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Risk Assessment For Human Metal Exposures

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Risk Assessment for Human Metal Exposures

Risk Assessment for Human Metal Exposures Book
Author : Gunnar F. Nordberg,Bruce A. Fowler
Publisher : Academic Press
Release : 2018-08-21
ISBN : 0128042680
Language : En, Es, Fr & De

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Book Description :

Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA –TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations. This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication—the classic risk assessment paradigm—with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment. Covers fundamental risk assessment concerns for the effects of metals on human health Provides an easy-to-use structure to quickly locate specific methods Uses case studies to illustrate the methods and theories described Written to be understood by students, researchers and industry workers who need to conduct risk assessment in metals and human health

Risk Assessment for Human Metal Exposures

Risk Assessment for Human Metal Exposures Book
Author : Gunnar F. Nordberg,Bruce A. Fowler
Publisher : Academic Press
Release : 2018-09-17
ISBN : 9780128042274
Language : En, Es, Fr & De

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Book Description :

Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA -TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations. This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication-the classic risk assessment paradigm-with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment. Covers fundamental risk assessment concerns for the effects of metals on human health Provides an easy-to-use structure to quickly locate specific methods Uses case studies to illustrate the methods and theories described Written to be understood by students, researchers and industry workers who need to conduct risk assessment in metals and human health

Toxicity Mechanisms Exposure Toxicokinetic and Risk Assessment Aspects of Metals Toxic for Animals and Humans

Toxicity Mechanisms  Exposure  Toxicokinetic and Risk Assessment Aspects of Metals  Toxic for Animals and Humans Book
Author : Yanzhu Zhu,Fatma Mohamady El-Demerdash,Xinwei Li,Michel Mansur Machado,Alex Boye
Publisher : Frontiers Media SA
Release : 2022-03-10
ISBN : 2889746402
Language : En, Es, Fr & De

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Book Description :

Download Toxicity Mechanisms Exposure Toxicokinetic and Risk Assessment Aspects of Metals Toxic for Animals and Humans book written by Yanzhu Zhu,Fatma Mohamady El-Demerdash,Xinwei Li,Michel Mansur Machado,Alex Boye, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Environmental Heavy Metal Pollution and Effects on Child Mental Development

Environmental Heavy Metal Pollution and Effects on Child Mental Development Book
Author : Lubomir I. Simeonov,Mihail V. Kochubovski,Biana G. Simeonova
Publisher : Springer Science & Business Media
Release : 2010-11-19
ISBN : 9400702523
Language : En, Es, Fr & De

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Book Description :

Heavy metals can be emitted into environment by both natural and anthropogenic sources, mainly mining and industrial activity. Human exposure occurs through all environmental media. Infants are more susceptible to the adverse effects of exposure. Increasing attention is now being paid to the mental development of children exposed to heavy metals. The purpose of this book is to evaluate the existing knowledge on intellectual impairment in children exposed to heavy metals in their living environment and to identify the research needs in order to obtain a clearer picture of the situation in countries and regions at risk, in which the economy is closely related to metallurgy and heavy metals emission, and to recommend a strategy for human protection. In greater detail the main objectives could be formulated as follows: to review the principal sources of single, and complex mixtures of, heavy metal pollutants in the environment; to identify suitable methodology for chemical analyses in the environment and in humans; to evaluate the existing methods for measuring mental impairment, including their reliability and validity; to recommend a standard testing protocol to be used in future research; to assess the future role of environmental heavy metal pollution in countries and regions at risk and its effects on children’s neurological development; to recommend a prevention strategy for protecting children’s health and development.

Metal Ions in Toxicology

Metal Ions in Toxicology Book
Author : Astrid Sigel,Helmut Sigel,Roland K. O. Sigel
Publisher : Royal Society of Chemistry
Release : 2011
ISBN : 1849730911
Language : En, Es, Fr & De

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Book Description :

It is an old wisdom that metals are indispensable for life. Indeed, severalof them, like sodium, potassium, and calcium, are easily discovered in livingmatter. However, the role of metals and their impact on life remainedlargely hidden until inorganic chemistry and coordination chemistryexperienced a pronounced revival in the 1950s. The experimental and theoreticaltools created in this period and their application to biochemicalproblems led to the development of the field or discipline now known asBioinorganic Chemistry, Inorganic Biochemistry, or more recently alsooften addressed as Biological Inorganic Chemistry. By 1970 Bioinorganic Chemistry was established and further promoted bythe book series Metal Ions in Biological Systems founded in 1973 (edited byH. S., who was soon joined by A.S.) and published by Marcel Dekker, Inc., New York, for more than 30 years. After this company ceased to be a familyendeavor and its acquisition by another company, we decided, after havingedited 44 volumes of the MIBS series (the last two together with R.K.O.S.)to launch a new and broader minded series to cover today's needs in the LifeSciences. Therefore, the Sigels new series is entitledMetal Ions in Life Sciences. After publication of the first four volumes (2006-2008) with John Wiley & Sons, Ltd., Chichester, UK, we are happy to join forces now in this still newendeavor with the Royal Society of Chemistry, Cambridge, UK; a mostexperienced Publisher in the Sciences.

Practical Environmental Analysis

Practical Environmental Analysis Book
Author : Miroslav Radojevic,Vladimir N Bashkin
Publisher : Royal Society of Chemistry
Release : 2015-11-09
ISBN : 1782625488
Language : En, Es, Fr & De

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Book Description :

New techniques, improved understanding and changes in regulations relating to environmental analysis means that students, technicians and lecturers alike need an up-to-date guide to practical environmental analysis. This unique book provides detailed instructions for practical experiments in environmental analysis. The comprehensive coverage includes the chemical analysis of important pollutants in air, water, soil and plant tissue, and the experiments generally require only basic laboratory equipment and instrumentation. The content is supported by theoretical material explaining, amongst other concepts, the principles behind each method and the importance of various pollutants. Also included are suggestions for projects and worked examples. Appendices cover environmental standards, practical safety and laboratory practice. Building on the foundations laid by the highly acclaimed first edition, this new edition has been revised and updated to include information on new monitoring techniques, the Air Quality Index, internet resources and professional ethics. Like its predecessor, this informative text is certain to be valued as an indispensable guide to practical environmental analysis by students on a variety of science courses and their lecturers. Reviews of the first edition: "I strongly urge academics in chemistry, biology, botany, soil science, geography and environmental science departments to give [this book] serious consideration as a course text." Malcolm Cresser, Environment Department, University of York, UK "Destined to become a course text for many university courses ... a high quality, informative introductory text ... there should be multiple copies on most university's library shelves." Environmental Conservation

Risk Management of Complex Inorganic Materials

Risk Management of Complex Inorganic Materials Book
Author : Violaine Verougstraete
Publisher : Academic Press
Release : 2017-11-21
ISBN : 0128110643
Language : En, Es, Fr & De

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Book Description :

Risk Management of Complex Inorganic Materials: A Practical Guide facilitates the risk assessment and management of complex inorganic materials around the world by providing accessible and specific guidance on their assessment. Inorganic complex materials, such as ores and concentrates, metal containing- glasses, ceramic and inorganic pigments, alloys, and UVCBs produced during the manufacturing of metals present specificities not addressed by most guidance documents. This book explains the main characteristics of inorganic complex materials affecting their hazard and risk assessment and management, including their source and main uses, also covering hazard and exposure assessment, risk characterization and risk management. It is an essential reference for regulators involved in risk assessment and risk management, industry experts charged of compliance with chemical management program requirements, consultants preparing chemicals management files for companies and regulators, and academics involved in research on complex inorganic materials. Focuses on key information required to globally manage the risk of inorganic complex material Includes user-friendly descriptions of methodologies and tools that facilitate chemicals management of such materials Provides key messages to assist communication on risk assessment and risk management to audiences like regulators, workers and communities living around industrial sites

Nordic comments on the Health Risk Assessment Guidance for Metals

Nordic comments on the Health Risk Assessment Guidance for Metals Book
Author : Anonim
Publisher : Nordic Council of Ministers
Release : 2007
ISBN : 9289315725
Language : En, Es, Fr & De

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Book Description :

Download Nordic comments on the Health Risk Assessment Guidance for Metals book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Handbook on the Toxicology of Metals

Handbook on the Toxicology of Metals Book
Author : Monica Nordberg,Gunnar F. Nordberg,Bruce A. Fowler,Lars Friberg
Publisher : Elsevier
Release : 2011-04-28
ISBN : 0080546102
Language : En, Es, Fr & De

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Book Description :

Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds. * Covers up-to-date toxicological information on 31 metallic elements and their compounds, each in a separate chapter * New chapters on general chemistry, biological monitoring and biomarkers, essential metals, principles for prevention of the toxic effects of metals, and more

Public Health Risk Assessment for Human Exposure to Chemicals

Public Health Risk Assessment for Human Exposure to Chemicals Book
Author : K. Asante-Duah
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401004811
Language : En, Es, Fr & De

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Book Description :

In fact, with the control and containment of most infectious conditions and diseases of the past millennium having been achieved in most developed countries, and with the resultant increase in life expectancies, much more attention seems to have shifted to degenerative health problems. Many of the degenerative health conditions have been linked to thousands of chemicals regularly encountered in human living and occupational/work environments. It is important, therefore, that human health risk assessments are undertaken on a consistent basis - in order to determine the potential impacts of the target chemicals on public health.

Issue Paper on Metal Exposure Assessment

Issue Paper on Metal Exposure Assessment Book
Author : Anonim
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Issue Paper on Metal Exposure Assessment book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Heavy Metals

Heavy Metals Book
Author : Hosam El-Din M. Saleh,Refaat Aglan
Publisher : BoD – Books on Demand
Release : 2018-06-27
ISBN : 1789233607
Language : En, Es, Fr & De

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Book Description :

Fundamental societal changes resulted from the necessity of people to get organized in mining, transporting, processing, and circulating the heavy metals and their follow-up products, which in consequence resulted in a differentiation of society into diversified professions and even societal strata. Heavy metals are highly demanded technological materials, which drive welfare and progress of the human society, and often play essential metabolic roles. However, their eminent toxicity challenges the field of chemistry, physics, engineering, cleaner production, electronics, metabolomics, botany, biotechnology, and microbiology in an interdisciplinary and cross-sectorial manner. Today, all these scientific disciplines are called to dedicate their efforts in a synergistic way to avoid exposure of heavy metals into the eco- and biosphere, to reliably monitor and quantify heavy metal contamination, and to foster the development of novel strategies to remediate damage caused by heavy metals.

Hazard Identification and Risk Assessment for Metals

Hazard Identification and Risk Assessment for Metals Book
Author : L. Surges
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Hazard Identification and Risk Assessment for Metals book written by L. Surges, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A Framework to Guide Selection of Chemical Alternatives

A Framework to Guide Selection of Chemical Alternatives Book
Author : Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Government and Industry Decision,Board on Chemical Sciences and Technology,Board on Environmental Studies and Toxicology,National Research Council,Division on Earth and Life Studies
Publisher : Unknown
Release : 2014-10-29
ISBN : 9780309310130
Language : En, Es, Fr & De

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Book Description :

Historically, regulations governing chemical use have often focused on widely used chemicals and acute human health effects of exposure to them, as well as their potential to cause cancer and other adverse health effects. As scientific knowledge has expanded there has been an increased awareness of the mechanisms through which chemicals may exert harmful effects on human health, as well as their effects on other species and ecosystems. Identification of high-priority chemicals and other chemicals of concern has prompted a growing number of state and local governments, as well as major companies, to take steps beyond existing hazardous chemical federal legislation. Interest in approaches and policies that ensure that any new substances substituted for chemicals of concern are assessed as carefully and thoroughly as possible has also burgeoned. The overarching goal of these approaches is to avoid regrettable substitutions, which occur when a toxic chemical is replaced by another chemical that later proved unsuitable because of persistence, bioaccumulation, toxicity, or other concerns. Chemical alternative assessments are tools designed to facilitate consideration of these factors to assist stakeholders in identifying chemicals that may have the greatest likelihood of harm to human and ecological health, and to provide guidance on how the industry may develop and adopt safer alternatives. "A Framework to Guide Selection of Chemical Alternatives" develops and demonstrates a decision framework for evaluating potentially safer substitute chemicals as primarily determined by human health and ecological risks. This new framework is informed by previous efforts by regulatory agencies, academic institutions, and others to develop alternative assessment frameworks that could be operationalized. In addition to hazard assessments, the framework incorporates steps for life-cycle thinking - which considers possible impacts of a chemical at all stages including production, use, and disposal - as well as steps for performance and economic assessments. The report also highlights how modern information sources such as computational modeling can supplement traditional toxicology data in the assessment process. This new framework allows the evaluation of the full range of benefits and shortcomings of substitutes, and examination of tradeoffs between these risks and factors such as product functionality, product efficacy, process safety, and resource use. Through case studies, this report demonstrates how different users in contrasting decision contexts with diverse priorities can apply the framework. This report will be an essential resource to the chemical industry, environmentalists, ecologists, and state and local governments.

MERAG

MERAG Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download MERAG book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Risk Assessment of Chemicals An Introduction

Risk Assessment of Chemicals  An Introduction Book
Author : C.J. van Leeuwen,T.G. Vermeire
Publisher : Springer Science & Business Media
Release : 2007-09-18
ISBN : 1402061013
Language : En, Es, Fr & De

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Book Description :

At last – a second edition of this hugely important text that reflects the progress and experience gained in the last decade and aims at providing background and training material for a new generation of risk assessors. The authors offer an introduction to risk assessment of chemicals as well as basic background information on sources, emissions, distribution and fate processes for the estimation of exposure of plant and animal species in the environment and humans exposed via the environment, consumer products, and at the workplace. The coverage describes the basic principles and methods of risk assessment within their legislative frameworks (EU, USA, Japan and Canada).

Mixture Toxicity

Mixture Toxicity Book
Author : Cornelis A. M. van Gestel,Martijs Jonker,Jan E. Kammenga,Ryszard Laskowski,Claus Svendsen
Publisher : CRC Press
Release : 2016-04-19
ISBN : 9781439830093
Language : En, Es, Fr & De

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Book Description :

In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology and classic human toxicology, Mixture Toxicity: Linking Approaches from Ecological and Human Toxicology incorporates extensive reviews of exposure to toxicants, toxicokinetics and toxicodynamics, toxicity of mixtures, and risk assessment. The book examines developments in both fields, compares and contrasts their current state of the art, and identifies where one field can learn from the other. Each chapter provides an essential overview of the state of the art in both human and ecotoxicological mixture risk assessment, focusing on the work published in the last fifteen years. The coverage progresses from exposure to risk assessment, at each step identifying the special complications typically raised by mixtures. Based on in-depth discussions among specialists representing different disciplines and approaches, the chapters each address: Exposure — how to quantify the amounts of chemicals that may enter the living organism Kinetics, dynamics, and metabolism — how the chemicals enter an organism, travel within the organism, how they are metabolized and reach the target site, and explain development of toxicity with time Toxicity — what are the chemicals’ detrimental effects on the organism Test design and complex mixture characterization — how chemicals interact, how to measure effects of mixtures, and how to identify responsible chemicals Risk assessment — how to assess for risks in humans and the environment An unusual combination of different points of view on exposure to and risk assessment of chemical mixtures, this book summarizes current knowledge on combined effects of toxicant mixtures, information that is generally only available in a very fragmented form as individual journal papers. It identifies possible crosslinks and includes recommendations for mutual developments that can improve the state of knowledge on mixture toxicity and ultimately lead to better and more integrated risk assessment.

Poisoning in the Modern World

Poisoning in the Modern World Book
Author : Ozgur Karcioglu,Banu Arslan
Publisher : BoD – Books on Demand
Release : 2019-06-19
ISBN : 1838807853
Language : En, Es, Fr & De

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Book Description :

Over 400 years ago, Swiss alchemist and physician Paracelsus (1493-1541) cited: "All substances are poisons; there is none that is not a poison. The right dose differentiates a poison from a remedy." This is often condensed to: "The dose makes the poison." So, why are we overtly anxious about intoxications?In fact, poisons became a global problem with the industrial revolution. Pesticides, asbestos, occupational chemicals, air pollution, and heavy metal toxicity maintain high priority worldwide, especially in developing countries. Children between 0 and 5 years old are the most vulnerable to both acute and chronic poisonings, while older adults suffer from the chronic effects of chemicals. This book aims to raise awareness about the challenges of poisons, to help clinicians understand current issues in toxicology.

Metallic Contamination and Its Toxicity

Metallic Contamination and Its Toxicity Book
Author : Ashutosh Gautam
Publisher : Daya Publishing House
Release : 2018
ISBN : 9789387057722
Language : En, Es, Fr & De

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Book Description :

Heavy metals, individually & their compounds can affect human health. These are all naturally occurring substances which are often present in the environment at low levels. In high levels, these can be dangerous. Toxic heavy metals entering the ecosystem may lead to geo-accumulation, bio-accumulation and bio-magnifications. Due to their widespread use in human activities such as industry, agriculture and even as medicine numerous health risks may be associated with exposure to these substances. Their toxicity depends on several factors including the dose, route of exposure, and chemical species, as well as the age, gender, genetics, and nutritional status of exposed individuals. These metallic elements are considered systemic toxicants that are known to induce multiple organ damage, even at lower levels of exposure. Considering the importance of this subject, the present book "Metallic contamination and its Toxicity" gives an overview of the main features of heavy metal and their health consequences. The present book provides sufficient information on toxicology and risk assessment & remedial measures. This book will be useful to Environmentalist, Scientist, Researchers, Industrialists, Social workers and Toxicologists providing useful data. This will help to setup standards/guideline to protect human health & environmental hazard from heavy metal.