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Signal Transduction In Physiology Pathophysiology And Drug Discovery

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Biased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology  Pharmacology and Therapeutics Book
Author : Brian J Arey
Publisher : Elsevier
Release : 2014-06-05
ISBN : 0124115071
Language : En, Es, Fr & De

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Book Description :

Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

Signal Transduction in the Cardiovascular System in Health and Disease

Signal Transduction in the Cardiovascular System in Health and Disease Book
Author : Ashok K. Srivastava,Madhu B. Anand-Srivastava
Publisher : Springer
Release : 2014-10-31
ISBN : 9781489998569
Language : En, Es, Fr & De

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Book Description :

Signal Transduction in Cardiovascular System Health and Disease highlights the major contributions of different signaling systems in modulating normal cardiovascular functions and how a perturbation in these signaling events leads to abnormal cell functions and cardiovascular disorders. This title is volume 3 in the new Springer series, Advances in Biochemistry in Health and Disease.

Signal Transduction in the Cardiovascular System in Health and Disease

Signal Transduction in the Cardiovascular System in Health and Disease Book
Author : Ashok K. Srivastava,Madhu B. Anand-Srivastava
Publisher : Springer Science & Business Media
Release : 2008-09-20
ISBN : 0387095527
Language : En, Es, Fr & De

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Book Description :

Signal Transduction in Cardiovascular System Health and Disease highlights the major contributions of different signaling systems in modulating normal cardiovascular functions and how a perturbation in these signaling events leads to abnormal cell functions and cardiovascular disorders. This title is volume 3 in the new Springer series, Advances in Biochemistry in Health and Disease.

RGS Protein Physiology and Pathophysiology

RGS Protein Physiology and Pathophysiology Book
Author : Anonim
Publisher : Academic Press
Release : 2015-06-23
ISBN : 0128029544
Language : En, Es, Fr & De

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Book Description :

RGS Protein Physiology and Pathophysiology describes the current, state-of-the-art research occurring in the laboratories of leaders in the RGS protein field that utilize genetic mouse models to interrogate the function of RGS proteins in vivo. Each chapter describes the elucidated role of a specific RGS protein or family of RGS proteins in normal physiology and/or disease with particular emphasis on how these discoveries inform healthcare and drug discovery. The work is a timely reference as drugs targeting G protein coupled receptors represent 40% of currently marketed therapeutics. Brings together information on the current state of the RGS protein field Contains comprehensive descriptions of the known pathophysiological and physiological functions of RGS proteins, the first such undertaking Gives particular emphasis to the ways these discoveries inform healthcare and drug discovery

Receptor Receptor Interactions

Receptor Receptor Interactions Book
Author : P. Michael Conn
Publisher : Academic Press
Release : 2013-10-18
ISBN : 0124104703
Language : En, Es, Fr & De

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Book Description :

This new volume of Methods in Cell Biology looks at receptor-receptor interactions, with sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes. With cutting-edge material, this comprehensive collection is intended to guide researchers of receptor-receptor interactions for years to come. Covers sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes Chapters are written by experts in the field Cutting-edge material

Pulmonary Vasculature Redox Signaling in Health and Disease

Pulmonary Vasculature Redox Signaling in Health and Disease Book
Author : Yong-Xiao Wang
Publisher : Springer
Release : 2017-10-18
ISBN : 3319632450
Language : En, Es, Fr & De

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Book Description :

The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field. The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others.

Targeting Trafficking in Drug Development

Targeting Trafficking in Drug Development Book
Author : Alfredo Ulloa-Aguirre,Ya-Xiong Tao
Publisher : Springer
Release : 2018-04-18
ISBN : 3319741640
Language : En, Es, Fr & De

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Book Description :

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System

Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System Book
Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2011-07-05
ISBN : 0309212243
Language : En, Es, Fr & De

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Book Description :

Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.

Heart Physiology and Pathophysiology

Heart Physiology and Pathophysiology Book
Author : Yoshihisa Kurachi,Andre Terzic,Michael V. Cohen
Publisher : Elsevier
Release : 2000-10-09
ISBN : 0080533884
Language : En, Es, Fr & De

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Book Description :

Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students. Key Features * The most comprehensive book available on this topic * Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology * Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology * Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology

Surface and Interfacial Aspects of Cell Adhesion

Surface and Interfacial Aspects of Cell Adhesion Book
Author : Alain Carré,Kash L. Mittal
Publisher : CRC Press
Release : 2011-01-19
ISBN : 9004190783
Language : En, Es, Fr & De

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Book Description :

Cell adhesion comes into play in almost all domains of life. The range of situations in which it occurs, involving organisms, living tissues, microorganisms or single cells, is endless. Cell adhesion is involved in the binding of a cell to a surface, extracellular matrix, or another cell using cell adhesion molecules. It is crucial in the formation and maintenance of coherent multicellular structures. Cell surface adhesion molecules (integrins, for example) which transmit information from the extracellular matrix to the cell play vital roles in numerous cellular processes. Some of these include: cell growth, differentiation, embryogenesis, immune cell transmigration and response, and cancer metastasis. Also cell adhesion is involved in most of pathological situations. This book is divided into four parts as follows: Part 1: Fundamentals of Cell Adhesion; Part 2: Methods to Study Cell Adhesion; Part 3: Surface Treatments to Control Cell Adhesion and Behavior; and Part 4: Cell Adhesion in Medicine and Therapy. A bountiful information is covered in this book which represents the cumulative wisdom of many world-renowned researchers( physicists, materials scientists, chemists and biologists) engaged in unraveling the mechanisms of cell adhesion and how to mitigate or control it. It quite patent from the topics covered in this book that the subject of cell adhesion is truly interdisciplinary. This book should be of great interest and value to anyone interested in cell adhesion which is vitally important to human life.

Advances in Bionanotechnology Research and Application 2011 Edition

Advances in Bionanotechnology Research and Application  2011 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464921350
Language : En, Es, Fr & De

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Book Description :

Advances in Bionanotechnology Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Bionanotechnology. The editors have built Advances in Bionanotechnology Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bionanotechnology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Bionanotechnology Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Experimental Biology and Medicine

Experimental Biology and Medicine Book
Author : Anonim
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Experimental Biology and Medicine book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neuromorphic Olfaction

Neuromorphic Olfaction Book
Author : Krishna C. Persaud,Santiago Marco,Agustin Gutierrez-Galvez
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1439871728
Language : En, Es, Fr & De

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Book Description :

Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)—a challenging and innovative European-funded project—introduce novel computing paradigms and biomimetic artifacts for chemical sensing. The implications of these findings are relevant to a wide audience, including researchers in artifical olfaction, neuroscientists, physiologists, and scientists working with chemical sensors. Developing neuromorphic olfaction from conceptual points of view to practical applications, this cross-disciplinary book examines: The biological components of vertebrate and invertebrate chemical sensing systems The early coding pathways in the biological olfactory system, showing how nonspecific receptor populations may have significant advantages in encoding odor intensity as well as odor identity The redundancy and the massive convergence of the olfactory receptor neurons to the olfactory bulb A neuromorphic approach to artificial olfaction in robots Reactive and cognitive search strategies for olfactory robots The implementation of a computational model of the mammalian olfactory system The book’s primary focus is on translating aspects of olfaction into computationally practical algorithms. These algorithms can help us understand the underlying behavior of the chemical senses in biological systems. They can also be translated into practical applications, such as robotic navigation and systems for uniquely detecting chemical species in a complex background.

Classification of instructional programs 2000 edition

Classification of instructional programs 2000 edition Book
Author : Anonim
Publisher : DIANE Publishing
Release : 2023-02-06
ISBN : 1428925724
Language : En, Es, Fr & De

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Book Description :

Download Classification of instructional programs 2000 edition book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Signal Transduction in Cancer

Signal Transduction in Cancer Book
Author : David A. Frank
Publisher : Springer Science & Business Media
Release : 2006-04-18
ISBN : 0306481588
Language : En, Es, Fr & De

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Book Description :

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Emerging Applications Perspectives and Discoveries in Cardiovascular Research

Emerging Applications  Perspectives  and Discoveries in Cardiovascular Research Book
Author : Malhotra, Ashim,Soni, Shivani
Publisher : IGI Global
Release : 2017-01-25
ISBN : 1522520937
Language : En, Es, Fr & De

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Book Description :

Scientific developments in recent years have led to significant strides and advancements within the medical field. By integrating these findings into medical practice, optimal healthcare can be delivered to the public. Emerging Applications, Perspectives, and Discoveries in Cardiovascular Research is a comprehensive reference source for the latest academic material on the exploration of cardiovascular diseases and provides an interdisciplinary examination of novel developments and applications for cardiovascular sciences. Highlighting a range of diverse topics, such as pharmacology, pathophysiology, and alternative medicine, this book is ideally designed for researchers, professionals, practitioners, graduate students, and academics interested in the latest medical advancements.

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research Book
Author : Anonim
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomedical Index to PHS supported Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Regenerative Medicine Technology

Regenerative Medicine Technology Book
Author : Sean V. Murphy,Anthony Atala
Publisher : CRC Press
Release : 2016-11-30
ISBN : 1315354152
Language : En, Es, Fr & De

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Book Description :

Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery. This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.

Medical Biochemistry E Book

Medical Biochemistry   E Book Book
Author : John W. Baynes,Marek H. Dominiczak
Publisher : Elsevier Health Sciences
Release : 2022-07-16
ISBN : 0323834515
Language : En, Es, Fr & De

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Book Description :

Written by carefully selected global experts, practicing physicians, and educators in the various sub-disciplines of biochemistry, Medical Biochemistry, 6th Edition, offers a unique combination of research and clinical practice tailored to today's integrated courses. Covering clinically relevant topics in greater detail than other texts, this outstanding resource provides a strong overview of traditional areas in medical biochemistry along with state-of-the-art coverage of today’s latest developments. You’ll learn basic science concepts alongside clinical cases that describe patients likely to be encountered in clinical training, as well as how to use laboratory tests to diagnose and monitor the most important conditions. Thorough yet accessible, this clinically focused text is useful from medical school to clinical practice. Features a strong clinical orientation, emphasizing the relevance of biochemistry to the daily practice of medicine. Highlights the latest developments in regulatory and molecular biology, signal transduction, age-related chronic disease, epigenetics, and bioinformatics and the “-omics, as well as important global medical issues such as diabetes mellitus, obesity and malnutrition, cancer and atherosclerotic cardiovascular disease, and nutrition and exercise. Emphasizes clinical evaluation, maintenance of good health, and disease prevention, as well as translational medicine and the diagnosis and treatment of disease. Contains organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused chapters on the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancer. Includes clear, colorful icons and illustrations that help you easily navigate the text and understand the material. Provides online features such as challenging “Active Learning questions for independent study, relevant websites that reinforce or supplement chapter content, 150+ multiple-choice and USMLE-style questions, a quick-reference glossary, additional images and case studies, references to current literature, and more.

Zinc Signaling in Physiology and Pathogenesis

Zinc Signaling in Physiology and Pathogenesis Book
Author : Toshiyuki Fukada,Taiho Kambe
Publisher : MDPI
Release : 2018-05-04
ISBN : 3038428213
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue "Zinc Signaling in Physiology and Pathogenesis" that was published in IJMS