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Separation Methods In Drug Synthesis And Purification

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Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification Book
Author : Klara Valko
Publisher : Elsevier
Release : 2020-06-19
ISBN : 0444640711
Language : En, Es, Fr & De

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Book Description :

Separation Methods in Drug Synthesis and Purification, Second Edition, Volume Eight, provides an updated on the analytical techniques used in drug synthesis and purification. Unlike other books on either separation science or drug synthesis, this volume combines the two to explain the basic principles and comparisons of each separation technique. New sections to this volume include enantiomer separation using capillary electrophoresis (CE) and capillary electro- chromatography, the computer simulation of chromatographic separation for accelerating method development, the application of chromatography and capillary electrophoresis used as surrogates for biological processes, and new developments in the established techniques of chromatography and preparative methods. Features descriptions and applications of all separation methods used in the pharmaceutical industry Written by the leading scientists in their respective fields, providing solutions for a wide range of industrial separation problems encountered within the pharmaceutical industry Thoroughly updated with brand new separation science techniques and the latest developments in the established techniques of chromatography

Chirality in Drug Research

Chirality in Drug Research Book
Author : Eric Francotte,Wolfgang Lindner
Publisher : John Wiley & Sons
Release : 2007-09-24
ISBN : 3527608710
Language : En, Es, Fr & De

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Book Description :

Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.

Recent Advances in QSAR Studies

Recent Advances in QSAR Studies Book
Author : Tomasz Puzyn,Jerzy Leszczynski,Mark T. Cronin
Publisher : Springer Science & Business Media
Release : 2010-01-19
ISBN : 9781402097836
Language : En, Es, Fr & De

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Book Description :

This book presents an interdisciplinary overview on the most recent advances in QSAR studies. The first part consists of a comprehensive review of QSAR methodology. The second part highlights the interdisciplinary aspects and new areas of QSAR modelling.

Chiral Separation Methods for Pharmaceutical and Biotechnological Products

Chiral Separation Methods for Pharmaceutical and Biotechnological Products Book
Author : Satinder Ahuja
Publisher : John Wiley & Sons
Release : 2011-03-31
ISBN : 9781118097755
Language : En, Es, Fr & De

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Book Description :

Discusses chiral separations and offers guidance for selectingthe optimum method for desired results Chiral separations represent the most intriguing and, by somemeasures, most difficultseparations of chemical compounds. Thisbook provides researchers and students an under-standing of chiralseparations and offers a convenient route to selecting the bestseparation method, saving considerable time and cost in productdevelopment. Considering chiral separations in the biotechnological andpharmaceutical industries, as well as for food applications, Dr.Ahuja provides insights into a broad range of topics. Opening witha broad overview of chiral separations, regulatory considerationsin drug product development, and basic issues in methoddevelopment, the book: Covers a variety of modern methods such as gas chromatography,high performance liquid chromatography, supercritical fluidchromatography, and capillary electrophoresis Deals with the impact of chirality on the biological activity ofsmall and large molecules Provides detailed information on useful chiral stationary phases(CSPs) for HPLC Includes handy information on selection of an appropriate CSP,including mechanistic studies Offers strategies for fast method development with HPLC, SFC,and CE Discusses preparatory methods utilized in the pharmaceuticalindustry With in-depth discussions of the current state of the field aswell as suggestions to assist future developments, ChiralSeparation Methods for Pharmaceutical and BiotechnologicalProducts is an essential text for laboratory investigators,managers, and regulators who are involved in chiral separations inthe pharmaceutical industry, as well as students preparing forcareers in these fields.

Physico Chemical Methods in Drug Discovery and Development

Physico Chemical Methods in Drug Discovery and Development Book
Author : Zoran Mandic
Publisher : IAPC Publishing
Release : 2012
ISBN : 9535694200
Language : En, Es, Fr & De

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Book Description :

Download Physico Chemical Methods in Drug Discovery and Development book written by Zoran Mandic, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Separation Techniques in Clinical Chemistry

Separation Techniques in Clinical Chemistry Book
Author : Hassan Y. Aboul-Enein
Publisher : CRC Press
Release : 2003-05-28
ISBN : 1135532788
Language : En, Es, Fr & De

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Book Description :

This reference examines innovations in separation science for improved sensitivity and cost-efficiency, increased speed, higher sample throughput and lower solvent consumption in the assessment, evaluation, and validation of emerging drug compounds. It investigates breakthroughs in sample pretreatment, HPLC, mass spectrometry, capillary electrophor

Bioanalytical Separations

Bioanalytical Separations Book
Author : Anonim
Publisher : Elsevier
Release : 2003-09-03
ISBN : 9780080527864
Language : En, Es, Fr & De

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Book Description :

Bioanalytical Separations is volume 4 of the multi-volume series, Handbook of Analytical Separations, providing reviews of analytical separation methods and techniques used for the determination of analytes across a whole range of applications. The theme for this volume is bioanalysis, in this case specifically meaning the analysis of drugs and their metabolites in biological fluids. - Discusses new developments in instrumentation and methods of analyzing drugs and their metabolites in biological fluids - Provides guidance to the different methods, their relative value to the user, and the advantages and pitfalls of their use - Future trends are identified, in terms of the potential impact of new technologies

Chiral Separation Techniques

Chiral Separation Techniques Book
Author : Ganapathy Subramanian
Publisher : John Wiley & Sons
Release : 2008-01-08
ISBN : 352761172X
Language : En, Es, Fr & De

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Book Description :

Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.

Integrated Strategies for Drug Discovery Using Mass Spectrometry

Integrated Strategies for Drug Discovery Using Mass Spectrometry Book
Author : Mike S. Lee
Publisher : John Wiley & Sons
Release : 2005-09-02
ISBN : 0471721026
Language : En, Es, Fr & De

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Book Description :

New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug discovery. The topicsrepresent current industry benchmarks in specific drug discoveryactivities that deal with proteomics, biomarker discovery,metabonomic approaches for toxicity screening, lead identification,compound libraries, quantitative bioanalytical support,biotransformation, reactive metabolite characterization, leadoptimization, pharmaceutical property profiling, sample preparationstrategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry areinterconnected * Discusses the uses and limitations of various types of massspectrometry in various aspects of drug discovery * Prominently features analytical applications that requiretrace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques toaid in the understanding of how and why new methods are now beingemployed to analyze samples

Drug Bioavailability

Drug Bioavailability Book
Author : Han van de Waterbeemd,Hans Lennernäs,Per Artursson
Publisher : John Wiley & Sons
Release : 2006-03-06
ISBN : 3527605150
Language : En, Es, Fr & De

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Book Description :

The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so-called bioavailability. Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer-aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance. Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching.

Separations Chemistry

Separations Chemistry Book
Author : Fedor Macášek,James D. Navratil
Publisher : Xlibris Corporation
Release : 2016-06-06
ISBN : 1514417308
Language : En, Es, Fr & De

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Book Description :

Separation of chemical species is a gate to final success of synthesis and preparation of compounds in pure and defined state. Variability of natural and artificial mixtures to be treated is enormous. Task of chemistry is to separate components of homogeneous mixtures (the gaseous and liquid solutions). The book concentrates on understanding the basic philosophies of both equilibrium and nonequilibrium chemical thermodynamics and engineering performance that lay in principle of separation technique such as distillation, crystallization, centrifugation, sorption, membrane separations, chromatography, and liquid-liquid extraction. Specific phenomena connected with photochemical separation, isotope composition, and radioactivity are discussed as well. The book is written for advanced students of chemistry having the knowledge of physical chemistry. Calculation examples are based on the international system of units. Unique list of over 1,300 full references covers scientific literature of the eighteenth to the twenty-first centuries.

Pharmaceutical Profiling in Drug Discovery for Lead Selection

Pharmaceutical Profiling in Drug Discovery for Lead Selection Book
Author : Ronald Borchardt,Edward Kerns,Christopher Lipinski,Dhrien Thakker,Binghe Wang
Publisher : Springer Science & Business Media
Release : 2005-12-05
ISBN : 9780971176799
Language : En, Es, Fr & De

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Book Description :

This volume focuses on how to increase the efficiency of drug discovery and development. It is written by experienced discovery scientists from diverse disciplines, including chemistry, drug metabolism, and development sciences. The volume details in silico, in vitro, and in vivo tools for prediction, measurement, and application of compound properties to select and improve potential drug candidates.

Physicochemical and Biomimetic Properties in Drug Discovery

Physicochemical and Biomimetic Properties in Drug Discovery Book
Author : Klara Valko
Publisher : John Wiley & Sons
Release : 2013-11-25
ISBN : 1118770323
Language : En, Es, Fr & De

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Book Description :

Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery. This practical guide includes detailed descriptions of state-of-the-art chromatographic techniques and uses real-life examples and models to help medicinal chemists and scientists and advanced graduate students apply measurement data for optimal drug discovery.

Absorption and Drug Development

Absorption and Drug Development Book
Author : Alex Avdeef
Publisher : John Wiley & Sons
Release : 2012-04-11
ISBN : 1118286030
Language : En, Es, Fr & De

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Book Description :

Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates. This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including: Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier Expanded information and methods to support pKa determination New examples explaining the treatment of practically insoluble test compounds Additional case studies demonstrating the use of the latest physicochemical techniques New, revised, and expanded database tables throughout the book Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book. This Second Edition is recommended as a reference for researchers in pharmaceutical R&D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.

Chemometric Methods in Capillary Electrophoresis

Chemometric Methods in Capillary Electrophoresis Book
Author : Grady Hanrahan,Frank A. Gomez
Publisher : John Wiley & Sons
Release : 2009-10-22
ISBN : 9780470530184
Language : En, Es, Fr & De

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Book Description :

Use chemometric techniques to develop optimum separation conditions for capillary electrophoreses For all its advantages, capillary electrophoresis (CE) also carries significant disadvantages for the researcher. Offering a unique blend of information from authors active in a variety of developments of chemometrics in CE, Chemometric Methods in Capillary Electrophoresis presents modern chemometric methods as an alternative to help alleviate the problems commonly encountered during routine analysis and method development. Focusing on current chemometric methods utilized in CE endeavours by research-active experts in the field, the book begins with a thorough introduction to CE and chemometric-related concepts and the need for modern chemometric methods in CE. Part 1 discusses differing types of screening designs and response surface methodology¿in an¿application based format Part 2 includes vital discussion on various exploratory data analysis, prediction, and classification techniques utilized in CE-related studies Part 3 provides practical information on modelling quantitative structure relationships Part 4 explores transformation techniques, in particular fundamental studies and applications of cross-correlation and Hadamard Transform Electrophoresis Showing how chemometric methods are applied in a wide array of applications including biological, medical, pharmaceutical, food, forensic, and environmental science, Chemometric Methods in Capillary Electrophoresis is not only highly significant to capillary electrophoresis-based endeavours, but instructive for investigators active in other areas of separation science who could benefit from its informative content.

Fundamentals of Preparative and Nonlinear Chromatography

Fundamentals of Preparative and Nonlinear Chromatography Book
Author : Georges Guiochon,Dean G. Shirazi,Attila Felinger,Anita M. Katti
Publisher : Academic Press
Release : 2006
ISBN : 0123705371
Language : En, Es, Fr & De

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Book Description :

The second edition of Fundamentals of Preparative and Nonlinear Chromatographyis book that discusses all the physico-chemical issues related to linear and nonlinear chromatography. It summarizes the essential issues involved in thermodynamics (single-component and competitive liquid-solid equilibrium isotherms, influence of the temperature, the pressure, and the mobile phase composition on these isotherms, heterogeneity of the surface of adsorbents), mass transfer kinetics (diffusion through bulk liquids, through particle beds, and through particles, surface diffusion, competitive diffusion), and flow through porous media (pressure drop, permeability, viscosity of mixtures, viscous fingering). It presents the different models used in chromatography (ideal, nonlinear model, linear, nonideal model, equilibrium-dispersive model, transport and transport-dispersive models, general rate model, POR model), their algebraic and numerical solutions, and the practical applications made of these solutions (elution, frontal analysis and displacement chromatography, gradient elution, system peaks). Also discussed are the various processes derived from chromatography, particularly the different modes of recycling, the true and the simulated moving bed separators, including the recent variants of this SMB process. Finally, it describes and illustrates the different methods used for the optimization of the experimental conditions with different objective functions.

Chiral Separations By Liquid Chromatography And Related Technologies

Chiral Separations By Liquid Chromatography And Related Technologies Book
Author : Hassan Y. Aboul-Enein,Imran Ali
Publisher : CRC Press
Release : 2003-06-03
ISBN : 9780203911112
Language : En, Es, Fr & De

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Book Description :

Unique in its systematic and detailed description of the various types, structures, and properties of chiral stationary phases (CSPs) and their preparation, application, and future scope, this volume highlights an assortment of liquid chromatographic approaches, including sub- and super-critical fluid chromatography, capillary electrochromatography

Comprehensive Chemometrics

Comprehensive Chemometrics Book
Author : Steven Brown
Publisher : Elsevier
Release : 2009-03-09
ISBN : 044452701X
Language : En, Es, Fr & De

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Book Description :

Designed to serve as the first point of reference on the subject, Comprehensive Chemometrics presents an integrated summary of the present state of chemical and biochemical data analysis and manipulation. The work covers all major areas ranging from statistics to data acquisition, analysis, and applications. This major reference work provides broad-ranging, validated summaries of the major topics in chemometrics—with chapter introductions and advanced reviews for each area. The level of material is appropriate for graduate students as well as active researchers seeking a ready reference on obtaining and analyzing scientific data. Features the contributions of leading experts from 21 countries, under the guidance of the Editors-in-Chief and a team of specialist Section Editors: L. Buydens; D. Coomans; P. Van Espen; A. De Juan; J.H. Kalivas; B.K. Lavine; R. Leardi; R. Phan-Tan-Luu; L.A. Sarabia; and J. Trygg Examines the merits and limitations of each technique through practical examples and extensive visuals: 368 tables and more than 1,300 illustrations (750 in full color) Integrates coverage of chemical and biological methods, allowing readers to consider and test a range of techniques Consists of 2,200 pages and more than 90 review articles, making it the most comprehensive work of its kind Offers print and online purchase options, the latter of which delivers flexibility, accessibility, and usability through the search tools and other productivity-enhancing features of ScienceDirect