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RNA Therapeutics

RNA Therapeutics Book
Author : Amanda L. Garner
Publisher : Springer
Release : 2017-09-26
ISBN : 3319680919
Language : En, Es, Fr & De

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Book Description :

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

RNA Therapeutics

RNA Therapeutics Book
Author : Paloma H. Giangrande,Vittorio Defranciscis,John J. Rossi
Publisher : Academic Press
Release : 2021-06-01
ISBN : 0128217391
Language : En, Es, Fr & De

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Book Description :

RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing, and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate cellular processes such as transcription, translation, and protein function. Approved RNA-based therapies and lessons learned from failed therapies are discussed in-depth, as are evolving advances in RNA biochemical analysis, and similar advances that are enabling clinical application of RNA-based therapies. Later sections discuss delivery technologies, remaining hurdles in research and translation; the therapy development process from the lab to the clinic; and novel RNA-based therapies currently in development. Features leading experts in the field of RNA therapeutics, spanning all classes of RNA therapies Provides detailed examination of approved RNA therapies and lessons learned from failed therapeutics Covers all aspects of therapeutic discovery and preclinical development, as well as clinical translation, manufacturing, and regulatory aspects

RNA Therapeutics

RNA Therapeutics Book
Author : Mouldy Sioud
Publisher : Humana Press
Release : 2010-09-16
ISBN : 9781607616566
Language : En, Es, Fr & De

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Book Description :

Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular BiologyTM series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.

Entering the RNA Wonderland Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System

Entering the RNA Wonderland  Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System Book
Author : Anna Zampetaki,Lars Maegdefessel
Publisher : Frontiers Media SA
Release : 2020-07-22
ISBN : 2889638820
Language : En, Es, Fr & De

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Book Description :

Download Entering the RNA Wonderland Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System book written by Anna Zampetaki,Lars Maegdefessel, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Tumor penetrating Delivery of Small Interfering RNA Therapeutics

Tumor penetrating Delivery of Small Interfering RNA Therapeutics Book
Author : Yin Ren (Ph. D.),Harvard--MIT Program in Health Sciences and Technology
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Efforts to sequence cancer genomes have begun to uncover comprehensive lists of genes altered in cancer. Unfortunately, the number and complexity of identified alterations has made dissecting the underlying biology of cancer difficult, as many genes are not amenable to manipulation by small molecules or antibodies. RNA interference (RNAi) provides a direct way to assess and act on putative cancer targets. However, the translation of RNAi into the clinic has been thwarted by the "delivery" challenge, as small interfering RNA (siRNA) therapeutics must overcome clearance mechanisms and penetrate into tumor tissues to access cancer cells. This thesis sought to develop nanotechnology-based platforms to rapidly discover and validate cancer targets in vivo. First, we developed versatile surface chemistries for nanoparticle tumor targeting. Leveraging new discoveries in amplified transvascular transport, we designed a siRNA delivery system that integrates the tumor specificity and tissue-penetrating ability of tumor-penetrating peptides with membrane penetration properties of protein transduction domains to direct siRNA to tumors in vivo. Second, we utilized this delivery system to bridge the gap between cancer genomic discovery and in vivo target validation. Comprehensive analysis of ovarian cancer genomes identified candidate targets that are undruggable by traditional approaches. Tumor-penetrating delivery of siRNA against these genes potently impeded the growth of ovarian tumors in mice and improved survival, thereby credentialing their roles in tumor initiation and maintenance. Lastly, we described efforts extending this platform for clinical translation. Mechanistic studies identified functional properties that favored receptor-specific siRNA delivery. We also explored a strategy to improve the microdistribution of successively dosed siRNA therapeutics through modulating the tumor microenvironment. Finally, we investigated the utility of the system in primary human tumors derived from patients with ovarian cancer. Together, these findings illustrate that the combination of cancer genomics with the engineering of siRNA delivery nanomaterials establishes a platform for discovering genes amenable to RNAi therapies. As efforts in genome sequencing accelerate, this platform illustrates a path to clinical translation in humans.

RNA Technologies and Their Applications

RNA Technologies and Their Applications Book
Author : Volker A. Erdmann,Jan Barciszewski
Publisher : Springer Science & Business Media
Release : 2010-09-02
ISBN : 9783642121685
Language : En, Es, Fr & De

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Book Description :

RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.

Therapeutic Oligonucleotides

Therapeutic Oligonucleotides Book
Author : Yoon S. Cho-Chung,Alan M. Gewirtz,Cy A. Stein,National Institutes of Health (U.S.). Therapeutic Oligonucleotide Interest Group
Publisher : Unknown
Release : 2003
ISBN : 9781573314701
Language : En, Es, Fr & De

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Book Description :

This work is concerned with various aspects of oligonucleotides including triplex DNA, transcription factor decoy, antisense DNA/RNA, ribozymes, PNA, 2',5'-oligoadenylates, RNAi, and CpG immune-stimulating oligomers, diagnostic oligonucleotide chips (DNA chips), and gene therapy vectors.

Goodman Gilman s the Pharmacological Basis of Therapeutics

Goodman   Gilman s the Pharmacological Basis of Therapeutics Book
Author : Louis Sanford Goodman,Alfred Goodman Gilman
Publisher : McGraw-Hill Professional Publishing
Release : 2001
ISBN : 9780071354691
Language : En, Es, Fr & De

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Book Description :

The Tenth Edition also brings the field of pharmacology up-to-date in terms of critical areas such as molecular biology, new drugs, and clinical studies that have contributed to the understanding of therapeutics and their role in the management of disease. Time-tested, yet up-to-the-minute, "G & G" is truly the most current, expert, and easy-to-use drug reference available today.Visit http://www.goodmanandgilman.com for more information.

The Journal of Pharmacology and Experimental Therapeutics

The Journal of Pharmacology and Experimental Therapeutics Book
Author : Anonim
Publisher : Unknown
Release : 1978
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Journal of Pharmacology and Experimental Therapeutics book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Antiviral Potential of Mammalian RNA Silencing

The Antiviral Potential of Mammalian RNA Silencing Book
Author : Leonid Gitlin
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Antiviral Potential of Mammalian RNA Silencing book written by Leonid Gitlin, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Encyclopedia of Genetics

Encyclopedia of Genetics Book
Author : Bryan D. Ness
Publisher : Salem PressInc
Release : 2004
ISBN : 9781587651502
Language : En, Es, Fr & De

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Book Description :

Looks at the field of genetics, covering such topics as autism, DNA, bioethics, cancer, diabetes, eugenics, and pseudogenes.

Acupuncture Electro therapeutics Research

Acupuncture   Electro therapeutics Research Book
Author : Anonim
Publisher : Unknown
Release : 1976
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Acupuncture Electro therapeutics Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

International Encyclopedia of Pharmacology and Therapeutics

International Encyclopedia of Pharmacology and Therapeutics Book
Author : Anonim
Publisher : Unknown
Release : 1966
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download International Encyclopedia of Pharmacology and Therapeutics book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Antisense Therapeutics

Antisense Therapeutics Book
Author : G. L. Trainor
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Antisense Therapeutics book written by G. L. Trainor, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Polymer Therapeutics II

Polymer Therapeutics II Book
Author : Valery Y. Alakhov
Publisher : Springer Science & Business Media
Release : 2006-01-12
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Physics is really important to game programmers who need to know how to add physical realism to their games. They need to take into account the laws of physics when creating a simulation or game engine, particularly in 3D computer graphics, for the purpose of making the effects appear more real to the observer or player.The game engine needs to recognize the physical properties of objects that artists create, and combine them with realistic motion. The physics ENGINE is a computer program that you work into your game that simulates Newtonian physics and predict effects under different conditions. In video games, the physics engine uses real-time physics to improve realism. This is the only book in its category to take readers through the process of building a complete game-ready physics engine from scratch. The Cyclone game engine featured in the book was written specifically for this book and has been utilized in iPhone application development and Adobe Flash projects. There is a good deal of master-class level information available, but almost nothing in any format that teaches the basics in a practical way. The second edition includes NEW and/or revised material on collision detection, 2D physics, casual game physics for Flash games, more references, a glossary, and end-of-chapter exercises. The companion website will include the full source code of the Cyclone physics engine, along with example applications that show the physics system in operation. --A truly accessible text that allows even novice programmers to create powerful physics engines for their games. --Covers particle effects, flight simulation, car pysics, crates, destructible objects, cloth and ragdolls, and more. --Supports each new concept with diagrams, code, end-of-chapter exercises and resources. --This edition includes completely NEW material on: collision detection, 2D physics, casual game physics for Flash games. --Powerful associated website offering: the full source code of the Cyclone physics engine, along with example applications that show the physics system in operation. The Cyclone engine has been used in commercial game development.

DNA and RNA Nanobiotechnologies in Medicine Diagnosis and Treatment of Diseases

DNA and RNA Nanobiotechnologies in Medicine  Diagnosis and Treatment of Diseases Book
Author : Volker A. Erdmann,Jan Barciszewski
Publisher : Springer Science & Business Media
Release : 2013-06-20
ISBN : 3642368530
Language : En, Es, Fr & De

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Book Description :

This book will provide latest insights in the functional potentials of ribonucleic acids in medine and the use of Spiegelmer and Spiegelzyme systems. It will also deal with a new type of delivery systems for cellular targeting.

Biomolecular Engineering of SiRNA Therapeutics

Biomolecular Engineering of SiRNA Therapeutics Book
Author : Joseph A. Gredell
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomolecular Engineering of SiRNA Therapeutics book written by Joseph A. Gredell, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Medical and Health Information Directory

Medical and Health Information Directory Book
Author : Hill, Sonya D.
Publisher : Gale / Cengage Learning
Release : 2004-09
ISBN : 9780787671105
Language : En, Es, Fr & De

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Book Description :

Download Medical and Health Information Directory book written by Hill, Sonya D., available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Wiley Encyclopedia of Chemical Biology Volume 3

Wiley Encyclopedia of Chemical Biology  Volume 3 Book
Author : Tadhg P. Begley
Publisher : Wiley
Release : 2009-02-03
ISBN : 9780470470190
Language : En, Es, Fr & De

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Book Description :

The first major reference at the interface of chemistry, biology, and medicine Chemical biology is a rapidly developing field that uses the principles, tools, and language of chemistry to answer important questions in the life sciences. It has enabled researchers to gather critical information about the molecular biology of the cell and is the fundamental science of drug discovery, playing a key role in the development of novel agents for the prevention, diagnosis, and treatment of disease. Now students and researchers across the range of disciplines that use chemical biology techniques have a single resource that encapsulates what is known in the field. It is an excellent place to begin any chemical biology investigation. Major topics addressed in the encyclopedia include: Applications of chemical biology Biomolecules within the cell Chemical views of biology Chemistry of biological processes and systems Synthetic molecules as tools for chemical biology Technologies and techniques in chemical biology Some 300 articles range from pure basic research to areas that have immediate applications in fields such as drug discovery, sensor technology, and catalysis. Novices in the field can turn to articles that introduce them to the basics, whereas experienced researchers have access to articles exploring the cutting edge of the science. Each article ends with a list of references to facilitate further investigation. With contributions from leading researchers and pioneers in the field, the Wiley Encyclopedia of Chemical Biology builds on Wiley's unparalleled reputation for helping students and researchers understand the crucial role of chemistry and chemical techniques in the life sciences.

Antisense Oligodeoxynucleotides and Antisense RNA

Antisense Oligodeoxynucleotides and Antisense RNA Book
Author : Benjamin Weiss
Publisher : CRC Press
Release : 1997-06-23
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A practical, up-to-date treatise on this technology and its potential application in therapeutics. It features critical analyses of the specificity of the agents, and the possibility of antisense oligomers acting through non-antisense mechanisms. The history of early development of antisense oligodeoxynucleotides and their chemical modification to increase their stability is followed by delivery and penetration into cells, non-antisense effects of antisense oligonucleotides, pharmacokinetic properties; in vitro and in vivo model systems, and clinical trials.