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Sex And Gender Differences In Alzheimers Disease

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Sex and Gender Differences in Alzheimer s Disease

Sex and Gender Differences in Alzheimer s Disease Book
Author : Maria Teresa Ferretti,Annemarie Schumacher Dimech,Antonella Santuccione Chadha
Publisher : Academic Press
Release : 2021-08-05
ISBN : 012819345X
Language : En, Es, Fr & De

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Book Description :

Sex and Gender Differences in Alzheimer’s Disease: The Women's Brain Project offers, for the first time, a critical overview of the evidence documenting sex and gender differences in AD neurobiology, biomarkers, clinical presentation, treatment, clinical trials and their outcomes and impact on caregivers. This knowledge is crucial for clinical development, digital health solutions, and as social and psychological support to AD families. Presents comprehensive and critical reviews of sex differences in Alzheimer’s disease Combines the knowledge and points-of-view of neuroscientists, medical doctors, psychologists and AI experts for a 360 degree view on the topic and its possible implications Edited by the Women’s Brain Project, the leading NGO in the field of sex differences in neuroscience

Sex and Gender Differences in Alzheimer s Disease

Sex and Gender Differences in Alzheimer s Disease Book
Author : Maria Teresa Ferretti,Annemarie Schumacher Dimech,Antonella Santuccione Chadha
Publisher : Elsevier
Release : 2021-08-19
ISBN : 0128193441
Language : En, Es, Fr & De

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Book Description :

Sex and Gender Differences in Alzheimer's Disease: The Women's Brain Project offers, for the first time, a critical overview of the evidence documenting sex and gender differences in AD neurobiology, biomarkers, clinical presentation, treatment, clinical trials and their outcomes and impact on caregivers. This knowledge is crucial for clinical development, digital health solutions, and as social and psychological support to AD families. Presents comprehensive and critical reviews of sex differences in Alzheimer's disease Combines the knowledge and points-of-view of neuroscientists, medical doctors, psychologists and AI experts for a 360 degree view on the topic and its possible implications Edited by the Women's Brain Project, the leading NGO in the field of sex differences in neuroscience

Cognitive Sex Differences in Normal and Pathological Aging

Cognitive Sex Differences in Normal and Pathological Aging Book
Author : Anonim
Publisher : Unknown
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cognitive Sex Differences in Normal and Pathological Aging book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Sex Differences in Physiology

Sex Differences in Physiology Book
Author : Gretchen Neigh,Megan Mitzelfelt
Publisher : Academic Press
Release : 2016-05-10
ISBN : 0128026081
Language : En, Es, Fr & De

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Book Description :

Sex Differences in Physiology is an all-encompassing reference that details basic science research into sex differences in all physiological fields. It includes scientific discoveries concerning sex differences in cardiovascular, respiratory, renal, gastrointestinal, and musculoskeletal physiology. In addition, coverage of the development, endocrinology, neurophysiology, immunity, and metabolism is included, making this important reference a resource that will meet the needs of investigators interested in incorporating sex differences into their research programs, while also providing clinicians with the basis for providing the best sex-based medical treatment options available. Provides a sweeping, organ-by-organ review of currently observed sex differences in animal models and human disease Explains how sex differences influence physiology and disease Provides the critical knowledge on sex differences for better understanding of prevention and treatment of diseases

Sex Differences in Alzheimer s Disease Pathologies and Symptoms

Sex Differences in Alzheimer s Disease Pathologies and Symptoms Book
Author : Miu Amaya
Publisher : CreateSpace
Release : 2013-12
ISBN : 9781494785758
Language : En, Es, Fr & De

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Book Description :

A novel hypothesis describing brain circuitries and synaptic plasticity variations between genders thus leading to susceptibilities of Alzheimer's disease in females. A clear, concise and current exploration into sex differences in the pathogenesis and presentation of Alzheimer's disease during their respective presymptomatic, early symptomatic and late stages. Effects of emotions, trauma and stress impacts upon the brain environment are also explored, along with gender brain dimorphism, cardiovascular and disease risk predisposing one to Alzheimer's disease onsets. Prevention and treatments are further discussed.

Sex Differences in Neurology and Psychiatry

Sex Differences in Neurology and Psychiatry Book
Author : Anonim
Publisher : Elsevier
Release : 2020-09-30
ISBN : 0444641246
Language : En, Es, Fr & De

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Book Description :

Sex Differences in Neurology and Psychiatry, Volume 175, addresses this important issue by viewing major neurological and psychiatric conditions through the lens of sexual dimorphism, providing an entirely novel approach to understanding vulnerability factors, as well as potential new treatment strategies in several common neuropsychiatric disorders. The handbook comprises four major sections: (1) Introduction to sex differences in neuroanatomy and neurophysiology, (2) Description of the impact of genetic, epigenetic, sex hormonal and other environmental effects on cerebral sex dimorphism, (3) Review of sex differences in neurologic disorders, and (4) Review of sex differences in psychiatric disorders. Explores sex differences in human neuroanatomy and neurophysiology Offers a pathway toward a gender-specific treatment of neurologic and psychiatric disorders Provides an overview of the genetics of sex hormones, human brain structure, and function, as well as the epigenetics, environment and social context

Sex and Gender Aspects in Clinical Medicine

Sex and Gender Aspects in Clinical Medicine Book
Author : Sabine Oertelt-Prigione,Vera Regitz-Zagrosek
Publisher : Springer Science & Business Media
Release : 2011-11-15
ISBN : 9780857298324
Language : En, Es, Fr & De

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Book Description :

This book is a concise, easy to read professional text with a focus on practical aspects. All chapters include tables on sex/gender differences in symptoms and management and a series of suggestions to the novice in the field. Chapters are specialty-specific. The focus is not on women’s health, but the presentation of differences in clinical symptoms, management and outcomes in women and men. Gender Medicine strives to employ the knowledge about these differences to improve diagnosis, better understand pathogenesis and advance patient-oriented therapy.

An Investigation Into the Role of Iron Copper and Gender in a Transgenic Mouse Model of Alzheimer s Disease

An Investigation Into the Role of Iron  Copper  and Gender in a Transgenic Mouse Model of Alzheimer s Disease Book
Author : Caitlin Marie Groeber
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Age-related diseases are more prevalent due to increasing longevity, with this comes increasing dietary supplementation to maintain a healthy lifestyle. Alzheimer's disease (AD) is the primary cause of dementia and the sixth leading cause of death in the United States. Previous studies of transgenic AD mouse models have found that long-term dietary supplementation of zinc (Zn) impairs spatial memory, while copper (Cu) shows remediation of this impairment. Iron (Fe) shows a similar impairment in these tasks, but the potential effects of remediation by Cu have not been studied. In humans, being female is a risk factor for cognitive impairment in AD, therefore it is important to examine gender differences in AD. To examine the effect and interaction of Fe and Cu on cognitive function, male and female transgenic (Tg)CRND8 and wild-type (Wt) mice were administered enhanced drinking water for 5 months: Fe (10ppm FeNO3), Fe+Cu (10ppm FeNO3 + 0.2ppm CuNO3), Cu (0.2ppm CuNO3), and LW. Assessments included the novel object recognition task (NOR; discrimination task) and the Morris water maze (MWM; spatial memory). Histological analysis was conducted on the brain to examine the plaque load, metal content, ceruloplasmin levels, and amyloid levels in these mice. In NOR, Tg Fe+Cu-treated animals showed decreased object recognition compared to Tg LW animals, while Wt Fe+Cu-treated animals performed well. In MWM, only the Fe+Cu-treated animals did not have a decrease in latency and were significantly different from the LW, who were the fastest. Even in normal animals, high levels of Fe+Cu showed negative effects. CRND8 animals were impaired on all assessed measures of learning and memory (NOR and MWM) compared to Wt animals. Females and males perform differently in behavioral tasks dependent upon the type of task. The level of NOR differed between male and female Wt mice, but not Tg. This indicates that female Wt mice are better at this task than male Wt mice; however, once these animals develop signs of AD the difference between the sexes disappears. In contrast, in MWM, males swam faster to the platform than females, and spent less time around the edge of the pool. This was the most pronounced in Tg males compared to Tg females. Sex differences were seen across the varying behavioral tasks of learning and memory, emphasizing the importance of studying both sexes. Plaque load analysis indicated that Fe+Cu-treated and LW Tg animals had the highest plaque burden, while Cu-treated animals had the lowest plaque burden. Females had more plaque area than males, with female Fe+Cu animals showing the highest plaque load of all animals. This measurement of plaque burden may be not be a predictive measure of NOR, but it may be predictive of MWM and it may be due to location of plaque accumulation. The reason may be due to the brain regions required for the completion of the task; MWM depends on the hippocampus, while the hippocampus and entorhinal cortex are required for NOR. Fe+Cu animals had more severe impairments on discrimination and spatial tasks than LW, Fe, or Cu groups alone, which is in contrast to previous findings where Cu remediates impairments caused by Zn. This study showed that it is the balance of metals, not just an overload of a specific metal, which cause harm or not.

Hormones Gender and the Aging Brain

Hormones  Gender and the Aging Brain Book
Author : Mary F. Morrison
Publisher : Cambridge University Press
Release : 2000-05-04
ISBN : 9781139426459
Language : En, Es, Fr & De

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Book Description :

The significance of hormone action in psychiatry has been long studied, now including the psychiatric effects of hormones on the aging process. This clinical reference addresses the hormonal basis of mental disorders in older people. Hormones influence a wide range of states and conditions, from pain tolerance and anorexia to attention, mood, immunity, cardiovascular and cognitive function, schizophrenia and Alzheimer's disease. Written by an eminent team of psychiatrists, psychologists, geriatricians and neuropharmacologists, this book brings together established information and findings in four sections: • An overview of the basic science of neurosteroids • Sex difference and the roles that cortisol, thyroid hormone, and the sex steroids estrogen, progesterone, dehydroepiandrosterone and testosterone play in common mental disorders and pain sensitivity • Psychoneuroimmunology in relation to age • Sex differences and hormones in psychotropic drug metabolism in the elderly.

Sexuality and Dementia

Sexuality and Dementia Book
Author : Douglas Wornell, MD
Publisher : Demos Medical Publishing
Release : 2013-12-13
ISBN : 161705190X
Language : En, Es, Fr & De

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Book Description :

The First Comprehensive Guide for Dealing with Dementia's Effect on Sex, Intimacy, and Relationships It is common for a person with dementia to exhibit inappropriate and uncharacteristic sexual behavior, including promiscuity, verbal abuse, aggression, grabbing, exhibitionism, and jealous paranoia. This behavior puts a strain on spouses and partners, as well as other loved ones and caregivers. Now, for the first time, esteemed geriatric neuropsychiatrist, Douglas Wornell, MD, provides essential information and practical solutions to cope with these troubling and often embarrassing actions by providing: information on the contributing role of medication (and overmedication), both prescribed and over-the-counter ways to handle inappropriate behaviors that respect the person with dementia, their loved ones, and their caregivers recommendations to minimize the legal risk and potential for injury in long-term care facilities personal stories of the many ways couples have chosen to deal with the changes to their sexual dynamic and relationship

How Sex and Gender Impact Clinical Practice

How Sex and Gender Impact Clinical Practice Book
Author : Marjorie R. Jenkins,Connie B. Newman
Publisher : Academic Press
Release : 2020-12-02
ISBN : 0128167505
Language : En, Es, Fr & De

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Book Description :

How Sex and Gender Impact Clinical Practice: An Evidence-Based Guide to Patient Care enables primary care clinicians by providing a framework to understand differences and better care for patients in their practice. Each chapter covers a subspecialty in medicine and discusses the influence of sex hormones on disease, along with sex and gender-based differences in clinical presentation, physical examination, laboratory results, treatment regimens, comorbidities and prognosis. Illustrative case examples and practical practice points help each chapter come alive. A special chapter on communication differences between men and women assists clinicians in their conversations with patients. This book fills an important need by applying years of research findings to sex and gender specific medical care and demonstrating that an individualized approach to patient care will lead to improved detection, treatment and prevention of disease. Explores the effects of sex and gender on disease presentation, treatment and prognosis, and how these differences influence clinical decision-making Provides practical guidance that helps clinicians implement a more individualized approach to patient care Contains information on diseases in each major specialty, as well as chapters on communication, pharmacology and public health challenges

Women s Mental Health An Issue of Psychiatric Clinics of North America E Book

Women s Mental Health  An Issue of Psychiatric Clinics of North America  E Book Book
Author : Susan G. Kornstein,Anita H. Clayton
Publisher : Elsevier Health Sciences
Release : 2017-05-11
ISBN : 0323530303
Language : En, Es, Fr & De

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Book Description :

This issue of Psychiatric Clinics, edited by Drs. Susan G. Kornstein and Anita H. Clayton, will cover a wide arrange of topics in the field of Women’s Mental Health. Topics covered in this issue include, but are not limited to Psychopharmacology in Pregnancy and Breastfeeding; Binge Eating Disorder; Substance Abuse in Women; Dementia in Women; Neuroendocrine Networks and Functionality; Lesbian and Transgender Mental Health; and Reproductive Rights and Women’s Mental Health, among others.

Gender The Basics

Gender  The Basics Book
Author : Hilary M. Lips
Publisher : Routledge
Release : 2013-10-23
ISBN : 1134682034
Language : En, Es, Fr & De

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Book Description :

Gender: The Basics is an engaging introduction which examines the impact of cultural, historical, biological, psychological and economic forces on qualities which have come to be defined as masculine or feminine. Highlighting that there is far more to gender than biological sex, it takes a global perspective to examine the interaction between gender and a wide range of topics including: • Relationships, intimacy and concepts of sexuality • The workplace and labour markets • Gender related violence and war • Public health, poverty and development • The ageing process Supporting theory with examples and case studies from a variety of contexts, suggestions for further reading and a detailed glossary, this text is an essential read for anyone approaching the study of gender for the first time.

The Female Brain

The Female Brain Book
Author : Cynthia L. Darlington
Publisher : CRC Press
Release : 2010-12-12
ISBN : 143983248X
Language : En, Es, Fr & De

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Book Description :

The first edition of The Female Brain laid the groundwork for gaining a better understanding of the female brain, examining the evidence for structural and functional differences between the brains of males and females. Addressing a wealth of new research, the second edition continues in this vein, leading readers through the basic principles of anatomy and physiology and on to the complex behavioral functions which constitute the workings of the normal and abnormal female brain. Examines Questions about Structural and Functional Differences The book addresses the question of structural and functional differences between the female brain and the male brain. Are there differences? How good is the evidence? Where do the differences lie? Are there differences in the neuroanatomy of females, and if so, where? Do females and males process information differently, and if so, how? The author puts the relative lack of information on the female brain into historical perspective and reviews empirical evidence relevant to the different aspects of brain structure and function. She elucidates laterality, the functional asymmetry of the brain, the left brain-right brain distinctions, and how they differ between females and males. A Clear Presentation and Evaluation of Medical and Scientific Evidence Filled with rigorous scientific analysis in an easily accessible format and detailed explanatory diagrams, the book systematically develops the topic from anatomy to behavior. It draws on current research to explain why men and women behave differently and why these differences should be exploited when designing research and clinical studies.

Sex and Gender Differences in Pharmacology

Sex and Gender Differences in Pharmacology Book
Author : Vera Regitz-Zagrosek
Publisher : Springer Science & Business Media
Release : 2012-10-02
ISBN : 3642307264
Language : En, Es, Fr & De

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Book Description :

This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

Sex Hormones in Neurodegenerative Processes and Diseases

Sex Hormones in Neurodegenerative Processes and Diseases Book
Author : Gorazd Drevensek
Publisher : BoD – Books on Demand
Release : 2018-05-02
ISBN : 1789230144
Language : En, Es, Fr & De

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Book Description :

The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.

Older Men s Lives

Older Men s Lives Book
Author : Edward H. Thompson
Publisher : SAGE
Release : 1994-06-07
ISBN : 0803950810
Language : En, Es, Fr & De

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Book Description :

In this multidisciplinary portrait of men and their concerns in later life, the contributors use both a life course and gendered perspective to point out that the image and self-image of men are continually reconstructed throughout the life cycle. Issues examined include: the position of older men in society and the changes wrought in their status and roles over time; men's relationships to spouse, children, grandchildren and friends; and policy implications.

Behavioral Pharmacology of the Cholinergic System

Behavioral Pharmacology of the Cholinergic System Book
Author : Mohammed Shoaib,Tanya L. Wallace
Publisher : Springer Nature
Release : 2020-08-29
ISBN : 3030560139
Language : En, Es, Fr & De

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Book Description :

The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.

Bridging Gaps Between Sex and Gender in Neurosciences

Bridging Gaps Between Sex and Gender in Neurosciences Book
Author : Annie Duchesne,Meng-Chuan Lai,Gillian Einstein,Belinda Pletzer,Marina A. Pavlova
Publisher : Frontiers Media SA
Release : 2020-07-14
ISBN : 2889638650
Language : En, Es, Fr & De

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Book Description :

Download Bridging Gaps Between Sex and Gender in Neurosciences book written by Annie Duchesne,Meng-Chuan Lai,Gillian Einstein,Belinda Pletzer,Marina A. Pavlova, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cognitive Sex Differences in Normal and Pathological Aging

Cognitive Sex Differences in Normal and Pathological Aging Book
Author : Paula Kay Shear
Publisher : Unknown
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cognitive Sex Differences in Normal and Pathological Aging book written by Paula Kay Shear, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.