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Biology and Engineering of Stem Cell Niches

Biology and Engineering of Stem Cell Niches Book
Author : Ajaykumar Vishwakarma,Jeffrey M Karp
Publisher : Academic Press
Release : 2017-04-01
ISBN : 9780128027349
Language : En, Es, Fr & De

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Book Description :

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system Authored and edited by authorities in this emerging and multidisciplinary field Includes valuable links to 5-10 minute YouTube� author videos per chapter that describe main points from these leaders in the field

Tissue Specific Stem Cell Niche

Tissue Specific Stem Cell Niche Book
Author : Kursad Turksen
Publisher : Springer
Release : 2015-10-05
ISBN : 3319217054
Language : En, Es, Fr & De

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Book Description :

This timely volume explores tissue-derived stem cells, summarizing and evaluating the current body of knowledge. Sixteen chapters cover hematopoietic, osteoblast, skeletal, cardiac, pancreatic, epithelial, corneal, hepatic, renal, testicular, ovarian, fingernail, hair follicle and other stem cells- discussing their individual development, functions and pathologies, as well as the commonalities and interdependence between niches. This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Tissue-Specific Stem Cell Niche is an ideal complementary volume to Biology of Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them.

Adult Stem Cell Niches

Adult Stem Cell Niches Book
Author : Sabine Wislet
Publisher : BoD – Books on Demand
Release : 2014-08-01
ISBN : 9535117181
Language : En, Es, Fr & De

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Book Description :

Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms. Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets. Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease. The third objective would be to review the therapeutical targets described within stem cell niches.

Biology and Engineering of Stem Cell Niches

Biology and Engineering of Stem Cell Niches Book
Author : Ajaykumar Vishwakarma,Jeffrey M Karp
Publisher : Academic Press
Release : 2017-03-22
ISBN : 0128027568
Language : En, Es, Fr & De

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Book Description :

Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system Authored and edited by authorities in this emerging and multidisciplinary field Includes valuable links to 5-10 minute YouTube© author videos that describe main points

Biology in Stem Cell Niche

Biology in Stem Cell Niche Book
Author : Kursad Turksen
Publisher : Springer
Release : 2015-10-15
ISBN : 331921702X
Language : En, Es, Fr & De

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Book Description :

This comprehensive volume explores functions, pathologies, and applications of stem cells in relation to the niches in which they develop. Ten chapters cover the subject in depth, from a historical perspective through signaling, hormonal control, quiescence, biomimetics, epigenetics, engineering strategies for emulating, tumorigenesis and more. The chapter authors represent a broad range of international expertise and perspectives. This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Biology of Stem Cell Niche is an ideal complementary volume to Tissue-Specific Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them.

Stem Cell Niche

Stem Cell Niche Book
Author : Kursad Turksen
Publisher : Humana
Release : 2019-06-07
ISBN : 9781493995073
Language : En, Es, Fr & De

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Book Description :

This updated collection addresses the intense efforts that have been underway to characterize the cellular-molecular-biochemical elements of not only the hematopoietic stem cell niche but the niches for other stem cells. These specialized microenvironments that regulate stem cell function have continued to inspire tremendous interest as a subject of study in the years since the publication of the first edition. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cell Niche: Methods and Protocols, Second Edition serves as an ideal guide for both experts and novices in the stem cell field.

The Cancer Stem Cell Niche

The Cancer Stem Cell Niche Book
Author : Susie Nilsson
Publisher : Academic Press
Release : 2021-02-15
ISBN : 0323853250
Language : En, Es, Fr & De

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Book Description :

The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche

Hematopoietic Stem Cell Niche

Hematopoietic Stem Cell Niche Book
Author : Anonim
Publisher : Elsevier
Release : 2017-03-10
ISBN : 0128113766
Language : En, Es, Fr & De

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Book Description :

Hematopoietic Stem Cell Niche focuses on an individual organ, looking at the stem cells in the organ itself (if they exist), their niches, and how to use them alongside relevant methods and protocols. This series addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Crosstalk between the osteogenic and neurogenic stem cell niches how far are they from each other

Crosstalk between the osteogenic and neurogenic stem cell niches  how far are they from each other  Book
Author : Wanda Lattanzi,Maria Concetta Geloso
Publisher : Frontiers Media SA
Release : 2016-03-14
ISBN : 2889197778
Language : En, Es, Fr & De

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Book Description :

Somatic stem cells reside in definite compartments, known as "niches", within developed organs and tissues, being able to renew themselves, differentiate and ensure tissue maintenance and repair. In contrast with the original dogmatic distinction between renewing and non-renewing tissues, somatic stem cells have been found in almost every human organism, including brain and heart. (HSCs) and mesenchymal stem cells (MSCs), that intensely interacts. HSCs represent the common precursors of all mature blood cells. (Bone, cartilage, blood vessels, adipose tissue, and.), And in the case of the skeletal muscle Supporting connective stroma). Despite this high plasticity, the claim that MSCs could be capable of transdifferentiation along non-mesodermal linesages, including neurons, has been strongly argued. Adult osteogenic and neurogenic niches display wide differences: embryo origin, microenvironment, progenitors' lifespan, lineages of supporting cells. Although similar pathways may be involved, it is hard to believe that the osteogenic and neurogenic lineages can share functional features. The outbreak of the disease is the most important cause of neurodegeneration and neurological disorders, including the development of neurological disorders. Based on this research, the research group is interested in the development of new technologies, and in the field of research and development. The results of the study are summarized in the following sections: In vivo transplantation, has been covered.

The Stem Cell Niche during Ageing

The Stem Cell Niche during Ageing Book
Author : Susie Prof. Nilsson
Publisher : Academic Press
Release : 2020-08-22
ISBN : 0128220201
Language : En, Es, Fr & De

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Book Description :

Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Biomaterials as Stem Cell Niche

Biomaterials as Stem Cell Niche Book
Author : Krishnendu Roy
Publisher : Springer Science & Business Media
Release : 2010-09-30
ISBN : 9783642138935
Language : En, Es, Fr & De

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Book Description :

Recent developments in stem cell biology have opened new directions in cell therapy. This book provides the state-of-the-art developments in using biomaterials as artificial niches for engineering stem cells, both for the purpose of better understanding their biology under 3D biomimetic conditions as well as for developing new strategies for efficient long term maintenance and directed differentiation of stem cells into various therapeutic lineages. Animal and human stem cells of both embryonic and adult origin are discussed with applications ranging from nerve regeneration, orthopedics, cardiovascular therapy, blood cell generation and cancer therapy. Both synthetic and natural biomaterials are reviewed with emphasis on how material-stem cell interactions direct specific signaling pathways and ultimately modulate the cell fate. This book is valuable for biomaterial scientists, tissue engineers, clinicians as well as stem cell biologists involved in basic research and applications of adult and embryonic stem cells.

Epidermal Stem Cell Niche

Epidermal Stem Cell Niche Book
Author : Mirna Perez-Moreno
Publisher : Academic Press
Release : 2019-08-09
ISBN : 0128184477
Language : En, Es, Fr & De

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Book Description :

Advances in Stem Cells and Their Niches, Volume Three, comprises a compilation of the latest findings on our understanding of skin biology. It extends the current knowledge on skin stem cells and provides in-depth discussions on their unique settings, niches and properties. Chapters in this new release include The biophysical regulation of epidermal fate and function, Epidermal stem cell lineages, Hair shaft progenitors that create a niche for hair pigmentation, Dermal papilla cells control of hair follicle growth and pigmentation, Molecular mechanisms regulating the hair follicle niche, Dermal fibroblasts and their niches and interactions with epidermal stem cells. Contains chapters written by international leaders in skin biology Provides a unique compilation of the latest findings and technologies in basic and translational skin biology Expands current knowledge on the regulation of skin stem cells as isolated entities, focusing on how skin stem cells and lineages of stem cells function in a coordinated manner Provides illustrations and comprehensive analyses of each subject

Stem Cell Microenvironments and Beyond

Stem Cell Microenvironments and Beyond Book
Author : Alexander Birbrair
Publisher : Springer
Release : 2017-12-03
ISBN : 3319691945
Language : En, Es, Fr & De

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Book Description :

This book discusses the main stem cell niches under distinct pathophysiological conditions. The role of tissue microenvironments in stem cell regulation, as well as modern methodologies and new techniques for the identification and characterization of stem cell niches, are discussed by leading experts in the field. Chapters describe the major components of various stem cell microenvironments, such as cellular components, soluble factors, cell-cell interactions, extra-cellular matrix proteins, and physical forces. Stem Cell Microenvironments and Beyond is part of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students and researchers in the field of stem cells or cell biology as well as clinicians.

Perspectives in Regenerative Medicine

Perspectives in Regenerative Medicine Book
Author : Ena Ray Banerjee
Publisher : Springer
Release : 2014-10-20
ISBN : 8132220536
Language : En, Es, Fr & De

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Book Description :

The information given in this book tries to capture the essence of the sheer dynamicity of the cell along with useful tips on how to address critical rate limiting steps in the process of exploration and investigation of its capacity to regenerate, rebuild and replenish from within. The definitions of stem cells, stemness, and the niche concept continue to undergo revisions. In adult vertebrates, hematopoietic and some non-hematopoietic progenitors are synthesized within specialized niches of bone marrow. They migrate to designated tissues, and are either trans-differentiated or become quiescent and settle down. These form the stem cell niche reservoir in all tissues. Not only the primary hematopoietic tissue but all organs and tissues are also capable of generating progenitors which are either synthesized from these migrants or are direct recruits from other tissues. In the niches, the cells settle down and await their turn to either make more clones like themselves or differentiate and mobilize in an exigency. Thus progenitors are important reserves, to be multiplied and deployed or travel as important message bearing molecules via blood as circulating progenitors which can home to their allocated destinations. Upon reaching, specific integrins and selectins help them “dock” and “port” and they may be reprogrammed to induce further differentiation and help repopulate the denuded tissue. In pulmonary fibrosis and asthma, progenitors from both systemic circulation and local stem cell niches have been found to participate in the myriad ramifications of repair, replacement and regeneration of lost or diseased tissue. Whether they are lung specific or global in origin and role remain to be explored. Research tools, fundamental concepts, techniques, methodologies and standard operating protocols and animal models and human extrapolations, have been discussed in a concise way along with detailed description and discussion on the appropriate rationale to introduce the subject to the casual reader and provide valuable tactical information to the specialist in Regenerative Medicine. I sincerely hope you enjoy the work and appreciate the hard work that has gone into designing and executing elegant experiments by many researchers in the field. The branch is multi-disciplinary and I hope that the readers will not be limited to biologists alone.

Intestinal Stem Cell Niche

Intestinal Stem Cell Niche Book
Author : Anonim
Publisher : Academic Press
Release : 2018-04-04
ISBN : 0128134828
Language : En, Es, Fr & De

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Book Description :

Advances in Stem Cells and their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Microfluidic Engineering of Artificial Stem Cell Niches

Microfluidic Engineering of Artificial Stem Cell Niches Book
Author : Anonim
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Microfluidic Engineering of Artificial Stem Cell Niches book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Shaping the Niche

Shaping the Niche Book
Author : Lindsey Marie Wingert
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Adult stem cells have the unique ability to either self-renew or differentiate, thus giving them tremendous therapeutic potential. These tissue-specific stem cells are directed to self-renew by signals from the local microenvironment termed the stem cell niche. While reconstitution assays have demonstrated the existence of stem cell niches in many adult organs, unambiguous identification of the resident stem cells and their niche cells continues to be a challenge. Accordingly, the mechanisms that direct specification and formation of a stem cell niche in vivo remain unclear. The Drosophila testis has emerged as a powerful system in which to study stem cell-niche interactions. The niche cells, called hub cells, form a small aggregate at the apical tip of the testis. Hub cells promote attachment and self-renewal in the germline stem cells and cyst stem cells, which are organized in a radial array around the hub. The signaling pathways that direct the maintenance and differentiation of these lineages have been well characterized; however, the initial specification and organization of the niche is still being elucidated. It was previously shown that Notch activation in a subset of somatic gonadal precursors specifies them as hub cells in the embryonic gonad. Here we use genetic analysis to show that Notch signaling activates a branched pathway for hub cell differentiation. Along one arm of the pathway, the Maf factor Traffic jam is downregulated to allow for niche signaling and adhesion. Along a separate arm, the transcription factor Bowl, promotes the assembly of hub cells at the anterior of the gonad where they recruit and organize stem cells. We also use live imaging to reveal two phases of niche morphogenesis; 1) a sorting and guidance phase in which hub cells are directed to the anterior by an extra-gonadal cue and 2) a compaction phase characterized by the formation of an acto-myosin cable around the compacting hub concomitant with the onset of oriented GSC divisions. These observations suggest a model in which the germ cells shape their own niche by driving hub compaction. These findings greatly advance our understanding of how a stem cell niche develops within a tissue.

Understanding Niche

Understanding Niche Book
Author : Syed Sultan Beevi,Lakshmi Kiran Chelluri
Publisher : LAP Lambert Academic Publishing
Release : 2013-01
ISBN : 9783659328183
Language : En, Es, Fr & De

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Book Description :

Hematopoietic stem cells (HSCs) have innate ability to remain in the dormant state till they receive molecular cues from the signaling molecules within their niche. Controlling the interaction between stem cells and their niche would offer an opportunity to manipulate stem cell proliferation and differentiation for therapeutic application. There has been immense interest in umbilical cord blood (UCB) as an important source of HSCs to treat malignant and metabolic disorders; as HSCs acquired from UCB have higher proliferative efficacy and longer telomeres than other somatic stem cells. The monograph focuses on the different stem cell niches, their components, signaling molecules, factors controlling the stem cell self-renewal and differentiation. It further recapitulates the current state of umbilical cord transplantation and critically dwells into both the advantages and limitations associated with it. The strategies involved in surmounting the immunological shortcomings and translating the improvisations of stem cell niche for the better clinical outcomes are the salient points of the monograph.

Stem Cells in Development and Disease

Stem Cells in Development and Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2014-01-15
ISBN : 0123914353
Language : En, Es, Fr & De

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Book Description :

This new volume of Current Topics in Developmental Biology covers Stem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as the mechanisms of pluripotency in vivo and in vitro, hematopoietic stem cell development, intestinal stem cells and their defining niche, epithelial stem cells in adult skin, the mammary stem cell hierarchy, satellite cells, neural stem cells of the hippocampus, lung stem and progenitor cells in tissue homeostasis and disease, spermatogonial stem cell functions in physiological and pathological conditions, the origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells, nephron progenitor cells, adult stem cell niches, cancer stem cells, pluripotency and cellular heterogeneity, and cellular mechanisms of somatic stem cell aging Covers the area of Stem Cells in Development and Disease International board of authors Provides a comprehensive set of reviews covering such topics as Intestinal Stem Cells, Nephron Stem Cells/Progenitors, Skin epithelial Stem Cells and Lung Stem Cells