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Sarcopenia Age Related Muscle Wasting and Weakness

Sarcopenia     Age Related Muscle Wasting and Weakness Book
Author : Gordon S. Lynch
Publisher : Springer Science & Business Media
Release : 2010-11-30
ISBN : 9789048197132
Language : En, Es, Fr & De

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Book Description :

Some of the most serious consequences of aging are its effects on skeletal muscle. ‘Sarcopenia’, the progressive age-related loss of muscle mass and associated muscle weakness, renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their functional independence. Not surprisingly, sarcopenia is a significant public health problem throughout the developed world. There is an urgent need to better understand the neuromuscular mechanisms underlying age-related muscle wasting and to develop therapeutic strategies that can attenuate, prevent, or ultimately reverse sarcopenia. Significant research and development in academic and research institutions and in pharmaceutical companies is being directed to sarcopenia and to related health issues in order to develop and evaluate novel therapeutics. This book provides the latest information on sarcopenia from leading international researchers studying the cellular and molecular mechanisms underlying age-related changes in skeletal muscle and identifies strategies to combat sarcopenia and related muscle wasting conditions and neuromuscular disorders. The book provides a vital resource for researchers and practitioners alike, with information relevant to gerontologists, geriatricians, sports medicine physicians, physiologists, neuroscientists, cell biologists, endocrinologists, physical therapists, allied health and musculoskeletal practitioners, strength and conditioning specialists, athletic trainers, and students of the medical and biomedical sciences.

Sarcopenia

Sarcopenia Book
Author : Dominique Meynial-Denis
Publisher : CRC Press
Release : 2019-11-20
ISBN : 1498765149
Language : En, Es, Fr & De

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Book Description :

Sarcopenia: Molecular, Cellular, and Nutritional Aspects describes the progressive loss of skeletal muscle mass and strength, defined by Rosenberg in 1997 as a hallmark of aging and referred to as “sarcopenia.” As life expectancy continues to increase worldwide, sarcopenia has become a major public health issue. The condition worsens in the presence of chronic diseases accelerating its progression. Sarcopenia is not considered to be “a process of normative aging” but according to the International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM), as a disease. As sarcopenia is an ineluctable process, prevention and management are the only options to promote healthy aging; these actions should perhaps be taken during youth. Included in this book: · Features essential information on sarcopenia, its current definition, and molecular and cellular aspects of this disease · Discusses the development of physical frailty, a complication of sarcopenia, and predicts its occurrence in the older population · Presents alterations in muscle protein turnover and mitochondrial dysfunction in the aging process · Provides data on the negative involvement of sarcopenia in certain chronic diseases · Describes presbyphagia or age-related changes in the swallowing mechanism in older people · Details possible strategies to combat muscle wasting in healthy older adults and their limits This book features information collected from pioneers or experts on human aging from around the globe, including Europe, Brazil, Canada, Japan and the United States. It is a valuable source of information for nutritional scientists, medical doctors, sports scientists, food scientists, dietitians, students in these fields, and for anyone interested in nutrition. We hope this book provides a better understanding of sarcopenia which inevitably occurs with aging without weight loss. Moreover, this book will supply information outlining strategies to prevent or limit muscle wasting due to normal aging in order to promote successful aging.

Sarcopenia

Sarcopenia Book
Author : Alfonso J. Cruz-Jentoft,John E. Morley
Publisher : John Wiley & Sons
Release : 2021-06-28
ISBN : 1119597870
Language : En, Es, Fr & De

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Book Description :

An in-depth examination of sarcopenia’s underexplored yet widespread impact within the field of gerontology Sarcopenia is common in older men and women, and yet awareness of its clinical relevance is still relatively low. Only formally included in the International Classification of Diseases in 2016, the condition may impact societies with serious health-related and financial consequences unless consistent, effective methods of identification and management are adopted. This second edition of Sarcopenia provides geriatricians and other healthcare professionals with a revised and expanded examination of this understudied and underdiagnosed condition. Edited by two leading authorities on the subject, it covers the epidemiology and diagnosis of sarcopenia, as well as treatment options and possible prevention strategies. Eight newly written chapters build upon existing knowledge with fresh data on topics including sarcopenia’s biomarkers and its impact on the healthcare economy. This important text: Defines sarcopenia and explains its clinical relevance Covers all recent scientific evidence Outlines treatment options Considers prevention strategies Discusses sarcopenia as a public health priority Features eight new chapters covering topics such as sarcopenia’s clinical management, its biomarkers, and its financial impact Containing vital information for clinicians and other professionals working in geriatric care, nursing homes, nutrition, cancer, endocrinology, surgery, sports medicine and many other specialties, Sarcopenia, second edition, is a groundbreaking and essential new resource.

Sarcopenia in Japanese Elderly with Diabetes Prevalence and Characteristics

Sarcopenia in Japanese Elderly with Diabetes  Prevalence and Characteristics Book
Author : Moyama Shota
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Background: Sarcopenia is a condition characterized by progressive and generalized loss of skeletal muscle mass and function; and causes serious health-related problems in the elderly with diabetes. Those aged u226565 years accounts for more than two third of patients with diabetes in Japan today, suggesting that a large fraction of Japanese individuals with diabetes suffer from sarcopenia. However, prevalence of sarcopenia and pre-sarcopenia among the elderly with diabetes in Japan remains unknown.Aims: The present study is designed to examine prevalence of sarcopenia in elderly Japanese patients with diabetes; and to find possible associations with severity of sarcopenia with dietary intake.Methods: From 2016 to 2017, we carried out a cross sectional study about 91 type 2 diabetes patients aged 65 and above (47 males and 44 females, mean age 72.7u00b15.5 years) without overt chronic diabetic complications. In all subjects, grip strength and body composition (SMI; skeletal muscle index, PBF; percent body fat) were measured using the digital hand dynamometer and the bioelectricity impedance measuring device (InBody s10). Based on the diagnostic criteria reported by Chen LK et al (2014), subjects were divided into 4 groups; sarcopenia group (Group S, loss of SMI and grip strength), pre-sarcopenia A group (Group PSa, loss of SMI only), pre-sarcopenia B group (Group PSb, loss of grip strength only), and non-sarcopenia group (Group NS, neither loss of SMI nor grip strength). We evaluated participant characteristics (age, body weight, SMI, PBF), dietary intake, glycemic control (HbA1c), and renal function (Creatinine, BUN, eGFR) among 4 groups.Results: The prevalence of sarcopenia was 11.0% (Group S, n=10), pre-sarcopenia was 27.0% (Group PSa, n=21; 23.0%, Group PSb, n=4; 4.0%), and the rest was 62.0% (Group NS, n=56). Ages in Group NS was the lowest among the groups. In addition, the body weight and SMI in 2 groups (Group S and PSa) were significantly lower than those in Group NS (p

Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy A Translational Approach

Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy  A Translational Approach Book
Author : Luciano Merlini,Paolo Bonaldo,Emanuele Marzetti
Publisher : Frontiers Media SA
Release : 2016-01-18
ISBN : 2889196844
Language : En, Es, Fr & De

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Book Description :

Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention.

Sarcopenia

Sarcopenia Book
Author : Kunihiro Sakuma
Publisher : Elsevier
Release : 2021-07-15
ISBN : 9780128221464
Language : En, Es, Fr & De

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Book Description :

As the global population ages, sarcopenia remains a therapeutic challenge and major public health concern. Difficulties in defining sarcopenia as a clinical phenotype remain and have hindered treatment. Sarcopenia: Molecular Mechanism and Management Strategies provides answers and guidance on this disease that has serious health consequences in terms of fractures, frailty, disability, and a diminished quality of life. Written by experts around the world, this book is for all those that care of our aging population. Presents physical, dietary, and pharmacological strategies to maintain adequate muscle mass to ensure healthy aging Provides a complete and up-to-date reference on molecular mechanisms of sarcopenia Identifies a clear definition of sarcopenia and presents the latest research together in one volume

Frailty and Sarcopenia

Frailty and Sarcopenia Book
Author : Yannis Dionyssiotis
Publisher : BoD – Books on Demand
Release : 2017-08-30
ISBN : 9535134833
Language : En, Es, Fr & De

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Book Description :

Frailty is considered a multisystem impairment that makes an individual vulnerable to external or internal stressors. Sarcopenia, the age-dependent loss of muscle mass and function, is proposed as the biological substrate and the pathway whereby the consequences of physical frailty develop. These syndromes are associated with a negative impact in quality of life and can lead to the occurrence of disability, institutionalization, and even mortality. The book focuses upon all the related aspects of frailty and sarcopenia and the new advancements in the related treatments including complex issues and research. It includes high-quality chapters in all related aspects for the syndromes of sarcopenia and frailty, which adversely affect the function and overall effectiveness of the musculoskeletal system and interventions to promote rehabilitation.

Recent Advances of Sarcopenia and Frailty in CKD

Recent Advances of Sarcopenia and Frailty in CKD Book
Author : Akihiko Kato,Eiichiro Kanda,Yoshihiko Kanno
Publisher : Springer Nature
Release : 2020-02-29
ISBN : 9811523657
Language : En, Es, Fr & De

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Book Description :

This book highlights recent advances in our understanding of sarcopenia and frailty in CKD. The prevalence of sarcopenia and frailty increases substantially as CKD progresses, and experimental studies have demonstrated the pivotal role of accumulated uremic toxin in the development of muscle wasting. Further, sarcopenia and frailty are associated with falls, bone fractures, cognitive impairment, and poor survival prognoses, especially in elderly CKD patients. The syndromes are also related to the risk of end-stage kidney disease. This book provides readers with a deeper understanding of the prevention and management of sarcopenia and frailty in CKD patients to improve their renal and overall health, and suggests directions for future basic and clinical research.

Sarcopenia u2013 Age Related Muscle Wasting and Weakness

Sarcopenia  u2013  Age Related Muscle Wasting and Weakness Book
Author : Gordon S. Lynch
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Some of the most serious consequences of aging are its effects on skeletal muscle. ‘Sarcopenia’, the progressive age-related loss of muscle mass and associated muscle weakness, renders frail elders susceptible to serious injury from sudden falls and fractures and at risk for losing their functional independence. Not surprisingly, sarcopenia is a significant public health problem throughout the developed world. There is an urgent need to better understand the neuromuscular mechanisms underlying age-related muscle wasting and to develop therapeutic strategies that can attenuate, prevent, or ultimately reverse sarcopenia. Significant research and development in academic and research institutions and in pharmaceutical companies is being directed to sarcopenia and to related health issues in order to develop and evaluate novel therapeutics. This book provides the latest information on sarcopenia from leading international researchers studying the cellular and molecular mechanisms underlying age-related changes in skeletal muscle and identifies strategies to combat sarcopenia and related muscle wasting conditions and neuromuscular disorders. The book provides a vital resource for researchers and practitioners alike, with information relevant to gerontologists, geriatricians, sports medicine physicians, physiologists, neuroscientists, cell biologists, endocrinologists, physical therapists, allied health and musculoskeletal practitioners, strength and conditioning specialists, athletic trainers, and students of the medical and biomedical sciences.

The Prognostic Role of Sarcopenia in Older Adults Undergoing Transcatheter Aortic Valve Replacement

The Prognostic Role of Sarcopenia in Older Adults Undergoing Transcatheter Aortic Valve Replacement Book
Author : Samuel Mamane
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Background: Sarcopenia is the "biologic substrate of frailty" defined as an age-related syndrome characterized by the loss of skeletal muscle mass and a decrease in muscle function. Our objective was to explore the role of sarcopenia in the pre-procedural evaluation of older adults undergoing transcatheter aortic valve replacement (TAVR) and to determine its incremental prognostic value above established risk stratification tools.Methods: After reviewing the literature on sarcopenia in the peri-operative setting, focusing on the use of CT-scan skeletal muscle cross-sectional area as a measure of muscle mass, we developed a novel software tool and methodology for measuring psoas muscle area (PMA). In the first study, we validated this tool in the retrospective two-center Montreal-Munich cohort study evaluating the predictive role of PMA on outcomes in older adults undergoing TAVR. In the second study, we conducted a pre-planned analysis of the prospective multicentre FRAILTY-AVR cohort study to evaluate the prognostic value of sarcopenia as measured by a combination of low PMA and low lower extremity muscle performance, deriving a sarcopenia score including muscle mass and function.Results: PMA measured on single axial image at the level of the L4 vertebrae correlated well with psoas muscle volume (r=0.91, p

Frailty and Sarcopenia in Cirrhosis

Frailty and Sarcopenia in Cirrhosis Book
Author : Puneeta Tandon,Aldo J. Montano-Loza
Publisher : Springer Nature
Release : 2019-11-06
ISBN : 303026226X
Language : En, Es, Fr & De

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Book Description :

This book provides a concise yet comprehensive overview of frailty and sarcopenia in the cirrhotic patient. The text presents a personalized approach to identifying cirrhotic patients at risk of higher morbidity and mortality due to frailty and sarcopenia. It reviews current and novel diagnostic methods, while spotlighting treatment and management strategies for frailty and sarcopenia. The book also focuses on special issues associated with these syndromes, such as the effect of gender, age, and ethnicity on frailty and sarcopenia, sarcopenic obesity, and frailty and sarcopenia after liver transplantation. Future considerations are outlined in the closing chapters, including emerging pharmacological and interventional therapies for these syndromes. Written by experts in the field, Frailty and Sarcopenia in Cirrhosis: The Basics, the Challenges, and the Future is a valuable resource for clinicians and practitioners who treat patients with cirrhosis.

Epidemiology of Sarcopenia and Frailty

Epidemiology of Sarcopenia and Frailty Book
Author : Harnish P Patel
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Sarcopenia and frailty are common in older persons and pose particular challenges for health and social care systems especially in the context of global population ageing. Sarcopenia, the loss of skeletal muscle mass, strength and function with age is associated with adverse individual physical and metabolic changes contributing to morbidity and mortality. The health and socioeconomic implications of sarcopenia are also considerable. Sarcopenia is a core component of physical frailty that together impact negatively on an individual's capability to live independently. Frailty is a biological syndrome of low reserve and resistance to stressors resulting from cumulative declines across multiple physiological systems that collectively predispose an individual to adverse outcomes. Frailty develops along a continuum from independence through to death as physiological reserves progressively diminish an individual's capacity to recover from an acute insult or illness. Managing sarcopenia and frailty involves the multidisciplinary led completion of a comprehensive care plan that is patient centred, responsive to the needs of the patient and adaptable therefore enabling an individual to maintain their independence.

Evaluation of Sarcopenia Screening and Diagnosis in Acute and Chronic Care Settings of Cardiovascular Disease

Evaluation of Sarcopenia Screening and Diagnosis in Acute and Chronic Care Settings of Cardiovascular Disease Book
Author : Aayushi Joshi
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Background: Sarcopenia is defined as an age-related loss of muscle strength and muscle mass and can be screened for and diagnosed in different ways in acute and chronic cardiovascular care. The main objectives of this thesis were to 1) investigate the incremental prognostic value of sarcopenia diagnosis by DXA-based appendicular muscle mass index (AMMI) and performance-based muscle strength in older adults undergoing cardiac surgery, and 2) determine the prognostic value of sarcopenia screening by SARC-F questionnaire and muscle strength parameters in community-dwelling older adults with heart failure.Methods: Following a literature review on sarcopenia in cardiovascular disease, two prospective cohort studies were performed. In the sub-study of the McGill Frailty Registry, older patients referred for coronary artery bypass or heart valve surgery who underwent a sarcopenia assessment involving a DXA scan prior to surgery were included. For the second multi-center prospective cohort study, FRAILTY HF, the cohort included older adults attending a heart failure clinic who completed a frailty assessment. Results: From the first study of 141 cardiac surgery patients, the prevalence of low AMMI, slow chair rise time, and sarcopenia (low AMMI and slow chair rise time) was 24%, 57%, 13%, respectively. Adjusted multivariable regression indicated each standard deviation of decreasing AMMI and increasing chair rise time was associated with a hazard ratio of 1.84 (95% CI 1.18, 2.86) and 1.79 (95% CI 1.26, 2.54), respectively, for all-cause mortality. From the second study of 100 heart failure patients, prevalence of slow chair rise time and probable sarcopenia (worse SARC-F score and slow chair rise time) was 60% and 31%, respectively. Probable sarcopenia was associated with a two-fold risk of all-cause mortality or worsening disability at 3-months (OR=2.7; 95% CI 0.87 to 8.42), although non-significant. However, probable sarcopenia was predictive of poor physical and mental health status at 3-months. Conclusions: Lower-extremity muscle strength and DXA-based measures of muscle mass are indicative of sarcopenia and predictive of survival in older adults referred for cardiac surgery. Additionally, screening for sarcopenia among heart failure patients indicated that a positive screen is strongly predictive of poor health-related quality of life at 3-months. Validation of findings by optimizing thresholds for sarcopenia and determining best methods for screening and diagnosis in future studies are needed"--

Australian Family Physician

Australian Family Physician Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Australian Family Physician book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Clinical Nutrition and Aging

Clinical Nutrition and Aging Book
Author : Chad Cox
Publisher : CRC Press
Release : 2017-10-02
ISBN : 1315359820
Language : En, Es, Fr & De

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Book Description :

This title includes a number of Open Access chapters. Sarcopenia—the loss of muscle mass and strength that occurs with advancing age—is a major health challenge, particularly in North America, Europe, and Japan, which have large aging populations. This compendium volume is a valuable addition to the existing literature, providing state-of-the-art information on the most effective prevention and treatment options. Included are research articles on nutrition management and the prevention of sarcopenia; protein therapy for sarcopenia; effect of exercise on sarcopenia; and other therapeutic strategies, including antioxidants and steroids.

Imaging of Sarcopenia

Imaging of Sarcopenia Book
Author : Anonim
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Highlights: Sarcopenia involves quantitative and qualitative changes of muscle mass with aging. Computed Tomography and Magnetic Resonance are the gold standard for the study of sarcopenia. Sonography' reliability has not been fully evaluated compared with other methods, yet. Dual X-ray Absorptiometry is the most used method to estimate the loss of muscle mass. Abstract: Sarcopenia is currently considered a geriatric syndrome increasing in older people. The consequences of sarcopenia – in terms of impaired mobility, limited self-sufficiency and disability – have been amply demonstrated, increasing the need to develop methods to identify muscle mass loss as early as possible. Although sarcopenia involves a reduction in both muscle mass and function, loss of muscle mass remains the essential criterion for diagnosing this condition in daily practice. Computed tomography and magnetic resonance imaging represent the gold standard for studying body composition, and can identify quantitative and qualitative changes in muscle mass. These techniques are costly, time-consuming and complex, however, so their applicability is limited to the research field. Sonography, on the other hand, has the advantage of being a relatively quick and inexpensive method for detecting loss of muscle fibers and fat infiltration by analyzing muscle thickness and echo intensity. To the best of our knowledge, however, only few studies have compared the results of ultrasound with those obtained by other methods in order to establish its reliability in this setting. Dual X-ray absorptiometry thus remains the most often used technology for studying body composition, detecting quantitative changes in muscle mass with the advantages of a low radiation dose, a simple technology and a rapid assessment.

Reverse Sarcopenia

Reverse Sarcopenia Book
Author : Joseph Tieri
Publisher : Simon and Schuster
Release : 2019-07-26
ISBN : 1612439187
Language : En, Es, Fr & De

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Book Description :

Take control of your physical and brain health with low-level strength training We all know that we lose muscle mass as we age. But did you know that sarcopenic obesity (a.k.a. being “skinny fat”) is linked to increasing your risk of developing dementia and/or Alzheimer’s? Not only is losing muscle bad for your body, it’s also bad for your brain. Don’t let muscle deterioration negatively affect your future. It’s time to take your physical and brain health into your own hands with strength training. This book is full of tips, techniques, and easy-to-follow strength-training routines to fight sarcopenia. From beginners to those already comfortable using weights, this book has solutions for everyone. Lose fat, improve muscle tone, and strengthen bones while guarding against sarcopenia and its negative impact on your body and your brain. This book makes it easy to regain the muscle mass you need to live a healthier and longer life.

Sarcopenia Relocating the Forest Among the Trees

Sarcopenia  Relocating the Forest Among the Trees Book
Author : Anonim
Publisher : Unknown
Release : 2021-05-12
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

As life expectancy continues to rise worldwide, health concerns associated with advanced age are increasingly becoming prominent public health concerns. Among these concerns, nearly 30 years of discussion and research have yielded a wealth of information regarding the pathophysiology, biologic etiology, and clinical implications of age-related declines in skeletal muscle mass and function (i.e., sarcopenia). Recent years have yielded several debates surrounding both the definition and terminology of sarcopenia, yet many questions remain regarding interventions to treat the condition. Among major future challenges in the area will be to design and conduct high-quality clinical trials to ultimately provide new therapeutic strategies for the treatment of sarcopenia.

The Journals of Gerontology

The Journals of Gerontology Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Journals of Gerontology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.