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Stem Cells and Aging

Stem Cells and Aging Book
Author : Surajit Pathak,Antara Banerjee
Publisher : Academic Press
Release : 2021-03-26
ISBN : 0128204133
Language : En, Es, Fr & De

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Book Description :

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Adult Stem Cells in Aging Diseases and Cancer

Adult Stem Cells in Aging  Diseases and Cancer Book
Author : K.L. Rudolph
Publisher : Karger Medical and Scientific Publishers
Release : 2014-12-22
ISBN : 3318027324
Language : En, Es, Fr & De

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Book Description :

The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.

Advances in Stem Cell Aging

Advances in Stem Cell Aging Book
Author : K.L. Rudolph
Publisher : Karger Medical and Scientific Publishers
Release : 2012-09-27
ISBN : 3318021717
Language : En, Es, Fr & De

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Book Description :

Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells.This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kröner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.

Stem Cell Aging Mechanisms Consequences Rejuvenation

Stem Cell Aging  Mechanisms  Consequences  Rejuvenation Book
Author : Hartmut Geiger,Heinrich Jasper,Maria Carolina Florian
Publisher : Springer
Release : 2015-07-06
ISBN : 370911232X
Language : En, Es, Fr & De

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Book Description :

Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.

Stem Cells and Aging

Stem Cells and Aging Book
Author : Kursad Turksen
Publisher : Humana Press
Release : 2013-02-13
ISBN : 9781627033169
Language : En, Es, Fr & De

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Book Description :

Over time, it has become clear that changes in stem cells do occur during aging, not only in their number but also in their relationship to their microenvironment and their functionality as reflected in changes to their metabolome. Stem Cells and Aging: Methods and Protocols brings together chapters from expert contributors with protocols critical for exploring the biology of stem cell aging, all of which is key for understanding these age-related stem cell changes at a basic biology level and at the level of their impacts for regenerative medicine. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy to use, Stem Cells and Aging: Methods and Protocols serves as an ideal reference to guide investigators toward further valuable answers to the problems of our aging population.

Molecular Mechanisms of Adult Stem Cell Aging

Molecular Mechanisms of Adult Stem Cell Aging Book
Author : K. Lenhard Rudolph
Publisher : Karger Medical and Scientific Publishers
Release : 2010
ISBN : 3805592434
Language : En, Es, Fr & De

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Book Description :

"There is growing evidence that adult stem cells age. This process can result in alterations in the number and function of stem cells, leading to distinct phenotypic outcomes in different organ systems. This publication provides an outstanding overview of this emerging field. The molecular causes of stem cell aging remain to be defined. Stem cell aging can involve cell-intrinsic as well as cell-extrinsic alterations affecting the stem cell niche or the macroenvironment. Stem cells have a longer life span than other cell populations and retain a capacity to proliferate and differentiate in adult organs. The aging of adult stem cells plays a key role in the decline of organ maintenance and regenerative potential during aging and during the end stage of chronic diseases. In addition, it can contribute to stem cell transformation and carcinogenesis. Molecular Mechanisms of Adult Stem Cell Aging will appeal to scientists working in the fields such as stem cells, aging, regeneration and cancer. This subject matter should be of interest to physicians and scientists specializing in geriatric medicine, internal medicine, and surgery. It is also likely to be an invaluable resource for medical students and biologists who wish to enhance their understanding of molecular and stem cell biology."--Publisher's description.

Time Cells and Aging

Time  Cells  and Aging Book
Author : Bernard Louis Strehler
Publisher : Unknown
Release : 1977
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Times, Cells, and Aging ...

The Immortal Cell

The Immortal Cell Book
Author : Michael D. West,H. W. Brands
Publisher : Doubleday Books
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A key player in the science of therapeutic cloning recounts the progress that has been made in reversing the aging process of cells, citing the unique qualities of stem cells and how they can be used to regenerate damaged cells and organs.

Effects of Aging on the Lymphoid Potential of Hematopoietic Stem Cells

Effects of Aging on the Lymphoid Potential of Hematopoietic Stem Cells Book
Author : Ying Kong
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Lymphocyte development declines with age, which in turn contributes to the reduced replenishment of na ve lymphocytes in secondary lymphoid organs. An impaired ability of old hematopoietic stem cells (HSCs) to generate lymphoid progeny is thought to contribute to this attenuation of lymphopoiesis. It is now recognized that the HSC compartment is heterogeneous and includes lymphoid biased (Ly-HSCs), myeloid biased (My-HSCs) and balanced (Bal-HSCs) hematopoietic stem cells. Previous studies have demonstrated that the frequency of Ly-HSCs is reduced with age, and this observation has resulted in the formulation of a model of stem cell aging which proposes that the age-related decline in lymphocyte development is due to a reduction in the number of these lymphoid biased precursors. However, findings from this thesis show that this model needs to be revised. In particular, Ly-HSCs do no decline and increase significantly during aging. The lymphoid potential of old Ly-HSCs is similar to young Ly-HSCs ex vivo shown by the number and aging marker expression of produced lymphoid cells. But the genomic pattern of old Ly-HSCs turns into a myeloid biased pattern indicated by RNA-Sequencing results, which correlates with altered myeloid production from old Ly-HSCs. In terms of reduced lymphoid development in vivo during aging, the fact that elevated level of pro inflammatory cytokines, one character of senescence-associated secretory phenotype, was detected to significantly and irreversibly prohibit the lymphoid differentiation from Ly-HSCs. Based on the above results, we propose the revised aging model of hematopoietic stem cells: Ly-HSCs do not decline during aging; their lymphoid potential remains similar to young Ly-HSCs ex vivo, but when being under the pro inflammatory cytokines, their differentiation is irreversible blocked; Whereas, their myeloid production is altered even removing from proinflammatory condition, which correlates with the fact that old Ly-HSCs show myeloid-biased transcriptional pattern. Throughout the projects, the methods utilized include cells staining, flow cytometry, cell sorting, lymphoid and myeloid assays, HSC-OP9 co-culture, cell transplantation, qPCR and RNA-Sequencing. Two supplementary files were also included separately: Table 2-11 "Ly-HSC and My-HSC gene expression estimates and differential expression results" and Table 2-12 "Ly-HSC and My-HSC gene signature analysis and functional enrichment results".

Telomeres and Telomerase in Aging Disease and Cancer

Telomeres and Telomerase in Aging  Disease  and Cancer Book
Author : K. Lenhard Rudolph
Publisher : Springer Science & Business Media
Release : 2007-11-07
ISBN : 354073709X
Language : En, Es, Fr & De

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Book Description :

Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Exploring the Promise of Embryonic Stem Cell Research

Exploring the Promise of Embryonic Stem Cell Research Book
Author : United States. Congress. Senate. Special Committee on Aging
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Exploring the Promise of Embryonic Stem Cell Research book written by United States. Congress. Senate. Special Committee on Aging, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Textbook of Aging Skin

Textbook of Aging Skin Book
Author : Miranda A. Farage,Kenneth W. Miller,Howard I. Maibach
Publisher : Springer Science & Business Media
Release : 2009-12-02
ISBN : 3540896554
Language : En, Es, Fr & De

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Book Description :

This comprehensive ‘Major Reference Book’ compiles all current and latest information on aging skin in a two-volume set. Highly structured with a reader-friendly format, it covers a wide range of areas such as basic sciences, the different diseases and conditions which occur with aging (from malignant to non-malignant), the latest techniques and methods being used such as bioengineering methods and biometrics as well as toxicological and safety considerations for the elderly population. It also illustrates the global consumers’ sociological and psychological implications, ethnicity and gender differences and includes marketing considerations for this elderly group. This unique and comprehensive guide will become the main reference textbook on this topic.

Effects of the Local Organ and Systemic Environments on Stem Cell Aging

Effects of the Local Organ and Systemic Environments on Stem Cell Aging Book
Author : Morgan Erik Carlson
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This work uncovers mechanisms of aging within stem cell niches that are evolutionarily conserved between mice and humans, and affect both embryonic and adult stem cells. Specifically, the effects of aged muscle and systemic niches on key molecular identifiers of regenerative potential of human embryonic stem cells (hESCs) and postnatal muscle stem cells (satellite cells) were examined. Results reveal that aged differentiated niches dominantly inhibit the expression of Oct4 in hESC and Myf-5 in activated satellite cells, and reduce proliferation and myogenic differentiation of both embryonic and tissue specific adult stem cells (ASCs). Therefore, the ability of hESCs, and the more differentiated myogenic ASCs to contribute to tissue repair in the old will be restricted, due to the conserved inhibitory influence of aged differentiated niches. Additionally, this work establishes that hESC-derived factors enhance the regenerative potential of both young and importantly, aged muscle stem cells in vitro and in vivo; thus, suggesting that the regenerative outcome of stem cell-based replacement therapies will be determined by a balance between negative influences of aged tissues on transplanted cells and positive effects of embryonic cells on the endogenous regenerative capacity.

Handbook of the Biology of Aging

Handbook of the Biology of Aging Book
Author : Finchc
Publisher : Van Nostrand Reinhold Company
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Handbook of the Biology of Aging book written by Finchc, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Immunology of Aging

Immunology of Aging Book
Author : Ahmad Massoud,Nima Rezaei
Publisher : Springer Science & Business Media
Release : 2013-11-29
ISBN : 3642394957
Language : En, Es, Fr & De

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Book Description :

The rapidity of scientific progress over the last few years guarantees the utility of this new collection of state-of-the-art reviews on the immunology of aging, which is the result of extensive collaboration of more than sixty of the greatest thinkers and scholars in the field, in cooperation with a number of junior colleagues. The book summarizes current knowledge on the cellular and molecular aspects of the aging immune system and their clinical relevance, providing insights into the effects of the aging process on susceptibilities to those diseases most common among elders. The retrieval strategies used to slow down the decline in the immune system in the elderly are another subject detailed extensively. By providing a broad overview of immunosenescence and its consequences, as well as their potential modulation, this book will fill a gap in a timely manner. It will be of value to all immunologists, whether novice or experienced, as well as geriatricians and epidemiologists.

Ageing Vulnerability

Ageing Vulnerability Book
Author : Gregory R. Bock,Tom Kirkwood,Jamie A. Goode,Novartis Foundation
Publisher : Wiley-Blackwell
Release : 2001-03-30
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Ageing at individual and population levels presents one of the greatest challenges to humankind as we begin the 21st century. Throughout the world, older adults are the fasts growing population group. Ageing is associated with an increased risk for development of chronic diseases that contribute to morbidity and mortality.

The Journals of Gerontology

The Journals of Gerontology Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Journals of Gerontology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Aging Cancer and Cell Membranes

Aging  Cancer  and Cell Membranes Book
Author : Carmia Borek,Cecilia M. Fenoglio-Preiser,Donald West King
Publisher : Unknown
Release : 1980
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Aging Cancer and Cell Membranes book written by Carmia Borek,Cecilia M. Fenoglio-Preiser,Donald West King, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Aging and Aging Related Diseases

Aging and Aging Related Diseases Book
Author : Zhao Wang
Publisher : Springer
Release : 2018-09-19
ISBN : 981131117X
Language : En, Es, Fr & De

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Book Description :

This book provides an overview of recent advances in the study of aging and aging related diseases, discussing the topics at individual, organ, tissue, cell, and molecular levels. It also presents studies on the biomarkers of aging and anti-aging interventions. Aging has been becoming a global health problem. However it was not possible to determine aging as we usually diagnose a disease because there are few biomarkers for age estimation. Since ancient times, people have been seeking anti-aging substances and methods for achieving immortality, while the scientific study of aging has only existed for 100 years. This book appeals to researchers both in institutes and in pharmaceutical companies interested in further studies in this field.

Aging in the Eighties and Beyond

Aging in the Eighties and Beyond Book
Author : Manfred Bergener
Publisher : Unknown
Release : 1983
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Aging in the Eighties and Beyond book written by Manfred Bergener, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.