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Secondary Findings in Genomic Research

Secondary Findings in Genomic Research Book
Author : Kyle B. Brothers
Publisher : Academic Press
Release : 2020-05
ISBN : 0128165499
Language : En, Es, Fr & De

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Book Description :

Secondary Findings in Genomic Research offers a single, highly accessible resource on interpreting, managing and disclosing secondary findings in genomic research. With chapters written by experts in the field, this book is the first to concisely explain the ethical and practical issues raised by secondary genomics findings for a multi and interdisciplinary audience of genomic researchers, translational scientists, clinicians, medical students, genetic counselors, ethicists, legal experts and law students, public policy specialists and regulators. Contributors from Europe, North America, and Asia effectively synthesize perspectives from a spectrum of different scientific, societal, and global contexts, and offer pragmatic approaches to a range of topics, including oversight, governance and policy surrounding secondary genomic results, criteria for identifying results for return, communication and consent, stakeholders' attitudes and perspectives, disclosing results, and clinical, patient-centered protocols. Thoroughly addresses the scientific, ethical, practical and clinical issues raised by secondary findings resulting from genomic research, including active debate and challenges in the field Provides researchers, clinicians, regulators, and stakeholders with a holistic, interdisciplinary approach to interpreting, managing and disclosing secondary findings Brings together expert analysis from scholars across Europe, North America, and Asia representing a wide variety of scientific and societal contexts

Clinical Genome Sequencing

Clinical Genome Sequencing Book
Author : Aad Tibben,Barbara B. Biesecker
Publisher : Academic Press
Release : 2019-03-30
ISBN : 0128133368
Language : En, Es, Fr & De

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Book Description :

Clinical Genome Sequencing: Psychological Aspects thoroughly details key psychological factors to consider while implementing genome sequencing in clinical practice, taking into account the subtleties of genetic risk assessment, patient consent and best practices for sharing genomic findings. Chapter contributions from leading international researchers and practitioners cover topics ranging from the current state of genomic testing, to patient consent, patient responses to sequencing data, common uncertainties, direct-to-consumer genomics, the role of genome sequencing in precision medicine, genetic counseling and genome sequencing, genome sequencing in pediatrics, genome sequencing in prenatal testing, and ethical issues in genome sequencing. Applied clinical case studies support concept illustration, making this an invaluable, practical reference for this important and multifaceted topic area within genomic medicine. Features contributions from leading international researchers and practitioners versed in the psychosocial dimensions of genomic medicine implementation Presents clinical case studies that support concept illustration, making this an invaluable reference for students, researchers, and clinicians looking for practical guidance in this important and multifaceted topic area Details the current state of genomic testing, expectations of genome sequencing, patient consent, patient responses to sequencing data, uncertainties in genome sequencing, direct-to-consumer genome sequencing, and more

Assessing Genomic Sequencing Information for Health Care Decision Making

Assessing Genomic Sequencing Information for Health Care Decision Making Book
Author : Institute of Medicine,Board on Health Sciences Policy,Roundtable on Translating Genomic-Based Research for Health
Publisher : National Academies Press
Release : 2014-08-19
ISBN : 0309304970
Language : En, Es, Fr & De

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Book Description :

Rapid advances in technology have lowered the cost of sequencing an individual's genome from the several billion dollars that it cost a decade ago to just a few thousand dollars today and have correspondingly greatly expanded the use of genomic information in medicine. Because of the lack of evidence available for assessing variants, evaluation bodies have made only a few recommendations for the use of genetic tests in health care. For example, organizations, such as the Evaluation of Genomic Applications in Practice and Prevention working group, have sought to set standards for the kinds of evaluations needed to make population-level health decisions. However, due to insufficient evidence, it has been challenging to recommend the use of a genetic test. An additional challenge to using large-scale sequencing in the clinic is that it may uncover "secondary," or "incidental," findings - genetic variants that have been associated with a disease but that are not necessarily related to the conditions that led to the decision to use genomic testing. Furthermore, as more genetic variants are associated with diseases, new information becomes available about genomic tests performed previously, which raises issues about how and whether to return this information to physicians and patients and also about who is responsible for the information. To help develop a better understanding of how genomic information is used for healthcare decision making, the Roundtable on Translating Genomic-Based Research for Health of the Institute of Medicine held a workshop in Washington,DC in February 2014. Stakeholders, including clinicians, researchers, patients, and government officials, discussed the issues related to the use of genomic information in medical practice. Assessing Genomic Sequencing Information for Health Care Decision Making is the summary of that workshop. This report compares and contrasts evidence evaluation processes for different clinical indications and discusses key challenges in the evidence evaluation process.

Issues in Returning Individual Results from Genome Research Using Population Based Banked Specimens with a Focus on the National Health and Nutrition Examination Survey

Issues in Returning Individual Results from Genome Research Using Population Based Banked Specimens  with a Focus on the National Health and Nutrition Examination Survey Book
Author : National Research Council,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Steering Committee for the Workshop on Guidelines for Returning Individual Results from Genome Research Using Population-Based Banked Specimens
Publisher : National Academies Press
Release : 2014-09-08
ISBN : 0309307074
Language : En, Es, Fr & De

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Book Description :

Population surveys traditionally collect information from respondents about their circumstances, behaviors, attitudes, and other characteristics. In recent years, many surveys have been collecting not only questionnaire answers, but also biologic specimens such as blood samples, saliva, and buccal swabs, from which a respondent's DNA can be ascertained along with other biomarkers (e.g., the level of a certain protein in the blood). The National Health and Nutrition Examination Survey (NHANES), sponsored by the National Center for Health Statistics (NCHS), has been collecting and storing genetic specimens since 1991, and other surveys, such as the Health and Retirement Study (HRS) funded by the National Institute on Aging, have followed suit. In order to give their informed consent to participate in a survey, respondents need to know the disposition and use of their data. Will their data be used for one research project and then destroyed, or will they be archived for secondary use? Sponsors of repeated cross-sectional surveys, such as NHANES, and of longitudinal surveys that follow panels of individuals over time, such as HRS, generally want to retain data for a wide range of secondary uses, many of which are not explicitly foreseen at the time of data collection. They typically inform respondents that their data will be stored in a secure manner and may be provided to researchers with suitable protections against individual identification. The addition of biologic specimens to a survey adds complications for storing, protecting, and providing access to such data and measurements made from them. There are also questions of whether, when, and for which biologic measurements the results should be reported back to individual respondents. Recently, the cost of full genomic sequencing has plummeted, and research findings are beginning to accumulate that bear up under replication and that potentially have clinical implications for a respondent. For example, knowing that one possesses a certain gene or gene sequence might suggest that one should seek a certain kind of treatment or genetic counseling or inform one's blood relatives. Biomedical research studies, in which participants are asked to donate tissues for genetic studies and are usually told that they will not be contacted with any results, are increasingly confronting the issue of when and which DNA results to return to participants. Issues in Returning Individual Results from Genome Research Using Population-Based Banked Specimens, with a Focus on the National Health and Nutrition Examination Survey is the summary of a workshop convened in February 2013 by the Committee on National Statistics in the Division of Behavioral and Social Sciences and Education of the National Research Council. This report considers how population surveys, in particular NHANES, should implement the reporting of results from genomic research using stored specimens and address informed consent for future data collection as well as for the use of banked specimens covered by prior informed consent agreements. The report will be of interest to survey organizations that include or contemplate including the collection of biologic specimens in population surveys for storing for genetic research. The issues involved are important for advancing social, behavioral, and biomedical knowledge while appropriately respecting and protecting individual survey respondents.

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies Book
Author : Sorin Hostiuc
Publisher : Academic Press
Release : 2018-08-07
ISBN : 0128137657
Language : En, Es, Fr & De

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Book Description :

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and the moral questions relating the implementation of genetic reproductive technology. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors and graduate and medical students. As the Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy, this book presents a timely resource. Provides practical analysis of the ethical issues raised by cutting-edge techniques and recent advances in prenatal and reproductive genetics Contains contributions from leading bioethicists and clinicians who offer a global, holistic perspective on applied challenges and moral questions relating to genetic and genomic reproductive technology Discusses preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, ethical issues, and more

Issues in Genomics and Non Human Genetic Research 2012 Edition

Issues in Genomics and Non Human Genetic Research  2012 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-01-10
ISBN : 1481647490
Language : En, Es, Fr & De

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Book Description :

Issues in Genomics and Non-Human Genetic Research: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Genomic Research. The editors have built Issues in Genomics and Non-Human Genetic Research: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Genomic Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Genomics and Non-Human Genetic Research: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Genome Research

Genome Research Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Genome Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Issues in Returning Individual Results from Genome Research Using Population Based Banked Specimens with a Focus on the National Health and Nutrition Examination Survey

Issues in Returning Individual Results from Genome Research Using Population Based Banked Specimens  with a Focus on the National Health and Nutrition Examination Survey Book
Author : Steering Committee on the Guidelines for Returning Individual Results from Genome Research Using Population-Based Banked Specimens,Committee on National Statistics,Division of Behavioral and Social Sciences and Education,National Research Council
Publisher : Unknown
Release : 2014-09-08
ISBN : 9780309386425
Language : En, Es, Fr & De

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Book Description :

Population surveys traditionally collect information from respondents about their circumstances, behaviors, attitudes, and other characteristics. In recent years, many surveys have been collecting not only questionnaire answers, but also biologic specimens such as blood samples, saliva, and buccal swabs, from which a respondent's DNA can be ascertained along with other biomarkers (e.g., the level of a certain protein in the blood). The National Health and Nutrition Examination Survey (NHANES), sponsored by the National Center for Health Statistics (NCHS), has been collecting and storing genetic specimens since 1991, and other surveys, such as the Health and Retirement Study (HRS) funded by the National Institute on Aging, have followed suit. In order to give their informed consent to participate in a survey, respondents need to know the disposition and use of their data. Will their data be used for one research project and then destroyed, or will they be archived for secondary use? Sponsors of repeated cross-sectional surveys, such as NHANES, and of longitudinal surveys that follow panels of individuals over time, such as HRS, generally want to retain data for a wide range of secondary uses, many of which are not explicitly foreseen at the time of data collection. They typically inform respondents that their data will be stored in a secure manner and may be provided to researchers with suitable protections against individual identification. The addition of biologic specimens to a survey adds complications for storing, protecting, and providing access to such data and measurements made from them. There are also questions of whether, when, and for which biologic measurements the results should be reported back to individual respondents. Recently, the cost of full genomic sequencing has plummeted, and research findings are beginning to accumulate that bear up under replication and that potentially have clinical implications for a respondent. For example, knowing that one possesses a certain gene or gene sequence might suggest that one should seek a certain kind of treatment or genetic counseling or inform one's blood relatives. Biomedical research studies, in which participants are asked to donate tissues for genetic studies and are usually told that they will not be contacted with any results, are increasingly confronting the issue of when and which DNA results to return to participants. "Issues in Returning Individual Results from Genome Research Using Population-Based Banked Specimens, with a Focus on the National Health and Nutrition Examination Survey" is the summary of a workshop convened in February 2013 by the Committee on National Statistics in the Division of Behavioral and Social Sciences and Education of the National Research Council. This report considers how population surveys, in particular NHANES, should implement the reporting of results from genomic research using stored specimens and address informed consent for future data collection as well as for the use of banked specimens covered by prior informed consent agreements. The report will be of interest to survey organizations that include or contemplate including the collection of biologic specimens in population surveys for storing for genetic research. The issues involved are important for advancing social, behavioral, and biomedical knowledge while appropriately respecting and protecting individual survey respondents.

Theoretical and Computational Methods in Genome Research

Theoretical and Computational Methods in Genome Research Book
Author : Sándor Suhai
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461559030
Language : En, Es, Fr & De

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Book Description :

The application ofcomputational methods to solve scientific and practical problems in genome research created a new interdisciplinary area that transcends boundaries tradi tionally separating genetics, biology, mathematics, physics, and computer science. Com puters have, of course, been intensively used in the field of life sciences for many years, even before genome research started, to store and analyze DNA or protein sequences; to explore and model the three-dimensional structure, the dynamics, and the function of biopolymers; to compute genetic linkage or evolutionary processes; and more. The rapid development of new molecular and genetic technologies, combined with ambitious goals to explore the structure and function ofgenomes ofhigher organisms, has generated, how ever, not only a huge and exponentially increasing body of data but also a new class of scientific questions. The nature and complexity of these questions will also require, be yond establishing a new kind ofalliance between experimental and theoretical disciplines, the development of new generations both in computer software and hardware technolo gies. New theoretical procedures, combined with powerful computational facilities, will substantially extend the horizon of problems that genome research can attack with suc cess. Many of us still feel that computational models rationalizing experimental findings in genome research fulfill their promises more slowly than desired. There is also an uncer tainty concerning the real position of a "theoretical genome research" in the network of established disciplines integrating their efforts in this field.

Pharmacogenomics A Primer for Clinicians

Pharmacogenomics  A Primer for Clinicians Book
Author : Jerika T. Lam,Mary A Gutierrez
Publisher : McGraw Hill Professional
Release : 2020-12-22
ISBN : 1260457117
Language : En, Es, Fr & De

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Book Description :

An invaluable resource to the rapidly emerging field of pharmacogenomics—complete with case studies, clinical pearls, and treatment recommendations The aim of pharmacogenomics is to improve personalized medicine by taking into account how genes affect an individual’s tolerability and response to drugs. Approaching pharmacogenomics from the current clinical, scientific, and implementation perspectives, this guide serves as an invaluable evidence-based resource to the subject. Reflecting the shift from genetics to genomics in the pharmaceutical sphere, the book covers pharmacogenomics fundamentals; genotyping tests and evidence; clinical implementation; ethical, legal, and social issues; and more. You’ll also find illuminating case scenarios, clinical pearls, and evidence-based recommendations for treatments and alternatives based on CPIC, PharmGKB, and FDA guidelines.

Forest Genomics and Biotechnology

Forest Genomics and Biotechnology Book
Author : Isabel Allona,Matias Kirst,Wout Boerjan,Steven Strauss,Ronald Sederoff
Publisher : Frontiers Media SA
Release : 2019-11-27
ISBN : 2889631788
Language : En, Es, Fr & De

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Book Description :

This Research Topic addresses research in genomics and biotechnology to improve the growth and quality of forest trees for wood, pulp, biorefineries and carbon capture. Forests are the world’s greatest repository of terrestrial biomass and biodiversity. Forests serve critical ecological services, supporting the preservation of fauna and flora, and water resources. Planted forests also offer a renewable source of timber, for pulp and paper production, and the biorefinery. Despite their fundamental role for society, thousands of hectares of forests are lost annually due to deforestation, pests, pathogens and urban development. As a consequence, there is an increasing need to develop trees that are more productive under lower inputs, while understanding how they adapt to the environment and respond to biotic and abiotic stress. Forest genomics and biotechnology, disciplines that study the genetic composition of trees and the methods required to modify them, began over a quarter of a century ago with the development of the first genetic maps and establishment of early methods of genetic transformation. Since then, genomics and biotechnology have impacted all research areas of forestry. Genome analyses of tree populations have uncovered genes involved in adaptation and response to biotic and abiotic stress. Genes that regulate growth and development have been identified, and in many cases their mechanisms of action have been described. Genetic transformation is now widely used to understand the roles of genes and to develop germplasm that is more suitable for commercial tree plantations. However, in contrast to many annual crops that have benefited from centuries of domestication and extensive genomic and biotechnology research, in forestry the field is still in its infancy. Thus, tremendous opportunities remain unexplored. This Research Topic aims to briefly summarize recent findings, to discuss long-term goals and to think ahead about future developments and how this can be applied to improve growth and quality of forest trees.

Pediatric Laboratory Medicine

Pediatric Laboratory Medicine Book
Author : Patricia M. Jones,Dennis J. Dietzen,Shannon Haymond,Michael J. Bennett
Publisher : McGraw Hill Professional
Release : 2017-05-22
ISBN : 0071839275
Language : En, Es, Fr & De

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Book Description :

A complete full-color guide to medical laboratory test selection and test result interpretation for disorders and diagnoses specific to pediatric and neonatal populations Laboratory medicine practiced at a pediatric institution has unique characteristics specific to infants and children, who differ both metabolically and biochemically from adults. Many aspects of laboratory medicine are affected by these differences, from basic, day-to-day operational issues through test selection for pediatric-specific disorders. However, most references in laboratory medicine merely touch upon pediatrics – and offer little if any coverage of variations in testing and results for different age groups, or the many diseases and disorders most common in infants and children. Pediatric Laboratory Medicine is specifically written to fill this critical void in the literature. Now, for the first time, all important reference material concerning pediatric laboratory medicine is available in one convenient, up-to-date resource. Pediatric Laboratory Medicine teaches the effective operation of a pediatric clinical operation, and also provides guidelines for teaching trainees. This unique text delivers the how-to instruction necessary to ensure proper handling and testing of pediatric specimens to ensure accurate diagnosis. Valuable learning aids include learning objectives, end-of-chapter review questions, and references for further study. Written by experienced clinicians, the book’s seventeen chapters cover virtually every important topic – from daily issues in the practice of pediatric laboratory medicine to common tests and considerations to inborn errors of metabolism and therapeutic drug monitoring. Enhanced by numerous tables and high-quality full-color images, this authoritative resource delivers everything necessary for effective pediatric laboratory medicine training and practice.

Relevance of Health Literacy to Precision Medicine

Relevance of Health Literacy to Precision Medicine Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Roundtable on Health Literacy
Publisher : National Academies Press
Release : 2016-11-04
ISBN : 0309447356
Language : En, Es, Fr & De

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Book Description :

On January 20, 2015, President Obama announced the Precision Medicine Initiative (PMI) in his State of the Union address. The PMI, by developing new approaches for detecting, measuring, and analyzing a wide range of biomedical information including molecular, genomic, cellular, clinical, behavioral, physiological, and environmental parameters, is intended to enable a new era of medicine in which researchers, providers, and patients work together to develop individualized care. Part of this effort included the creation of a national, large-scale research participant group, or cohort. The PMI Cohort Program is aimed at extending precision medicine to many diseases, including both rare and common diseases such as diabetes, heart disease, Alzheimer's disease, obesity, and mental illnesses such as depression, bipolar disorder, and schizophrenia, by building a national research cohort of 1 million or more U.S. participants. An important challenge to assembling the PMI Cohort will be to reach individuals who are socioeconomically disadvantaged. Individuals who are socioeconomically disadvantaged have lower health literacy; often belong to racial, ethnic, and minority communities; and are often less likely to participate in research studies and biorepositories. To explore possible strategies and messaging designs, the Roundtable on Health Literacy formed an ad hoc committee charged with planning and conducting a 1-day public workshop on the intersection of health literacy and precision medicine. The workshop participants discussed a variety of topics including an overview of precision medicine and its potential, the relevance of health literacy to the success of precision medicine efforts, and perspectives and understanding of different groups, such as health care providers, consumers, and insurers. This publication summarizes the presentations and discussions from the workshop.

Tea Genome and Genetics

Tea  Genome and Genetics Book
Author : Tapan Kumar Mondal
Publisher : Springer Nature
Release : 2020-12-22
ISBN : 9811588686
Language : En, Es, Fr & De

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Book Description :

Tea is an important non-alcoholic beverage plant of the world. Cultivation of tea is also commercially very important as it earns huge revenue for the tea growing nations especially the developing countries such as India. Although conventional breeding is well-established and contributes significantly for varietal improvement of this plant and other Camellia species with ornamental value, yet, applications of biotechnology vis a vis genomics are essential to improve the productivity and quality of the tea. This book brings out various aspects of breeding, biotechnology and genomics of tea plants. It covers i) Origin and descriptions of health benefits as well as morphological classification as first chapter, ii) Breeding and cytogenetics that comprise with various conventional approaches of varietal improvement of tea along with their genetic resources, iii) Micro-propagation which deals with in-depth study of clonal propagation, iv) Somatic embryogenesis along with alternative techniques such as suspension culture, cry-preservation etc, v) Molecular breeding that deals with application of various DNA based markers such as discovery of QTL, linkage map etc, vi) Genetic transformation and associated factors, vii) Stress physiology complied various works done in tea along with its wild relatives on abiotic as well as biotic stress and viii) Functional genomics that describes the various works of molecular cloning and characterizations, differential gene expression, high-throughput sequencing, bioinformatics transcriptomics study that described the application of next generation sequencing to discover various genes that are related to various trait of tea, Non-coding RNA which describes the discovery of various non-coding RNA in tea and related genera. The book also discusses recent developments in biotechnology such as metabolomics, proteomics, genome sequence and popular clone varieties of tea crops that are developed across the world. In conclusion, the book collates the work on tea plantations so far, identified the problems, analyzes the gaps on breeding and biotechnological works of tea as well as its wild species and discusses the future scopes as conclusion. The book aims to cover all latest information till june, 2020 . It will be useful resource for post-graduate, doctoral as well post-doctoral students working on tea as well as other woody plants. This will also be useful for the scientists working in the areas of life sciences, genomics, biotechnology and molecular biology.

Genetic Engineering of Plant Secondary Metabolism

Genetic Engineering of Plant Secondary Metabolism Book
Author : Brian E. Ellis,Gary W. Kuroki,Helen A. Stafford
Publisher : Springer
Release : 2013-10-03
ISBN : 9781461360858
Language : En, Es, Fr & De

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Book Description :

In this volume of Recent Advances in Phytochmistry you will find a record of the pioneering attempts of plant biochemists and molecular biologists to modify the patterns of secondary metabolism in plants, as presented at the 33rd annual meeting of the Phytochemical Society of North America, in Asilomar, California, on June 27 -July I, 1993. The studies described here represent a marriage of the newest of technologies with one of the oldest human activities, exploitation of plant chemistry. They also represent the beginning of a new era of phytochemical research, an era that will undoubtedly begin to provide answers to some of the long-standing questions that have absorbed plant biochemists for the past century. There is, for instance, a common deflating experience to which every worker in the area of plant secondary metabolism can probably relate. After hearing about the latest research findings regarding some aspect of remarkable compound "X", someone in the audience finally directs the inevitable question at the hapless speaker. "Tell me, is anything known as to the biological role of compound "X" in the plant?" The answer, in most cases, must be "essentially nothing"! This is a frustrating scenario for both the speaker and the audience, since the very fact that a complex biosynthetic pathway remains encoded in a plant genome points to an associated selective advantage. The problem is that establishing the nature and scale of that advantage is a very complex task.

Williams Hematology 10th Edition

Williams Hematology  10th Edition Book
Author : Kenneth Kaushansky,Marshall A. Lichtman,Josef T. Prchal,Marcel M. Levi,Linda J. Burns
Publisher : McGraw Hill Professional
Release : 2021-01-14
ISBN : 126046413X
Language : En, Es, Fr & De

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Book Description :

The landmark text that has guided generations of hematologists and related practitioners―updated with the latest research findings and improved format and presentation Long revered for its comprehensiveness and extraordinary depth of detail, Williams Hematology provides essential coverage of the origins, pathophysiological mechanisms, and management of benign and malignant disorders of blood and marrow cells and coagulation proteins. The text contains a wealth of basic science and translational pathophysiology for optimal, lifelong learning. Experts in research and clinical hematology, the editors are known worldwide for their contributions to the field. This new edition contains everything that has made Williams Hematology the go-to resource for decades and has been updated with new chapters and critical new research into the molecular mechanisms responsible for hematological disorders and the impact on diagnosis and treatment. And the new format enables you to access each chapter via content modules covering key topics, with summaries, infographics, and cases―all linked to review questions for self-assessment. The full-color presentation integrates images of blood and tissue findings where they are cited in the text. NEW TO THIS EDITION: Updated and revised content reflecting the latest research and developments Convenient format that streamlines the learning process and improves retention Additional chapters added on: Immune Checkpoint Inhibitors Immune Cell Therapy: Chimeric Antigen Receptor T Cell Therapy Immune Cell Therapy Dendritic Cell and Natural Killer Cell Therapy The processes of cell death and survival Application of Big Data and Deep Learning in Hematology Williams Hematology Cases with multiple-choice questions including detailed explanations—perfect preparation for the boards Continuously updated online content with comprehensive drug therapy database and other resources

Essentials of Nursing Informatics Study Guide

Essentials of Nursing Informatics Study Guide Book
Author : Juliana J. Brixey,Jack E. Brixey,Virginia K. Saba,Kathleen A. McCormick
Publisher : McGraw Hill Professional
Release : 2015-09-05
ISBN : 0071845879
Language : En, Es, Fr & De

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Book Description :

Introducing the most complete, compact guide to teaching and learning nursing informatics If you’re looking for a clear, streamlined review of nursing informatics fundamentals, Essentials of Nursing Informatics Study Guide is the go-to reference. Drawn from the newly revised 6th Edition of Saba and McCormick’s bestselling textbook, Essentials of Nursing Informatics, this indispensable study guide helps instructors sharpen their classroom teaching skills, while offering students an effective self-study and review tool both in and out of the classroom. Each chapter features a concise, easy-to-follow format that solidifies students’ understanding of the latest nursing informatics concepts, technologies, policies, and skills. For the nurse educator, the study guide includes teaching tips, class preparation ideas, learning objectives, review questions, and answer explanations—all designed to supplement the authoritative content of the core text. Also included is an online faculty resource to supplement classroom teaching,offering instructors PowerPoints with concise chapter outlines, learning objectives, key words, and explanatory illustrations and tables. To request To request Instructor PowerPoint slides: Visit www.EssentialsofNursingInformatics.com and under the "Downloads and Resources tab," click "Request PowerPoint" to access the PowerPoint request form. Focusing on topics as diverse as data processing and nursing informatics in retail clinics, the nine sections of Essentials of Nursing Informatics Study Guide encompass all areas of nursing informatics theory and practice: Nursing Informatics Technologies System Life Cycle Informatics Theory Standards/Foundations of Nursing Informatics Nursing Informatics Leadership Advanced Nursing Informatics in Practice Nursing Informatics/Complex Applications Educational Applications Research Applications Big Data Initiatives The comprehensive, yet concise coverage of Essentials of Nursing Informatics Study Guide brings together the best nursing informatics applications and perspectives in one exceptional volume. More than any other source, it enables registered nurses to master this vital specialty, so they can contribute to the overall safety, efficiency, and effectiveness of healthcare.

Clinical Genomics Practical Applications for Adult Patient Care

Clinical Genomics  Practical Applications for Adult Patient Care Book
Author : Michael T. Murray,Mark Babyatski,Monica Giovanni
Publisher : McGraw Hill Professional
Release : 2013-10-22
ISBN : 0071810595
Language : En, Es, Fr & De

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Book Description :

Convert the latest genomic data to the most effective patient management and treatment approaches Clinical Genomics helps healthcare providers translate the vast amount of new genomic data into successful clinical application. It is a comprehensive textbook and practical guide to the use of this information across a broad spectrum of adult diseases – from individual differences in drug responses, cardiac and cancer risks to Alzheimer's and other neurological and psychiatric disorders. While traditional textbooks on medical genetics focus on classic Mendelian disorders, Clinical Genomics discusses the everyday application of genetic assessment and the diagnostic, therapeutic, and preventive implications to the most common adult diseases that healthcare providers encounter. Covering approximately 200 conditions, it is a true clinical text for use across all of internal medicine. Coverage of each condition is presented in a consistent, clinically relevant manner and includes: Key Points Diagnostic Criteria and Clinical Characteristics Screening and C ounseling Management and Treatment Molecular Genetics and Molecular Mechanism Supplementary Information More than ten valuable appendices, include Genetic Privacy; Race, Ancestry, and Genetics; Personalized Medicine in Clinical Practice; Clinical Interpretation of Genomic Data; and Genetic Risk Profiling in the Genomics Era. Clinical Genomics is essential for internists, primary care physicians, and other healthcare providers who wish to increase their knowledge of the gene-and-protein level care of patients in a clinical setting.

Research Development

Research   Development Book
Author : Anonim
Publisher : Unknown
Release : 2006-07
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Research Development book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Essentials of Nursing Informatics 6th Edition

Essentials of Nursing Informatics  6th Edition Book
Author : Virginia K. Saba,Kathleen A. McCormick
Publisher : McGraw Hill Professional
Release : 2015-02-22
ISBN : 0071829563
Language : En, Es, Fr & De

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Book Description :

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Discover how technology can improve patient care -- and enhance every aspect of a nurse’s job performance, education, and career A Doody's Core Title for 2017! Written by leaders in nursing informatics, this comprehensive up-to-date text helps you understand how informatics can enhance every aspect of the nursing profession. This edition of Essentials of Nursing Informatics is highlighted by an outstanding team of international contributors and content that reflects the very latest concepts, technologies, policies, and required skills. Numerous case studies take the book beyond theory and add real-world relevance to the material. Essentials of Nursing Informatics is logically divided into ten sections edited by leading nurse informaticists: Nursing Informatics Technologies (Jacqueline Ann Moss) System Life Cycle (Virginia K. Saba) Informatics Theory Standards/Foundations of Nursing Informatics (Virginia K. Saba) Nursing Informatics Leadership (Kathleen Smith) Advanced Nursing Informatics in Practice (Gail E. Latimer) Nursing Informatics/Complex Applications (Kathleen A. McCormick) Educational Applications (Diane J. Skiba) Research Applications (Virginia K. Saba) Big Data Initiatives (Kathleen A. McCormick) International Perspectives (Susan K. Newbold) Essentials of Nursing Informatics is the best single resource for learning how technology can make the nursing experience as rewarding and successful as possible. New Feature! The 6th Edition introduces an online faculty resource to supplement classroom teaching, offering instructors PowerPoints with concise chapter outlines, learning objectives, key words, and explanatory illustrations and tables. To request Instructor PowerPoint slides: Visit www.EssentialsofNursingInformatics.com and under the "Downloads and Resources tab," click "Request PowerPoint" to access the PowerPoint request form. Also, for the first time, a companion study guide for the 6th Edition is available separately from McGraw-Hill (Essentials of Nursing Informatics Study Guide/ISBN: 978-007-184-5892; edited by Julianne Brixey, Jack Brixey, Virginia K. Saba, and Kathleen A. McCormick), presenting teaching modules for all major chapters, with content outlines, teaching tips, class preparation ideas, review questions, answer explanations, and online PowerPoint slides to aid understanding and retention of all major concepts covered in Essentials of Nursing Informatics, 6th Edition.