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Self assembling Biomaterials

Self assembling Biomaterials Book
Author : Helena S. Azevedo,Ricardo M. P. da Silva
Publisher : Woodhead Publishing
Release : 2018-04-17
ISBN : 0081020120
Language : En, Es, Fr & De

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Book Description :

Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. Explores both theoretical and practical aspects of self-assembly in biomaterials Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials Examines the use of dynamic self-assembling biomaterials

Engineering Modular Self assembling Biomaterials for Multifunctionality

Engineering Modular Self assembling Biomaterials for Multifunctionality Book
Author : Jangwook Philip Jung
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The objective of this thesis was to design self-assembling biomaterials whose physical and biological properties can be systematically adjusted to modulate cell growth and differentiation. The intended applications of these biomaterials include defined 3D cell culture scaffolds as well as coatings for existing prosthetics. The complex and dynamic nature of extracellular matrices necessitates the precise integration and adjustment of multiple physical, chemical, and biological features within engineered biomaterials, but this has been challenging for previous scaffolds owing to the fact that these features tend not to be adjustable independently. Instead, these properties tend to be conflated and entangled, limiting the ability to systematically engineer scaffolds with multiple components. As a step towards addressing this issue, this thesis describes the development of a modular self-assembling biomaterial system capable of incorporating multiple physical or biological functions into precisely defined biomaterials without affecting other material properties. Three families of different biological and physical functionalities were designed, synthesized, and investigated: those that modulate matrix mechanics, those that mediate cell-matrix binding, and those that can release soluble effector molecules. All materials were based on a short, synthetic, self-assembling peptide sequence, Q11, which formed self-supporting hydrogels in physiological conditions. To independently modulate matrix mechanics, Q11 derivatives were developed possessing chemoselective functional groups that could be polymerized via native chemical ligation. This method produced significantly stiffened gels, which also significantly enhanced endothelial cell proliferation in an independent manner. To develop modular self-assembling ligand-bearing peptides, endothelial cell-interactive ligands, RGDS, REDV, IKVAV, and YIGSR amino acid sequences were added to the N-terminus of Q11 (X-Q11). The incorporation of X-Q11 into hydrogels was quantitative and did not significantly alter stiffness when different ligands were included in the hydrogels. The ligands were physically presented on the surface of fibrils, retained their biological activities, and interacted with cell surface receptors to modulate endothelial cell behaviors. To develop Q11 derivatives capable of releasing soluble effectors, Q11 peptides were synthesized containing a nitric oxide (NO) donor compound. The conjugation efficiency was about 88%, and fibril morphologies were not significantly altered by the NO donor compound, allowing quantitative incorporation of this peptide into Q11 hydrogels. The last stage of the project employed a statistical method, design of experiments, to capitalize upon the modularity of the developed co-assembling matrices, with the purpose of maximizing the growth of endothelial cells on the materials. Through several rounds of multifactorial experimentation, an optimal formulation of multiple peptides was determined, resulting in endothelial cell attachment and proliferation comparable to the native matrix protein, fibronectin. Such a calculation of an optimal formulation would be prohibitively costly, both in terms of time and materials, for conventional biomaterials not constructed in a modular fashion. These results suggested that modular Q11-based self-assembling systems enable facile manipulation of multiple factors, allowing the efficient targeting of a desired response, in this case endothelial cell growth. This approach should allow for the systematic design of biomaterials for a wide range of applications, without relying on ad hoc strategies.

Design of Self assembling Nucleo peptide Hydrogels for Molecular Self assembly Study and Functional Biomaterials Development

Design of Self assembling Nucleo peptide Hydrogels for Molecular Self assembly Study and Functional Biomaterials Development Book
Author : Kiheon Baek
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Self-assembling peptide-based biomaterials are promising for use in biomedical applications due to their inherent extracellular matrix-like structure, comparable nanofiber dimensions and responsiveness to cells and proteins. Among them, short peptides and their derivatives have been studied because of their ease of synthesis and bottom-up design for controlling fibrillar supra-structure. In this dissertation, nucleo-tripeptides which can self-assemble into a hydrogel form were designed based on considerations of their gelation conditions and applications to functional cell scaffolds and controlled drug release. From the result of Fmoc modified short depsipeptides study, showing functional potential but cytotoxicity upon degradation, nucleobases were evaluated as a replacement for the Fmoc group. A small library, composed of 16 nucleo-tripeptides, was constructed in order to control the self-assembly conditions and to identify a molecule which can form a hydrogel under physiologic conditions. The resulting supra-structures were analyzed experimentally and computationally. We found that nucleo-tripeptides can self-assemble into nano-fibers which then lead to hydrogel formation under physiologic pH. Self-assembled nano-fibers have DNA-like structures, exhibiting nucleobase stacking and Watson-Crick-like interactions. By using these DNA-like structures as well as the self-healing capability of the nucleo-tripeptide hydrogel, applications as functional cell scaffolds and controlled drug release were studied. The self-assembled nucleo-tripeptide hydrogel can be functionalized via mixing with a second molecule having a complementary nucleobase via Watson-Crick interactions. A molecule possessing arginine-glycine-aspartic acid (RGD), interacting with integrin located on the surface of cells, and a nucleobase was incorporated into the self-assembled nucleo-tripeptide hydrogel. This incorporation resulted in improved viability and cell attachment during 3D culture of fibroblasts. Nucleobase stacking structures were applied to the sequestration and controlled release of the doxorubicin, a cancer drug which exerts its action by intercalated DNA. The self-assembled nucleo-tripeptide hydrogel was able to load doxorubicin effectively through its DNA-like interactions, and in vitro and in vivo studies showed that controlled release of doxorubicin can inhibit tumor growth over a long-term period

Comprehensive Biomaterials

Comprehensive Biomaterials Book
Author : Paul Ducheyne,Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
Publisher : Elsevier
Release : 2015-08-28
ISBN : 0080552943
Language : En, Es, Fr & De

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Book Description :

Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development

Comprehensive Biomaterials II

Comprehensive Biomaterials II Book
Author : Kevin Healy,Dietmar W. Hutmacher,David W. Grainger,C. James Kirkpatrick
Publisher : Elsevier
Release : 2017-05-18
ISBN : 0081006926
Language : En, Es, Fr & De

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Book Description :

Comprehensive Biomaterials II, Second Edition brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications

A Novel Biomaterial for Articular Cartilage Repair Generated by Self assembly a Histopathological Analysis for Cartilage Tissue Engineering Using a Self assembled Biomaterial in Rabbit Knee Joints

A Novel Biomaterial for Articular Cartilage Repair Generated by Self assembly  a Histopathological Analysis for Cartilage Tissue Engineering Using a Self assembled Biomaterial in Rabbit Knee Joints Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download A Novel Biomaterial for Articular Cartilage Repair Generated by Self assembly a Histopathological Analysis for Cartilage Tissue Engineering Using a Self assembled Biomaterial in Rabbit Knee Joints book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biomaterials Science and Tissue Engineering

Biomaterials Science and Tissue Engineering Book
Author : Bikramjit Basu
Publisher : Cambridge University Press
Release : 2017-09-15
ISBN : 1108246230
Language : En, Es, Fr & De

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Book Description :

A comprehensive text in the field of biomaterials science and tissue engineering, covering fundamental principles and methods related to processing-microstructure-property linkages as applied to biomaterials science. Essential concepts and techniques of the cell biology are discussed in detail, with a focus quantitatively and qualitatively evaluating cell-material interaction. It gives detailed discussion on the processing, structure and properties of metals, ceramics and polymers, together with techniques and guidelines. Comprehensive coverage of in vitro and in vivo biocompatibility property evaluation of materials for bone, neural as well as cardiovascular tissue engineering applications, together with representative protocols. Supported by several multiple-choice questions, fill in the blanks, review questions, numerical problems and solutions to selected problems, this is an ideal text for undergraduate and graduate students in understanding fundamental concepts and the latest developments in the field of biomaterials science.

Novel Biomaterials for Tissue Engineering 2018

Novel Biomaterials for Tissue Engineering 2018 Book
Author : Emmanuel Stratakis
Publisher : MDPI
Release : 2019-02-05
ISBN : 3038975435
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue "Novel Biomaterials for Tissue Engineering 2018" that was published in IJMS

Self Assembling Systems

Self Assembling Systems Book
Author : Li-Tang Yan
Publisher : John Wiley & Sons
Release : 2016-10-06
ISBN : 1119113156
Language : En, Es, Fr & De

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Book Description :

Provides comprehensive knowledge on concepts, theoretical methods and state-of-the-art computational techniques for the simulation of self-assembling systems Looks at the field of self-assembly from a theoretical perspective Highlights the importance of theoretical studies and tailored computer simulations to support the design of new self-assembling materials with useful properties Divided into three parts covering the basic principles of self-assembly, methodology, and emerging topics

Advances in Extracellular Space Research and Application 2013 Edition

Advances in Extracellular Space Research and Application  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-06-21
ISBN : 1481682628
Language : En, Es, Fr & De

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Book Description :

Advances in Extracellular Space Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Extracellular Fluid. The editors have built Advances in Extracellular Space Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Extracellular Fluid in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Extracellular Space Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Nanostructured Materials and Nanotechnology

Nanostructured Materials and Nanotechnology Book
Author : Hari Singh Nalwa
Publisher : Gulf Professional Publishing
Release : 2002
ISBN : 9780125139205
Language : En, Es, Fr & De

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Book Description :

Nanotechnology Provides comprehensive coverage of the dominant technology of the 21st century Written by a truly international list of contributors.

Self Assembled Peptide Nanostructures

Self Assembled Peptide Nanostructures Book
Author : Jaime Castillo,Luigi Sasso,Winnie Edith Svendsen
Publisher : CRC Press
Release : 2012-11-21
ISBN : 9814364479
Language : En, Es, Fr & De

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Book Description :

The self-organization of bionanostructures into well-defined functional machineries found in nature has been a priceless source of ideas for researchers. The molecules of life, proteins, DNA, RNA, etc., as well as the structures and forms that these molecules assume serve as rich sources of ideas for scientists or engineers who are interested in developing bio-inspired materials for innovations in biomedical fields. In nature, molecular self-assembly is a process by which complex three-dimensional structures with well-defined functions are constructed, starting from simple building blocks such as proteins and peptides. This book introduces readers to the theory and mechanisms of peptide self-assembly processes. The authors present the more common peptide self-assembled building blocks and discuss how researchers from different fields can apply self-assembling principles to bionanotechnology applications. The advantages and challenges are mentioned together with examples that reflect the state of the art of the use of self-assembled peptide building blocks in nanotechnology.

Micro and Nanofabrication Using Self Assembled Biological Nanostructures

Micro and Nanofabrication Using Self Assembled Biological Nanostructures Book
Author : Jaime Castillo-León,Winnie Svendsen
Publisher : William Andrew
Release : 2014-09-09
ISBN : 0323296521
Language : En, Es, Fr & De

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Book Description :

Self-assembled nanostructures based on peptides and proteins have been investigated and presented as biomaterials with an impressive potential for a broad range of applications such as microfabrication, biosensing platforms, drug delivery systems, bioelectronics and tissue reparation. Through self-assembly peptides can give rise to a range of well-defined nanostructures such as nanotubes, nanofibers, nanoparticles, nanotapes, gels and nanorods. However, there are challenges when trying to integrate these biological nanostructures in the development of sensing devices or drug-delivery systems – challenges such as controlling the size during synthesis, the stability in liquid environments and manipulation. In "Micro and Nanofabrication Using Self-assembled Biological Nanostructures" the options and challenges when using self-assembled peptide nanostructures in micro and nanofabrication are discussed. The publication covers different ways to manipulate, deposit and immobilize on specific locations these biological nanostructures in order to use them in the fabrication of new structures or as part of biosensing platforms. Examples where researchers used biological nanostructures for those types of applications are provided. Finally, future applications are discussed as well as parameters to accelerate and expand the use of these biological building blocks in nano- and micro-fabrication processes by taking advantage of their impressive properties such as low-cost and short synthesis time.

The Handbook of Nanomedicine

The Handbook of Nanomedicine Book
Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Release : 2008-02-24
ISBN : 9781603273190
Language : En, Es, Fr & De

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Book Description :

This handbook covers the broad scope of nanomedicine. Starting with the basics, the subject is developed to potential clinical applications, many of which are still at an experimental stage. The book features extensive coverage of nanodiagnostics and nanopharmaceuticals, which are two important components of nanomedicine. Written by a physician-scientist author who blends his clinical experience and scientific expertise in new technologies, this book provides a definitive account of nanomedicine. It offers more up-to-date and comprehensive coverage of nanomedicine than any other comparable work.

Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium

Transactions of the     Annual Meeting of the Society for Biomaterials and the     Annual International Biomaterials Symposium Book
Author : Society for Biomaterials. Meeting
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium book written by Society for Biomaterials. Meeting, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Vaccinology

Vaccinology Book
Author : Gregg N. Milligan,Alan D. T. Barrett
Publisher : John Wiley & Sons
Release : 2014-12-04
ISBN : 111863652X
Language : En, Es, Fr & De

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Book Description :

Vaccinology: An Essential Guide outlines in a clear,practical format the entire vaccine development process, fromconceptualization and basic immunological principles through toclinical testing and licensing of vaccines. With anoutstanding introduction to the history and practice ofvaccinology, it also guides the reader through the basic sciencerelating to host immune responses to pathogens. Covering the safety, regulatory, ethical, and economicand geographical issues that drive vaccine development and trials,it also presents vaccine delivery strategies, novel vaccineplatforms (including experimental vaccines and pathogens), antigendevelopment and selection, vaccine modelling, and the developmentof vaccines against emerging pathogens and agents of bioterror.There are also sections devoted to veterinary vaccines andassociated regulatory processes. Vaccinology: An Essential Guide is a perfect tool fordesigned for undergraduate and graduate microbiologists andimmunologists, as well as residents, fellows and trainees ofinfectious disease and vaccinology. It is also suitable for allthose involved in designing and conducting clinical vaccine trials,and is the ideal companion to the larger reference bookVaccinology: Principles and Practice.

A Laboratory Course in Biomaterials

A Laboratory Course in Biomaterials Book
Author : Wujing Xian
Publisher : CRC Press
Release : 2009-06-18
ISBN : 1420076159
Language : En, Es, Fr & De

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Book Description :

The field of biomedical engineering has vastly expanded in the past two decades, as reflected in the increased number of bioengineering and biomaterials programs at universities. The growth of this area has outpaced the development of laboratory courses that allow students hands-on experience, since the barriers involved in creating multidisciplinary biomaterials laboratory courses are high. A Laboratory Course in Biomaterials provides a teaching tool comprehensive in scope perspective. Multidisciplinary approach Suitable for junior or senior level laboratory courses in biomaterials and bioengineering, this volume trains students in laboratory skills, data analysis, problem solving, and scientific writing. The text takes a multidisciplinary approach, integrating a variety of principles that include materials science, chemistry, biochemistry, molecular and cell biology, and engineering. Step-by-step instructions The author presents flexible modules that allow the coursework to be adapted to the needs of different departments. Each module is organized around a central theme, such as drug delivery and natural biomaterials, to enhance student comprehension. This book provides step-by-step descriptions of lab procedures, reagents, equipment, and data processing guidelines. It also includes a series of thought-provoking questions and answers following each experiment, drawn from the author’s own experience in teaching a biomaterials laboratory course at the University of Illinois. Timely in its coverage, many of the experiments presented in the book are adapted from research papers reflecting the progress in various disciplines of bioengineering and biomaterials science.

BioMEMS and Biomedical Nanotechnology

BioMEMS and Biomedical Nanotechnology Book
Author : Tejal Desai,Sangeeta N. Bhatia
Publisher : Springer Science & Business Media
Release : 2007-05-26
ISBN : 0387258442
Language : En, Es, Fr & De

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Book Description :

Volume 3 of the multi-volume reference, BioMEMS and Biomedical Nanotechnology, will be the first comprehensive treatment of the emerging area of therapeutic micro- and nanotechnology. Subjects covered include: cell-based therapeutics, regenerative medicine - merging cells with micro- and nanosystems, and integrating MEMS with cells and tissues; Drug delivery - intravascular nanoparticles for drug targeting and nonvascular delivery (implantable, oral, inhalable); and, molecular surface engineering for the biological interface, biomolecule patterning and cell patterning. This volume is very well illustrated with many of the figures in color.

Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery

Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery Book
Author : Zhongwei Gu
Publisher : John Wiley & Sons
Release : 2015-03-09
ISBN : 3527334203
Language : En, Es, Fr & De

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Book Description :

Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues. Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.

Elastomeric Proteins

Elastomeric Proteins Book
Author : Peter R. Shewry,Arthur S. Tatham,Allen J. Bailey
Publisher : Cambridge University Press
Release : 2003-10-30
ISBN : 9781139438209
Language : En, Es, Fr & De

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Book Description :

This book was originally published in 2002. Elastic proteins occur in a wide range of biological systems where they have evolved to fulfil precise biological roles. The best known include proteins in vertebrate muscles and connective tissues, such as titin, elastin and fibrillin, and spider silks. However, other examples include byssus and abductin from bivalve molluscs, resilin from arthropods and gluten from wheat. Interest in elastomeric proteins has been high for several reasons. Firstly, their biological and medical significance, particularly in human disease. Secondly, the unusual properties of proteins such as spider silks provide opportunities to develop materials. Thirdly, the development of scanning probe microscopy makes it possible to study structures and biomechanical properties of these proteins at the single molecule level. This book will be of value to anyone with an interest in the various aspects of elastomeric proteins.