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Sialic Acids And Sialoglycoconjugates In The Biology Of Life Health And Disease

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Sialic Acids and Sialoglycoconjugates in the Biology of Life Health and Disease

Sialic Acids and Sialoglycoconjugates in the Biology of Life  Health and Disease Book
Author : Shyamasree Ghosh
Publisher : Academic Press
Release : 2020-01-08
ISBN : 0128161272
Language : En, Es, Fr & De

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Book Description :

Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease enables the reader to understand the role of sialylation as a post translational modification. The book provides insights on the latest knowledge in the field of sialoglycobiology. Sialic acids as terminal residues of oligosaccharide chains play crucial roles in several cellular recognition events. Synthesized post translationally, they play an important role in recognition, signaling, immunological response and cell-cell interaction. Improper sialylations have been associated with several diseases including cancer. In the post genomics and proteomics era, sialoglybiology has become more and more important in deciphering health and disease conditions. Discusses the sialic acids and their role in different diseases (other than cancer) Provides an understanding of sialylations as post translational modifications (PTM) Demonstrates the impact sialylation has on infectious diseases, the autoimmune system and health Gives insights on the importance of sialic acid biology through animal models

Organelle and Molecular Targeting

Organelle and Molecular Targeting Book
Author : Lara Scheherazade Milane,Mansoor M. Amiji
Publisher : CRC Press
Release : 2021-12-29
ISBN : 1000505936
Language : En, Es, Fr & De

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Book Description :

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.

Immunogenetics A Molecular and Clinical Overview

Immunogenetics  A Molecular and Clinical Overview Book
Author : Muneeb U. Rehman,Azher Arafah,Md. Niamat Ali,Shafat Ali
Publisher : Academic Press
Release : 2021-11-30
ISBN : 0323903355
Language : En, Es, Fr & De

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Book Description :

A Molecular Approach to Immunogenetics, Immunogenetics: A Molecular and Clinical Overview, Volume One provides readers with an exclusive, updated overview on the scientific knowledge, achievements and findings in the field of immunogenetics. The book presents readily available, updated information on the molecular and clinical aspects of immunogenetics, from origin and development to clinical applications and future prospects. The breadth of information goes from basics to developments, clinical applications and future prospects. The book's most attractive attribute is its academic and clinical amalgamation that covers both the theoretical and practical aspects of immunogenetics. An additional feature of the book is a special chapter on viral genetics that covers COVID-19. Above all, the book contains chapters that discuss immunogenetics in relation to pharmaco-genomics and immune-toxicology. Contains exclusive information about research on immunogenetics from around the globe Includes minute and recent details that will be the prerequisite requirement for any researcher who wants to work on immunogenetics and its applications Comes fully-equipped with pictures, illustrations and tables that deliver information in a meticulous manner

Stem Cells

Stem Cells Book
Author : Suchandra Chowdhury,Shyamasree Ghosh
Publisher : Springer Nature
Release : 2021-07-24
ISBN : 9811616388
Language : En, Es, Fr & De

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Book Description :

Stem cells hold great promise for cell therapy, tissue engineering, regenerative medicine and pharmaceutical and biotechnological applications. This book highlights the potency of stem cells, their property of self-renewal and their ability to differentiate into different cell lineages. It further describes the different markers to identify stem cells, sources, methods of isolation, culture including 2D, 3D and beyond and their cryopreservation. This is among the first books to discuss glycosylation and sialylation in stem cells. Chapters describe application of stem cells in regenerative medicine and therapy, and highlight their application in cancer therapy and spinal cord injury. The book talks about the important patents on stem cells. The book also highlights the plant stem cells, discussing their pluoripotent nature, role in organ regeneration after injury, specific stem cell niches, that signals to block differentiation studied in plants shoot, root, and vascular meristems, differentiation of plant stem cell, transcriptional regulation and epigenetic modification of plant stem cells. This book is exciting and cutting edge. It will be of great interest to doctors, students and researchers in the field of regenerative medicine, cancer , biotechnology and plant sciences.

Essentials of Glycobiology

Essentials of Glycobiology Book
Author : Ajit Varki,Maarten J. Chrispeels
Publisher : CSHL Press
Release : 1999
ISBN : 9780879696818
Language : En, Es, Fr & De

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Book Description :

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Edible Birds Nest Chemical Composition and Potential Health Efficacy and Risks

Edible Birds Nest   Chemical Composition and Potential Health Efficacy and Risks Book
Author : Karl Tsim,Ting Hun Lee,Geng Li,Gallant Chan
Publisher : Frontiers Media SA
Release : 2022-02-23
ISBN : 2889744914
Language : En, Es, Fr & De

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Book Description :

Download Edible Birds Nest Chemical Composition and Potential Health Efficacy and Risks book written by Karl Tsim,Ting Hun Lee,Geng Li,Gallant Chan, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Green Synthesis Characterization and Applications of Nanoparticles

Green Synthesis  Characterization and Applications of Nanoparticles Book
Author : Ashutosh Kumar Shukla,Siavash Iravani
Publisher : Elsevier
Release : 2018-11-26
ISBN : 0081025807
Language : En, Es, Fr & De

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Book Description :

Green Synthesis, Characterization and Applications of Nanoparticles shows how eco-friendly nanoparticles are engineered and used. In particular, metal nanoparticles, metal oxide nanoparticles and other categories of nanoparticles are discussed. The book outlines a range of methodologies and explores the appropriate use of each. Characterization methods include spectroscopic, microscopic and diffraction methods, but magnetic resonance methods are also included as they can be used to understand the mechanism of nanoparticle synthesis using organisms. Applications covered include targeted drug delivery, water purification and hydrogen generation. This is an important research resource for those wishing to learn more about how eco-efficient nanoparticles can best be used. Theoretical details and mathematical derivations are kept to a necessary minimum to suit the need of interdisciplinary audiences and those who may be relatively new to the field. Explores recent trends in growth, characterization, properties and applications of nanoparticles Gives readers an understanding on how they are applied through the use of case studies and examples Assesses the advantages and disadvantages of a variety of synthesis and characterization techniques for green nanoparticles in different situations

Lectin in Host Defense Against Microbial Infections

Lectin in Host Defense Against Microbial Infections Book
Author : Shie-Liang Hsieh
Publisher : Springer Nature
Release : 2020-03-09
ISBN : 9811515808
Language : En, Es, Fr & De

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Book Description :

This book systemically presents the latest research on lectins, covering all the major topics in the field, including the heterocomplex of lectins and Toll-like receptors, protective versus pathogenic functions in connection with microbial infections, and novel strategies for enhancing host immunity against infectious diseases caused by viruses, bacteria, and fungi. Lectins are a large group of glycan-binding proteins that recognize diverse glycan and non-glycan structures expressed on prokaryotic and eukaryotic cells, and are vital to cell-cell interactions, the attachment of microbes to host cells, and the recognition and activation of immune responses to exogenous and endogenous danger signals. The composition and structure of microbes are complex and include numerous ‘pathogen-associated molecular patterns’ or ‘damage-associated molecular patterns’. As such, microbes’ interactions with immune cells activate multiple innate immunity receptors and produce distinct inflammatory reactions, which can be protective to contain microbial invasion, or pathogenic to cause tissue damage and shock syndrome in the host. The book shares lessons learned from state-of-the art research in this field, highlights the latest discoveries, and provides insightful discussions on lectin-mediated inflammatory reactions, while also outlining future research directions.

Bioactive Components in Milk and Dairy Products

Bioactive Components in Milk and Dairy Products Book
Author : Young W. Park
Publisher : John Wiley & Sons
Release : 2009-06-29
ISBN : 0813819822
Language : En, Es, Fr & De

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Book Description :

Although bioactive compounds in milk and dairy products have been extensively studied during the last few decades – especially in human and bovine milks and some dairy products – very few publications on this topic are available, especially in other dairy species’ milk and their processed dairy products. Also, little is available in the areas of bioactive and nutraceutical compounds in bovine and human milks, while books on other mammalian species are non-existent. Bioactive Components in Milk and Dairy Products extensively covers the bioactive components in milk and dairy products of many dairy species, including cows, goats, buffalo, sheep, horse, camel, and other minor species. Park has assembled a group of internationally reputed scientists in the forefront of functional milk and dairy products, food science and technology as contributors to this unique book. Coverage for each of the various dairy species includes: bioactive proteins and peptides; bioactive lipid components; oligosaccharides; growth factors; and other minor bioactive compounds, such as minerals, vitamins, hormones and nucleotides, etc. Bioactive components are discussed for manufactured dairy products, such as caseins, caseinates, and cheeses; yogurt products; koumiss and kefir; and whey products. Aimed at food scientists, food technologists, dairy manufacturers, nutritionists, nutraceutical and functional foods specialists, allergy specialists, biotechnologists, medical and health professionals, and upper level students and faculty in dairy and food sciences and nutrition, Bioactive Components in Milk and Dairy Products is an important resource for those who are seeking nutritional, health, and therapeutic values or product technology information on milk and dairy products from the dairy cow and speciesbeyond. Areas featured are: Unique coverage of bioactive compounds in milks of the dairy cow and minor species, including goat, sheep, buffalo, camel, and mare Identifies bioactive components and their analytical isolation methods in manufactured dairy products, such as caseins, caseinates, and cheeses; yogurt products; koumiss and kefir; and whey products Essential for professionals as well as biotechnology researchers specializing in functional foods, nutraceuticals, probiotics, and prebiotics Contributed chapters from a team of world-renowned expert scientists

Food Proteins and Bioactive Peptides

Food Proteins and Bioactive Peptides Book
Author : Maria Hayes
Publisher : MDPI
Release : 2018-06-01
ISBN : 3038428639
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue "Food Proteins and Bioactive Peptides" that was published in Foods

New Insights Into Retinal Degenerative Diseases

New Insights Into Retinal Degenerative Diseases Book
Author : Robert E. Anderson,Matthew M. LaVail,Joe G. Hollyfield
Publisher : Springer Science & Business Media
Release : 2001-12-31
ISBN : 9780306466793
Language : En, Es, Fr & De

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Book Description :

Since 1984, we have organized satellite symposia on retinal degenerations that are held in conjunction with the biennial International Congress of Eye Research. The timing and location of our Retinal Degeneration Symposia have allowed scientists and clinicians from around the world to convene and present their exciting new findings. The symposia have been arranged to allow ample time for discussions and one-on-one interactions in a relaxed atmosphere, where international friendships and collaborations could be established. The IXth International Symposium on Retinal Degeneration was held on October 9-14, 2000 in Durango, Colorado and was attended by over 100 scientists from six continents. This book contains many of their presentations. Several events of note occurred at this meeting. First, thanks to the generous support of the Foundation Fighting Blindness, we were able to sponsor the travel of 11 young scientists from six countries. Most of them have contributed chapters to this volume. The response to the travel program was so overwhelming that we will make it regular feature of our meeting. This will allow other bright, young investigators to be introduced to the world experts who study retinal degenerations. Second, about 40% of the scientists who attended this meeting were there for the first time. We believe that this indicates a growing interest in retinal degeneration research and ensures that new talent will be attracted to this important area of investigation. The symposium received support from several organizations.

Milk and Dairy Products in Human Nutrition

Milk and Dairy Products in Human Nutrition Book
Author : Young W. Park,George F. W. Haenlein
Publisher : John Wiley & Sons
Release : 2013-04-09
ISBN : 1118534204
Language : En, Es, Fr & De

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Book Description :

Milk is nature’s most complete food, and dairy productsare considered to be the most nutritious foods of all. Thetraditional view of the role of milk has been greatly expanded inrecent years beyond the horizon of nutritional subsistence ofinfants: it is now recognized to be more than a source of nutrientsfor the healthy growth of children and nourishment of adulthumans. Alongside its major proteins (casein and whey), milk containsbiologically active compounds, which have important physiologicaland biochemical functions and significant impacts upon humanmetabolism, nutrition and health. Many of these compounds have beenproven to have beneficial effects on human nutrition andhealth. This comprehensive reference is the first to address such a widerange of topics related to milk production and human health,including: mammary secretion, production, sanitation, qualitystandards and chemistry, as well as nutrition, milk allergies,lactose intolerance, and the bioactive and therapeutic compoundsfound in milk. In addition to cow’s milk, the book alsocovers the milk of non-bovine dairy species which is of economicimportance around the world. The Editors have assembled a team of internationally renownedexperts to contribute to this exhaustive volume which will beessential reading for dairy scientists, nutritionists, foodscientists, allergy specialists and health professionals.

Physiological Basis of Aging and Geriatrics

Physiological Basis of Aging and Geriatrics Book
Author : Paola S. Timiras
Publisher : CRC Press
Release : 2007-08-16
ISBN : 1420007092
Language : En, Es, Fr & De

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Book Description :

Extensively revised and updated to reflect the current state of knowledge in the study of aging, this Fourth Edition offers a complete profile of the aging process at all levels, from molecules and cells to demography and evolution. Written by international experts in current basic and clinical aging research, this text includes aspects of individu

Biochemistry and Cell Biology of Ageing Part I Biomedical Science

Biochemistry and Cell Biology of Ageing  Part I Biomedical Science Book
Author : J. Robin Harris,Viktor I. Korolchuk
Publisher : Springer
Release : 2019-02-18
ISBN : 9811328358
Language : En, Es, Fr & De

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Book Description :

This new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.

Antibody Fc

Antibody Fc  Book
Author : Margaret Ackerman,Falk Nimmerjahn
Publisher : Academic Press
Release : 2013-08-06
ISBN : 0123948185
Language : En, Es, Fr & De

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Book Description :

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system

Biology of the Sialic Acids

Biology of the Sialic Acids Book
Author : A. Rosenberg
Publisher : Springer Science & Business Media
Release : 1995-07-31
ISBN : 9780306449741
Language : En, Es, Fr & De

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Book Description :

Abraham Rosenberg assembles the groundbreaking work of preeminent international scientists to provide the most current, state-of-the-art presentation of research in siabiology. This concise volume examines the historical development of the field and reviews current knowledge on the genetic, immunologic, oncologic, neurodevelopmental, pathogenic, and cell regulatory properties of sialic acid. Outstanding features of this work include exhaustive reference material and detailed information tables.

Animal Lectins Form Function and Clinical Applications

Animal Lectins  Form  Function and Clinical Applications Book
Author : G. S. Gupta
Publisher : Springer Science & Business Media
Release : 2012-11-13
ISBN : 3709110653
Language : En, Es, Fr & De

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Book Description :

Animal Lectins: Form, Function and Clinical Applications presents up-to-date knowledge of animal lectins. Detailed descriptions on biological activities, tissue and/or subcellular distribution, molecular structure, gene organization, possible functions, clinical applications, lectin-ligand interactions and their intervention for therapeutic purposes are provided. The recently discovered C-type lectins as well as further novel super-families of this group of molecules are described in detail. Furthermore, the clinical significance of animal lectins in inflammatory diseases, defects of immune defense and autoimmunity are described and their application as drugs and therapeutic targets is discussed. With the increasing interest in lectins in biomedical research and their therapeutic applications, this book on animal lectins and associated proteins is a must have for researchers in the area.

Plant Lectins

Plant Lectins Book
Author : A. Pusztai
Publisher : Cambridge University Press
Release : 1991
ISBN : 0521328241
Language : En, Es, Fr & De

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Book Description :

Lectins are natural products found mainly in plants. Their properties are examined in this book.

Synthesis and Characterization of Glycosides

Synthesis and Characterization of Glycosides Book
Author : Marco Brito-Arias
Publisher : Springer
Release : 2016-06-03
ISBN : 3319323105
Language : En, Es, Fr & De

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Book Description :

This second edition is a short and comprehensive study on the best known approaches for preparing the main types of glycosides. It covers synthetic pathways of challenging glycosides known as antiviral or antineoplastic drugs, and synthetic substrates used for enzymatic detection, including those used for detection of gene markers in plant biotechnology. The author pays special attention to the structural characterization of glycosides and provides the basic tools for the structural assignment through NMR, X-Ray and mass spectra techniques. The book also covers strategies for preparation of antiviral and antineoplastic drugs included in a drug design course.

Chemical Glycobiology

Chemical Glycobiology Book
Author : Randall Halcomb,American Chemical Society. Meeting,American Chemical Society. Division of Carbohydrate Chemistry,Peng George Wang
Publisher : Amer Chemical Society
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Although the process of understanding the biological functions of carbohydrates has developed slowly due to the lack of efficient approaches in obtaining and studying these structures, in the past two decades, remarkable advances have been made in chemical and chemoenzymatic synthesis of carbohydrates and glycoconjugates. The material presented in this volume shows how a better understanding of the structure and the function of carbohydrate-containing bacterial cell wall has revealed that carbohydrate-containing molecules and carbohydrate-like structures are useful as carbohydrate-based anti-microbial vaccines, anti-viral drugs, anti-coagulants, anti-cancer drugs, and potential anti-cancer vaccines. In addition, the text explores the important roles that novel glycolipids have been found to play in the immune system. Metabolic engineering has demonstrated itself as an efficient approach to probe and manipulate biological functions of carbohydrates both in vitro and in vivo. Automated glycan analysis, carbohydrate microarrays, and novel high-throughput screening methods have hastened the analysis and the understanding of carbohydrate-containing structures. Polypeptide-based glycopolymers have been developed for the study of multivalent binding events of carbohydrates and proteins. This text presents examples of these recent developments in using chemical techniques and tools to study glycobiology. This is an excellent reference book for upper-division undergraduate students, graduate students, and researchers who are interested in carbohydrate-related medicinal chemistry, organic chemistry, biology, and chemical biology.