The molecular mechanisms involved in the aging of stem cells are the same as the ones involved in the aging of somatic cells, including telomere shortening, oxidative stress, epigenetic dysregulation, miRNAs changes, alterations of DNA, RNA, proteome, and various cellular organelles. Aging impacts various pathways, such as insulin/insulin-like growth factor 1 (IGF-1), mTOR, FoxO, AMP-activated protein kinase (AMPK), sirtuin, and many others, resulting in senescent stem cells that exhibit functional and numerical impairment. Stem cells have developed special mechanisms to prevent age related damage accumulation and to sustain their stemness properties, however, these mechanisms lose their effectiveness over time. The most fatal consequence of this is found in the immune system, where both innate and adaptive immunity are affected, exhibiting a plethora of defects, including increased autoimmune disease occurrence, elevated tolerance to cancer and chronic inflammatory status. Stem cell therapies call for the best quality of stem cells grafts. Stem cell products should be devoid of cells containing a senescent phenotype, thus a comprehensive knowledge of the biology behind the senescence of stem cells should be taken into account in every cell based therapy.

The Stem Cell Niche during Ageing

The Stem Cell Niche during Ageing Book
Author : Susie Prof. Nilsson
Publisher : Academic Press
Release : 2020-08-22
ISBN : 0128220201
Language : En, Es, Fr & De

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Book Description :

Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Exosomes Stem Cells and MicroRNA

Exosomes  Stem Cells and MicroRNA Book
Author : Karl L. Mettinger,Pranela Rameshwar,Vinod Kumar
Publisher : Springer
Release : 2018-04-07
ISBN : 3319744704
Language : En, Es, Fr & De

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Book Description :

This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.