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Secondary Findings In Genomic Research

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Secondary Findings in Genomic Research

Secondary Findings in Genomic Research Book
Author : Kyle B. Brothers
Publisher : Academic Press
Release : 2020-05
ISBN : 0128165499
Language : En, Es, Fr & De

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Book Description :

Secondary Findings in Genomic Research offers a single, highly accessible resource on interpreting, managing and disclosing secondary findings in genomic research. With chapters written by experts in the field, this book is the first to concisely explain the ethical and practical issues raised by secondary genomics findings for a multi and interdisciplinary audience of genomic researchers, translational scientists, clinicians, medical students, genetic counselors, ethicists, legal experts and law students, public policy specialists and regulators. Contributors from Europe, North America, and Asia effectively synthesize perspectives from a spectrum of different scientific, societal, and global contexts, and offer pragmatic approaches to a range of topics, including oversight, governance and policy surrounding secondary genomic results, criteria for identifying results for return, communication and consent, stakeholders' attitudes and perspectives, disclosing results, and clinical, patient-centered protocols. Thoroughly addresses the scientific, ethical, practical and clinical issues raised by secondary findings resulting from genomic research, including active debate and challenges in the field Provides researchers, clinicians, regulators, and stakeholders with a holistic, interdisciplinary approach to interpreting, managing and disclosing secondary findings Brings together expert analysis from scholars across Europe, North America, and Asia representing a wide variety of scientific and societal contexts

The Drama of DNA

The Drama of DNA Book
Author : Karen H. Rothenberg JD, MPA,Lynn Wein Bush PhD, MS, MA
Publisher : Oxford University Press
Release : 2014-03-14
ISBN : 0199373159
Language : En, Es, Fr & De

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Book Description :

Through the use of dramatic narratives, The Drama of DNA brings to life the complexities raised by the application of genomic technologies to health care and diagnosis. This creative, pedagogical approach shines a unique light on the ethical, psychosocial, and policy challenges that emerge as comprehensive sequencing of the human genome transitions from research to clinical medicine. Narrative genomics aims to enhance understanding of how we evaluate, process, and share genomic information, and to cultivate a deeper appreciation for difficult decisions encountered by health care professionals, bioethicists, families, and society as this technology reaches the bedside. This innovative book includes both original genomic plays and theatrical excerpts that illuminate the implications of genomic information and emerging technologies for physicians, scientists, counselors, patients, blood relatives, and society. In addition to the plays, the authors provide an analytical foundation to frame the many challenges that often arise.

Genomic and Personalized Medicine

Genomic and Personalized Medicine Book
Author : N.A
Publisher : Academic Press
Release : 2012-10-30
ISBN : 0123822289
Language : En, Es, Fr & De

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Book Description :

Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Issues in Returning Individual Results from Genome Research Using Population Based Banked Specimens with a Focus on the National Health and Nutrition Examination Survey

Issues in Returning Individual Results from Genome Research Using Population Based Banked Specimens  with a Focus on the National Health and Nutrition Examination Survey Book
Author : National Research Council,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Steering Committee for the Workshop on Guidelines for Returning Individual Results from Genome Research Using Population-Based Banked Specimens
Publisher : National Academies Press
Release : 2014-09-08
ISBN : 0309307074
Language : En, Es, Fr & De

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Book Description :

Population surveys traditionally collect information from respondents about their circumstances, behaviors, attitudes, and other characteristics. In recent years, many surveys have been collecting not only questionnaire answers, but also biologic specimens such as blood samples, saliva, and buccal swabs, from which a respondent's DNA can be ascertained along with other biomarkers (e.g., the level of a certain protein in the blood). The National Health and Nutrition Examination Survey (NHANES), sponsored by the National Center for Health Statistics (NCHS), has been collecting and storing genetic specimens since 1991, and other surveys, such as the Health and Retirement Study (HRS) funded by the National Institute on Aging, have followed suit. In order to give their informed consent to participate in a survey, respondents need to know the disposition and use of their data. Will their data be used for one research project and then destroyed, or will they be archived for secondary use? Sponsors of repeated cross-sectional surveys, such as NHANES, and of longitudinal surveys that follow panels of individuals over time, such as HRS, generally want to retain data for a wide range of secondary uses, many of which are not explicitly foreseen at the time of data collection. They typically inform respondents that their data will be stored in a secure manner and may be provided to researchers with suitable protections against individual identification. The addition of biologic specimens to a survey adds complications for storing, protecting, and providing access to such data and measurements made from them. There are also questions of whether, when, and for which biologic measurements the results should be reported back to individual respondents. Recently, the cost of full genomic sequencing has plummeted, and research findings are beginning to accumulate that bear up under replication and that potentially have clinical implications for a respondent. For example, knowing that one possesses a certain gene or gene sequence might suggest that one should seek a certain kind of treatment or genetic counseling or inform one's blood relatives. Biomedical research studies, in which participants are asked to donate tissues for genetic studies and are usually told that they will not be contacted with any results, are increasingly confronting the issue of when and which DNA results to return to participants. Issues in Returning Individual Results from Genome Research Using Population-Based Banked Specimens, with a Focus on the National Health and Nutrition Examination Survey is the summary of a workshop convened in February 2013 by the Committee on National Statistics in the Division of Behavioral and Social Sciences and Education of the National Research Council. This report considers how population surveys, in particular NHANES, should implement the reporting of results from genomic research using stored specimens and address informed consent for future data collection as well as for the use of banked specimens covered by prior informed consent agreements. The report will be of interest to survey organizations that include or contemplate including the collection of biologic specimens in population surveys for storing for genetic research. The issues involved are important for advancing social, behavioral, and biomedical knowledge while appropriately respecting and protecting individual survey respondents.

Ethical Dilemmas in Genetics and Genetic Counseling

Ethical Dilemmas in Genetics and Genetic Counseling Book
Author : Janice Berliner MS, CGC
Publisher : Oxford University Press
Release : 2014-09-15
ISBN : 0190206640
Language : En, Es, Fr & De

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Book Description :

Knowledge of the genetic basis of human diseases is growing rapidly, with important implications for pre-conceptional, prenatal, and predictive testing. While new genetic testing offers better insight into the causes of and susceptibility for heritable diseases, not all inherited diseases that can be predicted on the basis of genetic information can be treated or cured. Should we test everyone who wants to know his or her genetic status, even when there are no possibilities for treatment? What is the role of the "right-not-to-know?" Do we test children for adult onset disorders because the parents just "have to know" or do we respect the children's right to choose when they are older? Do we allow commercial companies to offer genetic tests directly to consumers without the proper oversight regarding what the test results will mean? By using a creative approach that focuses on a single extended family as a case example to illustrate each chapter's key point, the authors elucidate ethical issues arising in the genetics clinic and laboratory surrounding many timely issues, including: · prenatal and pre-implantation genetic diagnosis · assisted reproductive technologies · incidental findings in genetic testing · gene patenting · testing children for adult onset disorders · direct to consumer testing Ethical Dilemmas in Genetic Counseling: Principles through Case Scenarios is essential reading for anyone interested in the ethical issues surfacing in common genetics practice. Written exclusively by genetic counselors, it makes a significant contribution to the field of ethics in genetics and thus will appeal not only to genetic counselors but to physicians, nurses, and all those concerned with bioethics and social science.

Abeloff s Clinical Oncology E Book

Abeloff s Clinical Oncology E Book Book
Author : John E. Niederhuber,James O. Armitage,James H Doroshow,Michael B. Kastan,Joel E. Tepper
Publisher : Elsevier Health Sciences
Release : 2013-09-12
ISBN : 1455728810
Language : En, Es, Fr & De

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Book Description :

Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies Book
Author : Sorin Hostiuc
Publisher : Academic Press
Release : 2018-08-07
ISBN : 0128137657
Language : En, Es, Fr & De

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Book Description :

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and the moral questions relating the implementation of genetic reproductive technology. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors and graduate and medical students. As the Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy, this book presents a timely resource. Provides practical analysis of the ethical issues raised by cutting-edge techniques and recent advances in prenatal and reproductive genetics Contains contributions from leading bioethicists and clinicians who offer a global, holistic perspective on applied challenges and moral questions relating to genetic and genomic reproductive technology Discusses preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, ethical issues, and more

Pediatric Laboratory Medicine

Pediatric Laboratory Medicine Book
Author : Patricia M. Jones,Dennis J. Dietzen,Shannon Haymond,Michael J. Bennett
Publisher : McGraw Hill Professional
Release : 2017-05-22
ISBN : 0071839275
Language : En, Es, Fr & De

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Book Description :

A complete full-color guide to medical laboratory test selection and test result interpretation for disorders and diagnoses specific to pediatric and neonatal populations Laboratory medicine practiced at a pediatric institution has unique characteristics specific to infants and children, who differ both metabolically and biochemically from adults. Many aspects of laboratory medicine are affected by these differences, from basic, day-to-day operational issues through test selection for pediatric-specific disorders. However, most references in laboratory medicine merely touch upon pediatrics – and offer little if any coverage of variations in testing and results for different age groups, or the many diseases and disorders most common in infants and children. Pediatric Laboratory Medicine is specifically written to fill this critical void in the literature. Now, for the first time, all important reference material concerning pediatric laboratory medicine is available in one convenient, up-to-date resource. Pediatric Laboratory Medicine teaches the effective operation of a pediatric clinical operation, and also provides guidelines for teaching trainees. This unique text delivers the how-to instruction necessary to ensure proper handling and testing of pediatric specimens to ensure accurate diagnosis. Valuable learning aids include learning objectives, end-of-chapter review questions, and references for further study. Written by experienced clinicians, the book’s seventeen chapters cover virtually every important topic – from daily issues in the practice of pediatric laboratory medicine to common tests and considerations to inborn errors of metabolism and therapeutic drug monitoring. Enhanced by numerous tables and high-quality full-color images, this authoritative resource delivers everything necessary for effective pediatric laboratory medicine training and practice.

Advances in Viral Genome Research and Application 2011 Edition

Advances in Viral Genome Research and Application  2011 Edition Book
Author : N.A
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464948941
Language : En, Es, Fr & De

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Book Description :

Advances in Viral Genome Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Viral Genome in a compact format. The editors have built Advances in Viral Genome Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Viral Genome in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Viral Genome Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Emery and Rimoin s Essential Medical Genetics

Emery and Rimoin s Essential Medical Genetics Book
Author : David L. Rimoin,Reed E. Pyeritz,Bruce Korf
Publisher : Elsevier
Release : 2013-05-15
ISBN : 0124169821
Language : En, Es, Fr & De

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Book Description :

For decades, Emery and Rimoin’s Principles and Practice of Medical Genetics has provided the ultimate source for practicing clinicians to learn how the study of genetics can be integrated into practice. Developed in parallel to the sixth edition, and featuring 174 original contributions from the many authors of the full set, this one volume work expertly condenses and synthesizes the most clinically relevant content, for convenient desk reference. Helping to bridge the gap between high-level molecular genetics and individual application, it follows the multi-volume set in encompassing scientific fundamentals, full spectrum discussion of major inherited disorders, and actionable therapies. Clinically oriented information is supported by concise descriptions of the principles of genetics, research approaches, and analytics to embrace the evolving population of students, researchers, and practitioners who are integrating their work to provide advanced diagnosis, prevention and treatment of human disease. This print volume is complemented and enhanced with online access to the complete text, online-only references, and high quality illustrations on www.expertconsult.com. Features 174 summarized contributions concisely discussing advances in cancer genetics, genomic technologies, and molecular genetics Contains hundreds of full colour illustrations supporting users with identification, concept illustration, and method processing Enhanced with full text online access, high quality illustrations, and online-only references at www.expertconsult.com

Essentials of Nursing Informatics Study Guide

Essentials of Nursing Informatics Study Guide Book
Author : Juliana J. Brixey,Jack E. Brixey,Virginia K. Saba,Kathleen A. McCormick
Publisher : McGraw Hill Professional
Release : 2015-09-05
ISBN : 0071845879
Language : En, Es, Fr & De

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Book Description :

Introducing the most complete, compact guide to teaching and learning nursing informatics If you’re looking for a clear, streamlined review of nursing informatics fundamentals, Essentials of Nursing Informatics Study Guide is the go-to reference. Drawn from the newly revised 6th Edition of Saba and McCormick’s bestselling textbook, Essentials of Nursing Informatics, this indispensable study guide helps instructors sharpen their classroom teaching skills, while offering students an effective self-study and review tool both in and out of the classroom. Each chapter features a concise, easy-to-follow format that solidifies students’ understanding of the latest nursing informatics concepts, technologies, policies, and skills. For the nurse educator, the study guide includes teaching tips, class preparation ideas, learning objectives, review questions, and answer explanations—all designed to supplement the authoritative content of the core text. Also included is an online faculty resource to supplement classroom teaching,offering instructors PowerPoints with concise chapter outlines, learning objectives, key words, and explanatory illustrations and tables. To request To request Instructor PowerPoint slides: Visit www.EssentialsofNursingInformatics.com and under the "Downloads and Resources tab," click "Request PowerPoint" to access the PowerPoint request form. Focusing on topics as diverse as data processing and nursing informatics in retail clinics, the nine sections of Essentials of Nursing Informatics Study Guide encompass all areas of nursing informatics theory and practice: Nursing Informatics Technologies System Life Cycle Informatics Theory Standards/Foundations of Nursing Informatics Nursing Informatics Leadership Advanced Nursing Informatics in Practice Nursing Informatics/Complex Applications Educational Applications Research Applications Big Data Initiatives The comprehensive, yet concise coverage of Essentials of Nursing Informatics Study Guide brings together the best nursing informatics applications and perspectives in one exceptional volume. More than any other source, it enables registered nurses to master this vital specialty, so they can contribute to the overall safety, efficiency, and effectiveness of healthcare.

Clinical Genomics Practical Applications for Adult Patient Care

Clinical Genomics  Practical Applications for Adult Patient Care Book
Author : Michael T. Murray,Mark Babyatski,Monica Giovanni
Publisher : McGraw Hill Professional
Release : 2013-10-22
ISBN : 0071810595
Language : En, Es, Fr & De

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Book Description :

Convert the latest genomic data to the most effective patient management and treatment approaches Clinical Genomics helps healthcare providers translate the vast amount of new genomic data into successful clinical application. It is a comprehensive textbook and practical guide to the use of this information across a broad spectrum of adult diseases – from individual differences in drug responses, cardiac and cancer risks to Alzheimer's and other neurological and psychiatric disorders. While traditional textbooks on medical genetics focus on classic Mendelian disorders, Clinical Genomics discusses the everyday application of genetic assessment and the diagnostic, therapeutic, and preventive implications to the most common adult diseases that healthcare providers encounter. Covering approximately 200 conditions, it is a true clinical text for use across all of internal medicine. Coverage of each condition is presented in a consistent, clinically relevant manner and includes: Key Points Diagnostic Criteria and Clinical Characteristics Screening and C ounseling Management and Treatment Molecular Genetics and Molecular Mechanism Supplementary Information More than ten valuable appendices, include Genetic Privacy; Race, Ancestry, and Genetics; Personalized Medicine in Clinical Practice; Clinical Interpretation of Genomic Data; and Genetic Risk Profiling in the Genomics Era. Clinical Genomics is essential for internists, primary care physicians, and other healthcare providers who wish to increase their knowledge of the gene-and-protein level care of patients in a clinical setting.

Essentials of Nursing Informatics 6th Edition

Essentials of Nursing Informatics  6th Edition Book
Author : Virginia K. Saba,Kathleen A. McCormick
Publisher : McGraw Hill Professional
Release : 2015-02-22
ISBN : 0071829563
Language : En, Es, Fr & De

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Book Description :

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Discover how technology can improve patient care -- and enhance every aspect of a nurse’s job performance, education, and career A Doody's Core Title for 2017! Written by leaders in nursing informatics, this comprehensive up-to-date text helps you understand how informatics can enhance every aspect of the nursing profession. This edition of Essentials of Nursing Informatics is highlighted by an outstanding team of international contributors and content that reflects the very latest concepts, technologies, policies, and required skills. Numerous case studies take the book beyond theory and add real-world relevance to the material. Essentials of Nursing Informatics is logically divided into ten sections edited by leading nurse informaticists: Nursing Informatics Technologies (Jacqueline Ann Moss) System Life Cycle (Virginia K. Saba) Informatics Theory Standards/Foundations of Nursing Informatics (Virginia K. Saba) Nursing Informatics Leadership (Kathleen Smith) Advanced Nursing Informatics in Practice (Gail E. Latimer) Nursing Informatics/Complex Applications (Kathleen A. McCormick) Educational Applications (Diane J. Skiba) Research Applications (Virginia K. Saba) Big Data Initiatives (Kathleen A. McCormick) International Perspectives (Susan K. Newbold) Essentials of Nursing Informatics is the best single resource for learning how technology can make the nursing experience as rewarding and successful as possible. New Feature! The 6th Edition introduces an online faculty resource to supplement classroom teaching, offering instructors PowerPoints with concise chapter outlines, learning objectives, key words, and explanatory illustrations and tables. To request Instructor PowerPoint slides: Visit www.EssentialsofNursingInformatics.com and under the "Downloads and Resources tab," click "Request PowerPoint" to access the PowerPoint request form. Also, for the first time, a companion study guide for the 6th Edition is available separately from McGraw-Hill (Essentials of Nursing Informatics Study Guide/ISBN: 978-007-184-5892; edited by Julianne Brixey, Jack Brixey, Virginia K. Saba, and Kathleen A. McCormick), presenting teaching modules for all major chapters, with content outlines, teaching tips, class preparation ideas, review questions, answer explanations, and online PowerPoint slides to aid understanding and retention of all major concepts covered in Essentials of Nursing Informatics, 6th Edition.

Nuclear Proteins Advances in Research and Application 2012 Edition

Nuclear Proteins   Advances in Research and Application  2012 Edition Book
Author : N.A
Publisher : ScholarlyEditions
Release : 2012-12-26
ISBN : 1464996024
Language : En, Es, Fr & De

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Book Description :

Nuclear Proteins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Nuclear Proteins. The editors have built Nuclear Proteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nuclear Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nuclear Proteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in Genetic Medicine 2011 Edition

Issues in Genetic Medicine  2011 Edition Book
Author : N.A
Publisher : ScholarlyEditions
Release : 2012-01-09
ISBN : 1464963789
Language : En, Es, Fr & De

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Book Description :

Issues in Genetic Medicine / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Genetic Medicine. The editors have built Issues in Genetic Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genetic Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Genetic Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Trends in Genome Research

Trends in Genome Research Book
Author : Clyde R. Williams
Publisher : Nova Biomedical
Release : 2006
ISBN :
Language : En, Es, Fr & De

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Book Description :

The genomic approach of technology development and large-scale generation of community resource data sets has introduced an important new dimension in biological and biomedical research. Interwoven advances in genetics, comparative genomics, high throughput biochemistry and bioinformatics are combining to attack basic understanding of human life and disease and to develop strategies to combat disease. Genomic Research began with The Human Genome Project (HGP), the international research effort that determined the DNA sequence of the entire human genome, completed in April 2003. The HGP also included efforts to characterise and sequence the entire genomes of several other organisms, many of which are used extensively in biological research. Identification of the sequence or function of genes in a model organism is an important approach to finding and elucidating the function of human genes. Integral to the HGP are similar efforts to understand the genomes of various organisms commonly used in biomedical research, such as mice, fruit flies and roundworms. Such organisms are called model organisms, because they can often serve as research models for how the human organism behaves. This book brings together leading research from throughout the world in this cutting-edge field.

Rudolph s Pediatrics 23rd Edition

Rudolph s Pediatrics  23rd Edition Book
Author : Mark W. Kline,Susan M. Blaney,Angelo P. Giardino,Jordan S. Orange,Daniel J. Penny,Gordon E. Schutze,Lara S. Shekerdemian,Abraham M. Rudolph,Colin D. Rudolph
Publisher : McGraw Hill Professional
Release : 2018-08-21
ISBN : 1259588602
Language : En, Es, Fr & De

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Book Description :

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The landmark pediatrics reference – completely reinvented by an all new team of editors Rudolph's Pediatrics has virtually defined the pediatric field for over a century, becoming one of the most important and well-respected pediatrics texts ever published. Renowned for its balance of clinical features and treatment of disease with underlying biological principles, this classic sourcebook has helped generations of pediatricians optimize their care of infants, children, and adolescents. The Twenty-Third Edition of Rudolph's has been completely restructured and streamlined thanks to an all new team of editors whose goal was to reinvent this classic with today’s busy practitioner in mind. Presented in full color, the Twenty-Third Edition provides an up-to-date, in-depth survey of pediatric medicine unmatched by any other text. With its algorithmic approach to pediatric systems, the book facilitates the diagnosis and treatment of both common and uncommon pediatric illnesses; and it reflects new technologies and advances in molecular medicine that continue to evolve with current thinking about normal childhood development and pediatric disease processes. • New team of editors achieves consistency in both tone and depth of content • Contributions from section editors and authors from leading academic pediatrics programs give expert coverage of general pediatrics and all of the pediatric sub-specialties • Streamlined and consistent format for most chapters outlining Pathogenesis and Epidemiology, Clinical Manifestations, Diagnosis, Treatment, and Prevention • New 2-Volume presentation improves portability • Hundreds of full-color illustrations and tables • The acclaimed balance between clinical applicability and underlying biological principles offers pediatricians a depth of coverage not found anywhere else • Brand new or significantly revised chapters include: Complementary and Integrative Pediatrics, Childhood Adversity and Toxic Stress, Autism Spectrum Disorder, Pediatric Depression and Bipolar Spectrum Disorders, Extracorporeal Membrane Oxygenation (ECMO), Palliative Care for Children with Chronic Diseases, Arboviruses (with new coverage of Zika virus and chikungunya virus), Physiologic Basis of Pulmonary Function; Acute Lymphoblastic Leukemia; Neuroblastoma

Genetic Engineering of Plant Secondary Metabolism

Genetic Engineering of Plant Secondary Metabolism Book
Author : Brian E. Ellis,Gary W. Kuroki,Helen A. Stafford
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461525446
Language : En, Es, Fr & De

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Book Description :

In this volume of Recent Advances in Phytochmistry you will find a record of the pioneering attempts of plant biochemists and molecular biologists to modify the patterns of secondary metabolism in plants, as presented at the 33rd annual meeting of the Phytochemical Society of North America, in Asilomar, California, on June 27 -July I, 1993. The studies described here represent a marriage of the newest of technologies with one of the oldest human activities, exploitation of plant chemistry. They also represent the beginning of a new era of phytochemical research, an era that will undoubtedly begin to provide answers to some of the long-standing questions that have absorbed plant biochemists for the past century. There is, for instance, a common deflating experience to which every worker in the area of plant secondary metabolism can probably relate. After hearing about the latest research findings regarding some aspect of remarkable compound "X", someone in the audience finally directs the inevitable question at the hapless speaker. "Tell me, is anything known as to the biological role of compound "X" in the plant?" The answer, in most cases, must be "essentially nothing"! This is a frustrating scenario for both the speaker and the audience, since the very fact that a complex biosynthetic pathway remains encoded in a plant genome points to an associated selective advantage. The problem is that establishing the nature and scale of that advantage is a very complex task.