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Stem Cell Manufacturing

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Stem Cell Manufacturing

Stem Cell Manufacturing Book
Author : Joaquim M. S. Cabral,Claudia Lobato da Silva,Lucas G. Chase,Maria Margarida Diogo
Publisher : Elsevier
Release : 2016-07-24
ISBN : 0444632662
Language : En, Es, Fr & De

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Book Description :

Stem Cell Manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product. The advent of stem cell research unveiled the therapeutic potential of stem cells and their derivatives and increased the awareness of the public and scientific community for the topic. The successful manufacturing of stem cells and their derivatives is expected to have a positive impact in the society since it will contribute to widen the offer of therapeutic solutions to the patients. Fully defined cellular products can be used to restore the structure and function of damaged tissues and organs and to develop stem cell-based cellular therapies for the treatment of cancer and hematological disorders, autoimmune and other inflammatory diseases and genetic disorders. Presents the first ‘Flowchart‘ of stem cell manufacturing enabling easy understanding of the various processes in a sequential and coherent manner Covers all bioprocess technologies required for the transfer of the bench findings to the clinic including the process components: cell signals, bioreactors, modeling, automation, safety, etc. Presents comprehensive coverage of a true multidisciplinary topic by bringing together specialists in their particular area Provides the basics of the processes and identifies the issues to be resolved for large scale cell culture by the bioengineer Addresses the critical need in bioprocessing for the successful delivery of stem cell technology to the market place by involving professional engineers in sections of the book

Stem Cell Bioprocessing and Manufacturing

Stem Cell Bioprocessing and Manufacturing Book
Author : Joaquim M. S. Cabral,Cláudia Lobato da Silva,Maria Margarida Diogo
Publisher : MDPI
Release : 2021-01-20
ISBN : 3039430386
Language : En, Es, Fr & De

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Book Description :

The next healthcare revolution will apply regenerative medicines using human cells and tissues. The aim of the regenerative medicine approach is to create biological therapies or substitutes in vitro for the replacement or restoration of tissue function in vivo lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is an immediate and long-term need for expertise with the necessary skills to face the engineering and life science challenges before the predicted benefits in human healthcare can be realized. Specifically, there is a need for the development of bioprocess technology for the successful transfer of laboratory-based practice of stem cell and tissue culture to the clinic as therapeutics through the application of engineering principles and practices. This Special Issue of Bioengineering on Stem Cell Bioprocessing and Manufacturing addresses the central role in defining the engineering sciences of cell-based therapies, by bringing together contributions from worldwide experts on stem cell biology and engineering, bioreactor design and bioprocess development, scale-up, and manufacturing of stem cell-based therapies.

Stem Cells and Cell Therapy

Stem Cells and Cell Therapy Book
Author : Mohamed Al-Rubeai,Mariam Naciri
Publisher : Springer Science & Business Media
Release : 2013-10-01
ISBN : 9400771967
Language : En, Es, Fr & De

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Book Description :

With the discovery of stem cells capable of multiplying indefinitely in culture and differentiating into many other cell types in appropriate conditions, new hopes were born in repair and replacement of damaged cells and tissues. The features of stem cells may provide treatment for some incurable diseases with some therapies are already in clinics, particularly those from adult stem cells. Some treatments will require large number of cells and may also require multiple doses, generating a growing demand for generating and processing large numbers of cells to meet the need of clinical applications. With this in mind, our aim is to provide a book on the subject of stem cells and cell therapy for researchers and students of cell biotechnology, bioengineering and bioproduction. This book is exceptional as it teaches researchers stem cells and cell therapy in that it covers the concepts and backgrounds necessary so that readers get a good understanding of the production of stem cells. The book covers three topics: The basics of stem cells and cell therapy, the use of stem cells for the treatment of human diseases, and stem cell processing. It includes chapters on neural and vascular stem vascular stem cell therapy, expansion engineering of embryonic stem cells, stem cell based production of blood cells and separation technologies for stem cells and cell therapy products. It is an informed and informative presentation of what modern research, science and engineering have learned about stem cells and their production and therapies. Addressing both the medical and production issues, this book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.

Stem Cells and Good Manufacturing Practices

Stem Cells and Good Manufacturing Practices Book
Author : Kursad Turksen
Publisher : Humana
Release : 2021-04-01
ISBN : 9781071613269
Language : En, Es, Fr & De

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Book Description :

This detailed book explores the utilization and delivery of stem cells for therapeutic purposes in patients in the clinic and the tightly controlled Good Manufacturing Practices (GMP) that make these powerful techniques possible. Fully updated and expanded from the first edition, this collection features a new set of protocols to arm stem cell biologists with protocols that are currently being used in a number of well-established facilities around the world. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up to date, Stem Cells and Good Manufacturing Practices: Methods, Protocols, and Regulations, Second Edition serves as an ideal guide for researchers aiming to drive continued improvements to GMP and accelerate new stem cell treatments for patients in need.

Perinatal Stem Cells

Perinatal Stem Cells Book
Author : Zhong Chao Han,Tsuneo A. Takahashi,Zhibo Han,Zongjin Li
Publisher : Springer
Release : 2019-04-06
ISBN : 9811327033
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive introduction to various types of perinatal stem cells. Given their unique regenerative abilities, stem cells offer a promising avenue in the treatment of degenerative diseases or injury. Currently, the limitations of postnatal cell sources and expanding efficiency may limit autologous stem cell therapies. Although embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can be cultured indefinitely ex vivo, and can differentiate into three germ layers, ethical issues, the teratoma formation of ESCs and oncogenic risk of iPSCs are major obstacles to their clinical application. More recently, perinatal stem cells have been isolated from the umbilical cord, Wharton’s Jelly, placenta, amniotic membrane and amniotic fluid, which are normally discarded as medical waste. This book, after describing perinatal stem cells in detail, introduces readers to the various types of perinatal stem cells, addressing their characterization, banking, quality control and stability. Importantly, it also reviews the clinical applications of perinatal stem cells to therapy of diseases. Accordingly, it offers a valuable resource for clinicians, researchers and graduate students alike.

Advances In Pharmaceutical Cell Therapy Principles Of Cell based Biopharmaceuticals

Advances In Pharmaceutical Cell Therapy  Principles Of Cell based Biopharmaceuticals Book
Author : Huss Ralf,Guenther Christine,Hauser Andrea Josefine
Publisher : World Scientific
Release : 2015-09-23
ISBN : 981461680X
Language : En, Es, Fr & De

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Book Description :

This textbook is a comprehensive overview of the development of cell-based biopharmaceuticals. Beginning with the underlying biology of stem cell and cell-based products, it traces the long and complex journey from preclinical concept to initiation of a pivotal clinical trial and the potential business model behind it.The book also takes into consideration the different regulatory landscapes and their continuous evolution in Europe, North America and other parts of the world. The authors describe a path to manufacture a clinical grade therapeutic that passes all necessary quality measures as a robust and marketable product including an outlook on next generation products and innovative strategies.This reference book is a must-have guide for any professional already active in biopharmaceuticals and anyone interested in getting involved in a scientific, medical or business capacity.

Perinatal Tissue Derived Stem Cells

Perinatal Tissue Derived Stem Cells Book
Author : Babak Arjmand
Publisher : Springer
Release : 2016-12-01
ISBN : 3319464108
Language : En, Es, Fr & De

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Book Description :

This book covers several aspects of perinatal tissue-derived stem cells, from theoretical concepts to clinical applications. Topics include functions and different sources, immunomodulatory properties, translational point of view, GMP facility design and manufacturing for clinical translation, therapeutic potentials, and finally ethical considerations. The text provides a brief review of each type of perinatal stem cells and then focuses on their multi- or pluripotent properties, regenerative capacity, and future therapeutic potential in regenerative medicine. Additionally, the book discusses GMP compliance in stem cell facilities and the manufacture of stem cells for clinical translation. The chapters are authored by world-renowned experts in the perinatal stem cell field. Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for basic and clinical scientists, clinicians, and pharmaceutical experts working or conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, and cellular therapy.

Stem Cells in Regenerative Medicine

Stem Cells in Regenerative Medicine Book
Author : Alain A. Vertes,Nasib Qureshi,Arnold I. Caplan,Lee E. Babiss
Publisher : John Wiley & Sons
Release : 2015-12-02
ISBN : 111997139X
Language : En, Es, Fr & De

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Book Description :

This book is a unique guide to emerging stem cell technologies and the opportunities for their commercialisation. It provides in-depth analyses of the science, business, legal, and financing fundamentals of stem cell technologies, offering a holistic assessment of this emerging and dynamic segment of the field of regenerative medicine. • Reviews the very latest advances in the technology and business of stem cells used for therapy, research, and diagnostics • Identifies key challenges to the commercialisation of stem cell technology and avenues to overcome problems in the pipeline • Written by an expert team with extensive experience in the business, basic and applied science of stem cell research This comprehensive volume is essential reading for researchers in cell biology, biotechnology, regenerative medicine, and tissue engineering, including scientists and professionals, looking to enter commercial biotechnology fields.

Stem Cell based Tissue Repair

Stem Cell based Tissue Repair Book
Author : Raphael Gorodetsky,Richard Schäfer
Publisher : Royal Society of Chemistry
Release : 2011
ISBN : 1849730016
Language : En, Es, Fr & De

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Book Description :

This unique book by leading experts reviews the key therapeutic issues related to stem cell technology.

Cell Therapy

Cell Therapy Book
Author : Adrian Gee
Publisher : Springer
Release : 2021-07-25
ISBN : 9783030755355
Language : En, Es, Fr & De

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Book Description :

This new edition presents a fully-updated and expanded look at current Good Manufacturing Practice (cGMP) for cell therapy products. It provides a complete discussion of facility design and operation including details specific to cord blood banking, cell processing, vector production and qualification of a new facility. Several chapters cover facility infrastructure including cleaning and maintenance, vendor qualification, writing a Standard Operating Procedure, staff training, and process validation. The detailed and invaluable product information covers topics like labelling, release and administration, transportation and shipment, et al. Further chapters cover relevant topics like writing and maintaining investigational new drug applications, support opportunities in North America and the European Union, commercial cell processing and quality testing services, and financial considerations for academic GMP facilities. A chapter on future directions rounds out Cell Therapy: cGMP Facilities and Manufacturing making it essential reading for any cell therapy professional involved in the development, use, or management of this type of facility.

Stem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering Book
Author : Rakesh Sharma
Publisher : BoD – Books on Demand
Release : 2018-05-02
ISBN : 1789230101
Language : En, Es, Fr & De

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Book Description :

Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.

Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine Book
Author : Walter C. Low,Catherine M. Verfaillie
Publisher : World Scientific
Release : 2008
ISBN : 9812775773
Language : En, Es, Fr & De

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Book Description :

The commercialization of biotechnology has resulted in an intensive search for new biological resources for the purposes of increasing food productivity, medicinal applications, energy production, and various other applications. Although biotechnology has produced many benefits for humanity, the exploitation of the planet's natural resources has also resulted in some undesirable consequences such as diminished species biodiversity, climate change, environmental contamination, and intellectual property right and patent concerns.This book discusses the role of biological, ecological, environmental, ethical, and economic issues in the interaction between biotechnology and biodiversity, using different contexts. No other book has discussed all of these issues in a comprehensive manner. Of special interest is their impact when biotechnology is shared between developed and developing countries, and the lack of recognition of the rights of indigenous populations and traditional farmers in developing countries by large multinational corporations.

Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy Book
Author : Lucas G. Chase,Mohan C Vemuri
Publisher : Springer Science & Business Media
Release : 2012-12-12
ISBN : 1627032002
Language : En, Es, Fr & De

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Book Description :

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Maturation of Stem Cell derived Cardiomyocytes Via Coculture for Cellular Manufacturing

Maturation of Stem Cell derived Cardiomyocytes Via Coculture for Cellular Manufacturing Book
Author : Kaitlin Kelly Dunn
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Heart disease is a burgeoning epidemic in the world today, resulting in an alarming increase of heart attacks each year. Myocardial infarctions cause irreversible damage to the heart, motivating the development of innovative therapies. Millions of heart muscle cells, called cardiomyocytes (CMs), are killed during a heart attack which decreases the functionality of the tissue. As adult CMs cannot regenerate, the only current treatment to restore contractile function is whole heart transplant. Human pluripotent stem cell-derived (hPSC-) CMs provide an abundant source of CMs to replenish those lost during a heart attack. While chemically-defined methods to produce virtually pure hPSC-CMs have been established, one drawback to these cells is their lack of maturity. hPSC-CMs are more fetal-like in physiology and functionality compared to their adult counterparts, resulting in arrhythmias when implanted into primate myocardial infarction models. Many methods to induce hPSC-CM maturation have been tested, including mechanical stimulation, electrical stimulation, and coculture with other cell types, yet no method has produced an adult-like hPSC-CM. Intercellular interactions have proven essential for proper heart formation. Presently, the cell-cell interactions necessary for CM maturation are unknown. The following work investigated the interaction of CMs and their progenitors (CPCs) with endothelial cells (ECs) and epicardial cells (EpiCs), two support cell types found within the heart, to determine if they provide maturation-inducing interactions. We discovered that EC-induced maturation of hPSC-CMs is dependent on the stage of differentiation of the CMs; hPSC-CPCs cocultured with ECs induced heightened maturation compared to cocultured hPSC-CMs. Additionally, we modeled the interactions of CMs with EpiCs during heart development using two different coculture systems. One maintained the identity of hPSC-EpiCs throughout the coculture and the second allowed the EpiCs to undergo an epithelial to mesenchymal transition into other stromal cells while in coculture with the CPCs. We found that EpiC and EpiC-derived cell cocultures affected CM maturation, each inducing different phenotypic changes associated with CM maturation. Overall these studies motivate the inclusion of intercellular interactions during hPSC-CM manufacturing and demonstrate the importance of integrating these interactions at earlier stages of differentiation to create mature hPSC-CMs for use in cardiac patches.

Organ Farm

Organ Farm Book
Author : Jenny Bryan,John Clare
Publisher : Carlton Books Limited
Release : 2001
ISBN : 9781842222492
Language : En, Es, Fr & De

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Book Description :

Rights obtained from Canadian distributor, Visual Education Centre. Closed captioned for the hearing impaired.

Scientific American

Scientific American Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Scientific American book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Manufacturing Engineering and Materials Handling 2005

Manufacturing Engineering and Materials Handling  2005 Book
Author : Anonim
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Manufacturing Engineering and Materials Handling 2005 book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Stem Cells as Targeted Drug Delivery Vehicles

Stem Cells as Targeted Drug Delivery Vehicles Book
Author : Rebecca Lim,Jessica E. Frith,Gina D. Kusuma,Christopher G. Sobey
Publisher : Frontiers Media SA
Release : 2021-02-03
ISBN : 2889664481
Language : En, Es, Fr & De

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Book Description :

Topic Editor RL is a patent inventor on exosome-related patents, PCT/AU2017/050821 and PCT/AU2016/050468. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Neural Stem Cells in Health and Disease

Neural Stem Cells in Health and Disease Book
Author : Ashok K Shetty
Publisher : World Scientific Publishing Company
Release : 2015-08-28
ISBN : 9814623199
Language : En, Es, Fr & De

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Book Description :

This book is a comprehensive guide on neural stem cell behavior in health and disease. The book confers the altered behavior of endogenous neural stem cells in neurodegenerative disease conditions and the prospects of neural stem cell therapy for alleviating brain dysfunction in a variety of neurodegenerative disorders. Neural stem cell activity and neurogenesis in the adult brain is now confirmed in virtually all mammalian species including humans. Hence, a series of chapters in the first half of the book discusses the current knowledge on mechanisms of neural stem cell activity, the extent and functional significance of neurogenesis in the adult brain under normal, aged and disease environments, the susceptibility of neural stem cells and the plasticity of neurogenesis to alcohol, drugs of abuse and anesthetic agents, and advanced techniques that trigger neurogenesis in non-neurogenic regions. A second series of chapters in this book are focused on discussing the promise and efficacy of grafting of neural stem cells and/or other stem cells for treating neurological disorders such as Parkinson's disease, stroke, temporal lobe epilepsy, Alzheimer's disease and spinal cord injury. The final chapter confers on advances that are made in manufacturing a variety of neural cell types from human pluripotent stem cells that can be used as donor cells for cell transplantation.

The Lancet

The Lancet Book
Author : Anonim
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Lancet book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.