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Second Generation Cell And Gene Based Therapies

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Second Generation Cell and Gene Based Therapies

Second Generation Cell and Gene Based Therapies Book
Author : Alain Vertes,Nathan J. Dowden,Devyn Smith,Nasib Qureshi
Publisher : Academic Press
Release : 2020-02-07
ISBN : 0128120339
Language : En, Es, Fr & De

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Book Description :

Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalisation serves as the only volume to the market to bridge basic science, clinical therapy, technology development, and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines, is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths, which will ultimately facilitate clinical delivery of cutting edge curative products. The next waves of innovation are reviewed in depth for hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as for enabling technologies such as gene and genome editing. Additionally, deep dives in product fundamentals, history of science, pathobiology of diseases, scientific and technological bases, and financing and technology adoption constraints are taken to unravel what will shape the cytotherapy industry to the horizon 2025 and beyond. The outcome is not simply a scientific book, but a global perspective on the nascent field combining science, business, and strategic fundamentals. Helps readers learn about the most current trends in cell-based therapy, their overall effectiveness from a clinical prospective, and how the industry is moving therapies forward for capitalization "Perspectives" section at the end of each chapter summarizes key learnings, hypotheses, and objectives highlighted and combines scientific and business insights Edited and authored by scientists representing both basic and clinical research and industry, presenting a complete story of the current state and future promise of cellular therapies

New Targeting in The Reversal of Resistant Glioblastomas

New Targeting in The Reversal of Resistant Glioblastomas Book
Author : Ali Syed Arbab
Publisher : Academic Press
Release : 2021-03-18
ISBN : 0128232765
Language : En, Es, Fr & De

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Book Description :

New Targeting in The Reversal of Resistant Glioblastomas discusses alternative treatment strategies that not only target tumor cells but also target the tumor microenvironment, metabolic pathways and interaction of cytokines in tumor cells. The current treatment for primary and recurrent glioblastomas is failing because clinicians are not considering the effect of bone marrow derived cells to the development of resistance to clinically practiced therapies. This book helps readers rethink treatment strategies to successfully fight glioblastomas. It is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field. Explains the effect of bone marrow derived cells on the development of resistance to clinically practiced therapies Provides information on the availability of alternate therapies for recurrent glioblastoma when standard practices have failed Discusses targeting tumor microenvironment using available FDA approved drugs as an alternative treatment strategy for glioblastoma

Gene Therapy of Cancer

Gene Therapy of Cancer Book
Author : Edmund C. Lattime,Stanton L. Gerson
Publisher : Unknown
Release : 2013
ISBN : 9780123942951
Language : En, Es, Fr & De

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Book Description :

Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response. Explains the underlying cancer biology necessary for understanding proposed therapeutic approaches Presents in-depth description of targeting systems and treatment strategies Covers the breadth of gene therapy approaches including immunotherapeutic, drug resistance,oncolytic viruses, as well as regulatory perspectives from both the NCI and FDA

Goodman Gilman s the Pharmacological Basis of Therapeutics

Goodman   Gilman s the Pharmacological Basis of Therapeutics Book
Author : Louis Sanford Goodman,Alfred Goodman Gilman
Publisher : McGraw-Hill Companies
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

For more than fifty years, scientists, clinicians, & students have relied on "Goodman & Gilman for the final word on the pharmacokinetics, mechanisms of action & therapeutic application of drugs. This edition sustains that proud tradition & infuses the latest information on molecular pharmacology as it redefines the definite database of pharmacologic therapeutics. As a course text or a daily reference in clinical practice, "G & G" offers the optimal mix of basic science & clinical coverage as it pertains to effective drug therapy.

Cardiac Cell and Gene Transfer

Cardiac Cell and Gene Transfer Book
Author : Joseph M. Metzger
Publisher : Humana Press
Release : 2010-10-28
ISBN : 9781617372926
Language : En, Es, Fr & De

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Book Description :

Heart disease is the leading cause of death in developed countries. Recent experimental advances featuring cellular, molecular, and genetic tools and technologies offer the potential for new therapeutic strategies directed toward remediation of inherited and acquired heart diseases. Whether these recent basic science advances will ultimately translate to clinical efficacy for patients with heart disease is unknown and is important to ascertain. Cardiac Cell and Gene Transfer: Principles, Protocols, and Applications is designed to provide the reader with up-to-date coverage of a myriad of specific methodo- gies and protocols for gene and cell transfer to the myocardium. Each chapter features a “Notes” section that provides useful “how to” problem-solving insights that are often left unstated in standard published protocols. Cardiac Cell and Gene Transfer: Principles, Protocols, and Appli- tions addresses principles and applications of cell and gene transfer to the heart, including protocols for vector production and purification. Detailed step-by-step methods and applications for first/second-generation adenoviral vectors, adeno-associated vectors, gutted adenoviral vectors, and lentiviral vectors are included. Additionally, detailed methods for cardiac cell grafting and transplantation are provided, and these chapters highlight the prospects of cell-based therapies for cardiac repair. The book also covers specific in vivo techniques for cardiac gene transfer, and specifies subsequent cellular and organ-level physiological assessment techniques and protocols. Accordingly, this book is designed for basic science and clinical researchers in the academic, pharmaceutical, and biotechnology sectors of the cardiovascular community.

Biopharmaceuticals

Biopharmaceuticals Book
Author : Gary Walsh
Publisher : Wiley
Release : 1998-06-18
ISBN : 9780471977889
Language : En, Es, Fr & De

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Book Description :

Biopharmaceuticals: Biochemistry and Biotechnology provides a comprehensive and up-to-date overview of the science and medical applications of biopharmaceutical products. Specific chapters detail therapeutic substances such as interferons, interleukins and growth factors, as well as hormones, therapeutic enzymes, blood products, antibodies, and vaccines. While the emphasis is placed upon polypeptide-based therapeutic agents, the potential applications of nucleic acids with regard to gene therapy and antisense technology are considered in the final chapter. In addition, other chapters detail regulatory issues as applied to biopharmaceuticals, and how such products are manufactured in practice. The author has produced an up-to-date, easy-to-read book and each chapter is supplemented with a substantial further reading section. It is of particular relevance to students undertaking advanced undergraduate or postgraduate courses in biotechnology, biochemistry, pharmaceutical science or medicine. Its scope also renders it an ideal reference for those already employed in the (bio)pharmaceutical sector who wish to gain a better overview of the industry in which they work.

Gene Therapy

Gene Therapy Book
Author : Gavin Brooks
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Considers the genetic basis of disease and gene therapies, concentrating in detail on specific genetic illnesses, such as AIDS, cancer and cardiovascular diseases, and their treatment. This text should be of interest to pharmacists and to those involved in the biological or medical sciences.

The Journal of the Australian Institute of Agricultural Science

The Journal of the Australian Institute of Agricultural Science Book
Author : Australian Institute of Agricultural Science
Publisher : Unknown
Release : 1956
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Journal of the Australian Institute of Agricultural Science book written by Australian Institute of Agricultural Science, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Gene Therapy for the Treatment of Hyperhomocysteinemia by Naked DNA Delivery

Gene Therapy for the Treatment of Hyperhomocysteinemia by Naked DNA Delivery Book
Author : Mi-Young Lee
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Gene Therapy for the Treatment of Hyperhomocysteinemia by Naked DNA Delivery book written by Mi-Young Lee, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Ansel s Pharmaceutical Dosage Forms and Drug Delivery Systems

Ansel s Pharmaceutical Dosage Forms and Drug Delivery Systems Book
Author : Loyd V. Allen,Nicholas G. Popovich,Howard C. Ansel
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Thanks to its comprehensive coverage, clear explanations, and logical organization, Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems has been a core pharmaceutics text in the pharmacy curriculum for more than 40 years. As you progress through this thoroughly updated Ninth Edition, you'll master all the principles, practices, and technologies essential for the preparation of pharmaceutical dosage forms and drug delivery systems. The text's integrated approach will help you understand the interrelationships among pharmaceutical and biopharmaceutical principles, product design, formulation, manufacturing, compounding, and the clinical application of dosage forms for effective patient care." --Book Jacket.

Human Gene Therapy

Human Gene Therapy Book
Author : Anonim
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Human Gene Therapy book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cardiac Cell and Gene Transfer

Cardiac Cell and Gene Transfer Book
Author : Joseph M. Metzger
Publisher : Humana Press
Release : 2002-12-19
ISBN : 9780896039940
Language : En, Es, Fr & De

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Book Description :

Heart disease is the leading cause of death in developed countries. Recent experimental advances featuring cellular, molecular, and genetic tools and technologies offer the potential for new therapeutic strategies directed toward remediation of inherited and acquired heart diseases. Whether these recent basic science advances will ultimately translate to clinical efficacy for patients with heart disease is unknown and is important to ascertain. Cardiac Cell and Gene Transfer: Principles, Protocols, and Applications is designed to provide the reader with up-to-date coverage of a myriad of specific methodo- gies and protocols for gene and cell transfer to the myocardium. Each chapter features a “Notes” section that provides useful “how to” problem-solving insights that are often left unstated in standard published protocols. Cardiac Cell and Gene Transfer: Principles, Protocols, and Appli- tions addresses principles and applications of cell and gene transfer to the heart, including protocols for vector production and purification. Detailed step-by-step methods and applications for first/second-generation adenoviral vectors, adeno-associated vectors, gutted adenoviral vectors, and lentiviral vectors are included. Additionally, detailed methods for cardiac cell grafting and transplantation are provided, and these chapters highlight the prospects of cell-based therapies for cardiac repair. The book also covers specific in vivo techniques for cardiac gene transfer, and specifies subsequent cellular and organ-level physiological assessment techniques and protocols. Accordingly, this book is designed for basic science and clinical researchers in the academic, pharmaceutical, and biotechnology sectors of the cardiovascular community.

The AIDS Knowledge Base

The AIDS Knowledge Base Book
Author : Philip T. Cohen,Merle A. Sande,Paul Volberding
Publisher : Little Brown GBR
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

(1E 1990; *Select List Medical) Covers epidemiology & transmission/testing for HIV/clinical manifestations/etc.

Plasma Cells Multiple Myeloma

Plasma Cells   Multiple Myeloma Book
Author : Selina Chen-Kiang
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Plasma Cells Multiple Myeloma book written by Selina Chen-Kiang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Trends in Gene Therapy Research

Trends in Gene Therapy Research Book
Author : Grace W. Redberry
Publisher : Nova Science Pub Incorporated
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This new book offers the latest research in a field bursting with new developments, hope and expectations.

Excerpta medica Section 22 Human genetics

Excerpta medica  Section 22  Human genetics Book
Author : Anonim
Publisher : Unknown
Release : 1990
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Excerpta medica Section 22 Human genetics book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

AIDS Research and Human Retroviruses

AIDS Research and Human Retroviruses Book
Author : Anonim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download AIDS Research and Human Retroviruses book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Gene Dependant Enzyme Prodrug Therapy for Head and Neck Cancer

Gene Dependant Enzyme Prodrug Therapy for Head and Neck Cancer Book
Author : Daniel Allan Hamstra
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Gene Dependant Enzyme Prodrug Therapy for Head and Neck Cancer book written by Daniel Allan Hamstra, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Soviet Genetics

Soviet Genetics Book
Author : Anonim
Publisher : Unknown
Release : 1976
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Soviet Genetics book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.