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Spinal Cord Injury Sci Repair Strategies

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Spinal Cord Injury SCI Repair Strategies

Spinal Cord Injury  SCI  Repair Strategies Book
Author : Giuseppe Perale,Filippo Rossi
Publisher : Woodhead Publishing
Release : 2019-10-30
ISBN : 0081028083
Language : En, Es, Fr & De

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Book Description :

Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering

Animal Models of Spinal Cord Repair

Animal Models of Spinal Cord Repair Book
Author : Aldskogius H Kan,Hakan Aldskogius
Publisher : Humana Press
Release : 2016-05-01
ISBN : 9781493961801
Language : En, Es, Fr & De

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Book Description :

This book in the Neuromethods series examines a range of experimental models for research on spinal cord injury, shows how they have contributed to our current state of knowledge, and describes their advantages in the further advancement of spinal cord repair.

Promoting Neuroplasticity to Repair the Injured Spinal Cord

Promoting Neuroplasticity to Repair the Injured Spinal Cord Book
Author : Nina Weishaupt
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This thesis explores strategies to promote neuronal plasticity in a rat model of cervical spinal cord injury (SCI) in an effort to achieve improved recovery of skilled forelimb use. I focused on investigating how motor pathways disrupted by an SCI may connect to spared, lesion-bridging relay pathways to re-establish communication with target regions below the injury level. In chapter 2, I attempted to promote a detour for the cervically injured corticospinal tract (CST) via spared reticulospinal tract (RtST) axons with a combined treatment including the neurotrophins BDNF, NT-3 and rehabilitative training. Although anatomical evidence for the desired rewiring was not obtained, I found a synergistic effect of BDNF treatment and training on recovery of skilled forelimb reaching. No effect of NT-3 administered rostral to the SCI was evident. The experiment in chapter 3 was designed to answer the question whether NT-3-induced CST collateral growth rostral to an SCI can be facilitated by systemic immune activation. Results indicate that NT-3 expression can promote collateral growth from the injured CST, irrespective of immune activation. Since results from chapter 2 did not shed light on the previously suggested role of the RtST in recovery of hand/paw function after cervical SCI, I next examined whether the mostly spared RtST responds to SCI with changes in its anatomical projection pattern. While collateral projections were unchanged rostral to the SCI, I observed a marked withdrawal of collaterals from grey matter regions directly caudal to the SCI. Results from chapter 2 combined with previous reports indicate that task-specific training does often not translate into untrained tasks and may even result in undesired side effects. To elucidate the functional relationship between trained tasks further, I next investigated how training the primarily affected forelimb (PAF) and/or the less affected forelimb (LAF) after unilateral cervical SCI influences performance outcomes for each limb. Results point towards training tasks competitively recruiting available neuronal "hardware". This work identifies promising leads for promoting plasticity of important motor tracts after SCI, and also points out targets for optimization of strategies employed. These new insights contribute to the exploration of urgently needed repair strategies for SCI.

AOSpine Masters Series Volume 7 Spinal Cord Injury and Regeneration

AOSpine Masters Series  Volume 7  Spinal Cord Injury and Regeneration Book
Author : Luiz Roberto Gomes Vialle,Michael G. Fehlings,Norbert Weidner
Publisher : Thieme
Release : 2016-10-30
ISBN : 1626232288
Language : En, Es, Fr & De

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Book Description :

World-renowned experts share the latest updates in translational research as well as surgical and nonsurgical strategies for treating spinal cord injury Spinal cord injury (SCI) is a devastating, clinically challenging injury, leading to varying degrees of neurological function impairment and paralysis. Underlying biological mechanisms either inhibit or promote new growth in the spinal cord. Researchers have been making important discoveries about how neurons and their axons grow in the central nervous system and why they fail to regenerate after SCI. Although progress has been steady, there remains an urgent need to address issues in acute management such as early decompression and the use of biologics, as well as potential solutions for regeneration. Written by renowned experts in the ever-evolving field of SCI research and clinical practice, the 7th volume in the AOSpine Masters series is a state-of-the-art compendium on the latest in SCI diagnosis, spine surgery interventions, and long-term management. Each chapter contains pearls from leading spine specialists gleaned from the research laboratory and years of hands-on experience treating SCI patients in the emergency setting and long term. Key Features: Pathobiology, assessment, and diagnostic considerations The use of biomarkers as predictors of functional recovery Surgical and nonsurgical interventions for traumatic SCI The role of neural stem cells and biologics in spinal cord repair Functional and epidural stimulation and brain-computer interfaces The AOSpine Masters series, a copublication of Thieme and the AOSpine Foundation, addresses current clinical issues featuring international masters sharing their expertise in the core areas in the field. The goal of the series is to contribute to an evolving, dynamic model of evidence-based approach to spine care. This essential textbook delivers invaluable insights to spine surgeons, spinal cord injury clinicians and researchers and trainees, from translational researchers to experienced researchers and clinicians experienced in the operative and non-operative management of spinal cord injury.

Neurobiology of Spinal Cord Injury

Neurobiology of Spinal Cord Injury Book
Author : Robert G. Kalb,Stephen M. Strittmatter
Publisher : Springer Science & Business Media
Release : 1999-10-22
ISBN : 1592592007
Language : En, Es, Fr & De

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Book Description :

Distinguished researchers review the latest scientific understanding of spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function. The authors examine the role of intracellular Ca2+ in neuronal death, the possibility of spinal learning, growth-promoting molecules for regenerating neurons, and the biochemistry and cell biology of microtubules. Among the treatment possibilities discussed are cell transplantation strategies beyond the use of fetal spinal cord tissue, remyelination in spinal cord demyelination models, high steroid therapy immediately after SCI, and the mixed use of anti- and proinflammatories. Comprehensive and highly promising, Neurobiology of Spinal Cord Injury summarizes and integrates the great progress that has been made in understanding and combating the paralysis that follows spinal cord injury.

Biomimetic Materials And Design

Biomimetic Materials And Design Book
Author : Angela Dillow,Anthony Lowman
Publisher : CRC Press
Release : 2002-08-28
ISBN : 9780203908976
Language : En, Es, Fr & De

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Book Description :

Detailing techniques in wound healing and reconstruction, this reference describes the mechanisms and architecture of biological systems to formulate and design natural and synthetic compounds, degradable and non-degradable scaffolds, and targeted drug delivery devices. It offers strategies to control adhesive interactions, elicit specific cellular responses, and improve the biocompatibility, performance, and durability of prosthetic materials. Covering advances in the field, the book discusses the effect of topographical features on cell behaviors such as orientation, adhesion, migration, proliferation, and differentation.

Spinal Cord Injury

Spinal Cord Injury Book
Author : Joost Verhaagen,John W. McDonald III
Publisher : Newnes
Release : 2012-12-31
ISBN : 0444535071
Language : En, Es, Fr & De

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Book Description :

Handbook of Clinical Neurology: Spinal Cord Injury summarizes advances in the clinical diagnosis, monitoring, prognostication, treatment, and management of spinal cord injuries. More specifically, it looks at new and important developments in areas such as high-resolution noninvasive neuroimaging, surgery, and electrical stimulation of motor, respiratory, bladder, bowel, and sexual functions. It also reviews the latest insights into spontaneous regeneration and recovery of function following rehabilitation, with emphasis on novel therapeutic strategies, such as gene therapy, transcranial stimulation, brain-machine interfaces, pharmacological approaches, molecular target discovery, and the use of olfactory ensheathing cells, stem cells, and precursor cells. Organized in five sections, the book begins with an overview of the development, maturation, biomechanics, and anatomy of the spinal cord before proceeding with a discussion of clinical diagnosis and prognosis as well as natural recovery, ambulation, and function following spinal cord injury. It then examines clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury; medical, surgical and rehabilitative management of spinal cord trauma; and some new approaches for improving recovery in patients, including restoration of function by electrical stimulation, locomotor training, and the use of robotics. Other chapters cover cell transplantation, artificial scaffolds, experimental pharmacological interventions, and molecular and combinatorial strategies for repairing the injured spinal cord. This volume should be of interest to neuroscience and clinical neurology research specialists and practicing neurologists. Comprehensive coverage of the latest scientific understanding of spinal cord injuries Detailed coverage of current treatment best practices and potential future treatments Connects leading edge research programs to future treatment opportunities

Spinal Cord Injury New Insights for the Healthcare Professional 2013 Edition

Spinal Cord Injury  New Insights for the Healthcare Professional  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-07-22
ISBN : 148166218X
Language : En, Es, Fr & De

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Book Description :

Spinal Cord Injury: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Spinal Cord Injury: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Spinal Cord Injury: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Handbook of Innovations in Central Nervous System Regenerative Medicine

Handbook of Innovations in Central Nervous System Regenerative Medicine Book
Author : Antonio Salgado
Publisher : Elsevier
Release : 2020-06-10
ISBN : 0128180854
Language : En, Es, Fr & De

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Book Description :

Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance Discusses the limitations of present therapies used in the clinics Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path

Spinal Trauma

Spinal Trauma Book
Author : Eric D. Schwartz,Adam E. Flanders
Publisher : Lippincott Williams & Wilkins
Release : 2007
ISBN : 0781762480
Language : En, Es, Fr & De

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Book Description :

Written by recognized experts, this volume is a comprehensive reference on the use of advanced imaging techniques in the diagnosis and management of spinal trauma. In one cohesive source, the book brings together information on state-of-the-art clinical imaging—including multidetector CT and high-field MRI techniques—and the pathophysiology, neurologic evaluation, medical management, surgical treatment, and postoperative assessment of spine trauma and spinal cord injury. Also included are cutting-edge reviews of experimental imaging techniques and their applications and experimental therapies such as neurotransplantation. More than 700 illustrations—including 180 in full color—complement the text.

Regenerative Biology of the Spine and Spinal Cord

Regenerative Biology of the Spine and Spinal Cord Book
Author : Rahul Jandial,Mike Y. Chen
Publisher : Springer Science & Business Media
Release : 2013-04-13
ISBN : 1461440904
Language : En, Es, Fr & De

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Book Description :

Editors hope that Regenerative Biology of the Spine and Spinal Cord appeals to the nostalgic sentiments of investigators and intellectuals in that it can be held in hand and provide a broad survey of leading edge science. At the same time its chapters can be digitally acquired for those established in the field to refine particular knowledge interests or gaps. Most importantly, we ask the reader, whomever that may be, to peruse without prejudice as countless more chapters will have been written before total spinal regeneration is achieved.

Therapeutic Strategies to Spinal Cord Injury

Therapeutic Strategies to Spinal Cord Injury Book
Author : Pavla Jendelova
Publisher : MDPI
Release : 2018-11-29
ISBN : 3038974064
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue "Therapeutic Strategies to Spinal Cord Injury" that was published in IJMS

Medical Science and Bioethics

Medical Science and Bioethics Book
Author : United States. Congress. House. Committee on Government Reform. Subcommittee on Criminal Justice, Drug Policy, and Human Resources
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Medical Science and Bioethics book written by United States. Congress. House. Committee on Government Reform. Subcommittee on Criminal Justice, Drug Policy, and Human Resources, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Spinal Cord Injury Rehabilitation

Spinal Cord Injury Rehabilitation Book
Author : Edelle Field-Fote
Publisher : F.A. Davis
Release : 2009-03-26
ISBN : 0803623194
Language : En, Es, Fr & De

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Book Description :

One of the world’s leading authorities in spinal cord injury, and a participant in the Human Brain Project brings you an evidenced-based guide to the state-of-the-art in spinal cord rehabilitation. She has assembled an expert team of clinicians, each with expertise in the content areas they address. Their work encompasses all of the new scientific knowledge and technological advances practitioners need to know to determine the most effective rehabilitation interventions for each patient and to attain maximum restoration of function in individuals with SCI.

Spinal Cord Injury

Spinal Cord Injury Book
Author : Anders Holtz, MD, PhD,Richard Levi, MD, PhD
Publisher : Oxford University Press
Release : 2010-08-03
ISBN : 0190208759
Language : En, Es, Fr & De

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Book Description :

Spinal cord injuries typically strike young, previously healthy persons, and leaves the individual with a severe, life-lasting impairment affecting all organ systems. Without adequate management, the risk of severe morbidity and mortality is very high. In contrast state-of-the-art management makes it possible for most persons with SCI to lead long, fulfilling, and autonomous lives despite neurological impairment. This book covers all medical and surgical aspects of modern SCI management from the scene of the accident through rehabilitation to the life-long follow up.

The Clinical Science of Neurologic Rehabilitation

The Clinical Science of Neurologic Rehabilitation Book
Author : Bruce H. Dobkin
Publisher : Oxford University Press, USA
Release : 2003
ISBN : 0195150643
Language : En, Es, Fr & De

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Book Description :

This monograph translates neuroscientific research to illuminate ongoing and future practices for the rehabilitation of patients with neurologic diseases. The author dissects fundamental concepts, current practices, and clinical trials to define what clinicians and researchers need to consider as they pursue best practices and areas ripe for exploration. Remarkable studies from functional anatomy, neural repair, physiologic imaging of the brain, and brain-machine interfaces reveal how the structure and function of the nervous system may respond to therapeutic manipulations for walking, grasping, and cognition. These concepts are brought forward into treating the medical complications and the impairments and disabilities of patients across neurologic diseases.

The Cognitive Neurosciences fifth edition

The Cognitive Neurosciences  fifth edition Book
Author : Michael S. Gazzaniga,George R. Mangun
Publisher : MIT Press
Release : 2014-10-24
ISBN : 0262027771
Language : En, Es, Fr & De

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Book Description :

The fifth edition of a work that defines the field of cognitive neuroscience, with entirely new material that reflects recent advances in the field. Each edition of this classic reference has proved to be a benchmark in the developing field of cognitive neuroscience. The fifth edition of The Cognitive Neurosciences continues to chart new directions in the study of the biological underpinnings of complex cognition—the relationship between the structural and physiological mechanisms of the nervous system and the psychological reality of the mind. It offers entirely new material, reflecting recent advances in the field. Many of the developments in cognitive neuroscience have been shaped by the introduction of novel tools and methodologies, and a new section is devoted to methods that promise to guide the field into the future—from sophisticated models of causality in brain function to the application of network theory to massive data sets. Another new section treats neuroscience and society, considering some of the moral and political quandaries posed by current neuroscientific methods. Other sections describe, among other things, new research that draws on developmental imaging to study the changing structure and function of the brain over the lifespan; progress in establishing increasingly precise models of memory; research that confirms the study of emotion and social cognition as a core area in cognitive neuroscience; and new findings that cast doubt on the so-called neural correlates of consciousness.

Cellular Transplantation

Cellular Transplantation Book
Author : Craig Halberstadt,Dwaine F. Emerich
Publisher : Elsevier
Release : 2011-10-10
ISBN : 0080469043
Language : En, Es, Fr & De

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Book Description :

There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. Provides detailed description of clinical trials in cell transplantation Review of current therapeutic approaches Coverage of the broad range of diseases addressed by cell therapeutics Discussion of stem cell biology and its role in transplantation

Pathology E Book

Pathology   E Book Book
Author : Catherine C. Goodman,Kenda S. Fuller
Publisher : Elsevier Health Sciences
Release : 2013-08-07
ISBN : 0323266460
Language : En, Es, Fr & De

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Book Description :

Understand how a patient’s conditions might affect physical therapy and outcomes so that you can design safe and effective interventions. The only pathology textbook written specifically for physical therapists, Pathology: Implications for the Physical Therapist, Third Edition, offers guidelines, precautions, and contraindications for interventions with patients who have musculoskeletal or neuromuscular problems as well as other conditions such as diabetes, heart disease, or pancreatitis. Learn about the cause of these conditions, the pathogenesis, medical diagnosis and treatment, and most importantly, the special implications for the therapist. In addition to addressing specific diseases and conditions, this text emphasizes health promotion and disease prevention strategies and covers issues with implications for physical therapy management, such as injury, inflammation, and healing; the lymphatic system; and biopsychosocial–spiritual impacts on health care. With this practical and evidence-based text, now enhanced with full-color illustrations and the latest research, you’ll know what to factor into your clinical decisions to achieve the best outcomes for your patients. Incorporates the Medical Model, the Disablement Model, and the ICF Model Incorporates Preferred Practice Patterns from the Guide to Physical Therapist Practice, Second Edition throughout the text Presents key information in at-a-glance format that is organized by body system for easy reference Provides the basic science information and the clinical implications of disease within the rehabilitation process, covering common illnesses and diseases, adverse effects of drugs, organ transplantation, laboratory values, and much more Focuses on health promotion and disease prevention throughout “Special Implications for the Therapist sections present the most likely practice patterns associated with each disease or disorder and address precautions, contraindications, and considerations specific to PTs. Current information on conditions, medical testing and treatment, and practice models keeps you up-to-date on the latest research findings and recent changes in the field. Companion Evolve site provides easy access to articles referenced in the text with links to Medline. Tables and text boxes throughout the text summarize important information and highlight key points.

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma Book
Author : Michael G. Fehlings,Brian Kwon,Alexander R. Vaccaro,F. Cumhur Oner
Publisher : Academic Press
Release : 2020-12-15
ISBN : 9780128198353
Language : En, Es, Fr & De

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Book Description :

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma. Contains contributions by international authors Covers recent clinical trial advancements and findings and updates on ongoing trials Presents an overview of clinical practice guidelines for the management of traumatic spinal cord injury featured Provides the reader with insights regarding the translation of research from bench to bedside and the skills needed to understand the translational pathway using real-life examples