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Spine Phenotypes

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Spine Phenotypes

Spine Phenotypes Book
Author : Dino Samartzis,Jaro Ilari Karppinen,Frances Mary Kingsley WILLIAMS
Publisher : Academic Press
Release : 2020-10
ISBN : 9780128227787
Language : En, Es, Fr & De

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Book Description :

The era of personalized spine care has arrived. Within that, imaging and clinical phenotypes are key in establishing personalized algorithms for patient care. This is particularly important in developing novel diagnostics and therapeutics as well as predicting outcomes and establishing preventative measures for various spinal disorders. Spine Phenotypes is a comprehensive resource that outlines phenotype descriptions, their radiographic measurement and epidemiological classification and provides an in-depth discussion regarding spine pathology and its clinical relevance. Multi-authored, with multi-disciplinary contributions from world leaders in the field of imaging, spine research and clinical practice, each chapter is rich in visual depiction of imaging phenotypes, providing examples of some established phenotypic measurements with a range of normal and pathologic images. Spine Phenotypes will be a first of its kind reference for researchers, orthopedists, spine specialists and many more.

Atlas of Spinal Imaging Phenotypes E Book

Atlas of Spinal Imaging Phenotypes  E Book Book
Author : Philip K Louie, MD,Howard S An, MD,Dino Samartzis
Publisher : Elsevier Health Sciences
Release : 2021-03-23
ISBN : 0323761127
Language : En, Es, Fr & De

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Book Description :

Spine-related pain is the world's leading disabling condition, affecting every population and a frequent reason for seeking medical consultation and obtaining imaging studies. Numerous spinal phenotypes (observations/traits) and their respective measurements performed on various spine imaging have been shown to directly correlate and predict clinical outcomes. Atlas of Spinal Imaging Phenotypes: Classifications and Radiographic Measurements is a comprehensive visual resource that highlights various spinal phenotypes on imaging, describes their clinical and pathophysiological relevance, and discusses and illustrates their respective measurement techniques and classifications. Helps readers better understanding spinal phenotypes and their imaging, and how today's knowledge will facilitate new targeted drug discovery, novel diagnostics and biomarker discovery, and outcome predictions. Features step-by-step instructions on performing the radiographic measurements with examples of normal and pathologic images to demonstrate the various presentations. Presents clinical correlation of the phenotypes as well as the radiographic measurements with landmark references. Includes validated classification systems that complement the phenotypes and radiographic measurements. Complies the knowledge and expertise of Dr. Dino Samartzis, the preeminent global authority on spinal phenotypes who has discovered and proposed new phenotypes and classification schemes; Dr. Howard S. An, a leading expert in patient management and at the forefront of 3D imaging of various spinal phenotypes; and Dr. Philip Louie, a prolific surgeon who is involved in one of the largest machine learning initiatives of spinal phenotyping.

Canadian Journal of Zoology

Canadian Journal of Zoology Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Canadian Journal of Zoology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Atlas of Spinal Imaging

Atlas of Spinal Imaging Book
Author : Philip K. Louie, MD,Howard S. An, MD,Dino Samartzis
Publisher : Unknown
Release : 2021-02
ISBN : 9780323761116
Language : En, Es, Fr & De

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Book Description :

Spine-related pain is the world's leading disabling condition, affecting every population and a frequent reason for seeking medical consultation and obtaining imaging studies. Numerous spinal phenotypes (observations/traits) and their respective measurements performed on various spine imaging have been shown to directly correlate and predict clinical outcomes. Atlas of Spinal Imaging Phenotypes: Classifications and Radiographic Measurements is a comprehensive visual resource that highlights various spinal phenotypes on imaging, describes their clinical and pathophysiological relevance, and discusses and illustrates their respective measurement techniques and classifications. Helps readers better understanding spinal phenotypes and their imaging, and how today's knowledge will facilitate new targeted drug discovery, novel diagnostics and biomarker discovery, and outcome predictions. Features step-by-step instructions on performing the radiographic measurements with examples of normal and pathologic images to demonstrate the various presentations. Presents clinical correlation of the phenotypes as well as the radiographic measurements with landmark references. Includes validated classification systems that complement the phenotypes and radiographic measurements. Complies the knowledge and expertise of Dr. Dino Samartzis, the preeminent global authority on spinal phenotypes who has discovered and proposed new phenotypes and classification schemes; Dr. Howard S. An, a leading expert in patient management and at the forefront of 3D imaging of various spinal phenotypes; and Dr. Philip Louie, a prolific surgeon who is involved in one of the largest machine learning initiatives of spinal phenotyping.

Abnormal Skeletal Phenotypes

Abnormal Skeletal Phenotypes Book
Author : Alessandro Castriota-Scanderbeg,Bruno Dallapiccola
Publisher : Springer Science & Business Media
Release : 2006-03-20
ISBN : 9783540303619
Language : En, Es, Fr & De

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Book Description :

Taking a symptom-oriented approach, this book focuses on the radiographic changes of malformation syndromes and skeletal dysplasias. Its clear structure makes it an essential, practical guide for radiologists, geneticists, and pediatricians.

The Journal of Neuroscience

The Journal of Neuroscience Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Journal of Neuroscience book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Rescue of FXS Phenotypes in Fmr1 Knockout Mice by the Small Molecule P21 activated Kinase Inhibitor FRAX486

Rescue of FXS Phenotypes in Fmr1 Knockout Mice by the Small Molecule P21 activated Kinase Inhibitor FRAX486 Book
Author : Bridget M. Dolan
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Autism is a diverse and complex family of disorders, and its prevalence is on the rise: 1 in 110 children have autism. There is no effective treatment for the symptoms which often include language and communication deficits, repetitive behavior, intellectual disability, epilepsy, attention deficits, and hyperactivity. The quest for a cure is challenging due to the heterogeneity of the disorder, but also because more than 90% of cases of autism are idiopathic, meaning the cause is unknown. Fortunately, one cause of autism has been discovered: silencing of a single gene causes an autism-like disorder called Fragile X Syndrome (FXS). The knowledge of the genetic basis of FXS allowed for the development of a mouse model of autism. The fmr1 knockout (KO) mouse displays phenotypes similar to symptoms in the human condition - including hyperactivity, repetitive behaviors, and seizures. Humans and mice share not only behavioral expression of the disease, but also analogous abnormalities in the density and morphology of dendritic spines - the sites of connections between neurons and critical substrates for learning. Abnormal dendritic spines is a common feature in FXS, idiopathic autism, and intellectual disability. Thus, this neuroanatomical abnormality may contribute to disease symptoms and severity. Here we take a hypothesis-driven, mechanism-based approach to the search for an effective therapy for FXS. We hypothesize that a treatment that rescues the dendritic spine defect may also ameliorate behavioral symptoms. Thus, we targeted a protein that regulates spines through modulation of actin cytoskeleton dynamics: p21-activated kinase (PAK). In a healthy brain, PAK and FMRP - the protein product of fmr1 - antagonize one another to regulate spine number and shape. Inhibition of PAK with a strategy utilizing mouse genetics reverses spine abnormalities as well as cognitive and behavioral symptoms in fmr1 KO mice, as we demonstrated in our previous publication. This discovery highlights PAK as a potential target for drug discovery research. In this thesis work, we build on this finding to test whether the small molecule FRAX486 - selected for its ability to inhibit PAK - can rescue behavioral, morphological, and physiological phenotypes in fmr1 KO mice. Our results demonstrate that seizures and behavioral abnormalities such as hyperactivity, repetitive movements, and habituation to a novel environment can all be rescued by FRAX486. Moreover, FRAX486 reverses spine phenotypes in adult mice, thereby supporting the hypothesis that a drug treatment which reverses the spine abnormalities can also treat neurological and behavioral symptoms.

Ecology

Ecology Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Ecology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Gammaridean Amphipoda of Australia Part III

Gammaridean Amphipoda of Australia  Part III Book
Author : Jerry Laurens Barnard,Margaret M. Drummond
Publisher : Unknown
Release : 1972
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Gammaridean Amphipoda of Australia Part III book written by Jerry Laurens Barnard,Margaret M. Drummond, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Ottawa 92

Ottawa  92 Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Ottawa 92 book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Factors Controlling Axial Variation in the Threespine Stickleback Gasterosteus Aculeatus Teleostei Gasterosteidae

Factors Controlling Axial Variation in the Threespine Stickleback  Gasterosteus Aculeatus  Teleostei  Gasterosteidae  Book
Author : Dae-Gwon Ahn
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Factors Controlling Axial Variation in the Threespine Stickleback Gasterosteus Aculeatus Teleostei Gasterosteidae book written by Dae-Gwon Ahn, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Role of Copper in the Phenotypic Expression of Scoliosis

Role of Copper in the Phenotypic Expression of Scoliosis Book
Author : William Patrick Opsahl
Publisher : Unknown
Release : 1984
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Role of Copper in the Phenotypic Expression of Scoliosis book written by William Patrick Opsahl, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Regulating Myoblast Phenotype Through Biomimetically Designed Hydrogels

Regulating Myoblast Phenotype Through Biomimetically Designed Hydrogels Book
Author : Tanyarut Boontheekul
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Regulating Myoblast Phenotype Through Biomimetically Designed Hydrogels book written by Tanyarut Boontheekul, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The First Conference on the Clinical Delineation of Birth Defects Phenotypic aspects of chromosomal aberrations

The First Conference on the Clinical Delineation of Birth Defects  Phenotypic aspects of chromosomal aberrations Book
Author : Daniel Bergsma
Publisher : Unknown
Release : 1969
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The First Conference on the Clinical Delineation of Birth Defects Phenotypic aspects of chromosomal aberrations book written by Daniel Bergsma, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Science of Genetics

The Science of Genetics Book
Author : George W. Burns,P. J. Bottino
Publisher : Prentice Hall
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The sixth edition of this successful introductory genetics retains its traditional appeal, but now incorporates current coverage of such areas as Recombinant DNA and Molecular Genetics. While covering all basic areas of genetics, this text allows for flexibility in course organization.

Lumbar Endplate and Modic Changes Epidemiology Determinants and Pain Profiles in Southern Chinese

Lumbar Endplate and Modic Changes  Epidemiology  Determinants and Pain Profiles in Southern Chinese Book
Author : Pik-Sze Mok,莫碧詩
Publisher : Open Dissertation Press
Release : 2017-01-27
ISBN : 9781361356692
Language : En, Es, Fr & De

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Book Description :

This dissertation, "Lumbar Endplate and Modic Changes, Epidemiology, Determinants and Pain Profiles in Southern Chinese" by Pik-sze, Mok, 莫碧詩, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Intervertebral disc(IVD) degeneration is associated with low back pain (LBP).Despite the endplates are located adjacent to the IVD, the phenotypes of endplate and vertebral bone marrow changes remain unclear. The objective of this study is to assess the prevalence and the associated determinants of these phenotypes of the lumbar spine. 2449 Southern Chinese subjects (aged 10 -88 years) undergone sagittal T2-weighted magnetic resonance imaging (MRI)examination to assess the presence of endplate and vertebral bone marrow changes including Schmorl's nodes (SN) and Modic changes (MC), respectively, and scored for additional radiographic features over the lumbar spine. Subjects' demographics, clinical profile, and functional status were assessed by means of standardized questionnaires. Anovel6-domain SN morphological classification based on MRI was developed to further analyze the characteristics of SN and its association with disc degeneration (DD). The prevalence of SN was 16.4%. Males, taller and heavier individuals had a significantly increased likelihood of SN. Overall presence of SN was age-independent, but was significantly associated with DD, and linearly correlated with increase in severity of DD. SN were particularly associated with severe DD at the upper two lumbar levels (L1/2 - L2/3). Based on the SN classification system, specific SN characteristics and endplate linkage patterns were found. Of these, two SN types were identified: "Typical SN" and "Atypical SN." "Typical SN" were those smaller size SN with various shapes that were frequently located at caudal endplates of L1/2-L3/4disc levels. One variant of "Atypical SN" were those rectangular shape SN, which predominantly located at the posterior region of the rostral endplates of L1/2-L2/3disc levels. The other variant of "Atypical SN" was larger size SN with irregular shape that frequently presented at the L4/5endplates, they were also likely to be associated with marrow changes. Despite "Atypical SN" only entailed 8.3% of all identified SN, they were associated with increased severity of DD than "Typical SN." Although the overall prevalence of MC among Southern Chinese was low (5.8%), after adjustments for other confounding factors, the presence of MC was associated with the presence and severity of LBP. Interestingly, the determinants of MC at upper (L1/2 - L3/4) and lower (L4/5 - L5/S1) lumbar showed distinct difference. The presence of MC at upper lumbar levels was only associated with the disc integrity only (i.e. the presence of disc displacement, and DD score), while the presence of MC at the lower levels, apart from the disc integrity, was also associated with increasing age, the presence of SN, smoking and obesity status. This study is the largest MRI study assessing the phenotypes of endplate and vertebral bone marrow changes in-vivo. The prevalence and distribution of SN and MC vary throughout the lumbar spine, and there are level and region-specific variations regarding these phenotypes. Determinants of SN and MC may be similar but do vary, suggesting distinct etiological factors. Findings of this study broaden the understanding of the various phenotypes of the lumbar spine and its association with DD. DOI: 10.5353/th_b5328055 Subjects: Lumbar vertebrae Intervertebral disk - Diseases

Biological Agricultural Index

Biological   Agricultural Index Book
Author : Anonim
Publisher : Unknown
Release : 1984
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biological Agricultural Index book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Local adaptation and phenotypic plasticity in response to predators

Local adaptation and phenotypic plasticity in response to predators Book
Author : Michael Francis Benard
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Local adaptation and phenotypic plasticity in response to predators book written by Michael Francis Benard, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Some Effects of the White Spine Uniform Color and Gynoecious Alleles on Quality and Certain Other Characters in the Cucumber Variety Wisconsin SMR 18

Some Effects of the White Spine  Uniform Color and Gynoecious Alleles on Quality and Certain Other Characters in the Cucumber Variety Wisconsin SMR 18 Book
Author : Benjamin Franklin George
Publisher : Unknown
Release : 1971
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Some Effects of the White Spine Uniform Color and Gynoecious Alleles on Quality and Certain Other Characters in the Cucumber Variety Wisconsin SMR 18 book written by Benjamin Franklin George, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.