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Signal Transduction In Physiology Pathophysiology And Drug Discovery

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Signal Transduction in the Cardiovascular System in Health and Disease

Signal Transduction in the Cardiovascular System in Health and Disease Book
Author : Ashok K. Srivastava,Madhu B. Anand-Srivastava
Publisher : Springer
Release : 2014-10-31
ISBN : 9781489998569
Language : En, Es, Fr & De

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Book Description :

Signal Transduction in Cardiovascular System Health and Disease highlights the major contributions of different signaling systems in modulating normal cardiovascular functions and how a perturbation in these signaling events leads to abnormal cell functions and cardiovascular disorders. This title is volume 3 in the new Springer series, Advances in Biochemistry in Health and Disease.

Signal Transduction in the Cardiovascular System in Health and Disease

Signal Transduction in the Cardiovascular System in Health and Disease Book
Author : Ashok K. Srivastava,Madhu B. Anand-Srivastava
Publisher : Springer Science & Business Media
Release : 2008-09-20
ISBN : 0387095527
Language : En, Es, Fr & De

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Book Description :

Signal Transduction in Cardiovascular System Health and Disease highlights the major contributions of different signaling systems in modulating normal cardiovascular functions and how a perturbation in these signaling events leads to abnormal cell functions and cardiovascular disorders. This title is volume 3 in the new Springer series, Advances in Biochemistry in Health and Disease.

Signal Transduction in the Cardiovascular System in Health and Disease

Signal Transduction in the Cardiovascular System in Health and Disease Book
Author : Ashok K. Srivastava,Madhu B. Anand-Srivastava
Publisher : Springer
Release : 2008-09-20
ISBN : 9780387095523
Language : En, Es, Fr & De

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Book Description :

Signal Transduction in Cardiovascular System Health and Disease highlights the major contributions of different signaling systems in modulating normal cardiovascular functions and how a perturbation in these signaling events leads to abnormal cell functions and cardiovascular disorders. This title is volume 3 in the new Springer series, Advances in Biochemistry in Health and Disease.

Tau Rings and Wreath Product Representations

Tau Rings and Wreath Product Representations Book
Author : Peter Hoffman
Publisher : Springer
Release : 2006-11-15
ISBN : 3540348603
Language : En, Es, Fr & De

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Book Description :

Signal Transduction in Cardiovascular System in Health and Disease Madhu B. Anand- Srivastava and Ashok K. Srivastava This book has addressed the contributions of several key signal transduction pathways which are central to our understanding of cardiovascular physiology and pathophysiology. Aberrations in these signaling events have been suggested to be involved in a host of cardiovascular pathologies, such as cardiac arrhythmias, congenital heart failure and hypertension. All the chapters have been written by well known leaders in the fields, which cover a wide range of intracellular events that regulate various aspects of cardiovascular functions. This book will be of interest to both basic as well as clinical scientists seeking to understand the molecular basis of cardiovascular diseases, and also to those interested in defining targets for cardiovascular pharmacotherapy. About the Authors Dr. Madhu B. Anand-Srivastava is a Professor, Department of Physiology, and a member of the Group de recherche sur le système nerveux autonome, University of Montréal. In 1990, she received a prestigious Scientist Award from Medical Research Council of Canada and in 2004, she was bestowed with the Vincenzo Panagia Distinguished Lecturer award from the Institute of Cardiovascular Sciences of the University of Manitoba, Winnipeg. She is an internationally recognized expert in the area of G-protein and natriuretic peptide receptor-C signaling, and has made significant contributions in defining the role of Gia proteins in the pathogenesis of hypertension. She has published more than 125 papers in refereed journals and edited 3 books in the area of G-proteins, hypertension and NPR-C receptor and cell signaling, and has been invited to several National and International conferences and academic institutions to present her work. Dr. Anand-Srivastava has served or is currently on different committees of the Canadian Institutes of Health Research and Heart and Stroke Foundation of Canada, and is also on the editorial boards of several scientific publications, including the Journal of Molecular and Cellular Cardiology and Molecular and Cellular Biochemistry. She has also organized several National and International conferences on cell signaling in cardiovascular system. Dr. Ashok K. Srivastava is a Professor at the Department of Medicine, Université de Montréal, and Head of the Laboratory of Cell Signaling at the Research Center of the Centre hospitalier de l'Université de Montréal (CHUM). He has over 100 publications in fields of insulin, vasoactive peptide and redox signaling, and cardiovascular complications. He has served or is serving as a guest editor of many journals such as Antioxidant and Redox Signaling, Canadian Journal of Physiology and Pharmacology, Cell Biochemistry and Biophysics and Molecular and Cellular Biochemistry, and is currently a member of the editorial boards of Advances in Biochemistry in Health and Disease and Recent Patents on Endocrine, Metabolic and Immune Drug Discovery. Dr. Srivastava is also on the grant review panels of the Canadian Institutes of Health Research, the Heart and Stroke Foundation of Canada and the National Institutes of Health. He has also organized several International symposia and workshops on Second Messengers and cell signaling.

RGS Protein Physiology and Pathophysiology

RGS Protein Physiology and Pathophysiology Book
Author : Anonim
Publisher : Academic Press
Release : 2015-06-23
ISBN : 0128029544
Language : En, Es, Fr & De

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Book Description :

RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics. Brings together information on the current state of the RGS protein field Contains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertaking Gives particular emphasis to the ways these discoveries inform healthcare and drug discovery

Receptor Receptor Interactions

Receptor Receptor Interactions Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2013-10-18
ISBN : 0124104703
Language : En, Es, Fr & De

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Book Description :

This new volume of Methods in Cell Biology looks at receptor-receptor interactions, with sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes. With cutting-edge material, this comprehensive collection is intended to guide researchers of receptor-receptor interactions for years to come. Covers sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes Chapters are written by experts in the field Cutting-edge material

Pulmonary Vasculature Redox Signaling in Health and Disease

Pulmonary Vasculature Redox Signaling in Health and Disease Book
Author : Yong-Xiao Wang
Publisher : Springer
Release : 2017-10-18
ISBN : 3319632450
Language : En, Es, Fr & De

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Book Description :

The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field. The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others.

Surface and Interfacial Aspects of Cell Adhesion

Surface and Interfacial Aspects of Cell Adhesion Book
Author : Alain Carré,Kash L. Mittal
Publisher : CRC Press
Release : 2011-01-19
ISBN : 9004190783
Language : En, Es, Fr & De

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Book Description :

Cell adhesion comes into play in almost all domains of life. The range of situations in which it occurs, involving organisms, living tissues, microorganisms or single cells, is endless. Cell adhesion is involved in the binding of a cell to a surface, extracellular matrix, or another cell using cell adhesion molecules. It is crucial in the formation and maintenance of coherent multicellular structures. Cell surface adhesion molecules (integrins, for example) which transmit information from the extracellular matrix to the cell play vital roles in numerous cellular processes. Some of these include: cell growth, differentiation, embryogenesis, immune cell transmigration and response, and cancer metastasis. Also cell adhesion is involved in most of pathological situations. This book is divided into four parts as follows: Part 1: Fundamentals of Cell Adhesion; Part 2: Methods to Study Cell Adhesion; Part 3: Surface Treatments to Control Cell Adhesion and Behavior; and Part 4: Cell Adhesion in Medicine and Therapy. A bountiful information is covered in this book which represents the cumulative wisdom of many world-renowned researchers( physicists, materials scientists, chemists and biologists) engaged in unraveling the mechanisms of cell adhesion and how to mitigate or control it. It quite patent from the topics covered in this book that the subject of cell adhesion is truly interdisciplinary. This book should be of great interest and value to anyone interested in cell adhesion which is vitally important to human life.

Drug Discovery and Evaluation Pharmacological Assays

Drug Discovery and Evaluation  Pharmacological Assays Book
Author : Hans Vogel
Publisher : Springer Science & Business Media
Release : 2007-10-30
ISBN : 3540714200
Language : En, Es, Fr & De

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Book Description :

The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.

Advances in Bionanotechnology Research and Application 2011 Edition

Advances in Bionanotechnology Research and Application  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464921350
Language : En, Es, Fr & De

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Book Description :

Advances in Bionanotechnology Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Bionanotechnology. The editors have built Advances in Bionanotechnology Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bionanotechnology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Bionanotechnology Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Experimental Biology and Medicine

Experimental Biology and Medicine Book
Author : Anonim
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Experimental Biology and Medicine book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Classification of instructional programs 2000 edition

Classification of instructional programs 2000 edition Book
Author : Anonim
Publisher : DIANE Publishing
Release : 2022-01-22
ISBN : 1428925724
Language : En, Es, Fr & De

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Book Description :

Download Classification of instructional programs 2000 edition book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Regenerative Medicine Technology

Regenerative Medicine Technology Book
Author : Sean V. Murphy,Anthony Atala
Publisher : CRC Press
Release : 2016-11-30
ISBN : 1315354152
Language : En, Es, Fr & De

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Book Description :

Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery. This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.

Heart Physiology and Pathophysiology

Heart Physiology and Pathophysiology Book
Author : Yoshihisa Kurachi,Andre Terzic,Michael V. Cohen
Publisher : Elsevier
Release : 2000-10-09
ISBN : 0080533884
Language : En, Es, Fr & De

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Book Description :

Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students. Key Features * The most comprehensive book available on this topic * Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology * Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology * Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology

Metallosurfactants

Metallosurfactants Book
Author : Surinder K. Mehta,Ravneet Kaur
Publisher : John Wiley & Sons
Release : 2022-04-04
ISBN : 3527348689
Language : En, Es, Fr & De

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Book Description :

Metallosurfactants Provides up-to-date coverage of the synthesis, properties, and applications of metallosurfactants Metallosurfactants: From Fundamentals to Catalytic and Biomedical Applications is a thorough introduction to amphiphilic compounds that allow to incorporate metal ions in the surfactant system. This comprehensive reference and guide describes the fundamentals of metal surfactant complexes, highlights recent advances in the field, and explores current and future applications and research areas. Gradually progressing from basic to advanced topics, the authors first explain the classification and characterization of metallosurfactants before delving into more complex concepts and various catalytic, sensing, and biomedical applications. The book begins with coverage of the synthesis of metallosurfactants and their surface, interfacial, and aggregation behavior. Subsequent chapters discuss applications of metallosurfactants in areas such as drug delivery, molecular machines, transfection, nanoparticle synthesis, and carbon monoxide-releasing molecules (CORMs). Other topics include the use of metallosurfactants as catalysts in organic reactions, and as anticancer and antimicrobial agents in drug delivery and formulation. This unique reference Provides an overview of the structure-function relationship, synthesis methods, and characterization of metallosurfactants Reviews current trends in metallosurfactant development and research Examines the use of metallosurfactants in a wide range of reactions, including esterolytic reactions and hydrogen generation Discusses advanced applications of metallosurfactants, e.g. as nanoreactors for nanoparticle synthesis, non-viral transfection vectors, and sensors Metallosurfactants: From Fundamentals to Catalytic and Biomedical Applications is an excellent introduction to the growing field of metallosurfactant chemistry as well as a concise, highly useful reference for researchers and scientists in both academia and industry.

Biased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology  Pharmacology and Therapeutics Book
Author : Brian J Arey
Publisher : Elsevier
Release : 2014-06-05
ISBN : 0124115071
Language : En, Es, Fr & De

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Book Description :

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

Progress in Drug Research Fortschritte der Arzneimittelforschung Progr s des recherches pharmaceutiques

Progress in Drug Research   Fortschritte der Arzneimittelforschung   Progr  s des recherches pharmaceutiques Book
Author : E. Jucker
Publisher : Birkhäuser
Release : 2013-03-08
ISBN : 3034871503
Language : En, Es, Fr & De

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Book Description :

Volume 41 of "Progress in Orug Research" contains eight reviews and the various indexes which facilitate its use and establish the con nection with the previous volumes. The articles in this volume deal with teratogenesis; nephrotoxicity; bacterial resistance to P. lactam antibiotics; eradication of diseases by vaccination; chirality and drug design; endogenous digitalis-like factors; erythropoietin; and sero tonin (5HT)-antagonists. 3 All these articles give an excellent overview of the respective fields of research. In the 33 years that POR has existed, the Editor has enjoyed the valu able help and advice of many colleagues. Readers, the authors of the reviews, and last but not least, the reviewers have all contributed greatly to the success of this series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series. So far, it has been the Editors intention to help disseminate informa tion on the vast domain of drug research, and to provide the reader with a tool with which to keep abreast of the latest developments and trends. The reviews in POR are useful to the non-specialists, who can obtain an overview of a particular field of research in a relatively short time. The specialist readers of POR will appreciate the reviews' comprehensive bibliographies, and, in addition, they may even get fresh impulses for their own research.

Biomedical Index to PHS supported Research pt A Subject access A H

Biomedical Index to PHS supported Research  pt  A  Subject access A H Book
Author : Anonim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomedical Index to PHS supported Research pt A Subject access A H book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Medical Biochemistry E Book

Medical Biochemistry E Book Book
Author : John W Baynes,Marek H. Dominiczak
Publisher : Elsevier Health Sciences
Release : 2018-01-03
ISBN : 0702073008
Language : En, Es, Fr & De

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Book Description :

Now fully revised, this acclaimed textbook efficiently links basic biochemistry with the day-to-day practice of medicine. You will learn basic science concepts and see them illustrated by clinical cases that describe patients you will likely encounter in your clinical training. You will also learn about the use of laboratory tests to diagnose and monitor the most important conditions. Brought to you in a thorough yet accessible manner, this new edition of Medical Biochemistry highlights the latest developments in regulatory and molecular biology, signal transduction, biochemistry and biomarkers of chronic disease, and bioinformatics and the ‘–omics’. It highlights the most important global medical issues: diabetes mellitus, obesity and malnutrition, cancer and atherosclerotic cardiovascular disease, and addresses the role of nutrition and exercise in medicine. Featuring a team of expert contributors that includes investigators involved in cutting-edge research as well as experienced clinicians, this book offers a unique combination of research and clinical practice tailored to today’s integrated courses. Read organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused ones addressing the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancer

Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis

Targeted Intracellular Drug Delivery by Receptor Mediated Endocytosis Book
Author : Padma V. Devarajan,Prajakta Dandekar,Anisha A. D'Souza
Publisher : Springer Nature
Release : 2019-11-09
ISBN : 3030291685
Language : En, Es, Fr & De

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Book Description :

This book elaborates on drug delivery targeting via intracellular delivery, specifically through the Receptor Mediated Endocytosis (RME) approach, due to the involvement of cellular receptors in various grave diseases. Targeted delivery relies on two basic approaches, passive and active targeting. While passive targeting approaches have shown great promise, the improved selectivity achieved with active targeting approaches has resulted in significantly higher efficacy. Interestingly there are numerous strategies for active targeting, many of which are already highlighted in , Targeted Drug Delivery: Concepts and Applications. Nevertheless an exciting and practical strategy for active targeting, which could enable high intracellular delivery, is through exploitation of RME. Cells in the body express receptors to enable various physiological and biochemical processes. As a result, many of these receptors are overexpressed in pathological conditions, or newer receptors expressed due to defective cellular functioning. RME is based on exploitation of such receptors to achieve intracellular delivery. While targeted delivery can have manifold applications, in this book we focus on two major and challenging therapeutic areas; i) Cancer and ii) Infectious Diseases. Targeted Intracellular Drug Delivery by Receptor Medicated Endocytosis discusses the major receptors that are useful for targeted delivery for these afflictions. A major section of this book is dedicated to details regarding their occurrence and location, the recognition domain of the receptor, structure activity relationship of substrate /ligand for selective binding, ligands explored, antagonists for ligand binding and relevance of these aspects for therapy of cancer and infectious diseases. These facets are elucidated with the help of specific examples from academic research and also emphasize commercial products, wherever relevant. In vitro cellular models relied on for assessing receptor mediated cellular targeting and in vivo models depicting clinical efficacy are focused on in a separate section. Finally, we briefly discuss the regulatory and toxicity issues that may be associated specifically with the RME approach of intracellular drug delivery.