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Sirtuin Biology In Cancer And Metabolic Disease

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Sirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease Book
Author : Kenneth Maiese
Publisher : Elsevier
Release : 2021-02-20
ISBN : 0128224843
Language : En, Es, Fr & De

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Book Description :

Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who elucidate the intimate relationship between cancer and metabolic disease that intersects with sirtuin pathways Presents the basic and clinical role of sirtuins in regard to cancer and metabolic disease Summarizes the multidiscipline views and publications for this exciting field of sirtuins for the development of new clinical treatments for cancer and metabolic disease Provides a vital foundation for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Introductory Review on Sirtuins in Biology Aging and Disease

Introductory Review on Sirtuins in Biology  Aging  and Disease Book
Author : Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev
Publisher : Academic Press
Release : 2018-04-20
ISBN : 012813500X
Language : En, Es, Fr & De

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Book Description :

Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

Sirtuin Biology in Medicine

Sirtuin Biology in Medicine Book
Author : Kenneth Maiese
Publisher : Academic Press
Release : 2021-03-04
ISBN : 0128141190
Language : En, Es, Fr & De

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Book Description :

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who discuss the broad role of sirtuins in health and disease Details the basic and clinical role of sirtuins for the development of new clinical treatments Summarizes the multidiscipline views and publications for the compelling discipline of sirtuins by covering systems throughout the body Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Sirtuins

Sirtuins Book
Author : Riekelt H. Houtkooper
Publisher : Springer
Release : 2016-11-17
ISBN : 9402409629
Language : En, Es, Fr & De

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Book Description :

The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.

Histone Deacetylases the Biology and Clinical Implication

Histone Deacetylases  the Biology and Clinical Implication Book
Author : Tso-Pang Yao,Edward Seto
Publisher : Springer Science & Business Media
Release : 2011-08-31
ISBN : 9783642216312
Language : En, Es, Fr & De

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Book Description :

The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunctions, heart disease, cancer, memory impairment, aging, and metabolic disorders.

Structure

Structure Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Structure book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chemical Mechanisms of Sir2 Protein Deacetylases

Chemical Mechanisms of Sir2 Protein Deacetylases Book
Author : Brian Christopher Smith
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Chemical Mechanisms of Sir2 Protein Deacetylases book written by Brian Christopher Smith, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular Biology of Aging

Molecular Biology of Aging Book
Author : Leonard Guarente,Linda Partridge,Douglas C. Wallace
Publisher : CSHL Press
Release : 2008
ISBN : 0879698241
Language : En, Es, Fr & De

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Book Description :

This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.

Sirtuins in Health and Disease

Sirtuins in Health and Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2018-02-03
ISBN : 0128122625
Language : En, Es, Fr & De

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Book Description :

Sirtuins in Health and Disease, Volume 154 presents the reactions catalyzed by sirtuins in terms of their unique coenzyme NAD+-dependent catalytic mechanisms, the ways to elucidate these mechanisms, and the design of the inhibitory compounds against the sirtuin-catalyzed reactions as potential therapeutic agents for human diseases. Sections cover the concepts and chemical tools in sirtuin research, SIRT4 and SIRT7, the regulatory effects of NAD metabolic pathways on sirtuin activity, sirtuins as modifiers of Huntington’s Disease (HD) pathology, parasite sirtuins as targets for novel chemotherapeutic agents, targeting sirtuins – substrate specificity and inhibitor design, and chemical probes in sirtuin research. This book focuses on the outstanding issues in the sirtuin field and implications for future sirtuin research. Presents an excellent subject, excellent structural organization, and authoritative contributions from world-renowned scholars in the sirtuin field Provides the latest updates on sirtuins in health and disease

American Journal of Respiratory and Critical Care Medicine

American Journal of Respiratory and Critical Care Medicine Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download American Journal of Respiratory and Critical Care Medicine book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mechanism based Peptidic and Peptideomimetic Human Sirtuin Inhibitors

Mechanism based Peptidic and Peptideomimetic Human Sirtuin Inhibitors Book
Author : Brett Hirsch
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Silent information regulator 2 (Sir2) enzymes or sirtuins are a family of intracellular protein deacetylases that can catalyze the [beta]-nicotinamide adenine dinucleotide ([beta]-NAD+)-dependent deacetylation of N[epsilon]-acetyl-lysine on protein substrates. These enzymes are evolutionarily conserved among all the three kingdoms of life, with the yeast Sir2 being the founding family member. In humans, seven sirtuins, SIRT1-7, have been identified. Protein acetylation/deacetylation plays a critical role in biological processes such as metabolism, gene transcription, neurodegeneration, apoptosis, the cell-cycle, aging, cell fate, and cytoskeletal organization. The past few years have witnessed a tremendous interest in investigating the unique mechanism for the sirtuin-catalyzed deacetylation reaction. There has also been a great deal of effort invested in the employment of different strategies to identify different types of inhibitors for this enzymatic deacetylation reaction. These inhibitors hold great potential toward a fuller exploration of sirtuin biology and pharmacology as well as toward developing novel therapeutics for metabolic and age-related diseases as well as cancer. This study discovered i) two potent, cell-permeable, and proteolytically stable small molecule human sirtuin inhibitors that harbor the previously identified sirtuin inhibitory acetyl-lysine analog, thioacetyl-lysine; and ii) a novel sirtuin inhibitory warhead, L-2-amino-7-carboxamidoheptanoic acid, that may function both to elucidate the sirtuin mechanism and in the development of new sirtuin inhibition therapies."--Abstract.

Genetic Engineering Biotechnology News

Genetic Engineering   Biotechnology News Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Genetic Engineering Biotechnology News book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biochemistry and Cell Biology

Biochemistry and Cell Biology Book
Author : Anonim
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biochemistry and Cell Biology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mitochondrial Signaling in Health and Disease

Mitochondrial Signaling in Health and Disease Book
Author : Sten Orrenius,Lester Packer,Enrique Cadenas
Publisher : CRC Press
Release : 2012-06-20
ISBN : 1439880026
Language : En, Es, Fr & De

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Book Description :

Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.

Wiley Encyclopedia of Chemical Biology Volume 4

Wiley Encyclopedia of Chemical Biology  Volume 4 Book
Author : Tadhg P. Begley
Publisher : Wiley-Blackwell
Release : 2009-02-03
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.

Biological Basis of Alcohol Induced Cancer

Biological Basis of Alcohol Induced Cancer Book
Author : Vasilis Vasiliou,Samir Zakhari,Helmut K. Seitz,Jan B. Hoek
Publisher : Springer
Release : 2014-11-26
ISBN : 3319096141
Language : En, Es, Fr & De

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Book Description :

In the recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated. This proceedings volume will contain chapters based upon the presentation of the 2nd International Conference on Alcohol and Cancer in Colorado, 2013. The various topics explore the affects of alcohol on: liver and breast cancer; cell signaling and cancer; stem cells; biomarkers and metabolomics; aerodigestive cancers; cancer and the immune system and more.

Dissertation Abstracts International

Dissertation Abstracts International Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Dissertation Abstracts International book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chronobiology Biological Timing in Health and Disease

Chronobiology  Biological Timing in Health and Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2013-07-27
ISBN : 0123972809
Language : En, Es, Fr & De

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Book Description :

This special volume of Progress in Molecular Biology and Translational Science focuses on chronobiology. Contributions from leading authorities Informs and updates on all the latest developments in the field

Hazzard s Geriatric Medicine and Gerontology 7E

Hazzard s Geriatric Medicine and Gerontology  7E Book
Author : Jeffrey B. Halter,Joseph G. Ouslander,Stephanie Studenski,Kevin P. High,Sanjay Asthana,Nancy Woolard,Christine S. Ritchie,Mark A. Supiano
Publisher : McGraw Hill Professional
Release : 2016-11-18
ISBN : 0071833463
Language : En, Es, Fr & De

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Book Description :

The gold-standard text on the diagnosis and treatment of disorders affecting the elderly – completely updated with a new full-color presentation A Doody's Core Title for 2017! The definitive treatise on the subject of geriatrics, this comprehensive text combines gerontology principles with clinical geriatrics, offering a uniquely holistic approach to this ever-expanding area of medicine. Written by some of the world’s most respected geriatricians, Hazzard’s Geriatric Medicine and Gerontology, Seventh Edition presents up-to-date, evidence-based information in a rich new full-color design. Unmatched as a textbook, this classic is also valuable to fellows in geriatric medicine. Hazzards’s Geriatric Medicine and Gerontology, Seventh Edition is logically divided into five parts: Principles of Gerontology, Principles of Geriatrics, Geriatric Syndromes, Principles of Palliative Medicine, and Organ Systems and Diseases. Within its pages, you will find balanced, authoritative coverage of every essential topic – from evaluation and management to nutrition and palliative medicine. Here’s why the Seventh Edition is the best edition ever: • NEW full-color design with hundreds of color photographs • NEW chapters: Quality of Care in Older Adults, Common Non-Pain Symptoms in Older Adults, Strategies of Effective Communication Around Advanced Illness, Palliative Medicine in the Continuum of Care Including Hospice, Coagulation Disorders, and Plasma Cell Disorders • MORE chapters on Palliative Medicine • NEW Learning Objectives and Key Points added to each chapter • MORE tables, drawings, and clinical algorithms • EVIDENCE-BASED through the use of the latest clinical practice guidelines , references to systemic reviews, and critically appraised topics • UPDATED to reflect the most current clinical breakthroughs and advances for managing older adults in various settings