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Rio Hortegas Third Contribution To The Morphological Knowledge And Functional Interpretation Of The Oligodendroglia

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Rio Hortega s Third Contribution to the Morphological Knowledge and Functional Interpretation of the Oligodendroglia

Rio Hortega s Third Contribution to the Morphological Knowledge and Functional Interpretation of the Oligodendroglia Book
Author : Jose R. Iglesias-Rozas,Manuel Garrosa
Publisher : Newnes
Release : 2013-06-05
ISBN : 0124116086
Language : En, Es, Fr & De

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Book Description :

Pío del Rio-Hortega, one of the pioneering neuroscientists and discoverer of microglia, has been recognized as one of the most important Spanish neurohistogists of the past century. His landmark research on oligodendroglia, originally published in Spanish in 1928, has been translated into English for the first time by Dr. José R. Iglesias-Rozas and Prof. Manuel Garrosa. The book establishes definitively the concept of oligodendroglia and describes in great detail its structure, varieties, function, origin and pathology, providing a thorough review. The entire 1928 writing is presented, including the 79 excellent drawings and photographs from the original publication. To complement the original book and provide historical context, the translators have also included an introduction to the research and a biography of Pío del Rio-Hortega. This book constitutes a milestone in the history of neuroscience, biology and medicine, and it will be valuable reading for researchers and practitioners in these fields. First English translation of seminal 1928 research Contains the broad descriptions and interpretations of the normal and pathological oligodendroglia Full original text and new introductory sections

Rio Hortega s Third Contribution to the Morphological Knowledge and Functional Interpretation of the Oligodendroglia

Rio Hortega s Third Contribution to the Morphological Knowledge and Functional Interpretation of the Oligodendroglia Book
Author : Jose R. Iglesias-Rozas,Manuel Garrosa
Publisher : Elsevier
Release : 2013-06-17
ISBN : 9780124116177
Language : En, Es, Fr & De

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Book Description :

Pío del Rio-Hortega, one of the pioneering neuroscientists and discoverer of microglia, has been recognized as one of the most important Spanish neurohistogists of the past century. His landmark research on oligodendroglia, originally published in Spanish in 1928, has been translated into English for the first time by Dr. José R. Iglesias-Rozas and Prof. Manuel Garrosa. The book establishes definitively the concept of oligodendroglia and describes in great detail its structure, varieties, function, origin and pathology, providing a thorough review. The entire 1928 writing is presented, including the 79 excellent drawings and photographs from the original publication. To complement the original book and provide historical context, the translators have also included an introduction to the research and a biography of Pío del Rio-Hortega. This book constitutes a milestone in the history of neuroscience, biology and medicine, and it will be valuable reading for researchers and practitioners in these fields. First English translation of seminal 1928 research Contains the broad descriptions and interpretations of the normal and pathological oligodendroglia Full original text and new introductory sections

The Major Discoveries of Cajal and His Disciples Consolidated Milestones for the Neuroscience of the XXIst Century

The Major Discoveries of Cajal and His Disciples  Consolidated Milestones for the Neuroscience of the XXIst Century Book
Author : Fernando de Castro,Miguel A. Merchán
Publisher : Frontiers Media SA
Release : 2017-04-25
ISBN : 288945066X
Language : En, Es, Fr & De

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Book Description :

When Santiago Ramón y Cajal started to unravel the fine structure of the nervous system in the last decades of the XIXth century maybe only his unbeatable soul of brave Spaniard imagined that most of the descriptions were scientific truths that lasted to date. Simple histological stainings, curiosity to ameliorate these, monocular microscopes, patience for drawing his observations and a rich imaginative open mind: this is the recipy for Cajal success. His descriptions of connectivity in the nervous system, compiled in Cajal's opus magna published in 1904 ("Textura del sistema nervioso del hombre y los vertebrados") and 1911 ("Histologie du systeme nerveux"), have been corroborated by modern techniques decade after decade. Even more, the main hypothesis that Cajal raised are universally recognised as biological laws, today: the neuron theory, the law on the dynamic polarization of the neuron and the chemotropic hypothesis. That is: the nervous system is not a sincitial network but is formed by individual cells; the transmission of the nerve impulses follow a main direction within a given neuron; the axons are guided by chemical substances in a chemotropic way, till form synapses with their targets. Attracted by Cajal's strong personality and scientific success, a number of medical students and doctors join him in the crusade to explore the nervous system. And the seed planted by the universal savant was really successful: Francisco Tello described interesting aspects of the regeneration of peripheral nerves which are very useful for neuroscientist currently working in this topic; Nicolás Achúcarro significantly contributed to study neuroglia and future microglia; Pío del Río-Hortega identified two out of the four main nervous cell types, the oligodendrocytes and microglia, and proposed an almost still valid classification for the CNS tumours; Fernando de Castro made was the first description of arterial chemoreceptors in the carotid body; Rafael Lorente de Nó was a dominant figure of Neuroscience for decades after the IInd World War, first describing the columnar organization of the cerebral cortex well before Mountcastle, Hubbel and Wiesel. Even less recognised co-workers and disciples of Cajal (his brother Pedro Ramón y Cajal, Domingo Sánchez, the neurologist Rodríguez-Lafora... protagonised discoveries that are consolidated scientific truths today). Altogether, it is difficult (if not impossible) to find a school in biology contributing in such a fundamental and variated way to the common acervo like the collectively known as Cajal School or Spanish Neurological School. Although the particular way to work of the Maestro, selecting a pleiade of brilliant collaborators with whom accomplish such a titanic feat, giving them freedom for their studies, has been recognised and confronted to antagonic systems followed by other relevant scientists and scientific schools, the general recognition of such a significant major milestones for Neuroscience and their vigency in the well-marched XXIst century is not: this is the purpose of this Ebook, to remind all these examples of how successful can be the scientific work when it is minutious, constant and performed by brilliant, imaginative and skilled scientists with a minimal conditions supporting their efforts.

Never resting microglia physiological roles in the healthy brain and pathological implications

Never resting microglia  physiological roles in the healthy brain and pathological implications Book
Author : Amanda Sierra,Marie-Eve Tremblay,Hiroaki Wake
Publisher : Frontiers E-books
Release : 2015-02-11
ISBN : 2889193691
Language : En, Es, Fr & De

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Book Description :

Microglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveries have challenged the current view of microglia, showing their active and positive contribution to normal brain function. This Research Topic reviewed the novel physiological roles of microglia in the developing, mature and aging brain, under non-pathological conditions. In particular, this Research Topic discussed the cellular and molecular mechanisms by which microglia contribute to the formation, pruning and plasticity of synapses; the regulation of adult neurogenesis as well as hippocampal learning and memory; among other important roles. Because these novel findings defy our understanding of microglial function in health as much as in disease, this Research Topic also summarized the current view of microglial nomenclature, phenotypes, origin and differentiation, and contribution to various brain pathologies. Additionally, novel imaging approaches and molecular tools to study microglia in their non-activated state have been discussed. In conclusion, this Research Topic seeked to emphasize how the current research in neuroscience is challenged by never-resting microglia.

Neuroglia

Neuroglia Book
Author : Helmut Kettenmann,Bruce R. Ransom
Publisher : Oxford University Press
Release : 2004-09-30
ISBN : 0198034741
Language : En, Es, Fr & De

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Book Description :

Neuroglia is the only comprehensive reference book on the basic biology and function of glial cells. This long-awaited second edition has been completely reorganized and rewritten to include the dramatic advances in this field since the first edition was published ten years ago. The impact of the second edition will be greater than that of the first because the majority of neuroscientists now acknowledge that neuroglia are elemental to most, if not all, brain functions. The second edition covers the entire field of glial research from the basic molecular and cellular principles of these cells to their involvement in neurological diseases including stroke, Alzheimer's disease, and multiple sclerosis. It includes new chapters on transmitter release from exocytosis from glia, glia derived stem cells, glia and synaptic transmission, glia and axon guidance, an entirely new section on mechanisms of glial injury, and several new chapters on the roles of glia in different diseases. The new edition was written with both students and experts in mind. It provides a basic introduction to the entire range of glial topics and detailed information with critical assessment of the research literature. Neuroscience textbooks focus on the properties of neurons, whereas this book fills the information void about the brain's other cells. Neuroglia, Second Edition, is an essential reference source for newcomers, including graduate students, to neuroanatomy, neurochemistry, neurophysiology, and molecular neurobiology. It is also a vital companion for established researchers in these fields as well as clinicians in neurology, neurosurgery, psychiatry, neuropathology, and neuro-oncology.

Microglia in Health and Disease A Unique Immune Cell Population

Microglia in Health and Disease  A Unique Immune Cell Population Book
Author : Alessandro Michelucci,Michel Mittelbronn,Diego Gomez-Nicola
Publisher : Frontiers Media SA
Release : 2018-10-05
ISBN : 2889456013
Language : En, Es, Fr & De

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Book Description :

Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.

The Lancet

The Lancet Book
Author : Anonim
Publisher : Unknown
Release : 1940
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Lancet book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Encephalitis Lethargica

Encephalitis Lethargica Book
Author : Paul Bernard Foley
Publisher : Springer
Release : 2018-02-07
ISBN : 1493903845
Language : En, Es, Fr & De

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Book Description :

Encephalitis lethargica (‘sleeping sickness’) was a mysterious disorder that swept the world in the decade following the First World War, before disappearing without its cause having been identified. Around 85% of its victims, predominantly children, adolescents and younger adults, survived the acute disorder, but most developed severe neurological syndromes, particularly severe post-encephalitic parkinsonism and other severe motor abnormalities, that incapacitated them for the remainder of their lives. Despite its brief history, encephalitis lethargica played a major role in a variety medical discussions between the two World Wars, as this epitome of neuropsychiatric disease – attacking both motor and mental functions – appeared just as the separation of neurology and psychiatry had reached a critical point. Encephalitis lethargica sufferers presented an unprecedented combination of neurologic and psychiatric symptoms – including previously puzzling phenomena primarily associated with schizophrenia and hysteria, as well as behavioral changes and attention deficit disorders in children – that not only underscored the unity of mind and movement in the CNS, but also illuminated the critical role played by subcortical structures in consciousness and other higher mental functions that had formerly been associated with the soul and more recently presumed to be localized to the human cerebral cortex. Encephalitis lethargica exerted a greater influence on clinical and theoretic neuroscientific thought between the two World Wars than any other single disorder and had an enduring impact upon neurology and psychiatry. This book will be of interest to an educated audience active or interested in clinical (neurology, psychiatry, psychology) or laboratory neuroscience, particularly those interested in neuropsychiatry, as well as to those interested in the history of the biomedical sciences.

Fundamental Neuroscience

Fundamental Neuroscience Book
Author : Larry Squire,Floyd E. Bloom,Nicholas C. Spitzer,Larry R. Squire,Darwin Berg,Sascha du Lac,Anirvan Ghosh
Publisher : Academic Press
Release : 2008-04-02
ISBN : 9780080561028
Language : En, Es, Fr & De

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Book Description :

Fundamental Neuroscience, 3rd Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts. Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! New to this edition: 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness Additional text boxes describing key experiments, disorders, methods, and concepts Multiple model system coverage beyond rats, mice, and monkeys Extensively expanded index for easier referencing

Introduction to Epilepsy

Introduction to Epilepsy Book
Author : Gonzalo Alarcón,Antonio Valentín
Publisher : Cambridge University Press
Release : 2012-04-26
ISBN : 0521691583
Language : En, Es, Fr & De

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Book Description :

Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.

Neuroglia

Neuroglia Book
Author : Helmut Kettenmann,Bruce R. Ransom
Publisher : Oxford University Press
Release : 2005
ISBN : 9780195152227
Language : En, Es, Fr & De

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Book Description :

Graduate students in neuroanatomy, neurochemistry, neurophysiology, and molecular neurobiology will find the book indispensable. It is also a vital companion for researchers in these fields as well as clinicians in neurology, neurosurgery, neuropathology, neuro-oncology, physiatry, and psychiatry."--BOOK JACKET.

Spinal Cord Injury SCI Repair Strategies

Spinal Cord Injury  SCI  Repair Strategies Book
Author : Giuseppe Perale,Filippo Rossi
Publisher : Woodhead Publishing
Release : 2019-10-30
ISBN : 0081028083
Language : En, Es, Fr & De

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Book Description :

Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering

Dendritic Cell and Macrophage Nomenclature and Classification

Dendritic Cell and Macrophage Nomenclature and Classification Book
Author : Florent Ginhoux,Martin Guilliams,Shalin Naik
Publisher : Frontiers Media SA
Release : 2016-07-14
ISBN : 2889199185
Language : En, Es, Fr & De

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Book Description :

The mononuclear phagocyte system (MPS) comprises dendritic cells (DCs), monocytes and macrophages (MØs) that together play crucial roles in tissue immunity and homeostasis, but also contribute to a broad spectrum of pathologies. They are thus attractive therapeutic targets for immune therapy. However, the distinction between DCs, monocytes and MØ subpopulations has been a matter of controversy and the current nomenclature has been a confounding factor. DCs are remarkably heterogeneous and consist of multiple subsets traditionally defined by their expression of various surface markers. While markers are important to define various populations of the MPS, they do not specifically define the intrinsic nature of a cell population and do not always segregate a bona fide cell type of relative homogeneity. Markers are redundant, or simply define distinct activation states within one subset rather than independent subpopulations. One example are the steady-state CD11b+ DCs which are often not distinguished from monocytes, monocyte-derived cells, and macrophages due to their overlapping phenotype. Lastly, monocyte fate during inflammation results in cells bearing the phenotypic and functional features of both DCs and MØs significantly adding to the confusion. In fact, depending on the context of the study and the focus of the laboratory, a monocyte-derived cell will be either be called "monocyte-derived DCs" or "macrophages". Because the names we give to cells are often associated with a functional connotation, this is much more than simple semantics. The "name" we give to a population fundamentally changes the perception of its biology and can impact on research design and interpretation. Recent evidence in the ontogeny and transcriptional regulation of DCs and MØs, combined with the identification of DC- and MØ-specific markers has dramatically changed our understanding of their interrelationship in the steady state and inflammation. In steady state, DCs are constantly replaced by circulating blood precursors that arise from committed progenitors in the bone marrow. Similarly, some MØ populations are also constantly replaced by circulating blood monocytes. However, others tissue MØs are derived from embryonic precursors, are seeded before birth and maintain themselves in adults by self-renewal. In inflammation, such differentiation pathways are fundamentally changed and unique monocyte-derived inflammatory cells are generated. Current DC, monocyte and MØ nomenclature does not take into account these new developments and as a consequence is quite confusing. We believe that the field is in need of a fresh view on this topic as well as an upfront debate on DC and MØ nomenclature. Our aim is to bring expert junior and senior scientists to revisit this topic in light of these recent developments. This Research Topic will cover all aspects of DC, monocyte and MØ biology including development, transcriptional regulation, functional specializations, in lymphoid and non-lymphoid tissues, and in both human and mouse models. Given the central position of DCs, monocytes and MØs in tissue homeostasis, immunity and disease, this topic should be of interest to a large spectrum of the biomedical community.

Glial Physiology and Pathophysiology

Glial Physiology and Pathophysiology Book
Author : Alexei Verkhratsky,Arthur Butt
Publisher : John Wiley & Sons
Release : 2013-01-31
ISBN : 1118402057
Language : En, Es, Fr & De

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Book Description :

Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells. Coverae includes: the morphology and interrelationships between glial cells and neurones in different parts of the nervous systems the cellular physiology of the different kinds of glial cells the mechanisms of intra- and inter-cellular signalling in glial networks the mechanisms of glial-neuronal communications the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system the cellular and molecular mechanisms of metabolic neuronal-glial interactions the role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it. An up-to-date and fully referenced text on the most numerous cells in the human brain Detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system Describes the role og glial cells in neuropathology Focus boxes highlight key points and summarise important facts Companion website with downloadable figures and slides

Cytology Cellular Pathology of the Nervous System

Cytology   Cellular Pathology of the Nervous System Book
Author : Wilder Graves Penfield
Publisher : Unknown
Release : 1932
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cytology Cellular Pathology of the Nervous System book written by Wilder Graves Penfield, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biology and Pathology of Perineuronal Satellite Cells in Sensory Ganglia

Biology and Pathology of Perineuronal Satellite Cells in Sensory Ganglia Book
Author : Ennio Pannese
Publisher : Springer
Release : 2018-05-09
ISBN : 3319601407
Language : En, Es, Fr & De

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Book Description :

This volume provides a comprehensive and updated review of perineuronal satellite cells in sensory ganglia. For a long time since their discovery by Valentin in the first half of the 19th century these cells received only modest attention. However, some years ago research findings suggested that satellite cells play a role in the development and maintenance of neuropathic pain. As a result, satellite cells are now considered as possible targets for neuropathic pain treatment. Thus, interest in satellite cells has burgeoned. The review is based on the author’s own work as well as on his critical evaluation and systematic arrangement of data scattered through a large number of research papers. The following aspects of perineuronal satellite cells are covered: Shape and structure; molecular characteristics; origin and development; biological and functional properties; relationships with the ganglion sensory neuron; age-related changes; roles under physiological conditions; reactions to experimental and pathological conditions; role in neuropathic pain.

Fundamental Neuroscience

Fundamental Neuroscience Book
Author : Larry Squire,Darwin Berg,Floyd E. Bloom,Sascha du Lac,Anirvan Ghosh,Larry R. Squire,Nicholas C. Spitzer,Susan K. McConnell,James L. Roberts,Michael J. Zigmond
Publisher : Elsevier
Release : 2002-11-19
ISBN : 0080521800
Language : En, Es, Fr & De

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Book Description :

With over 300 training programs in neuroscience currently in existence, demand is great for a comprehensive textbook that both introduces graduate students to the full range of neuroscience, from molecular biology to clinical science, but also assists instructors in offering an in-depth course in neuroscience to advanced undergraduates. The second edition of Fundamental Neuroscience accomplishes all this and more. The thoroughly revised text features over 25% new material including completely new chapters, illustrations, and a CD-ROM containing all the figures from the text. More concise and manageable than the previous edition, this book has been retooled to better serve its audience in the neuroscience and medical communities. Key Features * Logically organized into 7 sections, with uniform editing of the content for a "one-voice" feel throughout all 54 chapters * Includes numerous text boxes with concise, detailed descriptions of specific experiments, disorders, methodological approaches, and concepts * Well-illustrated with over 850 full color figures, also included on the accompanying CD-ROM

Neuroglia in Neurodegenerative Diseases

Neuroglia in Neurodegenerative Diseases Book
Author : Alexei Verkhratsky,Margaret S. Ho,Robert Zorec,Vladimir Parpura
Publisher : Springer Nature
Release : 2019-10-03
ISBN : 9811399131
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.

Society for Neuroscience Abstracts

Society for Neuroscience Abstracts Book
Author : Society for Neuroscience. Meeting
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Society for Neuroscience Abstracts book written by Society for Neuroscience. Meeting, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biology of Neuroglia

Biology of Neuroglia Book
Author : Anonim
Publisher : Elsevier
Release : 1965-01-01
ISBN : 9780080861395
Language : En, Es, Fr & De

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Book Description :

Biology of Neuroglia