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Stem Cell Therapy For Osteoarthritis

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Stem Cell Therapy for Osteoarthritis

Stem Cell Therapy for Osteoarthritis Book
Author : Yin Xiao
Publisher : Academic Press
Release : 2021-08-15
ISBN : 9780128219973
Language : En, Es, Fr & De

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Book Description :

Stem Cell Therapy for Osteoarthritis delivers state-of-the-art knowledge of current stem cell therapies for osteoarthritis. Current literature is dated or spread across many research articles. This volume will include different sources of adult stem cells, cell derived biological agents, stem cell derived exomes, secretion factors and more. In addition to covering current therapies and technologies, the authors summarize methodologies, applications and the inclusion/exclusion criteria. The authors are world-renown experts in the field and this book fills a gap in the market. Introduces the latest updates and technologies in stem cell therapy for osteoarthritis Covers mechanisms, stem cell-based products, clinical trials, current challenges and much more Written for academic researchers, to PhD students, medical doctors, including rheumatologists and orthopaedic surgeons, other physicians and nurses

Stem Cells for Osteoarthritis Volume 2

Stem Cells for Osteoarthritis Volume 2 Book
Author : Nathan Wei
Publisher : Unknown
Release : 2014-10-28
ISBN : 9781503017481
Language : En, Es, Fr & De

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Book Description :

Osteoarthritis is the most common form of arthritis... but like Rodney Dangerfield, it doesn't get much respect. The reason is that it is so hard to treat.The types of management techniques used haven't changed in almost forty years. Very few pharmaceutical and biotech companies are willing to tackle osteoarthritis because it is such a difficult task. The number of clinical trials involving new therapies for osteoarthritis is riddled with the bodies of the fallen.For those of us in clinical practice, it has been a frustrating experience... until now...The initial volume The Book On Stem Cells For Osteoarthritis was a compilation of articles I had written on the subject of mesenchymal stem cells in the earlier days of our experience with this technology. The impetus for the first volume was to provide readers instant access to all the articles I had written on the topic rather than having to click their way through the internet. While the first book- really a booklet- was received with a lot of enthusiasm, it was clear there was also a lot of repetitive information. Unfortunately, that is the nature of a compilation of articles... there is much repetitive information.I believe the key thing is that the information is good. It is understandable. And repetition is not necessarily a bad thing when it comes to understanding knee osteoarthritis and the options available for treatment. There have been new developments in our understanding of this condition, particularly when it comes to the knee. And that's exciting for those of us who are in the Boomer demographic.In this volume I also discuss other forms of knee pain that will shed light on how difficult the diagnosis can be in certain instances.I have also updated information on stem cell biology.As the reader might imagine, the science is constantly evolving. The same is true for the procedures themselves.If the goal is to delay or even eliminate the need for joint replacement, the optimal procedure for the application of stem cell therapy is going to go through a series of improvements with the passage of time.

Application of Stem Cells in Canine Osteoarthritis

Application of Stem Cells in Canine Osteoarthritis Book
Author : Shyamal Kanti Guha,Tarani Naskar
Publisher : LAP Lambert Academic Publishing
Release : 2015-04-14
ISBN : 9783659695612
Language : En, Es, Fr & De

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Book Description :

Stem cell therapy has emerged as a new direction in the field of regenerative medicine. Hundreds of workers throughout the world continue to refine and explore the role of bone marrow and cord blood stem cells for their regular use to solve hematological and immune mediated disorders since many years. Many of them are working to explore the uses of the different types of adult mesenchymal stem cells found in bone marrow and cord blood that could be corrected by replacing cells in the damaged tissues in their own lineages. In recent years stem cell research is being pursued in the hope of achieving major medical breakthroughs. Scientists are striving to create therapies that rebuild or replace damaged cells with tissues grown from stem cells and offer hope to people suffering from cancer, diabetes, cardiovascular disease, spinal-cord injuries, and many other neurodegenerative disorders. Both adult and embryonic stem cells may also provide a route for scientists to develop valuable new methods of drug discovery and testing.

Stem Cell Transplantation for Autoimmune Diseases and Inflammation

Stem Cell Transplantation for Autoimmune Diseases and Inflammation Book
Author : Phuc Van Pham
Publisher : Springer
Release : 2019-09-11
ISBN : 3030234215
Language : En, Es, Fr & De

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Book Description :

This book introduces many new technologies and clinical applications of hematopoietic stem cells and mesenchymal stem cell transplantation for the treatment of autoimmune diseases and inflammatory diseases. Presented in two parts, Part 1 focuses on stem cell therapies for autoimmune disease treatment; Part 2 focuses on stem cell therapies and their application in the treatment of common inflammatory diseases, including chronic knee osteoarthritis, chronic obstructive pulmonary disease, liver cirrhosis, Crohn's Disease, Multiple Sclerosis, and more. This book is an essential source for all advanced students and researchers involved with these diseases, stem cells, or both. Stem Cell Transplantation for Autoimmune Diseases and Inflammation and the other books in the Stem Cells in Clinical Applications series are invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine, or tissue engineering as well as cancer or genetics research.

Bone and Cartilage Regeneration

Bone and Cartilage Regeneration Book
Author : Phuc Van Pham
Publisher : Springer
Release : 2017-01-24
ISBN : 3319401440
Language : En, Es, Fr & De

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Book Description :

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in bone and cartilage regeneration. Each chapter is contributed by a pre-eminent scientist in the field and covers such topics as skeletal regeneration by mesenchymal stem cells, clinical improvement of mesenchymal stem cell injection in injured cartilage and osteoarthritis, Good manufacturing practice (GMP), minimal critera of stem cells for clinical applications, future directions of the discussed therapies and much more. Bone & Cartilage Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

PRP standardisation cells therapies

PRP standardisation cells therapies Book
Author : Collectif
Publisher : Favre
Release : 2018-03-01
ISBN : 2828912086
Language : En, Es, Fr & De

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Book Description :

Une monographie (en anglais) consacrée au PRP (Plasma Riche en Plaquettes) et thérapies cellulaires : les applications médicales, la fabrication, le fonctionnement, la standardisation et les études menées à ce jour avec les résultats. La médecine régénérative englobe un large éventail de techniques ayant pour but de réparer, voire remplacer, les tissus endommagés ou âgés. Le plasma riche en plaquettes (PRP) autologue représente l'approche de médecine régénérative la plus simple. Cette technique est basée sur les capacités intrinsèques du corps humain à réparer une lésion tissulaire. L'intérêt croissant qu'elle suscite s'explique à la fois par le fait qu'elle représente une alternative sûre et naturelle à d'autres formes de traitement plus invasives et par les résultats prometteurs qu'elle a démontrés jusqu'à maintenant pour un grand nombre d'indications. Le plasma riche en plaquettes (abréviation PRP), ou plasma riche en facteurs de croissance (abréviation PRGF) est du plasma sanguin enrichi en plaquettes par une centrifugation. Le PRP est une source concentrée de plaquettes autologues. Il contient et relâche par dégranulation différents facteurs de croissance et cytokines capables de stimuler la régénération de certains tissus. Il est ainsi utilisé dans de nombreuses indications médicales et esthétiques. Si le PRP est en train de devenir un acteur incontournable dans le monde médical, certaines limitations liées à un manque de procédure standardisée pour sa préparation rendent difficile la comparaison entre les données cliniques disponibles. La technologie développée par Regen Lab SA s'impose actuellement comme la seule capable d'apporter une solution à ce défi de standardisation des préparations de cellules fraîches. Sur la base d'une expérience de plus de 10 ans, ce livre a été conçu par Regen Lab SA afin d'aider les professionnels impliqués dans la médecine régénérative à mieux comprendre et utiliser le PRP. Il est en en premier lieu destiné aux médecins qui exercent et conduisent des recherches dans des disciplines où les thérapies avec le PRP représentent une option thérapeutique, mais il s'adresse également à quiconque recherchant des informations fiables et à jour sur cette technologie. ----- In the 60's, a scientist called Doctor Leonard Hayflick (Wistar Institute, Philadelphia) carefully characterized the serial cultivation of primary human fibroblast cell by demonstrating that primary human cell strains have a limited replicative lifespan or "doubling potential", restricted to 40-50 divisions. This finding led to the hypothesis that oxidative damage could be partially responsible for limiting in vitro lifespan, consistent with the free radical hypothesis of aging. We now know that senescence in response to repeated passage occurs because of critical shortening of the telomeres. The Hayflick theory has been greatly reconsidered by the observations from the INSERM group of Dr Barlovatz-Meimon published in 2003 in Paris regarding in vivo (i.e. on the patient himself) cell growth. These studies hypothesized that the fibroblasts may reach a 2 to 3 log growth, meaning that they could potentially undergo up to 500 to 5'000 cell divisions. Our GMP class II and III medical devices fully guarantee the patient's safety because they are non-pyrogenic. Moreover, our manufacture process respects a full compliance with the new European Medical Device Regulation (MDR) June 2017, FDA (USA), and CFDA Regulations. For all these reasons, we believe that we bring to the medical community a powerful and reliable tool to standardize PRP preparations and thus future cell therapy clinical outcomes.

Advances in Stem Cells

Advances in Stem Cells Book
Author : Ashton Silk
Publisher : Unknown
Release : 2020-09-08
ISBN : 9781632418678
Language : En, Es, Fr & De

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Book Description :

Stem cells are the cells that differentiate into other cells and divide upon self-renewal to produce more stem cells. There are two types of stem cells, embryonic stem cells and adult stem cells. Progenitor cells and stem cells serve as a repair system by replenishing adult tissues. In the developing embryo, stem cells differentiate into specialized cells- endoderm, ectoderm and mesoderm, and also maintain the normal turnover of regenerative organs like skin, blood and intestinal tissues. Embryonic stem cells are a theoretically potential source for the development of regenerative medicine and tissue replacement. Adult stem cells can be acquired from adipose tissue, blood and bone marrow, as well as from the blood of the umbilical cord after birth. They are used in medical therapies such as in bone marrow transplantation. They can also be artificially grown and differentiated into specialized cells. Stem cell therapy helps to treat and prevent diseases or conditions. Some of the diseases where stem cell treatment holds potential include Parkinson's disease, diabetes, osteoarthritis, spinal cord injury repair, rheumatoid arthritis, cancer, amyotrophic lateral sclerosis, etc. This book is a valuable compilation of topics, ranging from the basic to the most complex advances in stem cells. It explores all the important aspects of stem cell therapy in the present day scenario. Scientists and students actively engaged in this field will find this book full of crucial and unexplored concepts.

Update on Mesenchymal and Induced Pluripotent Stem Cells

Update on Mesenchymal and Induced Pluripotent Stem Cells Book
Author : Khalid Ahmed Al-Anazi
Publisher : BoD – Books on Demand
Release : 2020-04-22
ISBN : 1789238072
Language : En, Es, Fr & De

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Book Description :

This book represents an updated overview on selected topics related to mesenchymal stem cells as well as induced pluripotent stem cells. The book is divided into three main sections that cover several topics including: sources of both stem cell types, their preparation and general properties, as well as their therapeutic indications and clinical utilization with particular attention given to their use in infectious diseases, osteoarthritis, as well as immunological disorders.

Towards Cell Therapy for Osteoarthritis

Towards Cell Therapy for Osteoarthritis Book
Author : Anonim
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Towards Cell Therapy for Osteoarthritis book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Stem Cell Processing

Stem Cell Processing Book
Author : Phuc Van Pham
Publisher : Springer
Release : 2016-10-18
ISBN : 3319400738
Language : En, Es, Fr & De

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Book Description :

This invaluable resource delineates procedures for development and use of stem cells in the laboratory and explores the potential for clinical applications. The text discusses mesenchymal stem cell isolation, isolation of adipose derived stem cells, new trends of induced pluripotent stem cells in disease treatment, cord blood banking, future directions of the discussed therapies and much more. The chapters are contributed by preeminent scientists in the field and present a comprehensive picture of stem cell processes, from development in the laboratory to effects and side-effects of clinical application. Stem Cell Processing and the other books in the Stem Cells in Clinical Applications series, edited by Dr. Phuc Van Pham, is essential reading for scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Stem Cells

Stem Cells Book
Author : Rex Turner
Publisher : Unknown
Release : 2016-07-27
ISBN : 9781632414120
Language : En, Es, Fr & De

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Book Description :

Stem cells are found in multicellular organisms. They have two broad categories - embryonic stem cells and adult stem cells. They are generally found in undifferentiated form and can be transformed into specialized cells. In adults, they act as a repair system of the body. These cells are frequently used in medical therapies such as bone marrow transplant, etc. The viability of stem cell therapy is being investigated to treat diseases such as cancer, diabetes, rheumatoid arthritis, osteoarthritis, vision impairment, parkinson's disease, impaired hearing, etc. This book covers in detail some existent theories and innovative concepts revolving around developments in the field of stem cell research. It is an upcoming field of medical science that has undergone rapid development over the past few decades. This text aims to bring forth studies related to all the significant aspects of stem cells along with technological progress that will have future implications. For all those who are interested in this area of study, this book can prove to be an essential guide.

Optimization of Chondrogenic Potential in Transplanted Adipose derived Stem Cells for Treatment of Osteoarthritis

Optimization of Chondrogenic Potential in Transplanted Adipose derived Stem Cells for Treatment of Osteoarthritis Book
Author : Alec Sime
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Importance: Osteoarthritis (OA) has, and will continue to be, the leading form of musculoskeletal disease in the United States. More pragmatic and less invasive techniques for treating OA are required if physicians are to effectively manage and/or ameliorate the disorder. Observations: Adipose-derived stem cell (ADSC) and platelet-rich plasma (PRP) dual therapy has shown much promise with regard to cartilage regeneration in animal models and is currently undergoing testing in multiple human trials. This type of regenerative therapy involves multiple intra-articular injections of autologous ADSCs and PRP over a brief period of time (approximately one month). Growth factors (GFs) and bioactive proteins, such as Soluble Vascular Endothelial Growth Factor – 1 (sFlt) and Bone Morphogenic Protein – 4 (BMP-4), may influence the chondrogenic potential of the ADSCs used in the dual therapy approach. Conclusions and Relevance: It is reasonable to conclude that the addition of certain bioactive proteins, like sFlt and BMP-4, to the current ADSC and PRP dual-therapy approach for cartilage repair may result in heightened chondrogenic potential of the ADSCs used in the treatment.

Regenerative Medicine and Cell Therapy

Regenerative Medicine and Cell Therapy Book
Author : J. F. Stoltz
Publisher : IOS Press
Release : 2012
ISBN : 1614990751
Language : En, Es, Fr & De

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Book Description :

Most human tissues do not regenerate spontaneously. Cell therapy and tissue engineering, which involve collecting cells from either the patient or a donor and introducing them into injured tissues or organs, sometimes after modifying their properties, offer promising solutions for regenerative medicine. Indeed, so promising are these therapies that current research has shifted from organ growth to cell therapy. The range of therapeutic applications is wide, including cardiac insufficiency, atherosclerosis, cartilage defects, bone repair, burns, diabetes and liver or bladder regeneration.This book, whilst not covering all aspects

Stem Cell Dependent Therapies

Stem Cell Dependent Therapies Book
Author : Gerhard Gross,Thomas Häupl
Publisher : Walter de Gruyter
Release : 2013-10-29
ISBN : 3110298309
Language : En, Es, Fr & De

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Book Description :

Multipotent mesenchymal stem cells (MSCs) are a heterogeneous population of cells which reside in a variety of tissues. They differentiate into several mesodermal lineages, secrete a multitude of trophic factors and contribute to tissue homeostasis. MSCs are able to exert immunosuppressive activities by interfering with inflammatory cytokine production and with T- and B-cell proliferation. These immunomodulating properties make MSCs promising candidates for the treatment of chronic inflammatory and autoimmune disorders. There are, however, certain caveats involved including inappropriate migration of cells in the body, immune rejection, tumor formation, or graft versus host disease (GvHD). This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders and, lastly, tumors and solid organ transplantations. This book also questions the immunoprivileged status of MSCs, discusses the therapeutic role of MSCs in experimental animal disease models and their translation to the corresponding human disorders, envisions a role for MSCs in tumor interventions and, lastly, describes a systems biology approach for stem cells and inflammation.

Stem Cell and Gene Based Therapy

Stem Cell and Gene Based Therapy Book
Author : Alexander Battler,Jonathan Leor
Publisher : Springer Science & Business Media
Release : 2006-03-14
ISBN : 9781846281426
Language : En, Es, Fr & De

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Book Description :

Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.

Controversies in Rheumatology An Issue of Rheumatic Disease Clinics of North America EBook

Controversies in Rheumatology An Issue of Rheumatic Disease Clinics of North America EBook Book
Author : Jonathan Kay,Sergio Schwartzman
Publisher : Elsevier Health Sciences
Release : 2019-07-16
ISBN : 0323698298
Language : En, Es, Fr & De

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Book Description :

Guest edited by Drs. Jonathan Kay and Sergio Schwartzman, this issue of Rheumatic Disease Clinics will cover Controversies in Rheumatology. This issue is one of four selected each year by our series Consulting Editor, Dr. Michael Weisman of Cedars-Sinai. Articles explore several questions, including, but not limited to: Is triple therapy or methotrexate plus a biologic the initial treatment of choice for RA patients; Is hypo or hyper-uricemia a risk requiring treatment for cardiac morbidity and mortality; Are there benefits and risks to biosimilars from a patient perspective; Should platelet-rich plasma be used to treat osteoarthritis; Is there a role for stem cell therapy to treat cartilage defects in osteoarthritis; Should any rheumatology patient, today, be treated with bone marrow ablation and stem cell transplantation; Is there effective prevention, prophylaxis, or treatment for CPPD arthritis; Is fibromyalgia a psychiatric disease or a pain syndrome; Should cyclophosphamide still be used to treat ANCA-associated vasculitis; Does methotrexate have a place in the treatment of psoriatic arthritis; Should hydroxychloroquine dosing be limited because of potential ocular toxicity; and Should generalized immunosuppression or targeted organ treatment be the best principle for overall management of SLE.

Stem Cells and Bone Tissue

Stem Cells and Bone Tissue Book
Author : Rajkumar Rajendram,Victor R. Preedy,Vinood Patel
Publisher : CRC Press
Release : 2013-01-23
ISBN : 1466578416
Language : En, Es, Fr & De

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Book Description :

Stem cells potentially offer a novel therapeutic platform to treat bone disease. They also help the scientist understand the molecular and cellular aetiology of bone disorders. Gaining knowledge on the nature and application of stem cell sciences is a prerequisite for understanding their potential in treating or preventing bone disorders. Stem Cells and Bone Tissue is designed to address these areas in three sections: Introductory Text and Sources of Stem Cells for Skeletal Tissue Cellular and Molecular Aspects Conditions, Applications, Treatments and Repairs Coverage includes general aspects of stems cells, sources of stems cells, isolation and purification, applications in regeneration, nanoscale topography, myostatin (GDF-8) signalling, c-Jun, Lnk, cell-derived Factor 1/CXCR4, chromatin remodelling, osteoporosis, osteoarthritis, hypophosphatasia, osteopetrosis, osteogenesis, and many other areas of merit too numerous to mention.

Mesenchymal Stem Cells

Mesenchymal Stem Cells Book
Author : Vered Morad
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Mesenchymal Stem Cells book written by Vered Morad, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Stem Cell Revolution

Stem Cell Revolution Book
Author : Joseph Christiano
Publisher : Charisma Media
Release : 2018-01-16
ISBN : 162999507X
Language : En, Es, Fr & De

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Book Description :

The Answer to Your Health Problems IS NOT WHAT YOU EXPECT What is adult stem cell therapy? Are there different adult stem cell treatment options? What type of conditions does adult stem cell therapy treat? What is the success rate? How much does it cost? Are there any risks or side effects? What's so great about adult stem cell therapy? Joseph "Dr. Joe" Christiano clears away the confusion surrounding this groundbreaking new treatment. Discover how stem cell activators target adult stem cells to reverse twenty-six conditions that may be adversely affecting your health. IT'S TIME TO JOIN THE REVOLUTION!