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Stem Cells and Cell Therapy

Stem Cells and Cell Therapy Book
Author : Mohamed Al-Rubeai,Mariam Naciri
Publisher : Springer Science & Business Media
Release : 2013-10-01
ISBN : 9400771967
Language : En, Es, Fr & De

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Book Description :

With the discovery of stem cells capable of multiplying indefinitely in culture and differentiating into many other cell types in appropriate conditions, new hopes were born in repair and replacement of damaged cells and tissues. The features of stem cells may provide treatment for some incurable diseases with some therapies are already in clinics, particularly those from adult stem cells. Some treatments will require large number of cells and may also require multiple doses, generating a growing demand for generating and processing large numbers of cells to meet the need of clinical applications. With this in mind, our aim is to provide a book on the subject of stem cells and cell therapy for researchers and students of cell biotechnology, bioengineering and bioproduction. This book is exceptional as it teaches researchers stem cells and cell therapy in that it covers the concepts and backgrounds necessary so that readers get a good understanding of the production of stem cells. The book covers three topics: The basics of stem cells and cell therapy, the use of stem cells for the treatment of human diseases, and stem cell processing. It includes chapters on neural and vascular stem vascular stem cell therapy, expansion engineering of embryonic stem cells, stem cell based production of blood cells and separation technologies for stem cells and cell therapy products. It is an informed and informative presentation of what modern research, science and engineering have learned about stem cells and their production and therapies. Addressing both the medical and production issues, this book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.

Cardiovascular Regeneration and Stem Cell Therapy

Cardiovascular Regeneration and Stem Cell Therapy Book
Author : Annarosa Leri,Piero Anversa,William H. Frishman
Publisher : John Wiley & Sons
Release : 2008-04-15
ISBN : 0470994304
Language : En, Es, Fr & De

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Book Description :

This book is the definitive reference on two of the most exciting areas of cardiovascular research – myocardial regeneration and stem cell therapy – for the treatment of disease. Edited by pioneers in the area, with contributions from every major investigator worldwide, it covers: The biology of stem cells The actions of stem cells from the bone marrow, the heart, and embryos on the normal restorative and repair functions of the heart and blood vessels How stem cells could contribute to myocardial recovery in the face of injury and aging How adjuvant therapy with growth factors might enhance stem cell activity in regeneration and repair Clinical applications and clinical experiences This fully referenced publication presents the current state of knowledge in both basic science and clinical practice, and is an essential reference for scientists, students, and clinicians.

Stem Cell Therapy for Diabetes

Stem Cell Therapy for Diabetes Book
Author : Shimon Efrat
Publisher : Springer Science & Business Media
Release : 2009-12-01
ISBN : 9781607613664
Language : En, Es, Fr & De

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Book Description :

Stem Cell Therapy for Diabetes, one of the latest installments of the Stem Cell Biology and Regenerative Medicine series, reviews the three main approaches for generation of sufficient numbers of insulin-producing cells for restoration of an adequate beta-cell mass: beta-cell expansion, stem-cell differentiation, and nuclear reprogramming. Adeptly collecting the research of the leading scientists in the field, Stem Cell Therapy for Diabetes compares the merits of employing autologous versus banked allogeneic cell sources for generation of surrogate beta cells, and addresses tissue engineering and ways for cell protection from recurring autoimmunity and graft rejection. Stem Cell Therapy for Diabetes provides essential reading for those especially interested in tracking the progress in applying of one of the most exciting new developments in bio-medicine towards a cure for diabetes.

Stem Cell Therapy in Lysosomal Storage Diseases

Stem Cell Therapy in Lysosomal Storage Diseases Book
Author : Jaap Jan Boelens,Robert Wynn
Publisher : Springer Science & Business Media
Release : 2013-10-10
ISBN : 1461483573
Language : En, Es, Fr & De

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Book Description :

Stem Cell therapy for lysosomal diseases (LSDs) is developing rapidly. This volume discusses the history, current practice and future perspectives of stem cells in inborn errors of metabolism (IEM) and provides an international perspective on progress, limitations, and future directions (e.g. gene therapy, iPS, ES) in the field. Beginning with an overview of these diseases, the book covers the breadth of this topic from treatment options, bone marrow transplantation, and alternative treatment options, through long-term outcomes and future perspectives.

Stem Cells

Stem Cells Book
Author : Mariusz Z. Ratajczak
Publisher : Springer Nature
Release : 2020-01-02
ISBN : 3030312062
Language : En, Es, Fr & De

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Book Description :

Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.

Advances in Stem Cell Therapy

Advances in Stem Cell Therapy Book
Author : Nagwa El-Badri
Publisher : Humana Press
Release : 2016-11-18
ISBN : 3319291491
Language : En, Es, Fr & De

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Book Description :

The book reviews the main approaches for generation of differentiated cells from various types of stem cells, including embryonic, placental and cord blood stem cells through marrow, adipose tissue and dental pulp. The book starts with an overview of experimental protocols applied to generate insulin secreting cells, neural cells, heart cells, and other tissue specific cells ex vivo and in experimental animals. This is followed by exhaustive review of clinical trials in these pathologies. It continues with a comparison of the merits of successful transplantation in humans versus animal experimentation, and highlights the most promising clinical applications in the field. Special chapters are devoted to the topic of tissue engineering and modern synthetic and biological scaffolds. It is essential reading for scientists and researchers in tissue engineering and stem cell research as well as clinicians who are involved in developing or testing stem cell therapies.

Stem Cells

Stem Cells Book
Author : Nicole Arrighi
Publisher : Elsevier
Release : 2018-03-27
ISBN : 0081025882
Language : En, Es, Fr & De

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Book Description :

Stem Cells: Therapeutic Innovations under Control traces the discovery of stem cells and induced pluripotent cells. It establishes the link between knowledge about cell development and tissue engineering, and presents perspectives in regenerative medicine. Cell proliferation and tissue architecture open up unexpected applications in tissue engineering, with the development of tissues or organs. In this context emerges the need to address the issue of bioethics and regulatory considerations. Because stem cells can multiply and differentiate into cells specific to a particular tissue or organ, they represent vast potential in the health field. Traces the discovery of stem cells to link knowledge of cell development with tissue engineering Presents prospects in regenerative medicine Establishes the link between knowledge about cell development and tissue engineering

Stem Cell Therapy for Organ Failure

Stem Cell Therapy for Organ Failure Book
Author : Indumathi Somasundaram
Publisher : Springer
Release : 2015-01-02
ISBN : 8132221109
Language : En, Es, Fr & De

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Book Description :

The book “STEM CELL THERAPY FOR ORGAN FAILURES” edited by Dr. S. Indumathi demonstrates the In Vitro and In vivo therapeutic strategies and applications of pre- and post-natal stem cells for treating the failures of various organ systems of our body in a wide perspective. It explores the past, present and the futuristic approach of the exciting field of stem cells and its intriguing properties involved in tissue repair and regeneration. The prime focus of this volume is to unravel the basic, advanced, therapeutic and translational approaches put-forth so far in the field of stem cells and regenerative medicine at research, pre-clinical and clinical levels. Stem cells has ushered in widespread interest and exciting possibilities for cell based therapies, albeit failures do prevail and small uncontrolled phase I/II studies are only signals generating, rather than definite proof of concept thereby limiting its applicability in curative therapeutics. Despite certain initiatives and meticulous untiring efforts, bringing this basic bench side research into advanced transitional bedside remained a challenge. Thus, this book embarked upon the expanding researches in these areas that seem decisive in improvising regenerative medical therapeutics, thereby leading to further path-breaking studies that cure all health challenges facing mankind. Overall, this book reveals the imperativeness of various stem cell sources and its utility in curative therapeutics.

Handbook of Cardiac Stem Cell Therapy

Handbook of Cardiac Stem Cell Therapy Book
Author : Ioannis Dimarakis
Publisher : World Scientific
Release : 2009
ISBN : 1848162561
Language : En, Es, Fr & De

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Book Description :

This book is an impressive compilation of contributions on the hot topic of cardiac stem cell therapy from leading groups all over the world. In the assembly of chapters, a structured approach is adopted; starting from the clinician's perspective, all developments in both the experimental and clinical research areas are covered. This journey will take the reader from the bench-top to the bedside, with all chapters written by leading authorities in their respective fields, including data still in press with medical journals. So, beyond being excellent as an overall update for scientists in the field of cardiac stem cell therapy, this book will likely prove an indispensable tool for every budding scientist considering a research project within this field.

The Secret World of Stem Cell Therapy

The Secret World of Stem Cell Therapy Book
Author : Ernst von Schwarz
Publisher : Unknown
Release : 2021-05-17
ISBN : 9781631957079
Language : En, Es, Fr & De

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Book Description :

The Secret World of Stem Cell Therapy is the only comprehensive overview of the secrets and currently known facts about stem cell therapy. Prof. Dr. Ernst von Schwarz is a world-renowned researcher and clinical and academic cardiologist, who has published more than 150 scientific articles in international peer-reviewed journals, several books' chapters, and books in cardiovascular medicine. He is also a sought-after speaker at international scientific conferences worldwide, an expert on stem cell therapy and research, and a public figure in medical media. From an academic and clinical point of view, stem cell therapy represents one of the most promising advances in modern medicine. While several business entities make unsubstantiated claims without having appropriate scientific evidence, The Secret World of Stem Cell Therapy provides the one and only inside view from a researcher and clinical cardiologist, who has himself participated in countless basic research studies and clinical trials using stem cells for different conditions over the last 25 years. It gives readers interested in stem cell therapy appropriate advice on how to approach the subject, what questions to ask, and how to be alerted to red flags.

Stem Cell Therapy for Autoimmune Disease

Stem Cell Therapy for Autoimmune Disease Book
Author : Richard K. Burt
Publisher : CRC Press
Release : 2019-11-11
ISBN : 1000724670
Language : En, Es, Fr & De

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Book Description :

Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.

Breast Cancer Stem Cells Therapy Resistance

Breast Cancer Stem Cells   Therapy Resistance Book
Author : Phuc Van Pham
Publisher : Springer
Release : 2015-11-26
ISBN : 3319220209
Language : En, Es, Fr & De

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Book Description :

This volume thoroughly examines breast cancer stem cells (BCSCs), from basic definitions to techniques for identifying, isolating, culturing, and targeting BCSCs for therapy; there is additional focus on pre-clinical and clinical results. The text begins with a discussion of breast cancer, focusing especially on the limitations of current therapies in its treatment. The subsequent chapters introduce and compare stem cells and cancer stem cells, describe properties and isolation techniques of BCSCs, and examine BCSC-targeting approaches. The text concludes with a discussion of controversy surrounding the BCSC hypothesis and of future research directions. Breast Cancer Stem Cells & Therapy Resistance, part of the SpringerBriefs in Stem Cells series, provides a succinct yet comprehensive overview of BCSCs for advanced students, graduate students and researchers as well as those working with breast cancer or stem cells in a clinical setting.

Embryonic Stem Cell Therapy for Osteo Degenerative Diseases

Embryonic Stem Cell Therapy for Osteo Degenerative Diseases Book
Author : Nicole I. Nieden
Publisher : Humana Press
Release : 2016-08-23
ISBN : 9781493957231
Language : En, Es, Fr & De

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Book Description :

Embryonic stem cells (ESCs) offer an unlimited self-renewing capacity, as opposed to the limits of adult stem cells; therefore, ESCs represent an almost bottomless resource for regenerative medicine and tissue engineering approaches. In Embryonic Stem Cell Therapy for Osteo-Degenerative Diseases: Methods and Protocols, accomplished investigators provide detailed descriptions on how to expand ESCs from the most commonly used species ex vivo, i.e. mouse and human, in static culture as well as in controllable bioreactor processes. The thorough and timely volume summarizes the methods that may be used to differentiate these cells along the desired lineage of choice, be it osteoblasts, osteoclasts, or chondrocytes, and consequentially also offers analysis tools for the characterization of resulting cells and evaluation of differentiation effectiveness. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert tips on troubleshooting and avoiding known pitfalls. Dependable and cutting-edge, Embryonic Stem Cell Therapy for Osteo-Degenerative Diseases: Methods and Protocols supplies the tools necessary to allow researchers to carry out critical research needed in order to bring this burgeoning and vitally important field closer to the clinic and to ensure the widespread application of a successful strategy.

Stem Cell Therapy for Vascular Diseases

Stem Cell Therapy for Vascular Diseases Book
Author : Tulio Pinho Navarro,Lara Lellis Navarro Minchillo Lopes,Alan Dardik
Publisher : Springer Nature
Release : 2020-11-05
ISBN : 3030569543
Language : En, Es, Fr & De

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Book Description :

Vascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers.

Stem Cells Basics and Clinical Translation

Stem Cells  Basics and Clinical Translation Book
Author : Robert Chunhua Zhao
Publisher : Springer
Release : 2015-09-14
ISBN : 9401772738
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of regenerative medicine since the day they were discovered. As stem cell research is complicated and making progress rapidly, it is important to have expertise in this field to share their views and perspectives. This book provides a wonderful platform for those who are interested in stem cells to learn from and communicate with experts. Particularly, it highlights the roles of stem cell based therapy for a variety of diseases. Furthermore, this book gives a detailed introduction to the great works related to stem cells in China. The readers could gain a profound knowledge of the state-of-art research done by scientists in the field of stem cells. Overall, this book will be a valuable reference resource for both experienced investigators pursuing stem cell research as well as those are just entering into this field. Dr. Robert Chunhua Zhao, a Cheung Kong Professor of Stem Cell Biology, is Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College (PUMC), Beijing, China. He is Director of the Center for Tissue Engineering, PUMC and Chief Scientist of the National Basic Research Program of China (“973 Program”). He also serves as Regional Editor of Stem Cells and Development.

Biomaterials for Stem Cell Therapy

Biomaterials for Stem Cell Therapy Book
Author : Loredana De Bartolo,Augustinus Bader
Publisher : CRC Press
Release : 2013-01-28
ISBN : 1466576391
Language : En, Es, Fr & De

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Book Description :

Focused on stem cell applications, this book bridges the fields of biomaterials, offering new insights into constructing and regenerating tissues and organs. Its unique feature is linking diseases of the human body to current thinking on how to deal with them in the context of current concepts and technologies by means of an in-depth focus on biomaterials. The book assembles recent advances and covers a range of topics related to stem cell biology, biomaterials and technological approaches such as bioreactors written by top researchers in the field. Stem cells of both embryonic and adult origin are discussed with applications ranging, but not limited to, nerve regeneration, liver, pancreas, skin, trachea, cartilage and bone repair and cardiovascular therapy. Developments in the field reflecting the design and construction of the human body and its principal anatomy are discussed from a materials point of view. The book will be a valuable tool for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells. It will also be a source of reference for students in biotechnology, biomedical engineering, biology, biochemistry, materials sciences, pharmaceuticals, and veterinary and human medicine.

Stemformatics Fascinating Navigator for Stem Cell Therapy

Stemformatics  Fascinating Navigator for Stem Cell Therapy Book
Author : Shivi Sharma,Eliza Chakraborty
Publisher : Unknown
Release : 2017-06-03
ISBN : 9783330087903
Language : En, Es, Fr & De

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Book Description :

Download Stemformatics Fascinating Navigator for Stem Cell Therapy book written by Shivi Sharma,Eliza Chakraborty, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cell Therapy

Cell Therapy Book
Author : George Morstyn,William Sheridan
Publisher : Cambridge University Press
Release : 1996-03-29
ISBN : 9780521473156
Language : En, Es, Fr & De

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Book Description :

Examines the current state and future prospects of haematopoietic cell therapy, including gene therapy and immunotherapy.

Stem Cells A Very Short Introduction

Stem Cells  A Very Short Introduction Book
Author : Jonathan Slack
Publisher : OUP Oxford
Release : 2012-02-23
ISBN : 0191633941
Language : En, Es, Fr & De

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Book Description :

The topic of stem cells has been very high profile in the media in recent years. There is much public interest in stem cells but also much confusion and misinformation, with some companies already offering 'stem cell products' and bogus 'stem cell therapies'. In this Very Short Introduction, Jonathan Slack introduces stem cells; what they are, what scientists do with them, what stem cell therapies are available today, and how they might be used in future. Despite important advances, clinical applications of stem cells are still in their infancy. Most real stem cell therapy today is some form of bone marrow transplantation. Slack introduces stem cells by explaining the difference between embryonic stem cells, which exist only in laboratory cultures, and tissue-specific stem cells, which exist in our bodies. Embryonic stem cells can become any cell type in the body, so diseases that may in future be treated by functional cells derived from these sorts of stem cell include diabetes, Parkinson's disease, heart disease, and spinal trauma. He then goes on to discuss the properties of tissue-specific stem cells and the important technique of bone marrow transplantation. Slack concludes by analysing how medical innovation has occurred in this area in the past, and draws out some of the lessons for the development of new therapies in the future. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Perinatal Stem Cells

Perinatal Stem Cells Book
Author : Anthony Atala,Kyle J. Cetrulo,Rouzbeh R. Taghizadeh,Curtis L Cetrulo,Sean Murphy
Publisher : Academic Press
Release : 2018-06-14
ISBN : 0128120630
Language : En, Es, Fr & De

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Book Description :

Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells