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Retrovirus Cell Interactions

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Retrovirus Cell Interactions

Retrovirus Cell Interactions Book
Author : Leslie Parent
Publisher : Academic Press
Release : 2018-08-09
ISBN : 0128111933
Language : En, Es, Fr & De

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Book Description :

Retrovirus-Cell Interactions provides an up-to-date review of the interactions between retroviruses and the cells they infect, offering a comprehensive understanding of how retroviruses hijack cellular factors to facilitate virus replication. Drugs targeting viral enzymes have been developed to treat HIV; the next challenge is to inhibit virus-cell interactions as next generation treatment strategies. Organized according to the retrovirus' replication cycle, this book does not focus exclusively on HIV, but rather includes important findings in other retroviral systems, including animal retroviruses, retrotransposons, and endogenous retroelements to allow broad comparisons on important commonalities and differences. Provides a valuable starting point for people who want to develop a detailed understanding of retroviral replication Includes future-thinking strategies, such as next-generation treatment and anti-retroviral therapeutics Features important commonalities and differences among retroviral systems

Cellular Factors Involved in Early Steps of Retroviral Replication

Cellular Factors Involved in Early Steps of Retroviral Replication Book
Author : John A.T. Young
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 364219012X
Language : En, Es, Fr & De

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Book Description :

The articles in this volume provide a comprehensive overview of our current understanding of the roles played by cellular factors in the early steps of retroviral replication. A better understanding of these functions will provide critical new insights into retrovirus-host cell interactions and is likely to prove useful for the future development of effective antiretroviral therapies.

Cellular Factors Involved in Early Steps of Retroviral Replication

Cellular Factors Involved in Early Steps of Retroviral Replication Book
Author : John A.T. Young
Publisher : Springer
Release : 2003-07-23
ISBN : 9783540008446
Language : En, Es, Fr & De

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Book Description :

The articles in this volume provide a comprehensive overview of our current understanding of the roles played by cellular factors in the early steps of retroviral replication. A better understanding of these functions will provide critical new insights into retrovirus-host cell interactions and is likely to prove useful for the future development of effective antiretroviral therapies.

Interactions Between Retroviruses and Herpesviruses

Interactions Between Retroviruses and Herpesviruses Book
Author : Hsing-Jien Kung
Publisher : World Scientific
Release : 1994
ISBN : 9789810216252
Language : En, Es, Fr & De

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Book Description :

Retroviruses and herpesviruses are two important human pathogens. Together, they occupy one of the most important places in modern Medical Virology. Coinfections of these two viruses in the same individuals are frequently observed, especially in patients afflicted with AIDS. Potential consequences of such interactions include the exacerbation of the disease, changing of the disease courses and the release of new viruses, etc. An understanding of the underlying mechanism is important, but, thus far, few insights have been gained. The present monograph, arranged in eight chapters, is intended to provide an updated and concise review of recent works regarding the molecular and cellular mechanisms of such interactions. The topics covered range from transcriptional regulation, receptor modulation, genetic recombination, to AIDS and oncogenesis. Human immunodeficiency virus, avian leukosis virus, reticuloendotheliosis virus, herpes simplex virus, cytomegalovirus, herpesvirus-6 and Marek's disease virus are among the viruses discussed. The contributing authors are among the leaders in this field and are responsible for many of the original discoveries presented. This should serve as a valuable research and teaching reference for both beginning and advanced researchers in virology and oncology.

Retroviral Vectors for Gene Therapy

Retroviral Vectors for Gene Therapy Book
Author : Massimo Pizzato
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Retroviral Vectors for Gene Therapy book written by Massimo Pizzato, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cell virus Interactions During Retroviral Infection

Cell virus Interactions During Retroviral Infection Book
Author : Tai Yun Roe
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cell virus Interactions During Retroviral Infection book written by Tai Yun Roe, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Interactions of Retroviral Transforming Gene Products with the Host Cell

Interactions of Retroviral Transforming Gene Products with the Host Cell Book
Author : Jeffrey Edmund De Clue
Publisher : Unknown
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Interactions of Retroviral Transforming Gene Products with the Host Cell book written by Jeffrey Edmund De Clue, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Virus host Interactions of Human Retroviruses

Virus host Interactions of Human Retroviruses Book
Author : Betty Poon
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Virus host Interactions of Human Retroviruses book written by Betty Poon, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

H 2Kb Gene Retrovirus Interactions in the Regulation of BL6 Melanoma Cell Sensitivity to Tumor Necrosis Factor alpha

H 2Kb Gene Retrovirus Interactions in the Regulation of BL6 Melanoma Cell Sensitivity to Tumor Necrosis Factor  alpha  Book
Author : Misoon Kim
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download H 2Kb Gene Retrovirus Interactions in the Regulation of BL6 Melanoma Cell Sensitivity to Tumor Necrosis Factor alpha book written by Misoon Kim, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

AIDS Research and Human Retroviruses

AIDS Research and Human Retroviruses Book
Author : Anonim
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Viral Envelope Proteins and the HIV 1 Accessory Gene Vpu Mediate Selectivity of Viral and Host Proteins in Retroviral Assembly

Viral Envelope Proteins and the HIV 1 Accessory Gene Vpu Mediate Selectivity of Viral and Host Proteins in Retroviral Assembly Book
Author : Tiffany M. Lucas
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Retroviruses are enveloped RNA viruses that assemble primarily at the plasma membrane of the host cell. During budding from the membrane, they acquire their own glycoproteins as well as a lipid bilayer derived from the cell. The assembly process is complex and involves protein:protein, protein:RNA, and, likely, protein:lipid interactions between viral components and the cell. These interactions appear to be specific and retroviruses are selective in acquisition of proteins. Compatibility during retrovirus assembly appears to be mediated by multiple factors: physical compatibility between glycoproteins and viral structural proteins, trafficking of proteins to appropriate locations, lipid interactions between Gag, Env and the plasma membrane, and microdomain association. In addition to mediating coalescence of appropriate factors, retroviruses appear equally equipped at excluding select host cell proteins and have evolved a number of genes to do so. Surprisingly, retrovirus assembly has remained enigmatic and there are no anti-retroviral drugs that target the assembly stage of HIV replication. Much of the knowledge we have garnered on retrovirus assembly has been through a process known as pseudotyping, where the core structural proteins will accept the glycoproteins of an unrelated virus. Here we present work outlining contributions of the envelope protein from murine leukemia virus to assembly with the lentiviral vector human immunodeficiency virus-1 (HIV-1). We subsequently observed an interesting phenotype, where an HIV-1 accessory gene known as Vpu restricts the envelope protein from gibbon ape leukemia virus (GaLV Env) from assembling with HIV-1. Further studies from our lab demonstrated that Vpu recognizes GaLV Env in a manner almost identical to CD4, the natural cellular target of Vpu, and that GaLV Env is essentially a CD4 analogue. Interestingly, we have found that Vpu restricts both target proteins in a manner that does not fit with the previously described Vpu-restriction model for CD4. Collectively, the GaLV Env model offers a new tool for more carefully investigating how the HIV-1 accessory gene Vpu downmodulates the host cell receptor CD4.

Viruses Genes and Cancer

Viruses  Genes  and Cancer Book
Author : Eric Hunter,Klaus Bister
Publisher : Springer
Release : 2017-08-25
ISBN : 3319618040
Language : En, Es, Fr & De

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Book Description :

This volume focuses on virus-host cell interactions, cellular genes acquired or modulated by viruses, the pathological effects of these interactions, and therapeutic interventions. Several chapters specifically address the role of viruses and genes – such as oncogenes, proto-oncogenes, or tumor suppressor genes – in the etiology of human cancer. Oncogenic signaling by PI3 kinase, mTOR, Akt, or the major cancer drivers MYC and RAF, and the role of tumor suppressors like p53, are discussed in detail. The volume also explores the emerging role of noncoding RNAs such as microRNAs in tumorigenesis and cancer therapeutics, and offers new insights into the role of HIV-host interactions relevant to pathogenesis and treatment. Gathering contributions written by leading scientists in their respective fields, the volume offers a valuable resource for researchers and clinicians alike.

Analysis of T Cell Receptor antigen Interaction Using Retrovirus mediated Gene Transfer microform

Analysis of T Cell Receptor antigen Interaction Using Retrovirus mediated Gene Transfer  microform  Book
Author : Joonsoo Kang
Publisher : National Library of Canada = Bibliothèque nationale du Canada
Release : 1994
ISBN : 9780315926233
Language : En, Es, Fr & De

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Book Description :

Download Analysis of T Cell Receptor antigen Interaction Using Retrovirus mediated Gene Transfer microform book written by Joonsoo Kang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cell specific Targeting of Retroviral Vectors Via Ligand receptor Interaction

Cell specific Targeting of Retroviral Vectors Via Ligand receptor Interaction Book
Author : Noriyuki Kasahara
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cell specific Targeting of Retroviral Vectors Via Ligand receptor Interaction book written by Noriyuki Kasahara, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Functional Control of HIV 1 Post transcriptional Gene Expression by Host Cell Factors

Functional Control of HIV 1 Post transcriptional Gene Expression by Host Cell Factors Book
Author : Amit Sharma
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract: Retroviruses are etiological agents of several human and animal immunosuppressive disorders. They are associated with certain types of cancer and are useful tools for gene transfer applications. All retroviruses encode a single primary transcript that encodes a complex proteome. The RNA genome is reverse transcribed into DNA, integrated into the host genome, and uses host cell factors to transcribe, process and traffic transcripts that encode viral proteins and act as virion precursor RNA, which is packaged into the progeny virions. The functionality of retroviral RNA is governed by ribonucleoprotein (RNP) complexes formed by host RNA helicases and other RNA-binding proteins. The 5' leader of retroviral RNA undergoes alternative inter- and intra-molecular RNA-RNA and RNA-protein interactions to complete multiple steps of the viral life cycle. Retroviruses do not encode any RNA helicases and are dependent on host enzymes and RNA chaperones. Several members of the host RNA helicase superfamily are necessary for progressive steps during the retroviral replication. RNA helicase A (RHA) interacts with the redundant structural elements in the 5' untranslated region (UTR) of retroviral and selected cellular mRNAs and this interaction is necessary to facilitate polyribosome formation and productive protein synthesis. The research presented in this dissertation has: (1) outlined the approaches to define the function of host RNA helicases in viral replication, (2) determined that the ATPase-dependent helicase function of RHA is necessary for HIV-1 translation, (3) determined that the RHA chaperone function promotes efficient morphogenesis of infectious HIV-1, and (4) identified a novel viral strategy to sustain HIV-1 proteins synthesis during downregulation of eIF4E-dependent translation initiation by HIV-1. In summary, the functionality of HIV-1 RNA is governed in part by RNP complexes formed by host RNA-binding proteins. Interaction with these host factors facilitate RNA:RNA and RNA:protein interactions thereby making the HIV-1 RNPs dynamic in nature. Dynamic changes in the RNP complexes are necessary for efficient viral protein synthesis, trafficking and morphogenesis of progeny virions that productively infect host lymphocytes to complete the viral life cycle.

AIDS Acquired Immune Deficiency Syndrome and Other Manifestations of HIV Infection

AIDS  Acquired Immune Deficiency Syndrome  and Other Manifestations of HIV Infection Book
Author : Gary P. Wormser,Rosalyn E. Stahl,Edward J. Bottone
Publisher : Noyes Data Corporation/Noyes Publications
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download AIDS Acquired Immune Deficiency Syndrome and Other Manifestations of HIV Infection book written by Gary P. Wormser,Rosalyn E. Stahl,Edward J. Bottone, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Retroviridae

The Retroviridae Book
Author : Jay A. Levy
Publisher : Unknown
Release : 1992
ISBN : 9781489916297
Language : En, Es, Fr & De

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Book Description :

Providing both historical background and recent advances, this series reviews in-depth the biologic, molecular, immunologic, and patholic features of this facinating virus family. The current volume focuses on the avian and murine species which have generated novel insights into cancer, and the evolution of the retroviridae.