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Simulated Moving Bed Technology

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Simulated Moving Bed Technology

Simulated Moving Bed Technology Book
Author : Alirio Rodrigues
Publisher : Butterworth-Heinemann
Release : 2015-05-23
ISBN : 0128020512
Language : En, Es, Fr & De

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Book Description :

Simulated Moving Bed Technology is one of only a few books solely dedicated to SMB. It aims to equip you with the tools and skills needed for SMB modelling, simulation, design and operation. The theory presented is supported by real-world examples from the petrochemical, sugar and pharma industries. The core of the book focuses on SMB process development and model validation. It explains basic process concepts and definitions, fundamental principles and equations, as well as typical applications and recent advances made to address challenges. Its specialist content makes it a must have book for people working with SMB technology, chemical engineering post-graduate students and process and R&D engineers in industry. Will provide you with the tools and predictive approaches for use in SMB design and performance assessment Covers SMB modelling, simulation, design and operation as applied to separation and reaction processes Discusses process intensification through coupling SMB and reaction in SMBR, membrane permeation and SMBR in PermSMBR and introduces the design of SCPC

Protein Recovery Using Simulated Moving Bed Technology and Macroporous Chromatographic Support Material

Protein Recovery Using Simulated Moving Bed Technology and Macroporous Chromatographic Support Material Book
Author : Jonatan Andersson
Publisher : Unknown
Release : 2007
ISBN : 9789189627529
Language : En, Es, Fr & De

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Book Description :

Download Protein Recovery Using Simulated Moving Bed Technology and Macroporous Chromatographic Support Material book written by Jonatan Andersson, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Optimization of Chiral Separation of Nadolol by Simulated Moving Bed Technology

Optimization of Chiral Separation of Nadolol by Simulated Moving Bed Technology Book
Author : Nesma Nehad Hashem
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Simulated Moving Bed (SMB) technology has gained increasing attention as one of the most powerful techniques for chromatographic separations due to its cost-effectiveness and efficiency. Application of SMB technology is especially important in the pharmaceutical industry for production of enantiopure drugs, as required under strict FDA regulations, to avoid possible adverse effects of racemic drugs. In this study, the performance of the SMB process in separation of racemic nadolol on a perphenyl carbamoylated beta cyclodextrin ( -CD) stationary phase was investigated. The equilibrium dispersive model coupled with bi-Langmuir adsorption isotherm and lumped kinetic approximation, constitute the mathematical model used to simulate the dynamic behavior of SMB. Multi-objective optimization was carried out using a robust state-of-the-art optimization technique, non-dominated sorting genetic algorithm (NSGA). Two optimization problems were solved to simultaneously maximize productivity and purity of the product and minimize consumption of desorbent. The generated Pareto optimal solutions showed that selection of operating conditions can significantly affects the performance of SMB to meet the desired objectives.

Simulated Moving Bed Chromatography for Chiral Separation

Simulated Moving Bed Chromatography for Chiral Separation Book
Author : Ki Bong Lee,Nien-Hwa Linda Wang
Publisher : LAP Lambert Academic Publishing
Release : 2013
ISBN : 9783659389870
Language : En, Es, Fr & De

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Book Description :

Simulated moving bed (SMB) chromatography has received attention for chiral separations since early 1990s and is, today, considered as a cost-effective preparative-scale purification technology. In this book, development and verification of a design method for chiral SMB separation by both simulations and experiments are introduced. The verified design method can be further used for optimization and for understanding the effects of various parameters on SMB performance.

Novel Simulated Moving Bed Technologies

Novel Simulated Moving Bed Technologies Book
Author : Purdue University
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Cellulose and hemicellulose from plants and other biomass can be hydrolyzed to produce sugars (i.e. glucose and xylose). Once these sugars are separated from other impurities, they can serve as feedstock in fermentation to produce ethanol (as fuels), lactic acid, or other valuable chemicals. The need for producing fuels and chemicals from renewable biomass has become abundantly clear over the last decade. However, the cost of producing fermentable sugars from biomass hydrolyzate using existing technology is relatively high and has been a major obstacle. The objective of this project is to develop an efficient and economical simulated moving bed (SMB) process to recover fermentable sugars from biomass hydrolyzate. Sulfuric acid can hydrolyze the cellulose and hemicellulose in biomass to sugars, but this process can generate byproducts such as acetic acid, and can lead to further degradation of the xylose to furfural and glucose to hydroxymethyl furfural (HMF). Also, lignin and other compounds in the biomass will degrade to various phenolic compounds. If the concentrations of these compounds exceed certain threshold levels, they will be toxic to the downstream fermentation, and will severely limit the usefulness of the derived sugars. Standard post-hydrolysis processing involves neutralization of sulfuric acid, usually with lime (calcium hydroxide). A study by Wooley et al.showed that the limed hydrolyzate gave a low ethanol yield in fermentation test (20% of theoretical yield compared to 77% of theoretical yield from fermentation of pure sugars). They showed that instead of adding lime, an ion exclusion chromatography process could be used to remove acids, as well as to isolate the sugars from the biomass hydrolyzate. In this project, we investigated the feasibility of developing an economical SMB process based on (1) a polymeric adsorbent, Dowex99, which was used by Wooley et al., (2) a second polymeric adsorbent, poly-4-vinyl pyridine (or PVP in short, Reilly Industries Inc., Indianapolis, IN), which has been used for organic acid separations, and (3) an activated carbon adsorbent. The adsorption isotherms and mass transfer parameters of the two polymeric adsorbents were estimated using single-component pulse tests and frontal tests. The parameters were then validated using batch elution chromatography test of a corn-stover hydrolyzate, which was provided gratis by NREL. The sugars recovered in batch chromatography were then fermented using yeast developed at Dr. Ho's LORRE laboratory. A standard mixture of pure sugars and an overlimed corn-stover hydrolyzate were fermented using the same procedure simultaneously. The fermentability of the overlimed hydrolyzate was the worst, and that of the sugars recovered using the PVP column was similar to that of the pure sugar mixture. The sugars recovered using the Dowex99 column had an intermediate fermentability. Since the sugars were the ''center cut'' in the Dowex99 column, a tandem SMB (two SMB's in series) design was needed to obtain sugars of high purity. By contrast, sugars were the fast-moving components in the PVP column, and only a single SMB was needed to recover sugars from the hydrolyzate. The impurities, such as sulfuric acid, acetic acid, HMF, and furfural, had higher affinities for PVP. Caustic regeneration was needed to efficiently remove these impurities from PVP. Therefore, a five-zone SMB, which includes a regeneration zone and a reequilibration zone, was developed. The isotherms and mass transfer parameters estimated from batch chromatography experiments were used in the design of SMB processes. A Standing Wave Design method was developed for the five-zone SMB and the tandem SMB. Cost analysis was carried out based on the resulting operating conditions. The analysis showed that the PVP five-zone SMB process was more economical than the Dowex99 tandem SMB process. The cost analysis also showed that elution and equipment costs are dominant for the Dowex99 SMB and the regeneration cost is dominant (60%) for the PVPSMB. Both the cost analysis and the fermentation tests of the sugars obtained from batch chromatography suggested that the PVP was a better choice than Dowex99. We thus focused on experimental testing of the PVP five-zone SMB. Three SMB experiments were conducted. The sugar yields were very high (> 99%), but the purities were from 93-95%.

Innovative Food Processing Technologies

Innovative Food Processing Technologies Book
Author : Kai Knoerzer,Pablo Juliano,Geoffrey W Smithers
Publisher : Woodhead Publishing
Release : 2016-06-29
ISBN : 008100298X
Language : En, Es, Fr & De

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Book Description :

Innovative Food Processing Technologies: Extraction, Separation, Component Modification and Process Intensification focuses on advances in new and novel non-thermal processing technologies which allow food producers to modify and process food with minimal damage to the foodstuffs. The book is highly focused on the application of new and novel technologies, beginning with an introductory chapter, and then detailing technologies which can be used to extract food components. Further sections on the use of technologies to modify the structure of food and the separation of food components are also included, with a final section focusing on process intensification and enhancement. Provides information on a variety of food processing technologies Focuses on advances in new and novel non-thermal processing technologies which allow food producers to modify and process food with minimal damage to the foodstuffs Presents a strong focus on the application of technologies in a variety of situations Created by editors who have a background in both the industry and academia

Innovative Food Processing Technologies

Innovative Food Processing Technologies Book
Author : Kai Knoerzer, PhD,Pablo Juliano, PhD,Peter Roupas, PhD,Cornelis Versteeg, PhD
Publisher : John Wiley & Sons
Release : 2011-01-31
ISBN : 9780470959428
Language : En, Es, Fr & De

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Book Description :

Part of the IFT (Institute of Food Technologists) series, this book discusses multiphysics modeling and its application in the development, optimization, and scale-up of emerging food processing technologies. The book covers recent research outcomes to demonstrate process efficiency and the impact on scalability, safety, and quality, and technologies including High Pressure Processing, High Pressure Thermal Sterilization, Radiofrequency, Ultrasound, Ultraviolet, and Pulsed Electric Fields Processing. Ideal for food and process engineers, food technologists, equipment designers, microbiologists, and research and development personnel, this book covers the importance and the methods for applying multiphysics modeling for the design, development, and application of these technologies.

Ion Exchange Technology II

Ion Exchange Technology II Book
Author : Dr. Inamuddin,Mohammad Luqman
Publisher : Springer Science & Business Media
Release : 2012-06-05
ISBN : 9400740263
Language : En, Es, Fr & De

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Book Description :

Ion-exchange Technology II: Applications presents an overview of the numerous industrial applications of ion-exchange materials. In particular, this volume focuses on the use of ion-exchange materials in various fields including chemical and biochemical separations, water purification, biomedical science, toxic metal recovery and concentration, waste water treatment, catalysis, alcohol beverage, sugar and milk technologies, pharmaceuticals industry and metallurgical industries. This title is a highly valuable source not only to postgraduate students and researchers but also to industrial R&D specialists in chemistry, chemical, and biochemical technology as well as to engineers and industrialists.

Scale Up and Optimization in Preparative Chromatography

Scale Up and Optimization in Preparative Chromatography Book
Author : Anurag Rathore,Ajoy Velayudhan
Publisher : CRC Press
Release : 2002-09-26
ISBN : 9780203909287
Language : En, Es, Fr & De

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Book Description :

Presenting guidelines to predict and improve separation system performance, this book contains numerous case studies illustrating the practice of scale-up principles in process development. It offers solutions to limitations that occur in real-world purification schemes; methods to model, optimize, and characterize nonlinear separation processes; d

Chiral Separation of Racemic Mandelic Acid by the Coupling Crystallization Process and Simulated Moving Bed Technology

Chiral Separation of Racemic Mandelic Acid by the Coupling Crystallization Process and Simulated Moving Bed Technology Book
Author : Shimin Mao
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Chirality is a major concern in the modern pharmaceutical, food and agricultural industries. The importance of enantiopure drugs has risen dramatically in recent years due to Food and Drug Administration regulations requiring that all chiral bioactive molecules must be isolated and tested for the efficacy and safety, and have to be as pure as possible containing a single pure enantiomer. There are essentially three strategies that can be applied to obtain pure isomers: (a) extraction from plants and animal materials (b) enantio-selective asymmetric synthesis so that only one isomer is formed in the first place, or (c) making a racemate and finding a method for separating the enantiomers. Only few enantiomers exist in nature and most of them are racemates. A highly efficient chiral asymmetric synthesis route would be the ideal situation, but it usually takes about 10-15 years to develop a synthesis recipe. Hence, the best strategy would be to synthesize the drug in racemate form and separate the isomers to produce single pure enantiomer. Among the variety of enantioseparation methods, chromatography and crystallization are the most dominant methods for the recovery of pure enantiomers. However, both methods have limitations. Crystallization cannot obtain enantiopure enantiomers from the racemic compound directly. In Simulated Moving Bed (SMB), solvent consumption increases exponentially if desired purity requirement is close to 100%. In this work, the coupling of SMB for enrichment followed by direct crystallization is applied for the chiral resolution to circumvent limitations of each method. In order to take advantage of both the processes, SMB chromatography is used for partial enrichment thereby reducing solvent consumption followed by direct crystallization to obtain 100% pure enantiomers. Here, the chiral resolution of mandelic acid (MA) as racemic compound was considered to investigate the performance of the hybrid SMB-crystallization process theoretically as well as experimentally. The solubility and metastable zone limit of (R, S)-MA and (R)-MA in water and the crystallization kinetics parameters of (R, S)-MA and (R)-MA by optimization of the crystallization model based on the necessary experimental data collected in unseeded cooling batch crystallizers were determined. For the SMB part, the choice of mobile phase and determination of binary competitive equilibrium isotherms parameters of (R, S)-MA and the experimental and modeling studies of SMB process have also been accomplished.

Systematic Process Development by Simultaneous Modeling and Optimization of Simulated Moving Bed Chromatography

Systematic Process Development by Simultaneous Modeling and Optimization of Simulated Moving Bed Chromatography Book
Author : Jason A. Bentley
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Adsorption separation processes are extremely important to the chemical industry, especially in the manufacturing of food, pharmaceutical, and fine chemical products. This work addresses three main topics: first, systematic decision-making between rival gas phase adsorption processes for the same separation problem; second, process development for liquid phase simulated moving bed chromatography (SMB); third, accelerated startup for SMB units. All of the work in this thesis uses model-based optimization to answer complicated questions about process selection, process development, and control of transient operation. It is shown in this thesis that there is a trade-off between productivity and product recovery in the gaseous separation of enantiomers using SMB and pressure swing adsorption (PSA). These processes are considered as rivals for the same separation problem and it is found that each process has a particular advantage that may be exploited depending on the production goals and economics. The processes are compared on a fair basis of equal capitol investment and the same multi-objective optimization problem is solved with equal constraints on the operating parameters. Secondly, this thesis demonstrates by experiment a systematic algorithm for SMB process development that utilizes dynamic optimization, transient experimental data, and parameter estimation to arrive at optimal operating conditions for a new separation problem in a matter of hours. Comparatively, the conventional process development for SMB relies on careful system characterization using single-column experiments, and manual tuning of operating parameters, that may take days and weeks. The optimal operating conditions that are found by this new method ensure both high purity constraints and optimal productivity are satisfied. The proposed algorithm proceeds until the SMB process is optimized without manual tuning. In some case studies, it is shown with both linear and nonlinear isotherm systems that the optimal performance can be reached in only two changes of operating conditions following the proposed algorithm. Finally, it is shown experimentally that the startup time for a real SMB unit is significantly reduced by solving model-based startup optimization problems using the SMB model developed from the proposed algorithm. The startup acceleration with purity constraints is shown to be successful at reducing the startup time by about 44%, and it is confirmed that the product purities are maintained during the operation. Significant cost savings in terms of decreased processing time and increased average product concentration can be attained using a relatively simple startup acceleration strategy.

Continuous Biomanufacturing

Continuous Biomanufacturing Book
Author : Ganapathy Subramanian
Publisher : John Wiley & Sons
Release : 2017-09-12
ISBN : 3527699910
Language : En, Es, Fr & De

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Book Description :

This is the most comprehensive treatise of this topic available, providing invaluable information on the technological and economic benefits to be gained from implementing continuous processes in the biopharmaceutical industry. Top experts from industry and academia cover the latest technical developments in the field, describing the use of single-use technologies alongside perfusion production platforms and downstream operations. Special emphasis is given to process control and monitoring, including such topics as 'quality by design' and automation. The book is supplemented by case studies that highlight the enormous potential of continuous manufacturing for biopharmaceutical production facilities.

Modeling of Process Intensification

Modeling of Process Intensification Book
Author : Frerich Keil
Publisher : John Wiley & Sons
Release : 2007-04-09
ISBN : 3527311432
Language : En, Es, Fr & De

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Book Description :

Combining the knowledge involved in process engineering and process modeling, this title covers modeling methods applicable to process intensification.

Separation and Purification Technologies in Biorefineries

Separation and Purification Technologies in Biorefineries Book
Author : Shri Ramaswamy,Hua-Jiang Huang,Bandaru V. Ramarao
Publisher : John Wiley & Sons
Release : 2013-02-04
ISBN : 111849346X
Language : En, Es, Fr & De

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Book Description :

Separation and purification processes play a critical role in biorefineries and their optimal selection, design and operation to maximise product yields and improve overall process efficiency. Separations and purifications are necessary for upstream processes as well as in maximising and improving product recovery in downstream processes. These processes account for a significant fraction of the total capital and operating costs and also are highly energy intensive. Consequently, a better understanding of separation and purification processes, current and possible alternative and novel advanced methods is essential for achieving the overall techno-economic feasibility and commercial success of sustainable biorefineries. This book presents a comprehensive overview focused specifically on the present state, future challenges and opportunities for separation and purification methods and technologies in biorefineries. Topics covered include: Equilibrium Separations: Distillation, liquid-liquid extraction and supercritical fluid extraction. Affinity-Based Separations: Adsorption, ion exchange, and simulated moving bed technologies. Membrane Based Separations: Microfiltration, ultrafiltration and diafiltration, nanofiltration, membrane pervaporation, and membrane distillation. Solid-liquid Separations: Conventional filtration and solid-liquid extraction. Hybrid/Integrated Reaction-Separation Systems: Membrane bioreactors, extractive fermentation, reactive distillation and reactive absorption. For each of these processes, the fundamental principles and design aspects are presented, followed by a detailed discussion and specific examples of applications in biorefineries. Each chapter also considers the market needs, industrial challenges, future opportunities, and economic importance of the separation and purification methods. The book concludes with a series of detailed case studies including cellulosic bioethanol production, extraction of algae oil from microalgae, and production of biopolymers. Separation and Purification Technologies in Biorefineries is an essential resource for scientists and engineers, as well as researchers and academics working in the broader conventional and emerging bio-based products industry, including biomaterials, biochemicals, biofuels and bioenergy.

Preparative Chromatography

Preparative Chromatography Book
Author : H. Schmidt-Traub
Publisher : John Wiley & Sons
Release : 2006-03-06
ISBN : 3527605908
Language : En, Es, Fr & De

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Book Description :

This interdisciplinary approach combines the chemistry and engineering involved to describe the conception and improvement of chromatographic processes. The book covers recent developments in preparative chromatographic processes for the separation of "smaller" molecules using standard laboratory equipment as well as the detailed conception of industrial chemical plants. Following an introductory section on the history of chromatography, the current state of research and the design of chromatographic processes, the book goes on to define the general terminology. There then follow sections on solid materials and packed columns process concepts. Final chapters on modeling and determination of model parameters, the design and optimization of preparative chromatographic processes and chromatographic reactors allow for the optimum selection of chromatographic systems. Essential for chemists and engineers working in the chemicals and pharmaceutical industries as well as for food technologies, due to the interdisciplinary nature of these processes.

Advances in Chromatography Volume 57

Advances in Chromatography  Volume 57 Book
Author : Nelu Grinberg,Peter W. Carr
Publisher : CRC Press
Release : 2020-08-05
ISBN : 1000062015
Language : En, Es, Fr & De

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Book Description :

For more than five decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to date information on a wide range of developments in chromatographic methods and applications. The clear presentation of topics and vivid illustrations for which this series has become known makes the material accessible and engaging to analytical, biochemical, organic, polymer, and pharmaceutical chemists at all levels of technical skill. This volume considers the achievements and legacy of Lloyd R. Snider in separation science and analytical chemistry. Key Features: • Provides a historical perspective of the evolution of SMB technology together with a theoretical analysis of the most relevant underlying phenomena. • Presents a brief survey of the polar columns suitable for HILIC separations and pays special attention to the role of the mobile phase in RP and HILIC modes. • Describes recent strategies of method development in Kosmotropic chromatography. • Surveys the many approaches to avert the effects of temperature in reversed-phase liquid chromatographic separations. • Reviews separation of isotopic compounds by HPLC in relation to the advances of columns and stationary phases.