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Stem Cells and Cell Therapy

Stem Cells and Cell Therapy Book
Author : Mohamed Al-Rubeai,Mariam Naciri
Publisher : Springer Science & Business Media
Release : 2013-10-01
ISBN : 9400771967
Language : En, Es, Fr & De

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Book Description :

With the discovery of stem cells capable of multiplying indefinitely in culture and differentiating into many other cell types in appropriate conditions, new hopes were born in repair and replacement of damaged cells and tissues. The features of stem cells may provide treatment for some incurable diseases with some therapies are already in clinics, particularly those from adult stem cells. Some treatments will require large number of cells and may also require multiple doses, generating a growing demand for generating and processing large numbers of cells to meet the need of clinical applications. With this in mind, our aim is to provide a book on the subject of stem cells and cell therapy for researchers and students of cell biotechnology, bioengineering and bioproduction. This book is exceptional as it teaches researchers stem cells and cell therapy in that it covers the concepts and backgrounds necessary so that readers get a good understanding of the production of stem cells. The book covers three topics: The basics of stem cells and cell therapy, the use of stem cells for the treatment of human diseases, and stem cell processing. It includes chapters on neural and vascular stem vascular stem cell therapy, expansion engineering of embryonic stem cells, stem cell based production of blood cells and separation technologies for stem cells and cell therapy products. It is an informed and informative presentation of what modern research, science and engineering have learned about stem cells and their production and therapies. Addressing both the medical and production issues, this book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.

Breast Cancer Stem Cells Therapy Resistance

Breast Cancer Stem Cells   Therapy Resistance Book
Author : Phuc Van Pham
Publisher : Springer
Release : 2015-11-26
ISBN : 3319220209
Language : En, Es, Fr & De

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Book Description :

This volume thoroughly examines breast cancer stem cells (BCSCs), from basic definitions to techniques for identifying, isolating, culturing, and targeting BCSCs for therapy; there is additional focus on pre-clinical and clinical results. The text begins with a discussion of breast cancer, focusing especially on the limitations of current therapies in its treatment. The subsequent chapters introduce and compare stem cells and cancer stem cells, describe properties and isolation techniques of BCSCs, and examine BCSC-targeting approaches. The text concludes with a discussion of controversy surrounding the BCSC hypothesis and of future research directions. Breast Cancer Stem Cells & Therapy Resistance, part of the SpringerBriefs in Stem Cells series, provides a succinct yet comprehensive overview of BCSCs for advanced students, graduate students and researchers as well as those working with breast cancer or stem cells in a clinical setting.

Stem Cell Therapy for Diabetes

Stem Cell Therapy for Diabetes Book
Author : Shimon Efrat
Publisher : Springer Science & Business Media
Release : 2009-12-01
ISBN : 9781607613664
Language : En, Es, Fr & De

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Book Description :

Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.

Stem Cell Therapy for Organ Failure

Stem Cell Therapy for Organ Failure Book
Author : Indumathi Somasundaram
Publisher : Springer
Release : 2015-01-02
ISBN : 8132221109
Language : En, Es, Fr & De

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Book Description :

The book “STEM CELL THERAPY FOR ORGAN FAILURES” edited by Dr. S. Indumathi demonstrates the In Vitro and In vivo therapeutic strategies and applications of pre- and post-natal stem cells for treating the failures of various organ systems of our body in a wide perspective. It explores the past, present and the futuristic approach of the exciting field of stem cells and its intriguing properties involved in tissue repair and regeneration. The prime focus of this volume is to unravel the basic, advanced, therapeutic and translational approaches put-forth so far in the field of stem cells and regenerative medicine at research, pre-clinical and clinical levels. Stem cells has ushered in widespread interest and exciting possibilities for cell based therapies, albeit failures do prevail and small uncontrolled phase I/II studies are only signals generating, rather than definite proof of concept thereby limiting its applicability in curative therapeutics. Despite certain initiatives and meticulous untiring efforts, bringing this basic bench side research into advanced transitional bedside remained a challenge. Thus, this book embarked upon the expanding researches in these areas that seem decisive in improvising regenerative medical therapeutics, thereby leading to further path-breaking studies that cure all health challenges facing mankind. Overall, this book reveals the imperativeness of various stem cell sources and its utility in curative therapeutics.

Stem Cells Basics and Clinical Translation

Stem Cells  Basics and Clinical Translation Book
Author : Robert Chunhua Zhao
Publisher : Springer
Release : 2015-09-14
ISBN : 9401772738
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of regenerative medicine since the day they were discovered. As stem cell research is complicated and making progress rapidly, it is important to have expertise in this field to share their views and perspectives. This book provides a wonderful platform for those who are interested in stem cells to learn from and communicate with experts. Particularly, it highlights the roles of stem cell based therapy for a variety of diseases. Furthermore, this book gives a detailed introduction to the great works related to stem cells in China. The readers could gain a profound knowledge of the state-of-art research done by scientists in the field of stem cells. Overall, this book will be a valuable reference resource for both experienced investigators pursuing stem cell research as well as those are just entering into this field. Dr. Robert Chunhua Zhao, a Cheung Kong Professor of Stem Cell Biology, is Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College (PUMC), Beijing, China. He is Director of the Center for Tissue Engineering, PUMC and Chief Scientist of the National Basic Research Program of China (“973 Program”). He also serves as Regional Editor of Stem Cells and Development.

Biomaterials for Stem Cell Therapy

Biomaterials for Stem Cell Therapy Book
Author : Loredana De Bartolo,Augustinus Bader
Publisher : CRC Press
Release : 2013-01-28
ISBN : 1466576391
Language : En, Es, Fr & De

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Book Description :

Focused on stem cell applications, this book bridges the fields of biomaterials, offering new insights into constructing and regenerating tissues and organs. Its unique feature is linking diseases of the human body to current thinking on how to deal with them in the context of current concepts and technologies by means of an in-depth focus on biomaterials. The book assembles recent advances and covers a range of topics related to stem cell biology, biomaterials and technological approaches such as bioreactors written by top researchers in the field. Stem cells of both embryonic and adult origin are discussed with applications ranging, but not limited to, nerve regeneration, liver, pancreas, skin, trachea, cartilage and bone repair and cardiovascular therapy. Developments in the field reflecting the design and construction of the human body and its principal anatomy are discussed from a materials point of view. The book will be a valuable tool for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells. It will also be a source of reference for students in biotechnology, biomedical engineering, biology, biochemistry, materials sciences, pharmaceuticals, and veterinary and human medicine.

Regenerative Medicine and Cell Therapy

Regenerative Medicine and Cell Therapy Book
Author : Hossein Baharvand,Nasser Aghdami
Publisher : Springer Science & Business Media
Release : 2012-08-09
ISBN : 1627030980
Language : En, Es, Fr & De

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Book Description :

Therapeutic applications within regenerative biomedicine has gained tremendous interest from a growing, multidisciplinary community of investigators in recent years, driven by the hope of finding cures for several diseases. Regenerative Medicine and Cell Therapy discusses cutting-edge science in the field of regenerative biomedicine and its therapeutic applications to various medical disorders. The chapters are written by renowned scientists in the specific fields. This will be a useful book for basic and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research. The editors’ goal is that the new knowledge and research outlined in this book will help contribute to new therapies for a wide variety of diseases that presently afflict humanity.

Novel Perspectives of Stem Cell Manufacturing and Therapies

Novel Perspectives of Stem Cell Manufacturing and Therapies Book
Author : Diana Kitala,Ana Colette Maurício
Publisher : BoD – Books on Demand
Release : 2021-04-14
ISBN : 1839625031
Language : En, Es, Fr & De

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Book Description :

In the 1950s, Nobel Prize winner Dr. E. Donnall Thomas was the first to successfully transplant hematopoietic stem cells. Since then, studies on stem cells have evolved and expanded worldwide. There are more than 650,000 scientific publications on stem cells and more than 8000 stem cell clinical trials. This book summarizes types of stem cells, key studies, ongoing trials, and future perspectives. It also includes ethical, formal, and legal aspects to give the reader a comprehensive view of the field.

Stem Cells A Very Short Introduction

Stem Cells  A Very Short Introduction Book
Author : Jonathan Slack
Publisher : OUP Oxford
Release : 2012-02-23
ISBN : 0191633941
Language : En, Es, Fr & De

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Book Description :

The topic of stem cells has been very high profile in the media in recent years. There is much public interest in stem cells but also much confusion and misinformation, with some companies already offering 'stem cell products' and bogus 'stem cell therapies'. In this Very Short Introduction, Jonathan Slack introduces stem cells; what they are, what scientists do with them, what stem cell therapies are available today, and how they might be used in future. Despite important advances, clinical applications of stem cells are still in their infancy. Most real stem cell therapy today is some form of bone marrow transplantation. Slack introduces stem cells by explaining the difference between embryonic stem cells, which exist only in laboratory cultures, and tissue-specific stem cells, which exist in our bodies. Embryonic stem cells can become any cell type in the body, so diseases that may in future be treated by functional cells derived from these sorts of stem cell include diabetes, Parkinson's disease, heart disease, and spinal trauma. He then goes on to discuss the properties of tissue-specific stem cells and the important technique of bone marrow transplantation. Slack concludes by analysing how medical innovation has occurred in this area in the past, and draws out some of the lessons for the development of new therapies in the future. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Stem Cell Therapy for Vascular Diseases

Stem Cell Therapy for Vascular Diseases Book
Author : Tulio Pinho Navarro,Lara Lellis Navarro Minchillo Lopes,Alan Dardik
Publisher : Springer Nature
Release : 2020-11-05
ISBN : 3030569543
Language : En, Es, Fr & De

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Book Description :

Vascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers.

Stem Cell Transplantation

Stem Cell Transplantation Book
Author : Carlos López-Larrea,Antonio López Vázquez,Beatriz Suárez Álvarez
Publisher : Springer Science & Business Media
Release : 2012-03-28
ISBN : 1461420989
Language : En, Es, Fr & De

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Book Description :

Organ transplantation has been the most important therapeutic advance in the last third of the 20th century. Its development has revolutionized medicine, as demonstrated by the fact that a large number of researchers in this field have been awarded Nobel Prizes. In the beginning of this century, we are witnessing with great expectations the emergence of a new field of medicine related to the arrival of a new player on the scene: “stem cells” and their potential use in regenerative medicine. This volume aims to cover important aspects of the various facets of organ transplantation and regenerative medicine, with leading specialists in these fields setting out their vision. We try to rigorously explain current and novel scientific research in these fields—areas which arouse great interest from society in general, due to their potential use in modern medicine for the treatment of a great number of diseases.

Stem Cell Transplantation

Stem Cell Transplantation Book
Author : Anthony Dick Ho,Ronald Hoffman,Esmail D. Zanjani
Publisher : John Wiley & Sons
Release : 2006-08-21
ISBN : 3527608532
Language : En, Es, Fr & De

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Book Description :

This is the first handbook on the whole field of stem cell research covering (1) molecular and cellular fundamentals, (2) clinical applications and (3) GMP processing. It provides a timely overview of the potential and plasticity of adult stem cells. With its focus on standardization and quality control of cell lines suited for processing and clinical trials, the book features novel therapeutic approaches that offer great promise for new ways of treating neural, hematological and cardiovascular diseases. The editors are leading international experts in adult stem cell research, and their successful networking in the US and Europe has resulted in a distinguished team of authors from around the world.

Handbook of Cardiac Stem Cell Therapy

Handbook of Cardiac Stem Cell Therapy Book
Author : Ioannis Dimarakis
Publisher : World Scientific
Release : 2009
ISBN : 1848162561
Language : En, Es, Fr & De

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Book Description :

This book is an impressive compilation of contributions on the hot topic of cardiac stem cell therapy from leading groups all over the world. In the assembly of chapters, a structured approach is adopted; starting from the clinician's perspective, all developments in both the experimental and clinical research areas are covered. This journey will take the reader from the bench-top to the bedside, with all chapters written by leading authorities in their respective fields, including data still in press with medical journals. So, beyond being excellent as an overall update for scientists in the field of cardiac stem cell therapy, this book will likely prove an indispensable tool for every budding scientist considering a research project within this field.

The Secret World of Stem Cell Therapy

The Secret World of Stem Cell Therapy Book
Author : Prof. Dr. Ernst von Schwarz
Publisher : Morgan James Publishing
Release : 2022-02-01
ISBN : 1631957082
Language : En, Es, Fr & De

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Book Description :

The Secret World of Stem Cell Therapy is the only comprehensive overview of the secrets and currently known facts about stem cell therapy. Prof. Dr. Ernst von Schwarz is a world-renowned researcher and clinical and academic cardiologist, who has published more than 150 scientific articles in international peer-reviewed journals, several books’ chapters, and books in cardiovascular medicine. He is also a sought-after speaker at international scientific conferences worldwide, an expert on stem cell therapy and research, and a public figure in medical media. From an academic and clinical point of view, stem cell therapy represents one of the most promising advances in modern medicine. While several business entities make unsubstantiated claims without having appropriate scientific evidence, The Secret World of Stem Cell Therapy provides the one and only inside view from a researcher and clinical cardiologist, who has himself participated in countless basic research studies and clinical trials using stem cells for different conditions over the last 25 years. It gives readers interested in stem cell therapy appropriate advice on how to approach the subject, what questions to ask, and how to be alerted to red flags.

Stem Cell Therapy for Autoimmune Disease

Stem Cell Therapy for Autoimmune Disease Book
Author : Richard K. Burt
Publisher : CRC Press
Release : 2019-11-11
ISBN : 1000724670
Language : En, Es, Fr & De

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Book Description :

Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.

Stem Cells in Regenerative Medicine

Stem Cells in Regenerative Medicine Book
Author : Alain A. Vertes,Nasib Qureshi,Arnold I. Caplan,Lee E. Babiss
Publisher : John Wiley & Sons
Release : 2015-12-02
ISBN : 111997139X
Language : En, Es, Fr & De

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Book Description :

This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine. • Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics • Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline • Written by an expert team with extensive experience in the business, basic and applied science of stem cell research This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.

Stem Cell and Regenerative Medicine

Stem Cell and Regenerative Medicine Book
Author : Herman S. Cheung
Publisher : Bentham Science Publishers
Release : 2010-12-10
ISBN : 1608050084
Language : En, Es, Fr & De

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Book Description :

"The potential use of stem cells in transplantation for the purpose of tissue regeneration is an exciting area of research currently undergoing rapid development. Implantation of human embryonic or autologous, ex vivo-expanded adult stem cells, particularl"

Stem Cells

Stem Cells Book
Author : Nicole Arrighi
Publisher : Iste Press - Elsevier
Release : 2018-03
ISBN : 9781785482540
Language : En, Es, Fr & De

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Book Description :

Stem Cells: Therapeutic Innovations under Control traces the discovery of stem cells and induced pluripotent cells. It establishes the link between knowledge about cell development and tissue engineering, and presents perspectives in regenerative medicine. Cell proliferation and tissue architecture open up unexpected applications in tissue engineering, with the development of tissues or organs. In this context emerges the need to address the issue of bioethics and regulatory considerations. Because stem cells can multiply and differentiate into cells specific to a particular tissue or organ, they represent vast potential in the health field. Traces the discovery of stem cells to link knowledge of cell development with tissue engineering Presents prospects in regenerative medicine Establishes the link between knowledge about cell development and tissue engineering

Umbilical Cord Stem Cell Therapy

Umbilical Cord Stem Cell Therapy Book
Author : David A. Steenblock,Anthony G. Payne
Publisher : Basic Health Publications
Release : 2006-03
ISBN : 9781681628387
Language : En, Es, Fr & De

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Book Description :

The debate over the use of Embryonic stem cells and the questionable effectiveness of adult stem cells have led many scientists and clinicians to concentrate their energies on umbilical-cord-derived stem cells from healthy newborn babies. Amassing a very respectable track record in terms of safety and clinical utility, cord-blood stem cells can treat many diseases such as multiple sclerosis, amyotrophic lateral sclerosis, stroke, diabetes, heart disease and certain degenerative eye disorders.