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Sertoli Cell Biology

Sertoli Cell Biology Book
Author : Michael D. Griswold
Publisher : Academic Press
Release : 2014-11-19
ISBN : 012417048X
Language : En, Es, Fr & De

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Book Description :

Sertoli Cell Biology, Second Edition summarizes the progress since the last edition and emphasizes the new information available on Sertoli/germ cell interactions. This information is especially timely since the progress in the past few years has been exceptional and it relates to control of sperm production in vivo and in vitro. Fully revised Written by experts in the field Summarizes 10 years of research Contains clear explanations and summaries Provides a summary of references over the last 10 years

Sertoli Cell Metabolism and Spermatogenesis

Sertoli Cell Metabolism and Spermatogenesis Book
Author : Pedro F. Oliveira,Marco G. Alves
Publisher : Springer
Release : 2015-11-29
ISBN : 3319197916
Language : En, Es, Fr & De

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Book Description :

This book is focused on Sertoli cell physiology and its role in the spermatogenic event. These cells, known as “nurse cells”, are essential for the normal development of germ cells by offering not only physical support and creating an immune-privileged environment, but also for providing nutritional support. The presence of Sertoli cells promotes the establishment of the appropriate microenvironment so that spermatogenesis may occur. Spermatogenesis maintenance in vivo is highly dependent on the metabolic cooperation established between Sertoli cells and developing germ cells. For many years this metabolic cooperation between testicular cells has been disregarded, but recent advances have highlighted the relevance of these processes for male fertility. Thus, the understanding of the functioning and regulation of these metabolic processes is a crucial step to identify key mechanisms associated with Sertoli cell (dys)function and to enlighten their influence on male fertility.

Regulation of Sertoli Cell and Germ Cell Differentiation

Regulation of Sertoli Cell and Germ Cell Differentiation Book
Author : R. Brehm,Klaus Steger
Publisher : Springer Science & Business Media
Release : 2005-12-21
ISBN : 3540294465
Language : En, Es, Fr & De

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Book Description :

Unwanted childlessness affects approximately one in six couples worldwide. - though the exact proportion of the predominant cause of the problem remains controversial, according to the World Health Organization (WHO), in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. Based on these ?gures, the - cidence of male factor infertility in the general population is approximately 7%. The majority of these men, approximately 30%, experience irreversible idiopathic infertility and cannot father children without some form of medical intervention. Male factor infertility, in addition, may be caused by testicular germ cell cancer, which is known to represent the most common cancer among young men, aged 15 to 35 years, in Western industrialized countries. The number of affected men has increased dramatically over the past 50 years. There is now growing evidence that human testicular germ cell cancer originates from fetal germ cells exhibiting an aberrant programme of gene expression, and tumour progression may be favoured by an aberrant Sertoli cell-germ cell communication.

Sertoli Cells and Leydig Cells in Man

Sertoli Cells and Leydig Cells in Man Book
Author : Cornelia Schulze
Publisher : Springer
Release : 1984-09-01
ISBN : 9783540136033
Language : En, Es, Fr & De

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Book Description :

The testis is composed of seminiferous tubules and interstitial tissue. The most important component of the interstitial tissue are the testosterone-producing Leydig cells. The seminiferous tubules contain the successive generations of germ cells, which can only exist in the presence of Sertoli cells. Sertoli cells mediate the effect of testosterone, which is indispensable for the maintenance of spermatogenesis. Consequently, the function of the Sertoli cells depends large lyon the function of the Leydig cells, and a local control mechanism between the two cell systems has been assumed. Sertoli cells are supposed to interfere with the regulation of Leydig cell hormone production (Aoki and Fawcett 1978; Sharpe et al. 1981). Few cell types of the testis have received as much attention in recent years as have the Sertoli cells. While comprehensive data had accumulated concerning the differentiation of germ cells, there was formerly little information available on the influence of Sertoli cells on this process. Only through recently developed methods and experimental approaches could their central role in spermatogene sis be verified. Sertoli cells are the only somatic cells in the seminiferous tubules. Their origin is still disputed (for references see Ritzen et al. 1981). They supposedly stem either from the coelomic epithelium or from mesenchymal cells of the genital ridges. According to Wartenberg (1978) they are derived from a gonadal blas tema containing cells from both the coelomic epithelium and the mesonephros.

Cell Biology of the Testis and Epididymis

Cell Biology of the Testis and Epididymis Book
Author : M.-C. Orgebin-Crist,B. J. Danzo
Publisher : Unknown
Release : 1987
ISBN : 9780897664226
Language : En, Es, Fr & De

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Book Description :

Download Cell Biology of the Testis and Epididymis book written by M.-C. Orgebin-Crist,B. J. Danzo, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cell and Molecular Biology of the Testis

Cell and Molecular Biology of the Testis Book
Author : Des Jardins
Publisher : Oxford University Press, USA
Release : 1993
ISBN : 9780195062694
Language : En, Es, Fr & De

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Book Description :

This book is a comprehensive, multi-authored work on the structure and function of the mammalian testis. The approach emphasizes gene expression, translation and production of specific gene products and the cellular and molecular regulation of these fundamental processes. Rather than provide a global survey of all aspects of male reproduction, this book stresses specific mechanisms that underscore the structure and function of the testis. It explains old and new concepts from a cellular and molecular perspective. This novel approach allows the authors to forge links between cell and molecular biology and well-established aspects of spermatogenesis and steroidogenesis. The result is a well-focused, comprehensive, and synthetic analysis of testicular biology.

The Cell Biology of the Testis

The Cell Biology of the Testis Book
Author : C. Wayne Bardin,Richard J. Sherins
Publisher : Unknown
Release : 1982
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Cell Biology of the Testis book written by C. Wayne Bardin,Richard J. Sherins, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Sertoli Cell Regulation of Leydig Cell Growth and Function

Sertoli Cell Regulation of Leydig Cell Growth and Function Book
Author : John O. Ojeifo
Publisher : Unknown
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Sertoli Cell Regulation of Leydig Cell Growth and Function book written by John O. Ojeifo, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

International Review of Cytology

International Review of Cytology Book
Author : Kwang W. Jeon
Publisher : Elsevier
Release : 2007-05-09
ISBN : 9780080522494
Language : En, Es, Fr & De

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Book Description :

International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume include Cell Proliferation in pathogenesis of Oesophagogastric Lesions in Pigs; Molecular Mechanism of Phase-I and Phase-II Drug-Metabolizing Enzymes: Implications for Detoxification; Effects of Growth Factors on Testicular Morphogenesis; Flagellar Length Control in Chlamydomonas – a Paradigm for Organelle Size Regulation; and Molecular Mechanism and Evolutional Significance of Epithelial-mesenchymal Interactions in the Body- and Tail-Dependent Metamorphic Transformation of Anuran Larval Skin.

Regulation of Testin and Prostaglandin D2 Synthetase Expression in Sertoli Cells

Regulation of Testin and Prostaglandin D2 Synthetase Expression in Sertoli Cells Book
Author : Eileen Teresa Samy
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Regulation of Testin and Prostaglandin D2 Synthetase Expression in Sertoli Cells book written by Eileen Teresa Samy, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular Biology of the Male Reproductive System

Molecular Biology of the Male Reproductive System Book
Author : David de Kretser
Publisher : Elsevier
Release : 2012-12-02
ISBN : 008091764X
Language : En, Es, Fr & De

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Book Description :

Written by experts in their respective fields, this book reviews the expanding knowledge concerning the mechanisms regulating male reproduction at the molecular and cellular levels. It covers the development of the testes and regulatory controls for spermatogenesis and steroidogenesis, and it considers aspects of Sertoli cell function. Areas of emphasis include communication between the various cell types involved in reproduction by hormone and growth factors and the mechanisms by which these factors regulate gene expression. A number of mammalian systems, including humans, are covered. The carefully selected authors provide a clear synopsis of the concepts in each area as well as the latest references, enabling the reader to investigate the topic further. This book is of interest to those seeking an understanding of the regulatory mechanisms in male reproduction and is written for the graduate and postgraduate levels. Key Features * Provides up-to-date reviews of the molecular and cellular biology of male reproduction * Includes chapters on the developmental biology of the testes * Links conventional hormonal control of testicular function with the evolving role of growth factors and proto-oncogenes

Molecular Mechanisms in Spermatogenesis

Molecular Mechanisms in Spermatogenesis Book
Author : C.Y. Cheng
Publisher : Springer Science & Business Media
Release : 2009-10-24
ISBN : 9780387095974
Language : En, Es, Fr & De

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Book Description :

In the past thirty years, significant advances have been made in the field of reproductive biology in unlocking the molecular and biochemical events that regulate spermatogenesis in the mammalian testis. It was possible because of the unprecedented breakthroughs in molecular biology, cell biology, immunology, and biochemistry. In this book entitled, Molecular Mechanisms in Spermatogenesis, a collection of chapters has been included written by colleagues on the latest development in the field using genomic and proteomic approaches to study spermatogenesis, as well as different mechanisms and/or molecules including environmental toxicants and transcription factors that regulate and/or affect spermatogenesis. The book begins with a chapter that provides the basic concept of cellular regulation of spermatogenesis. A few chapters are also dedicated to some of the latest findings on the Sertoli cell cytoskeleton and other molecules (e.g., proteases, adhesion proteins) that regulate spermatogenesis. These chapters contain thought-provoking discussions and concepts which shall be welcomed by investigators in the field. It is obvious that many of these concepts will be updated and some may be amended in the years to come. However, they will serve as a guide and the basis for investigation by scientists in the field.

Cell Biology and Toxicology

Cell Biology and Toxicology Book
Author : Anonim
Publisher : Unknown
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cell Biology and Toxicology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Sertoli Cells

Sertoli Cells Book
Author : Marco G. Alves,Pedro F. Oliveira
Publisher : Humana
Release : 2019-06-06
ISBN : 9781493985432
Language : En, Es, Fr & De

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Book Description :

This detailed volume explores the use of Sertoli cells as models in male reproductive biology or as supporters for other cell types, and it answers the need for standardized protocols for their in vitro culture. Prepared for non-specialists as well as experienced researchers that may be interested in a multidisciplinary approach to study these cells, the book examines these remarkable cells that present some unique features that go far beyond the physical and nutritional support of spermatogenesis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Sertoli Cells: Methods and Protocols serves as a valuable resource for experienced researchers in reproductive biology, particularly andrologists, but also for future investigators and young students starting to study these extraordinary cells.

The Y Chromosome And Male Germ Cell Biology In Health And Diseases

The Y Chromosome And Male Germ Cell Biology In Health And Diseases Book
Author : Chris Yun-fai Lau,Wai-yee Chan
Publisher : World Scientific
Release : 2007-04-16
ISBN : 9814476595
Language : En, Es, Fr & De

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Book Description :

The completion of the human genome and technological advances developed by the Human Genome Project have dramatically changed our understanding of the mechanisms underlying the development and differentiation of male germ cells, and our ability to investigate such mechanisms. This book is a timely document of advances made in the field of male gonad and germ cell research in the postgenomic era.The coverage includes the role of Y chromosome genes in male reproduction, gene expression in spermatogonial stem cells and male germ cells, and the regulation of germ cell genes in reproduction and in germ cell tumors.

International Review of Cell and Molecular Biology

International Review of Cell and Molecular Biology Book
Author : Kwang W. Jeon
Publisher : Academic Press
Release : 2011
ISBN : 0123858593
Language : En, Es, Fr & De

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Book Description :

International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2008: 4.935. * Authored by some of the foremost scientists in the field * Provides up-to-date information and directions for future research * Valuable reference material for advanced undergraduates, graduate students and professional scientists

The Endocrine Regulation of Sertoli Cell Function

The Endocrine Regulation of Sertoli Cell Function Book
Author : Peter Kenneth Nicholls
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The 'nurse' cell of the testis, known as the Sertoli cell, directs testicular differentiation, development and fertility; endocrine signalling upon the Sertoli cell is essential for male fertility. This thesis examines how the Sertoli cell responds to endocrine signalling, particularly the molecular and cellular effects of acute hormone suppression.Using an acute model of FSH and testosterone suppression in rats, this thesis identifies hormonally regulated expression of a class of non-coding RNA, known as micro-RNAs (miRNA) within the Sertoli cell. By analysing the predicted functions of regulated miRNA, a novel role for FSH and testosterone signalling upon the formation of the tubulobulbar complex (TBC) is described. Loss of the TBC function upon hormone suppression likely impedes the removal of adhesive junctions between the Sertoli cell and the spermatid, which may contribute to spermiation failure.To determine the function of systemic activin upon Sertoli cell function, a mouse model with activin A over-expression from a distal site identifies a novel effect of activin signalling upon established adult spermatogenesis. This thesis demonstrates that activin induces a hypospermatogenic phenotype in the mouse testis, with circulating activin concentration found to directly correlate with testis mass. Significantly, activin was shown to regulate BTB function and Sertoli cell maturity in primary cell cultures. As such, activin is the first identified factor capable of re-programming Sertoli cells to an immature, de-differentiated phenotype. These findings transform the traditional view about the nature of 'terminally' differentiated Sertoli cells in non-seasonal breeding animals and implicate Sertoli cell 'de-differentiation' in some forms of infertility and testicular dysgenesis.The findings of this thesis produce a paradigm shift in understanding Sertoli cell biology. Importantly, the data presented offer significant insights into the endocrine regulation of Sertoli cell maturation and function. This is of particular importance to the aetiology of infertility and the development of novel male contraceptive regimes.

Seasonal Spermatogenesis in the Mute Swan Cygnus olor

Seasonal Spermatogenesis in the Mute Swan  Cygnus olor  Book
Author : H. Breucker
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642684602
Language : En, Es, Fr & De

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Book Description :

Of all the classes in the animal kingdom, birds represent the best known. There are in total about 8600 living species, and the systematic study of this class is more or less complete. Extensive observations - to a large extent by amateur ornithologists - with respect to geographical distribution, life cycles, demands on and adaptations to the environment, breeding habits, migration, and so forth have contributed towards basic and more widely relevant knowledge, e. g. , in the areas of ethology, ecology, and evo lution and also in social biology (Hilprecht 1970; Farner and King 1971). Together, all these aspects are affected by the reproductive biology of birds, and studies have therefore been carried out for many years with special emphasis on this subject. How ever, until now this emphasis in avian reproductive biology has been physiological and in particular endocrinological (Murton and Westwood 1977; Roosen-Runge 1977). The morphology of the gonads has been treated in far less detail, and has been confined to a comparatively small number of species, compared with other classes of vertebrates. Reproduction is the section in the life cycle of an animal which is most dependent upon environmental conditions. Reproduction therefore usually takes place at a par ticular time, when stress for the adult animals is at its lowest and the chances of sur vival for the newborn are at their highest, i. e.

Cell Biology

Cell Biology Book
Author : Julio E. Celis
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

V. 1: cell and tissue culture and associated techniques; Primary cultures from embyonic and newborn tissues; Culture of specific cell types; Cell separation techniques; Model systems to study differentiation; cell cycle analysis; Assays of tumorigenicity, invasion, and others; Cytotoxic and cell growth assays; Senescence and apoptosis; Electrophysiological methods; Histocultures and organ cultures; Other cell types and organisms; Viruses; Appendices; v. 2: Organelles and cellular structures; Assays; Antibodies; Immunocytochemistry; Vital staining of cells; v. 3: Light microscopy and contrast generation; Electron microscopy; Intracellular measurments; Cytogenetics and in situ hybridization; transgenic and gene knockouts; v. 4: Transfer of macromelcules and small molecules; Expression systems; Differential gene expression; Proteins; Appendix; List of suppliers; Subject index.

The Process of Spermatogenesis in Animals

The Process of Spermatogenesis in Animals Book
Author : Edward C. Roosen-Runge
Publisher : CUP Archive
Release : 1977
ISBN : 9780521212335
Language : En, Es, Fr & De

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Book Description :

Download The Process of Spermatogenesis in Animals book written by Edward C. Roosen-Runge, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.