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Biomaterials as Stem Cell Niche

Biomaterials as Stem Cell Niche Book
Author : Krishnendu Roy
Publisher : Springer Science & Business Media
Release : 2010-09-30
ISBN : 9783642138935
Language : En, Es, Fr & De

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Book Description :

Recent developments in stem cell biology have opened new directions in cell therapy. This book provides the state-of-the-art developments in using biomaterials as artificial niches for engineering stem cells, both for the purpose of better understanding their biology under 3D biomimetic conditions as well as for developing new strategies for efficient long term maintenance and directed differentiation of stem cells into various therapeutic lineages. Animal and human stem cells of both embryonic and adult origin are discussed with applications ranging from nerve regeneration, orthopedics, cardiovascular therapy, blood cell generation and cancer therapy. Both synthetic and natural biomaterials are reviewed with emphasis on how material-stem cell interactions direct specific signaling pathways and ultimately modulate the cell fate. This book is valuable for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells.

Biology and Engineering of Stem Cell Niches

Biology and Engineering of Stem Cell Niches Book
Author : Ajaykumar Vishwakarma,Jeffrey M Karp
Publisher : Academic Press
Release : 2017-03-22
ISBN : 0128027568
Language : En, Es, Fr & De

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Book Description :

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system Authored and edited by authorities in this emerging and multidisciplinary field Includes valuable links to 5-10 minute YouTube© author videos that describe main points

The Cancer Stem Cell Niche

The Cancer Stem Cell Niche Book
Author : Susie Nilsson
Publisher : Academic Press
Release : 2021-02-01
ISBN : 0323853269
Language : En, Es, Fr & De

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Book Description :

The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche

Epidermal Stem Cell Niche

Epidermal Stem Cell Niche Book
Author : Mirna Perez-Moreno
Publisher : Academic Press
Release : 2019-08-09
ISBN : 0128184477
Language : En, Es, Fr & De

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Book Description :

Advances in Stem Cells and Their Niches, Volume Three, comprises a compilation of the latest findings on our understanding of skin biology. It extends the current knowledge on skin stem cells and provides in-depth discussions on their unique settings, niches and properties. Chapters in this new release include The biophysical regulation of epidermal fate and function, Epidermal stem cell lineages, Hair shaft progenitors that create a niche for hair pigmentation, Dermal papilla cells control of hair follicle growth and pigmentation, Molecular mechanisms regulating the hair follicle niche, Dermal fibroblasts and their niches and interactions with epidermal stem cells. Contains chapters written by international leaders in skin biology Provides a unique compilation of the latest findings and technologies in basic and translational skin biology Expands current knowledge on the regulation of skin stem cells as isolated entities, focusing on how skin stem cells and lineages of stem cells function in a coordinated manner Provides illustrations and comprehensive analyses of each subject

Stem Cell Niche

Stem Cell Niche Book
Author : Kursad Turksen
Publisher : Unknown
Release : 2019
ISBN : 9781493995080
Language : En, Es, Fr & De

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Book Description :

This updated collection addresses the intense efforts that have been underway to characterize the cellular-molecular-biochemical elements of not only the hematopoietic stem cell niche but the niches for other stem cells. These specialized microenvironments that regulate stem cell function have continued to inspire tremendous interest as a subject of study in the years since the publication of the first edition. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cell Niche: Methods and Protocols, Second Edition serves as an ideal guide for both experts and novices in the stem cell field.

The Stem Cell Niche during Ageing

The Stem Cell Niche during Ageing Book
Author : Susie Prof. Nilsson
Publisher : Academic Press
Release : 2020-08-22
ISBN : 0128220201
Language : En, Es, Fr & De

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Book Description :

Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Adult Stem Cell Niches

Adult Stem Cell Niches Book
Author : Sabine Wislet
Publisher : BoD – Books on Demand
Release : 2014-08-01
ISBN : 9535117181
Language : En, Es, Fr & De

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Book Description :

Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms. Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets. Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease. The third objective would be to review the therapeutical targets described within stem cell niches.

Tissue Specific Stem Cell Niche

Tissue Specific Stem Cell Niche Book
Author : Kursad Turksen
Publisher : Springer
Release : 2015-10-05
ISBN : 3319217054
Language : En, Es, Fr & De

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Book Description :

This timely volume explores tissue-derived stem cells, summarizing and evaluating the current body of knowledge. Sixteen chapters cover hematopoietic, osteoblast, skeletal, cardiac, pancreatic, epithelial, corneal, hepatic, renal, testicular, ovarian, fingernail, hair follicle and other stem cells- discussing their individual development, functions and pathologies, as well as the commonalities and interdependence between niches. This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Tissue-Specific Stem Cell Niche is an ideal complementary volume to Biology of Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them.

Crosstalk between the osteogenic and neurogenic stem cell niches how far are they from each other

Crosstalk between the osteogenic and neurogenic stem cell niches  how far are they from each other  Book
Author : Wanda Lattanzi,Maria Concetta Geloso
Publisher : Frontiers Media SA
Release : 2016-03-14
ISBN : 2889197778
Language : En, Es, Fr & De

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Book Description :

Somatic stem cells reside in definite compartments, known as "niches", within developed organs and tissues, being able to renew themselves, differentiate and ensure tissue maintenance and repair. In contrast with the original dogmatic distinction between renewing and non-renewing tissues, somatic stem cells have been found in almost every human organism, including brain and heart. (HSCs) and mesenchymal stem cells (MSCs), that intensely interacts. HSCs represent the common precursors of all mature blood cells. (Bone, cartilage, blood vessels, adipose tissue, and.), And in the case of the skeletal muscle Supporting connective stroma). Despite this high plasticity, the claim that MSCs could be capable of transdifferentiation along non-mesodermal linesages, including neurons, has been strongly argued. Adult osteogenic and neurogenic niches display wide differences: embryo origin, microenvironment, progenitors' lifespan, lineages of supporting cells. Although similar pathways may be involved, it is hard to believe that the osteogenic and neurogenic lineages can share functional features. The outbreak of the disease is the most important cause of neurodegeneration and neurological disorders, including the development of neurological disorders. Based on this research, the research group is interested in the development of new technologies, and in the field of research and development. The results of the study are summarized in the following sections: In vivo transplantation, has been covered.

Hematopoletic Stem Cell Niches from Fetal Stages to Teh Aging Bone Marrow

Hematopoletic Stem Cell Niches from Fetal Stages to Teh Aging Bone Marrow Book
Author : Patrick Michael Helbling
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Hematopoletic Stem Cell Niches from Fetal Stages to Teh Aging Bone Marrow book written by Patrick Michael Helbling, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Lmx1a is a Novel Regulator of Drosophila Ovarian Stem Cell Niche Establishment and Ovary Morphogenesis

Lmx1a is a Novel Regulator of Drosophila Ovarian Stem Cell Niche Establishment and Ovary Morphogenesis Book
Author : Andrew W. Albee
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The Drosophila ovary has served as a model for pioneering studies of the interaction between stem cells and their niches, with defined cell types and signaling pathways contributing to the regulation and maintenance of both germline and somatic stem cells in individual ovarioles. The most crucial component of the Drosophila ovarian niche is the terminal filament-cap structure (TF-cap), which is a stack of cells central not only for adult stem cell regulation, but also the coordinated morphogenesis of the ovary. While the function of these ovarian niches has been extensively studied, the genetics underlying their development remains largely unknown. Here we show that a highlyconserved LIM-homeobox transcription factor, Lmx1a, is required specifically for Drosophila ovary morphogenesis. We found that Lmx1a is expressed in early ovarian somatic lineages and that its expression is progressively restricted to terminal filaments and cap cells. Without Lmx1a, the cells comprising TF-cap structures are not fully specified and fail to form proper stacks. This results in the failure of the muscle sheaths to develop, an almost complete absence of ovaries, and sterility by adulthood. We further show that Lmx1a is required specifically in terminal filaments at the time of their formation, is controlled by key transcription factors necessary for ovarian morphogenesis and regulates several conserved signaling pathways essential to stem cell niche development and function. Strikingly, we found that expression of chicken Lmx1b, an ortholog of Drosophila Lmx1a, is sufficient to rescue the null Lmx1a phenotype, indicating functional conservation across the animal kingdom. In mammals, Lmx1a and Lmx1b are known to be essential to several developing and adult tissues, with involvement in several human diseases, including Parkinson's Disease, Nail-Patella syndrome and multiple forms of cancer, including ovarian carcinoma. Consistent with such pleiotropic requirements, we provide evidence that Drosophila Lmx1a and Lmx1b also play roles in multiple other tissues, including the nervous system and the gut. These results will expand our understanding not only of how stem cell niche units are established, but also of the mechanisms through which LIM-HD factors serve as core mediators of tissue morphogenesis and contribute to pathology

Hematopoietic Stem Cell Niche

Hematopoietic Stem Cell Niche Book
Author : Dominique Bonnet
Publisher : Academic Cell
Release : 2017-03-16
ISBN : 9780128113752
Language : En, Es, Fr & De

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Book Description :

Hematopoietic Stem Cell Niche focuses on an individual organ, looking at the stem cells in the organ itself (if they exist), their niches, and how to use them alongside relevant methods and protocols. This series addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Intestinal Stem Cell Niche

Intestinal Stem Cell Niche Book
Author : Anonim
Publisher : Academic Press
Release : 2018-04-24
ISBN : 9780128134818
Language : En, Es, Fr & De

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Book Description :

Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Neural Stem Cells and Adult Neurogenesis

Neural Stem Cells and Adult Neurogenesis Book
Author : Arie S. Mobley
Publisher : Academic Press
Release : 2019-03-15
ISBN : 0128110147
Language : En, Es, Fr & De

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Book Description :

Neural Stem Cells and Adult Neurogenesis provides graduate students and neuroscientists with a basic understanding of what neural stem cells are and the cell types they produce. This early graduate level reference describes their physiology and potential for medicine and provides students with fundamental stem cell information. An overview of stem cell sources in the human body and a brief mention of relevant diseases provide context for the value of this knowledge. The book also includes chapters on induced pluripotent stem cells (iPSCs), the methods used to obtain them, and a review of the ethical challenges associated with stem cell research. For each region, the book provides a description of its neurogenic niche, cellular and molecular biology, and information on the neurons' contribution to normal and diseased brain function. The level of information is appropriate for early graduate students, introducing technology and molecular biology in an accessible format. Provides a basic understanding of what a stem cell is, the different types, and their potential in health and research Details adult neurogenesis and its role in behavior, stroke and disease Includes walkthrough and technology boxes that illustrate experimental concepts, new approaches and techniques

Cancer Metastasis and Cancer Stem Cell Niche

Cancer Metastasis and Cancer Stem Cell Niche Book
Author : Takanori Kawaguchi
Publisher : Bentham Science Publishers
Release : 2016-11-04
ISBN : 1681083477
Language : En, Es, Fr & De

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Book Description :

A malignant tumor is an actively growing tissue, composed of cells derived from a single cell line that has undergone irreversible differentiation. These cells are invasive and also metastasize in the body, resulting in malignant cancer. Recent research suggests that a malignant tumor originates from cancer stem cells (CSC) accompanied with physiological niches. Cancer Metastasis and Stem Cell/Niche explains the invasiveness and metastasis of cancer cells I the light of information gained from the CSC / niche theory. Five chapters present a review on the fundamental relationships between CSCs, their niche and metastasis, the regulation of cell surface glycan expression in CSCs, tumor endothelial cells and metastasis, toll-like receptor 4 (TLR4)-mediated premetastatic microenvironment, and in surgical cancer metastasis. This monograph is intended as a primary reference on CSC research for physiologists, clinical oncologists, stem cell researchers and molecular biologists.

3D Biomimetic Matrices to Design in Vitro Stem Cell Niches

3D Biomimetic Matrices to Design in Vitro Stem Cell Niches Book
Author : Lara Isabel Martins Figueiredo
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download 3D Biomimetic Matrices to Design in Vitro Stem Cell Niches book written by Lara Isabel Martins Figueiredo, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Stem Cell Microenvironments and Beyond

Stem Cell Microenvironments and Beyond Book
Author : Alexander Birbrair
Publisher : Springer
Release : 2017-12-03
ISBN : 3319691945
Language : En, Es, Fr & De

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Book Description :

This book discusses the main stem cell niches under distinct pathophysiological conditions. The role of tissue microenvironments in stem cell regulation, as well as modern methodologies and new techniques for the identification and characterization of stem cell niches, are discussed by leading experts in the field. Chapters describe the major components of various stem cell microenvironments, such as cellular components, soluble factors, cell-cell interactions, extra-cellular matrix proteins, and physical forces. Stem Cell Microenvironments and Beyond is part of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students and researchers in the field of stem cells or cell biology as well as clinicians.

Gating of Small RNA Mobility in Plant Stem Cell Niches

Gating of Small RNA Mobility in Plant Stem Cell Niches Book
Author : Simon Klesen
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Gating of Small RNA Mobility in Plant Stem Cell Niches book written by Simon Klesen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Regulatory Networks in Stem Cells

Regulatory Networks in Stem Cells Book
Author : Vinagolu K. Rajasekhar
Publisher : Springer Science & Business Media
Release : 2009-03-04
ISBN : 9781603272278
Language : En, Es, Fr & De

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Book Description :

Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellular homeostasis in organ t- sues. The characteristics of stem cells that distinguish them from other cells have been the fascinating subjects of stem cell research. The important properties of stem cells, such as ma- tenance of quiescence, self-renewal capacity, and differentiation potential, have propelled this exciting ?eld and presently form a common theme of research in developmental biology and medicine. The derivation of pluripotent embryonic stem cells, the prospective identi?cation of multipotent adult stem cells, and, more recently, the induced pluripotent stem cells (popularly called iPS) are important milestones in the arena of stem cell biology. Complex networks of transcription factors, different signaling molecules, and the interaction of genetic and epi- netic events constantly modulate stem cell behavior to evoke programming and reprogramming processes in normal tissue homeostasis during development. In any given cellular scenario, the regulatory networks can pose considerable complexity and yet exert an orderly control of stem cell differentiation during normal development. An aberration in these ?nely tuned processes during development usually results in a spectrum of diseases such as cancers and neurological disorders. Thisunderscorestheimminentneedforamorecompleteunderstandingofmolecular mechanisms underlying the regulatory circuitries required for stem cell maintenance. Overthepast3–5years,adiversegroupofbenchandphysicianscientistshaveprospectively enhanced our knowledge of stem cell biology. These studies are unveiling many unrecognized or previously unknown fundamentals of developmental biology.