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Stem Cell And Gene Therapy For Cardiovascular Disease

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Stem Cell and Gene Therapy for Cardiovascular Disease

Stem Cell and Gene Therapy for Cardiovascular Disease Book
Author : Emerson C. Perin,Leslie W. Miller,Doris Taylor,James T. Willerson
Publisher : Academic Press
Release : 2015-08-21
ISBN : 0128018631
Language : En, Es, Fr & De

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Book Description :

Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI Covers the prevailing opinions on how to harness the body’s natural repair mechanisms Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals

Stem Cell and Gene Therapy for Cardiovascular Disease

Stem Cell and Gene Therapy for Cardiovascular Disease Book
Author : Leslie W. Miller,Emerson C. Perin
Publisher : Academic Press
Release : 2015-09-01
ISBN : 9780128018880
Language : En, Es, Fr & De

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Book Description :

Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI Covers the prevailing opinions on how to harness the body's natural repair mechanisms Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals

Stem Cell and Gene Based Therapy

Stem Cell and Gene Based Therapy Book
Author : Alexander Battler,Jonathan Leor
Publisher : Springer Science & Business Media
Release : 2007-06-26
ISBN : 9781846286766
Language : En, Es, Fr & De

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Book Description :

Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.

Gene Therapy for Cardiovascular Diseases and Arrhythmia

Gene Therapy for Cardiovascular Diseases and Arrhythmia Book
Author : Kamilla Kelemen
Publisher : Nova Science Publishers
Release : 2012
ISBN : 9781619427549
Language : En, Es, Fr & De

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Book Description :

Cardiovascular disease has evolved into an epidemic health concern. During the past decades, considerable effort has been made to develop novel and safer therapeutic options. Gene therapy has offered much renewed hope and instigated the present book. For the treatment of cardiovascular disease gene therapy has risen to an interesting and important point of view of curing disease. Although most of the studies are still experimental beneath a well defined number of clinical studies, more and more studies are designed to be carried out in humans. Based on a rich compilation of scientific as well as clinical studies around the world, this book gives insights into the general principles of gene transfer as well as therapeutic strategies including stem cell therapy as an alternative approach to gene therapy.

Molecular Cardiology

Molecular Cardiology Book
Author : Zhongjie Sun
Publisher : Springer Science & Business Media
Release : 2005
ISBN : 159259879X
Language : En, Es, Fr & De

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Book Description :

This book provides the researcher with detailed molecular and genetic techniques useful in the study of cardiac physiology and heart disease. It consists of 26 chapters dealing with various aspects of molecular cardiology, including gene transfer and gene therapy for cardiovascular disease, cellular therapy for cardiovascular disease, gene analysis in the injured and hypertrophied heart, and transgenesis in cardiovascular research.

Gene and Stem Cell Therapy for Heart Failure and Other Cardiovascular Diseases

Gene and Stem Cell Therapy for Heart Failure and Other Cardiovascular Diseases Book
Author : Francisco Fernández-Avilés
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Gene and Stem Cell Therapy for Heart Failure and Other Cardiovascular Diseases book written by Francisco Fernández-Avilés, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular Cardiology

Molecular Cardiology Book
Author : Zhongjie Sun
Publisher : Humana Press
Release : 2004-12-29
ISBN : 9781588293633
Language : En, Es, Fr & De

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Book Description :

The aim of Molecular Cardiology: Methods and Protocols is to document state-of-the-art molecular and genetic techniques in the area of cardiology. These modern approaches enable researchers to readily study heart diseases at the molecular level and will promote the development of new therapeutic str- egies. Methods for genetic dissection, signal transduction, and microarray analysis are excellent tools for the study of the molecular mechanisms of cardiovascular diseases. Protocols for transgenesis take advantage of recent advances in many areas of molecular and cell biology. Transgenic models of heart diseases (cardiac hypertrophy, cardiac dysfunction, and so on. ) are powerful tools for the study of heart disease pathogenesis. Methods for gene transfer to heart tissue using viral and nonviral vectors form the basis of gene therapy for heart diseases. Heart-specific promoters containing a hypox- inducible cardioprotective gene switch are key for protection of the heart from ischemia. Gene and stem cell therapies open novel and exciting avenues for the prevention and treatment of heart diseases. Molecular Cardiology: Methods and Protocols consists of 26 chapters de- ing with various aspects of molecular cardiology, including gene transfer and gene therapy for cardiovascular disease, stem cell therapy for cardiovascular disease, gene analysis in the injured and hypertrophied heart, and transgenesis in cardiovascular research. This book provides step-by-step methods for the successful completion of experimental procedures, and would be useful for both experienced and new investigators in the field of molecular cardiology.

Proceedings of 7th International Conference and Exhibition on Cell and Gene Therapy 2018

Proceedings of 7th International Conference and Exhibition on Cell and Gene Therapy 2018 Book
Author : ConferenceSeries
Publisher : ConferenceSeries
Release : 2021-10-21
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

March 15-16, 2018 London,UK Key Topics : Stem Cell Therapies, Cell Culture and Bioprocessing, Viral Gene Therapy, Gene and Cell Therapy for Rare & Common Diseases, Tissue Science & Regenerative Medicine, Molecular Basis of Epigenetics, Clinical Trials on Cell & Gene Therapy, Cell Science and Stem Cell Research, Bioengineering Therapeutics, Nano Therapy, Gene Editing Technology, Advanced Gene Therapeutics, Genetics & Genomic Medicine, Ethical Issues in Cell and Gene Therapy, Markets & Future Prospects for Cell & Gene Therapy, Cell Therapy, Gene Therapy, Cell Therapy of Cardiovascular Disorders, Cell Therapy for Neurological Disorders, Regulatory and Safety Aspects of Cell and Gene Therapy, Commercialization,

Gene Therapy and Cell Fusion Enhances Stem Cell Mediated Cardiac Repair

Gene Therapy and Cell Fusion Enhances Stem Cell Mediated Cardiac Repair Book
Author : Pearl Jennine Quijada
Publisher : Unknown
Release : 2015
ISBN : 9781321741278
Language : En, Es, Fr & De

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Book Description :

Cardiovascular disease is the leading cause of mortality in the United States. Myocardial infarction (MI) induces massive cellular death and leads to a decline in cardiac function. Cardiomyocytes have limited proliferative capacity sparking interests in molecular and cellular strategies to promote stem cell conversion into new cardiomyocytes. Cardiac progenitor cells (CPCs) are tissue resident stem cells that give rise to cardiomyogenic structures. Although, CPCs introduced into the heart confer improvements in cardiac function after MI, these effects are not sufficient to support complete heart regeneration and prevent heart failure. Studying molecular pathways that contribute to CPC survival and commitment is essential in advancing CPC based therapeutic approaches. Ca2+/Calmodulin-dependent protein kinase II[Delta]B (CaMKII[Delta]B) regulates survival and growth in cardiomyocytes. However, the role of CaMKII[Delta] in CPCs has not been previously explored. CPCs increase nuclear CaMKII after MI and in vitro differentiation suggesting that CaMKII[Delta]B contributes to the regulation of CPC commitment. Overexpression of CaMKII[Delta]B in CPCs reduces proliferation, enhances resistance to death and increases cardiac specific differentiation. CaMKII[Delta]B may serve as a novel modulatory kinase to promote CPC survival and commitment. Despite increasing use of stem cells for regenerative-based cardiac therapy, the optimal stem cell population(s) remains uncertain. In the past decade there has been increasing interest and characterization of stem cell populations reported to directly and/or indirectly contributes to cardiac regeneration through processes of cardiomyogenic commitment and / or release of cardioprotective paracrine factors. Future therapies require development of unprecedented concepts to enhance myocardial healing. Combinatorial cell therapy utilizing CPCs and bone marrow derived mesenchymal stem cells (MSCs) promote enhanced reparative functions in vivo. However, identifying cell specific mechanisms of cardiac repair are difficult using dual cell systems. Here, we performed cell fusion between CPCs and MSCs to obtain hybrids with combined cell characteristics called CardioChimeras. Our ideal cell therapy is to combine the beneficial properties of CPCs to undergo cardiac specific commitment as well as MSCs that foster an improved microenvironment with protective paracrine secretion.

Gene Stem cell therapy for cardiovascular diseases

Gene   Stem cell therapy for cardiovascular diseases Book
Author : Anonim
Publisher : Unknown
Release : 2005*
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Gene Stem cell therapy for cardiovascular diseases book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pioneering Stem Cell Gene Therapy Trials

Pioneering Stem Cell Gene Therapy Trials Book
Author : Roger Bertolotti
Publisher : CRC Press
Release : 2003-10-15
ISBN : 1482298481
Language : En, Es, Fr & De

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Book Description :

The first unequivocal success for Gene Therapy was reported in April 2000 for X-SCID patients. Pioneering stem cell/gene therapy clinical trials are the focus of this book. Therapy successes such as the X-SCID trial and improved ADA-SCID ones are presented together with pioneering angio/vasculogenic clinical trials mediated either by transient gene

Stem Cell Transplantation

Stem Cell Transplantation Book
Author : Anthony Dick Ho,Ronald Hoffman,Esmail D. Zanjani
Publisher : John Wiley & Sons
Release : 2006-08-21
ISBN : 3527608532
Language : En, Es, Fr & De

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Book Description :

This is the first handbook on the whole field of stem cell research covering (1) molecular and cellular fundamentals, (2) clinical applications and (3) GMP processing. It provides a timely overview of the potential and plasticity of adult stem cells. With its focus on standardization and quality control of cell lines suited for processing and clinical trials, the book features novel therapeutic approaches that offer great promise for new ways of treating neural, hematological and cardiovascular diseases. The editors are leading international experts in adult stem cell research, and their successful networking in the US and Europe has resulted in a distinguished team of authors from around the world.

Stem Cell Therapy and Tissue Engineering for Cardiovascular Repair

Stem Cell Therapy and Tissue Engineering for Cardiovascular Repair Book
Author : Nabil Dib,Doris A. Taylor,Edward B. Diethrich
Publisher : Springer Science & Business Media
Release : 2006-04-09
ISBN : 038730939X
Language : En, Es, Fr & De

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Book Description :

In excess of 7 million people worldwide die of coronary heart disease each year. Only one-third of these heart attack victims recover completely. The remainder suffer the consequences of myocardial infarction and its ill fated remodeling process, resulting in chronic congestive heart failure. This malady alone is the leading cause of hospital admissions in the United States. New breakthroughs in stem cell therapy and tissue engineering have promised to reverse this dismal outcome by cardiovascular repair. World authorities, including scientists and regulatory authorities, have joined in a collaborative effort to present for the reader the first collective review of stem cell therapy for the treatment of cardiovascular disease. These contributions in basic science, pre-clinical and clinical experience guided by the regulatory pathways, assure a rapid course of translational research and clinical trials. The contents of this publication will become a prerequisite for those preparing to meet the challenges of this exciting and potentially rewarding field of stem cell research.

Proceedings of 9th International Conference and Exhibition on Advanced Cell and Gene Therapy 2019

Proceedings of 9th International Conference and Exhibition on Advanced Cell and Gene Therapy 2019 Book
Author : ConferenceSeries
Publisher : ConferenceSeries
Release : 2019-03-13
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

March 21-22, 2019 , Rome, Italy Key Topics : Cell Therapy,Gene Therapy,Stem Cell Therapies,Cell Culture and Bioprocessing,Viral Gene Therapy,Cell and Gene Therapy for Rare & Common Diseases,Tissue Science & Regenerative Medicine,Molecular Basis of Epigenetics,Bioengineering Therapeutics,Cell Science and Stem Cell Research,Clinical Trials on Cell & Gene Therapy,Nano Therapy,Genetic Engineering,Advanced Gene Therapeutics,Genetics & Genomic Medicine,Ethical Issues in Cell and Gene Therapy,Cell Therapy for Cardiovascular and Neurological Disorders,Regulatory and Safety Aspects of Cell and Gene Therapy,Markets & Future Prospects for Cell & Gene Therapy,Commercialization,

Cardiac regeneration and repair

Cardiac regeneration and repair Book
Author : Ren-Ke Li,Richard D. Weisel
Publisher : Elsevier
Release : 2014-02-16
ISBN : 0857096702
Language : En, Es, Fr & De

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Book Description :

Cardiac Regeneration and Repair, Volume One reviews the pathology of cardiac injury and the latest advances in cell therapy. Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration, and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Chapters in part three move on to highlight novel stem cells for cardiac repair, including human embryonic stem cells and human pluripotent stem cells, and detail their current status and future potential for cardiac therapy. Finally, part four explores gene therapy, and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration. Cardiac Regeneration and Repair, Volume One is complemented by a second volume covering biomaterials and tissue engineering. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function Highlights new approaches to cell therapy for cardiac regeneration and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function Explores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration

Cardiac Regeneration and Repair

Cardiac Regeneration and Repair Book
Author : Ren-Ke Li,Richard D. Weisel
Publisher : Elsevier
Release : 2014-01-31
ISBN : 1782424326
Language : En, Es, Fr & De

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Book Description :

Heart disease is the leading cause of death in the United Kingdom and the United States. Advanced cell therapies, tissue engineering and biomaterials technologies now offer the potential to reverse the damage caused by heart disease. The two volumes of Cardiac Regeneration and Repair present a complete picture of our current understanding of cardiac pathologies, and the novel therapies and technologies being developed to address heart disease. Volume One explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. It highlights new approaches to cell therapy for cardiac regeneration, covering alternative routes of cell delivery, monitoring cell engraftment, and using allogeneic stem cells to restore cardiac function. This volume also explores gene therapy, including ultrasound-targeted or direct gene delivery as well as cell-based gene therapy. Volume Two surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. This volume also focuses on tissue engineering for cardiac repair, including clinical considerations for cardiac tissue engineering, and explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels. Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function Surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Explores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration Explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels

Gene Therapy

Gene Therapy Book
Author : Mauro Giacca
Publisher : Springer Science & Business Media
Release : 2010-11-01
ISBN : 9788847016439
Language : En, Es, Fr & De

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Book Description :

I entered the gene therapy field in the mid-1990s, being fascinated by the immense potential of genes as drugs for the treatment of human disease. Since then, I have experienced the ups and downs of this discipline, and tried to contribute with my work and that of my laboratory to the development of innovative approaches to the treatment of cardiovascular disorders. During these years, I have had several opp- tunities to speak on gene therapy at lectures and academic lessons, and have often noticed that the field is very attractive to scientists of all disciplines. However, as yet no comprehensive book on the subject has been published. Indeed, most books in the field are either a collection of gene transfer laboratory protocols or deal with the subject in a rather superficial manner. Hence the idea to write a gene therapy textbook that is broad and comprehensive, but at the same time provides sufficient molecular and clinical detail to be of interest to students, professors, and specialists in the various disciplines that contribute to gene therapy. I have tried to keep the language plain and, whenever possible, non-technical. Since the book is intended to be a textbook in the field of gene therapy in both the basic science and clinical areas, whenever technical descriptions are required, they are provided.

Cardiac Regeneration and Repair Two Volume Set

Cardiac Regeneration and Repair  Two Volume Set  Book
Author : Ren-Ke Li,Richard D. Weisel
Publisher : Woodhead Pub Limited
Release : 2014-01-31
ISBN : 9781782422990
Language : En, Es, Fr & De

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Book Description :

Heart disease is the leading cause of death in the United Kingdom and the United States. Advanced cell therapies, tissue engineering and biomaterials technologies now offer the potential to reverse the damage caused by heart disease. The two volumes of Cardiac Regeneration and Repair present a complete picture of our current understanding of cardiac pathologies, and the novel therapies and technologies being developed to address heart disease. Volume One explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. It highlights new approaches to cell therapy for cardiac regeneration, covering alternative routes of cell delivery, monitoring cell engraftment, and using allogeneic stem cells to restore cardiac function. This volume also explores gene therapy, including ultrasound-targeted or direct gene delivery as well as cell-based gene therapy. Volume Two surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. This volume also focuses on tissue engineering for cardiac repair, including clinical considerations for cardiac tissue engineering, and explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels. Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function Surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Explores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration Explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels

Gene and Cell Therapy

Gene and Cell Therapy Book
Author : Nancy Smyth Templeton
Publisher : CRC Press
Release : 2008-10-06
ISBN : 9780849387999
Language : En, Es, Fr & De

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Book Description :

Since the publication of the second edition of this book in 2004, gene therapy and cell therapy clinical trials have yielded some remarkable successes and some disappointing failures. Now in its third edition, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies assembles many of the new technical advances in gene delivery, clinical applications, and new approaches to the regulation and modification of gene expression. New Topics Covered in this Edition: Gene and Cell Therapies for Diabetes and Cardiovascular Diseases Clinical Trials Human Embryonic Stem Cells Tissue Engineering Combined with Cell Therapies Novel Polymers Relevant Nanotechnologies SiRNA Therapeutic Strategies Dendrimer Technologies Comprised of contributions from international experts, this book begins with a discussion of delivery systems and therapeutic strategies, exploring retroviral vectors and adenovirus vectors, as well as other therapeutic strategies. The middle section focuses on gene expression and detection, followed by an examination of various therapeutic strategies for individual diseases, including hematopoietic disorders, cardiovascular conditions, cancer, diabetes, cystic fibrosis, neurological disorders, and childhood-onset blindness. The final section discusses recent clinical trials and regulatory issues surrounding the new technology. This compendium is assembled by noted molecular biologist and biochemist Nancy Smyth Templeton. Baylor College of Medicine and several other institutions have used Dr. Templeton’s non-viral therapeutics in clinical trials for the treatment of lung, breast, head and neck, and pancreatic cancers, as well as Hepatitis B and C. She continues to work at the forefront of research in gene and cell therapies. Her contributions, as well as those contained in this volume, are sure to advance the state of the art of these revolutionary life-saving technologies.

Stem Cell Therapy

Stem Cell Therapy Book
Author : Erik V. Greer
Publisher : Nova Publishers
Release : 2006
ISBN : 9781594548482
Language : En, Es, Fr & De

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Book Description :

Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, auto-immune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This new book brings together leading research from throughout the world in this frontier field.