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Sleep Epilepsies And Cognitive Impairment

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Sleep Epilepsies and Cognitive Impairment

Sleep  Epilepsies  and Cognitive Impairment Book
Author : Peter Halasz,Anna Szucs
Publisher : Academic Press
Release : 2018-02-26
ISBN : 0128125802
Language : En, Es, Fr & De

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Book Description :

Translational research connects science and clinical medicine from "the bench to the bedside." In Sleep, Epilepsies and Cognitive Impairment, the authors look back from the bedside to the brain function underlying clinical symptoms and reveal mechanisms explored by contemporary neuroimaging and signal analysis in the overlapping fields of sleep and epilepsy. This book will help the reader to see epilepsy from a new viewpoint. The common pathophysiology binding together the diverse manifestations of epilepsies is the exaggeration of plastic functions of the brain involving the hippocampus, the non-specific thalamocortical system and the perisylvian cognitive network. Epileptic derailment seems to be the price for the latest achievements of the mammal and human brain; namely the highly developed ability to change and learn. The contemporary results of sleep research provide new viewpoints to explain why sleep and epilepsy are bedfellows. Converging evidence supports the concept that one of the most important biological roles of NREM sleep is the renewal of synaptic balance ensuring learning ability from one day to the next and consolidation of new memories. Epilepsy and NREM sleep use overlapping structures and functions, therefore epilepsy beginning in early childhood may interfere with sleep plastic functions. NREM sleep, which affects original learning and memory, may become the hidden source of chronic cognitive impairment when epilepsy occurs during sleep and blocks the plastic processes. Sleep, Epilepsies and Cognitive Impairment abandons the academic classification of epilepsy by following the system epilepsy concept, binding major epilepsies with structures and functions of physiological brain systems. It tries to show within this system the close interrelationship between sleep, epilepsy and cognition. Neuroscientists, clinical epileptologists and neurologists interested in brain processes underlying brain plasticity, sleep and epilepsy will find this book thought provoking. It offers good "brain-gymnastics" for reconsidering the ideas on epilepsy. It provides contemporary knowledge about the neurophysiological and functional anatomical background of major epilepsies Treats major epilepsies as system epilepsies of brain networks Reveals the interrelationship of sleep, epilepsy and cognitive impairment showing how epileptic manifestations became facilitated in NREM sleep and interferes with sleep plastic functions

Encephalopathy related to Status Epilepticus during slow Sleep

Encephalopathy related to Status Epilepticus during slow Sleep Book
Author : Guido Rubolli,Carlo-Alberto Tassinari
Publisher : John Libbey Eurotext
Release : 2019-12-05
ISBN : 2742016252
Language : En, Es, Fr & De

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Book Description :

In the last years, clinical data, neurophysiological and imaging investigations, as well as genetic studies have renewed the interest on ESES. In addition, experimental findings from sleep research have opened fascinating perspectives on some possible pathophysiological mechanisms involved in this condition. These issues are presented and discussed in this book by clinicians, neurophysiologists, sleep physiologists and geneticists. They all have been working on ESES with the aim to provide an updated overview of this special syndrome in the light of recent research.

Pediatric Neurology Part I

Pediatric Neurology Part I Book
Author : Patrick Van Bogaert
Publisher : Elsevier Inc. Chapters
Release : 2013-04-24
ISBN : 0128077719
Language : En, Es, Fr & De

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Book Description :

Epileptic encephalopathy with continuous spike-waves during slow-wave sleep (CSWS) is a spectrum of epileptic conditions best defined by the association of cognitive or behavioral impairment acquired during childhood and not related to another factor other than the presence of abundant interictal epileptiform discharges (IED) during sleep, which tend to diffuse over the whole scalp. It is part of the childhood focal epileptic syndromes, some cases being idiopathic and overlapping with benign rolandic epilepsy, and others being symptomatic of a structural brain lesion. Landau–Kleffner syndrome (LKS) is a particular presentation where acquired aphasia is the core symptom. Clinical, neurophysiological, and cerebral glucose metabolism data support the hypothesis that IED play a prominent role in the cognitive deficits by interfering with the neuronal networks at the site of the epileptic foci but also at distant connected areas. Therefore, the treatment should aim to suppress IED. This may be achieved using conventional antiepileptic drugs, but corticosteroids seem to have more pronounced and sustained efficacy. Outcome for epilepsy is usually good, CSWS being an age-dependent EEG pattern, whereas outcome for cognition, language, and behavior is variable. Rehabilitation represents an important part of the treatment and visual forms of language should be encouraged in children with LKS.

Cognitive Dysfunction in Children with Temporal Lobe Epilepsy

Cognitive Dysfunction in Children with Temporal Lobe Epilepsy Book
Author : Alexis Arzimanoglou,Albert Aldenkamp,Helen Cross,Maryse Lassonde
Publisher : John Libbey Eurotext
Release : 2005
ISBN : 9782742005628
Language : En, Es, Fr & De

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Book Description :

Much has been written about the cognitive function of children with epilepsy but despite there being extensive study of the neuropsychological status of adults with intractable temporal lobe epilepsy, it has been more limited in children. Although cognitive development in children is influenced by similar factors to adults, the role of early damage, modification of cerebral organisation and interruption of the learning process are also likely to be important. Devoted to cognitive function and dysfunction in children with temporal lobe epilepsy, this book highlights those domains that demand further research and those for which immediate established techniques for a better global care can be undertaken.

Encephalopathy related to status epilepticus during slow sleep

Encephalopathy related to status epilepticus during slow sleep Book
Author : Guido Rubboli,Carlo Alberto Tassinari
Publisher : Unknown
Release : 2019-12-07
ISBN : 9782742016167
Language : En, Es, Fr & De

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Book Description :

Encephalopathy with Electrical Status Epilepticus during Sleep (ESES) was described almost 50 years ago; however its clinical spectrum and its boundaries, the diagnostic criteria, the pathophysiology and the therapeutic management are still debated. In the last years, clinical data, neurophysiological and imaging investigations, as well as genetic studies have renewed the interest on ESES. In addition, experimental findings from sleep research have opened fascinating perspectives on some possible pathophysiological mechanisms involved in this condition. These issues are presented and discussed in this book by clinicians, neurophysiologists, sleep physiologists and geneticists. They all have been working on ESES with the aim to provide an updated overview of this special syndrome in the light of recent research.

Neuropsychology in the Care of People with Epilepsy

Neuropsychology in the Care of People with Epilepsy Book
Author : Christoph Helmstaedter, Bruce Hermann, Maryse Lassonde, Philippe Kahane, Alexis Arzimanoglou
Publisher : John Libbey Eurotext
Release : 2011-01-01
ISBN : 274200808X
Language : En, Es, Fr & De

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Book Description :

Having appeared in the 1930s in Montreal, standardised neuropsychological evaluation has become an essential tool in the clinical diagnosis and evaluation of surgical epileptic patients. Nevertheless, despite great progress over the last 20 to 30 years in the diagnosis and medical treatment of epilepsy, clinical neuropsychology still remains largely associated with surgical epilepsy, particularly surgery of the temporal lobe. Clinical neurology has still not managed to clear a way in the daily practice with patients with all types of epilepsy despite significant advances in cognitive neuroscience and a large number of clinical studies on epilepsy and cognition. How is it that there are only rarely major advances in the field of clinical neuropsychology? It has long been time for this question to be asked, and for an attempt to be made to bring about changes. This was the aim of the Toronto workshop and the result of this book. Every approach was debated, providing important elements to reflect on and allowing a great forum for exchanges. This book includes the communications from the main participants and comments from some others on specific subjects.

Dravet syndrome

Dravet syndrome Book
Author : Charlotte Dravet,Renzo Guerrini
Publisher : John Libbey Eurotext
Release : 2013-09-18
ISBN : 2742012311
Language : En, Es, Fr & De

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Book Description :

Dravet syndrome is a rare and severe type of epilepsy. “Severe myoclonic epilepsy in infancy” was first described in 1978 by Charlotte Dravet, who observed common features: onset in the first year of life, fever sensitivity, multiple seizure types, often including myoclonic seizures, and cognitive deterioration. Subsequent descriptions contributed to delineating a newly recognised epilepsy syndrome. Renzo Guerrini contributed to the knowledge of the genetic basis and response to anti epileptic drugs of Dravet syndrome. New molecules have emerged, and studies on cognitive development have qualified the impairment. Families’ associations have also contributed to a better knowledge of the syndrome. Charlotte Dravet and Renzo Guerrini present here the state of current knowledge about this epilepsy type. This book aims to provide more information on the syndrome to those neurologists, child neurologists, and pediatricians confronted with infants, children and adults who either have or are suspected to have Dravet syndrome. Even if significant gaps in our understanding of the syndrome remain, the authors hope this contribution may assist in the understanding of the disease and optimization of treatments.

The Contribution of Sleep to Cognitive Function in Children with Epilepsy

The Contribution of Sleep to Cognitive Function in Children with Epilepsy Book
Author : Samantha Yuen-Sum Chan
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Contribution of Sleep to Cognitive Function in Children with Epilepsy book written by Samantha Yuen-Sum Chan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neuropsychology of Childhood Epilepsy

Neuropsychology of Childhood Epilepsy Book
Author : Isabelle Jambaqué,Maryse Lassonde,Olivier Dulac
Publisher : Springer Science & Business Media
Release : 2006-04-11
ISBN : 0306476126
Language : En, Es, Fr & De

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Book Description :

This book is devoted to the neuropsychological description of childhood epilepsy, a neurolo- cal condition that constitutes one of the most prevalent forms of chronic and disabling childhood illnesses. Indeed, one child out of 20 experiences one or more seizures before the age of 5, and one in a hundred develops epilepsy as a chronic disorder. Approximately half of these children with epilepsy display academic difficulties and/or behavioral disorders. Moreoever, it is now believed that a sizable proportion of children with learning disability suffer from undiagnosed epilepsy. While a great number of textbooks have been devoted to various medical aspects of chi- hood epilepsy (diagnosis, genetics, etiology, drug and surgical treatment, etc.), there have been no comprehensive accounts of the cognitive consequences of this condition. Advance of medical knowledge has shown that childhood epilepsy should not be considered as a single disorder but encompasses a whole range of different conditions that exhibit specific clinical EEG and outcome characteristics. It is not becoming apparent that these various clinical entities have different cognitive expression that yet need to be specified. The purpose of this book is to provide a complete up-to-date analysis of this multi-faceted pathology.

Social Cognitive Impairment in People with Epilepsy

Social Cognitive Impairment in People with Epilepsy Book
Author : Man-Kiu Ma,馬文嬌
Publisher : Open Dissertation Press
Release : 2017-01-26
ISBN : 9781361321188
Language : En, Es, Fr & De

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Book Description :

This dissertation, "Social Cognitive Impairment in People With Epilepsy" by Man-kiu, Ma, 馬文嬌, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Epilepsy is a highly prevalent neurological disorder affecting people from all walks of life. Psychosocial adjustment and psychological morbidity have been longstanding challenges for people with this clinical diagnosis. However, very little is known about the psychosocial correlates of psychological morbidity, such as anxiety and depression, among people with epilepsy in Hong Kong. Previous clinical studies suggest social cognitive impairment may contribute to the poor psychosocial integration of people with epilepsy. An important aspect of social cognition is the ability to attribute mental states to others so as to understand their behavior, desires, and intentions. This prerequisite for successful social interactions is termed mentalizing. This thesis reports two studies conducted to examine the psychosocial correlates of psychological morbidity among people with epilepsy, and their mentalizing ability with regard to the neuropsychological basis of mentalizing deficits that are specific to this neurological disorder. Study 1 examines the association of psychological morbidity with a broad array of personality traits and social skills in a sample of 54 local Chinese people with epilepsy. Participants completed the Temperament and Character Inventory (TCI), the Social Performance Survey Schedule (SPSS), and the Hospital Anxiety and Depression Scale (HADS) via semi-structured interviews. The findings showed that, independent of demographic and medical variables and perceived illness-related impact, three personality traits (harm avoidance temperament, self-directedness, and cooperation) and two subscales of interpersonal behaviors (both positive and negative social skills) are significant psychosocial predictors of adjustment among Chinese people with epilepsy. Study 2 examines the neuropsychological basis of mentalizing deficits in people with epilepsy. Thirty-nine right-handed local Chinese people with epilepsy and 38 matched healthy controls were recruited for this study. The eyes test and the faux pas test were employed to study the decoding and reasoning stages of mentalizing, respectively. The findings showed that, relative to the healthy controls, the participants with epilepsy were impaired in decoding and reasoning about the affective aspect of social materials; and at the same time, they were impaired in reasoning about the cognitive aspects of others' mental states-that is, in inferring intentionality. Such a pattern of mentalizing deficits suggests a wider structural abnormality that may be implicated in the brains of people with epilepsy. In conclusion, epilepsy is associated with social cognitive impairment in emotion recognition and intentionality inference, involving both decoding and reasoning about the affective and cognitive aspects of others' mental state, which may predispose people with epilepsy to maladaptive psychosocial adjustment and functioning. The significance and implications of the results are discussed. DOI: 10.5353/th_b4819925 Subjects: Epileptics - Psychology

Pediatric Neurology Part I

Pediatric Neurology Part I Book
Author : I. Jambaqué,C. Pinabiaux,M. Lassonde
Publisher : Elsevier Inc. Chapters
Release : 2013-04-24
ISBN : 012807776X
Language : En, Es, Fr & De

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Book Description :

Childhood epilepsy may cause cognitive disorders and the intellectual quotient is indeed not normally distributed in epileptic children, a fair proportion of whom show an IQ in the deficient range. Some epileptic syndromes happen during vulnerability periods of brain maturation and interfere with the development of specific cognitive functions. This is the case for the Landau–Kleffner syndrome, which generally appears during speech development and affects language. Similarly, West syndrome – or infantile spasms – is an epileptogenic encephalopathy appearing during the first years of life and induces a major delay in social and oculo-motor development. Specific impairments can also be identified in partial childhood epilepsies in relation with seizure focus localization. For instance, left temporal and frontal epilepsies are frequently associated with verbal impairments. Moreover, episodic memory disorders have been described in children suffering from temporal lobe epilepsy whereas executive deficits (planning, self-control, problem solving) have been reported in frontal lobe epilepsy. In most cases, including its mildest forms, childhood epilepsy induces attention deficits, which may affect academic achievement. These observations militate in favor of individual neuropsychological assessments as well as early interventions in order to provide the child with an optimal individualized treatment program.

Pediatric Neurology Part I

Pediatric Neurology Part I Book
Author : Camfield Peter,Carol Camfield
Publisher : Elsevier Inc. Chapters
Release : 2013-04-24
ISBN : 0128077530
Language : En, Es, Fr & De

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Book Description :

Epilepsy has protean manifestations and may be diagnosed when two unprovoked seizures have occurred. This determination is nearly always based on the available history because most seizures have stopped long before patients arrive at medical care. Great care must be taken, even by experts, to correctly interpret the history and there is strong evidence that incorrect diagnoses are frequent. An abnormal EEG cannot rule epilepsy in or out unless an actual seizure is recorded. When the diagnosis of epilepsy is based only on two seizures, the seizures are usually generalized tonic–clonic. Less “severe” seizure types usually occur multiple times before prompting a medical visit. Some patients present with what seems to be a first generalized tonic–clonic seizure but have a history of less severe attacks that have not brought them to medical attention – epilepsy can then be diagnosed. Others present with staring spells, episodes of confusion, body jerks, spasms, drops, loss of speech and social interactions and/or cognitive function, paroxysmal events during sleep, and febrile seizures. This chapter examines and considers the differential diagnoses for each of these modes of presentation. The consequences of a missed alternate diagnosis, such as cardiac arrhythmia, may be profound.

Childhood Seized

Childhood Seized Book
Author : M. Canal Frechilla
Publisher : Balboa Press
Release : 2021-09-22
ISBN : 1982284099
Language : En, Es, Fr & De

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Book Description :

To date, little research has been conducted to the effects of epilepsy on cognitive and language issues. This study is a response to this knowledge gap. A careful matched-subject, mixed-factors description, designed to identify cognitive decline during the process and treatment of this illness. The research is focused on description and exploration, of linguistic considerations in Rolandic epilepsy. Rolandic epilepsy, is also known as Benign focal epilepsy with centrotemporal spikes (BECS). The intention is to shed light from a neurolinguistic perspective, on reasons that might underline cognitive and behavioral complications, in children with epilepsy. This study has been approached corroborating ‘structural connectivity’, which defines language network in the brain. The rational derives from research of neurological data, from prestigious neurological and scientific international journals, on the topic that illustrates our case. Conclusions are based upon careful evaluation on how epilepsy affects cognitive skills, and language issues upon observations drawn on results. Deficits in language patterns have been associated to different brain areas, in patients who suffer from different pathologies. Degenerative illnesses have opened a milestone in the study on reasons leading to cognitive decline, in children affected from “Benign childhood epilepsy”. Medical history has been well documented to current day. Lack of consistent information internationally recognized on cognitive issues toughen consensus on best medical procedure to follow, in best interest of the child. Our research confronted this shortage of information, in the light of the new literature coming through. Overall, the results indicate that when working with language skills in people with epilepsy or with degenerative diseases, clinicians should account for the presence of anti-epileptic medication or amalgamation of medications as possible cause of cognitive decline.

Epilepsy and the Interictal State

Epilepsy and the Interictal State Book
Author : Erik K. St Louis,David M. Ficker,Terence J. O'Brien
Publisher : John Wiley & Sons
Release : 2015-03-16
ISBN : 0470656239
Language : En, Es, Fr & De

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Book Description :

Epilepsy care traditionally focuses on seizures, yet for most epilepsy sufferers, other interictal factors such as mood, cognitive abilities, and treatment adverse effects most influence how they feel and function day to day. Epilepsy and the Interictal State is a practical and comprehensive text that covers quality of life issues, cognition and therapy, adverse effects of epilepsy treatments, mood state and psychiatric co-morbidity and general health aspects of epilepsy. Each chapter employs a standard structure providing background, epidemiology, pathophysiology, etiology, diagnosis, treatment, prognosis and further practical advice. From an international team of expert editors and contributors, Epilepsy and the Interictal State is a valuable resource for specialist epileptologists and neurologists, as well as for neurosurgeons, neurology nurses, psychiatrists, family physicians and general practitioners.

Cognitive and Behavioural Disorders of Epileptic Origin in Children

Cognitive and Behavioural Disorders of Epileptic Origin in Children Book
Author : Thierry Deonna,Eliane Roulet-Perez
Publisher : Mac Keith Press
Release : 2005-01-14
ISBN : 1898683433
Language : En, Es, Fr & De

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Book Description :

Clinics in Developmental Medicine No. 168 This book describes the effects that different kinds of epilepsy in children can have on the child's behavior and cognitive development. It is mainly based on the authors' extensive studies over many years. These are described in the book, together with the available diagnostic methods and therapies. It is written so that the various professionals dealing with such children (pediatricians, neurologists, psychologists) can see their contribution and have a general view of the complex interrelation between medical psychological and educational problems in these children.

The Clinical Psychologist s Handbook of Epilepsy

The Clinical Psychologist s Handbook of Epilepsy Book
Author : Christine Cull,Laura H. Goldstein
Publisher : Routledge
Release : 2002-01-31
ISBN : 1134791453
Language : En, Es, Fr & De

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Book Description :

Psychological techniques have a major role to play in the treatment and management of epilepsy. The Clinical Psychologist's Handbook of Epilepsy is the first comprehensive reference text written specifically from a psychological angle. A team of experts review the latest research and give practical advice for the clinician in areas including neuropsychological assessment, the impact of anti-epileptic medication, behaviour problems in children with epilepsy, and the impact of epilepsy in people with learning disabilities. A practical handbook for all psychologists working in the area, whether new to the field or more experienced, The Clinical Psychologist's Handbook of Epilepsy will also provide a useful resource for research.

Imaging the Brain

Imaging the Brain Book
Author : Hilde Maria Henrica Braakman
Publisher : Unknown
Release : 2013
ISBN : 9789090274942
Language : En, Es, Fr & De

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Book Description :

Download Imaging the Brain book written by Hilde Maria Henrica Braakman, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Pediatric Neurology Part I

Pediatric Neurology Part I Book
Author : Dominique M. Ijff,Albert P. Aldenkamp
Publisher : Elsevier Inc. Chapters
Release : 2013-04-24
ISBN : 0128077786
Language : En, Es, Fr & De

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Book Description :

Although the causes of cognitive impairment in patients with epilepsy have not been completely elucidated, three factors are clearly involved: the underlying etiology of epilepsy, the effects of seizures or the epileptiform EEG discharges themselves, and the central nervous system effects of antiepileptic drugs (AEDs). All commonly used AEDs have some effect on cognitive function, and the effect may be substantial when crucial functions are involved, such as learning in children. With phenobarbital, there is a high risk for serious cognitive effects impacting attention and memory. Phenytoin may affect mental speed, mainly in higher dosing and polytherapy. Moderate monotherapy doses do not seem to induce much effect. Valproate does not seem to impair cognition if sufficiently controlled for hyperammonemia. For carbamazepine, there are conflicting reports, which may be due to selection bias or dosing. For oxcarbazepine, there is no evidence for any detrimental change compared to valproate but mild improvements on attentional tests. For topiramate, there is clear evidence for topiramate-induced cognitive impairment (attention, memory, and language function) in adults and children. Although data is sketchy, levetiracetam does not seem to have a negative impact on cognition. For lamotrigine, there is evidence of a cognitive-enhancing effect on attention. No evidence for cognitive side-effects has been found for vigabatrin. Ethosuximide is not associated with cognitive impairment although the evidence is sketchy. For gabapentin, tiagabine, zonisamide, and rufinamide no studies in children are available.

Sleep related Epilepsy and Electroencephalography An Issue of Sleep Medicine Clinics

Sleep related Epilepsy and Electroencephalography  An Issue of Sleep Medicine Clinics Book
Author : Madelieine Grigg-Damberger,Nancy R Foldvary-Schaefer
Publisher : Elsevier Health Sciences
Release : 2012-03-26
ISBN : 1455743143
Language : En, Es, Fr & De

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Book Description :

This issue on Sleep Electroencephalography (EEG) gives an overview of Electrophysiological readings in sleep with such articles as “The Nuts and Bolts of EEG and “How the Sleep/Wake EEG Changes Across the Lifespan. Identifying abnormal EEG activity and patterns in the Electroencephalographic readings is also discussed. The issue then further focuses in on Seizures and the EEG; specifically, how EEG can be used to diagnosis and identify seizure disorders and differentiate seizures from other paroxysmal nocturnal events, and to diagnose other primary sleep disorders in people with epilepsy.

Epilepsy Behaviour and Cognitive Function

Epilepsy  Behaviour and Cognitive Function Book
Author : Michael R. Trimble,Edward H. Reynolds
Publisher : John Wiley & Sons Incorporated
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The cognitive and behavioral complications of epilepsy are recognized as important factors in the management of patients, and a group of specialists presents here the latest information on the relationships among seizures, EEG discharges, and the effects of anticonvulsant drugs on cognition and behavior. The methods and the problems inherent in measuring the effects of epilepsy, its complications and its treatment on mood, memory, performance and achievement are examined and discussed.