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Stellate Cells In Health And Disease

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Stellate Cells in Health and Disease

Stellate Cells in Health and Disease Book
Author : Chandrashekhar Gandhi,Massimo Pinzani
Publisher : Academic Press
Release : 2015-04-10
ISBN : 0128005440
Language : En, Es, Fr & De

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Book Description :

Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.

Cooperation of Liver Cells in Health and Disease

Cooperation of Liver Cells in Health and Disease Book
Author : Z. Kmiec
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 3642565530
Language : En, Es, Fr & De

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Book Description :

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Role of Hepatic Stellate Cell expressed Endosialin in Liver Health and Disease

Role of Hepatic Stellate Cell expressed Endosialin in Liver Health and Disease Book
Author : Matthias Wieland
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Role of Hepatic Stellate Cell expressed Endosialin in Liver Health and Disease book written by Matthias Wieland, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Discoidin Domain Receptors in Health and Disease

Discoidin Domain Receptors in Health and Disease Book
Author : Rafael Fridman,Paul H. Huang
Publisher : Springer
Release : 2016-08-13
ISBN : 149396383X
Language : En, Es, Fr & De

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Book Description :

The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.

Vitamin A in Health and Disease

Vitamin A in Health and Disease Book
Author : Rune Blomhoff
Publisher : CRC Press
Release : 1994-02-01
ISBN : 9780824791209
Language : En, Es, Fr & De

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Book Description :

This text details the metabolism of vitamin A and the mechanisms of action of vitamin A and the provitamin A carotenoids. It presents up-to-date information on the critical role vitamin A plays in vision, reproduction, foetal development, and the regulation and proliferation of cells. In addition, the book investigates evidence relating vitamin A intake to lung, breast, colon, rectal and prostate cancer.

Endothelial Cells in Health and Disease

Endothelial Cells in Health and Disease Book
Author : William C. Aird
Publisher : CRC Press
Release : 2005-02-28
ISBN : 1135534608
Language : En, Es, Fr & De

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Book Description :

This reference serves as the first source to gather current data from endothelial cell biologists in various disciplines to summarize recent progress in the field-providing a complete understanding of the endothelium in health and disease and demonstrating its potential as a therapeutic target.

The Warburg Effect Regulation Under Siege The Intertwined Pathways in Health and Disease

The Warburg Effect Regulation Under Siege  The Intertwined Pathways in Health and Disease Book
Author : Concetta Bubici,Salvatore Papa
Publisher : Frontiers Media SA
Release : 2019-10-17
ISBN : 2889630013
Language : En, Es, Fr & De

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Book Description :

Many cells, including immune, neuronal, cancer and stem cells, become dependent on aerobic glycolysis to escape apoptosis and accommodate their bioenergetics needs. How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where it was first observed with the aim of decoding the molecular networks controlling its activation for therapeutic purposes. This Research Topic aimed to discuss and review all the intracellular signaling regulating the Warburg effect in cancerous and normal non-cancerous cells though original research articles, mini reviews and reviews.

The Human Gut Liver Axis in Health and Disease

The Human Gut Liver Axis in Health and Disease Book
Author : Aleksander Krag,Torben Hansen
Publisher : Springer
Release : 2018-11-09
ISBN : 3319988905
Language : En, Es, Fr & De

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Book Description :

The book brings together the current knowledge and future perspectives of the complex physiology and pathophysiology of gut-liver interactions in health and disease. It provides readers with a unique overview and access to knowledge that cannot be obtained elsewhere. The structure is logical and covers all aspect including the normal physiology, changes in various liver diseases, technology, sample collection and various interventions. Thus suitable for general reading, lookup for specific questions or as a reference book within the area. The book allows the reader to access all the knowledge that has been generated within the last 10 years in this field.

Motor Control Mechanisms in Health and Disease

Motor Control Mechanisms in Health and Disease Book
Author : John E. Desmedt
Publisher : Unknown
Release : 1983
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Motor Control Mechanisms in Health and Disease book written by John E. Desmedt, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Alcohol in Health and Disease

Alcohol in Health and Disease Book
Author : Dharam Agarwal,Helmut K. Seitz
Publisher : CRC Press
Release : 2001-06-01
ISBN : 9780203902172
Language : En, Es, Fr & De

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Book Description :

This volume, based on presentations from the symposium on the health effects of alcohol held in Titisee, Germany, examines the physical and psychological consequences of alcohol use and abuse, and considers environmental and ethnic factors that lead to addiction and dependence. Discusses epidemiological studies that show the influence of light

Tea in Health and Disease Prevention

Tea in Health and Disease Prevention Book
Author : Victor R. Preedy
Publisher : Academic Press
Release : 2012-10-01
ISBN : 0123849381
Language : En, Es, Fr & De

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Book Description :

While there have been many claims of the benefits of teas through the years, and while there is nearly universal agreement that drinking tea can benefit health, there is still a concern over whether the lab-generated results are representative of real-life benefit, what the risk of toxicity might be, and what the effective-level thresholds are for various purposes. Clearly there are still questions about the efficacy and use of tea for health benefit. This book presents a comprehensive look at the compounds in black, green, and white teas, their reported benefits (or toxicity risks) and also explores them on a health-condition specific level, providing researchers and academics with a single-volume resource to help in identifying potential treatment uses. No other book on the market considers all the varieties of teas in one volume, or takes the disease-focused approach that will assist in directing further research and studies. Interdisciplinary presentation of material assists in identifying potential cross-over benefits and similarities between tea sources and diseases Assists in identifying therapeutic benefits for new product development Includes coverage and comparison of the most important types of tea - green, black and white

Cytokine Effector Functions in Tissues

Cytokine Effector Functions in Tissues Book
Author : Maria Foti,Massimo Locati
Publisher : Academic Press
Release : 2017-07-17
ISBN : 0128042192
Language : En, Es, Fr & De

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Book Description :

Cytokine Effector Functions in Tissues discusses the cytokines networks in the context of the specific-tissue environment. It is an up-to-date collection of articles that addresses the specific issue of how the cytokines are able to condition tissue specific homeostasis. The book helps the reader understand how cytokines network inside the tissues and highlights whether tissue-protection or exacerbation will be finally controlled. It describes the cytokines detected and regulated in different tissues, such as the brain, lungs, spleen, liver, pancreas and intestine, also addressing the issue of timing in specific cell types. Categorizes the cytokines based primarily on tissue and target cells Emphasizes different roles and outcomes observed during innate and adaptive response Represents a rapid guide to cytokines in health and disease in tissue and organ context Presents a different view on how known mediators may work if analyzed in a different perspective, determining the final outcome on tissue-specific target cells

Polyphenols in Human Health and Disease

Polyphenols in Human Health and Disease Book
Author : Ronald Ross Watson,Victor R. Preedy,Sherma Zibadi
Publisher : Academic Press
Release : 2013-10-26
ISBN : 012398467X
Language : En, Es, Fr & De

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Book Description :

Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more. Explores neuronal protection by polyphenol metabolites and their application to medical care Defines modulation of enzyme actions to help researchers see and study polyphenols’ mechanisms of action, leading to clinical applications Includes insights on polyphenols in brain and neurological functions to apply them to the wide range of aging diseases

Cytokines in Health and Disease

Cytokines in Health and Disease Book
Author : Steven L. Kunkel,Daniel G. Remick
Publisher : Marcel Dekker Incorporated
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A comprehensive text providing much of the currently available knowledge in the field of cytokines. There are four areas covered, including general overviews of each of the major cytokines, listings of the important interactions these cytokines have with inflammatory cells, discussions of current an

Liver Immunology

Liver Immunology Book
Author : M. Eric Gershwin,John M. Vierling,Michael P. Manns
Publisher : Springer Science & Business Media
Release : 2008-01-24
ISBN : 9781597455183
Language : En, Es, Fr & De

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Book Description :

Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. This volume is a must-read for novice and expert alike. In an easy-to-read and thorough format, it covers bacterial, parasitic and viral infections of the liver, autoimmune liver disease, alcoholic and nonalcoholic fatty liver diseases, and transplantation.

The Neuropilins Role and Function in Health and Disease

The Neuropilins  Role and Function in Health and Disease Book
Author : Gera Neufeld,Ofra Kessler
Publisher : Springer
Release : 2017-02-06
ISBN : 3319488244
Language : En, Es, Fr & De

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Book Description :

This book covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases. The two neuropilin genes encode scaffold receptors that can bind several different ligands, and also associate with many other receptors and modify their activity. Further, it has been confirmed that they play important roles in the shaping of major organs and tissues such as the nervous system and the vascular system, and that they can modulate immune responses. The book offers a helpful guide for biomedical researchers and all scientists active in the neurosciences, vascular and molecular biology, as well as developmental biology and immunology.

10 Years of Inflammation Pharmacology

10 Years of Inflammation Pharmacology Book
Author : Paola Patrignani,Dieter Steinhilber
Publisher : Frontiers Media SA
Release : 2020-07-07
ISBN : 288963857X
Language : En, Es, Fr & De

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Book Description :

The past and future of inflammatory pharmacology research: a hot topic in health and disease Inflammation is a physiological response to a traumatic injury, bacterial, or viral infection. However, if not appropriately controlled, it contributes to a long list of diseases, including asthma, atherosclerosis, multiple sclerosis, arthritis, and cancer. Different are the types of inflammatory responses. Acute inflammation is an immediate body response to the cellular damage induced by pathogens, noxious stimuli, or physical injury – it is a short-term response resulting in healing via time-dependent changes of leukocyte functions. First, a leukocytes infiltration happens within the damaged region with the purpose of eliminating the stimulus and repairing the tissue. Chronic inflammation, by contrast, is a prolonged and dysregulated response where the active inflammation contributes both to tissue destruction and to the development of many chronic human conditions and diseases. In the context of exaggerated inflammation, which occurs as a consequence of severe burns or trauma, the body response called sepsis can be associated with fatal outcome. Increased knowledge of the cellular and molecular mechanisms taking part in the different types of inflammation is a central requirement to develop more effective and safer treatments. This is a necessary step to prevent potential severe consequences, i.e., organ failure associated with tissue fibrosis. The mission of Inflammation Pharmacology (section of Frontiers in Pharmacology) is to publish scientifically sound studies that advance our knowledge on different aspects of inflammation and contribute to the development of more effective and safer anti-inflammatory agents. Within the present eBook are collected the top articles published in the Inflammation Pharmacology section in the last 10 years. Some articles explored the roles played by different lipid mediators generated from arachidonic acid, including leukotrienes and prostanoids [such as prostacylin and prostaglandin(PG)F2a], in inflammatory conditions. Moreover, the protectin (PD) family of specialized pro-resolving mediators biosynthesized from the two omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and n–3 docosapentaenoic acid (n–3 DPA) were described for their biological effects, the G-coupled protein receptors pharmacology, biosynthesis, and medicinal chemistry. Some other articles focused on the development of novel strategies to counteract inflammation or to induce its resolution. The current concepts and controversies on classification, pathogenesis, and clinical management of cutaneous adverse events induced by biologic agents used in the treatment of rheumatologic conditions were discussed in another article. The whole-exome and whole-genome sequencing data identifying new and old loci associated with atherosclerosis will lead to discovering new molecular targets for blocking atherosclerosis even in its early stages. This critical issue was reviewed in another paper. Numerous information on an individual clinical condition is held in their platelet-derived microparticles (MPs); the assessment of their number and size together with their content can represent the signature to acquire diagnostic information and to monitor the efficacy of therapeutic agents. Some other articles discussed the role of fibroblasts in the development of fibrosis and potential therapies under investigation. It was enlightened the role of the activation and transdifferentiation of hepatic stellate cells (HSCs) into contractile, matrix-producing myofibroblasts (MFBs) as central events in hepatic fibrogenesis, and summarized the current strategies for targeted delivery of drugs to pro-fibrogenic liver cells, including the development of therapeutics specifically targeting HSCs. (Continued in eBook)

Stem Cell Biology in Health and Disease

Stem Cell Biology in Health and Disease Book
Author : Thomas Dittmar,Kurt S. Zänker
Publisher : Springer Science & Business Media
Release : 2009-10-13
ISBN : 9789048130405
Language : En, Es, Fr & De

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Book Description :

Stem Cell Biology in Health and Disease presents an up-to-date overview about the dual role of stem cells in health and disease. The Editors have drawn together an international team of experts providing chapters which, in this fully-illustrated volume, discuss: - the controversial debate on the great expectations concerning stem cell based regeneration therapies raised by the pluripotency of various stem cells. - the advantages and concerns about embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and adult stem cells, such as bone marrow-derived stem cells (BMDCs). - the type of stem cells, which has become of interest in the past decade, namely so-called cancer stem cells (CSCs). CSCs are now in the focus of cancer research since the eradication of tumour initiating cells would raise the changes of definitely cure cancer. Professor Dittmar and Professor Zänker have edited a must-read book for researchers and professionals working in the field of regenerative medicine and/or cancer.

Hepatobiliary Transport in Health and Disease

Hepatobiliary Transport in Health and Disease Book
Author : Dieter Häussinger,Verena Keitel,Ralf Kubitz
Publisher : Walter de Gruyter
Release : 2012-05-29
ISBN : 3110279347
Language : En, Es, Fr & De

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Book Description :

The transport systems involved in hepatobiliary transport have been cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases. This book provides surveys on the structure and function of transport molecules involved in hepatobiliary transport, on the role of different bile acids receptors in various organs and their function in health and disease. The book will be of interest for biochemists, structural chemists, biologists and clinicians.

Cortical Oscillations in Health and Disease

Cortical Oscillations in Health and Disease Book
Author : Roger D. Traub,Miles A. Whittington
Publisher : Oxford University Press, USA
Release : 2010
ISBN : 0195342798
Language : En, Es, Fr & De

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Book Description :

This book first reviews the case that brain oscillations not only are important for cognition, as long suspected, but also play a part in the expression of signs and symptoms of neuropsychiatric disorders. The cellular mechanisms of many of the clinically relevant oscillations have been studied by the authors and their colleagues, using in vitro slice methods as well as detailed computer simulations. A surprising insight is that gap junctions between principal neurons play an absolutely critical role in so many types of oscillation in neuronal populations; oscillations are not just the result of properties of individual neurons and their synaptic connections. Furthermore, the way in which gap junctions produce oscillations in the cortex is novel, involving as it does global properties of networks, rather than just the time constants of membrane currents. This insight has implications for therapeutics as well as for our understanding of normal brain functions.