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Reproductive And Developmental Toxicology

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Reproductive and Developmental Toxicology

Reproductive and Developmental Toxicology Book
Author : Ramesh C. Gupta
Publisher : Academic Press
Release : 2022-01-15
ISBN : 9780323897730
Language : En, Es, Fr & De

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Book Description :

Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource providing the latest literature on this complex subject, focusing on the core three components - parent, placenta, and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife. Completely revised and updated to include the most recent developments in the field, Reproductive and Developmental Toxicology, Third Edition is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists, and teratologists from academia, industry, and regulatory agencies. Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis Includes new chapters covering developments in: systems toxicology and predictive modeling of male developmental toxicity, adverse outcome pathways in reproductive and developmental toxicology, ovarian and endometrial toxicity, developmental neurotoxicity of air pollution, toxicology of reproductive processes and the problems of infertility, nutraceuticals, pharmaceuticals, micro and nanoplastics, hemp/cannabis and UV screening chemicals

Reproductive and Developmental Toxicity of Metals

Reproductive and Developmental Toxicity of Metals Book
Author : Tom Clarkson
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461593468
Language : En, Es, Fr & De

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Book Description :

The Permanent Commission and International Association on Occupational Health (PCIAOH) established in 1969 a Subcommittee on the Toxicology of Metals under the chairmanship of Lars Friberg. This committee, which later was named the Scientific Committee on the Toxicology of Metals, has organized a number of previous meetings that have led to publications in three major areas of metal toxicology: a preliminary meeting in Slanchev Bryag, Bulgaria in- 1971, followed by a meeting in 1972 in Buenos Aires, Argentina which produced two reports (Dukes and Friberg, 1971; Task Group on Metal Accumulation, 1973), that discussed the metabolism of metals with special reference to absorption, excretion and biological half-times. The effects and dose-response relationships of toxic metals, including a discussion of general principles, was the second major topic addressed by the Scientific Committee at a meeting in Tokyo in 1974 (Nordberg, 1976). The philosophy of this conference, as well as the previous one in Buenos Aires, was based on the concept of a "threshold dose" for the occurrence of adverse effects. In a conference held in Atlanta, USA in 1980, the scope of discussion on metal effects was broadened to include the role of metals in carcinogenesis. Thus, for the first time, the Scientific Committee took under consideration the possibility of non-threshold relationships (Belman and Nordberg, 1981). In addition, the Scientific Committee on the Toxicology of Metals organized a workshop on metal interactions in Stockholm 1977 (Nordberg et al.

Reproductive and Developmental Toxicology

Reproductive and Developmental Toxicology Book
Author : Kenneth S . Korach
Publisher : CRC Press
Release : 1998-03-27
ISBN : 1420002899
Language : En, Es, Fr & De

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Book Description :

This timely resource offers extensive discussions on the pharmacological, environmental,endocrinological, and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction. Describing biological actions common to both genders as well as gender-specific processes, Reproductive and Developmental Toxicology provides an overview of the basic biology and physiology of organ systems affected by toxicants furnishes detailed examples of developmental toxicology analyzes germ cell toxicity and infertility covers the developmental effects of neurotoxicity considers periods of exposure and long-term toxicological consequences explains how gonadal processes may be susceptible to toxicants in other reproductive organ systems and more! With over 3700 bibliographic citations and more than 100 photographs, drawings, and tables, Reproductive and Developmental Toxicology is a useful reference for toxicologists; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; obstetricians/gynecologists; pediatricians; pharmacists and pharmacologists; physiologists; geneticists; poison control specialists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity

Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity Book
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Toxicology,Subcommittee on Reproductive and Developmental Toxicity
Publisher : National Academies Press
Release : 2001-04-13
ISBN : 0309073162
Language : En, Es, Fr & De

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Book Description :

The United States Navy has been concerned for some time with protecting its military and civilian personnel from reproductive and developmental hazards in the workplace. As part of its efforts to reduce or eliminate exposure of Naval personnel and their families to reproductive and developmental toxicants, the Navy requested that the National Research Council (NRC) recommend an approach that can be used to evaluate chemicals and physical agents for their potential to cause reproductive and developmental toxicity. The NRC assigned this project to the Committee on Toxicology, which convened the Subcommittee on Reproductive and Developmental Toxicology, to prepare this report. In this report, the subcommittee recommends an approach for evaluating agents for potential reproductive and developmental toxicity and demonstrates how that approach can be used by the Navy. This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the NRC's Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: James Chen (National Center for Toxicological Research), George Daston (Procter and Gamble Company), Jerry Heindel (National Institute of Environmental Health Sciences), Grace Lemasters (University of Cincinnati), and John Young (National Center for Toxicological Research).

Developmental and Reproductive Toxicology

Developmental and Reproductive Toxicology Book
Author : Ronald D Hood
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1841848212
Language : En, Es, Fr & De

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Book Description :

Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers evaluating and interpreting data. Originally titled Handbook of Developmental Toxicology, the second edition's new name reflects significant changes in its content and scope. New coverage in the Second Edition: Genomics and proteomics Tests for endocrine disruptors Testing for male and female reproductive toxicity Extensive treatment of the significance, reliability, and interpretation of developmental and reproductive toxicity data Toxicity testing in neonatal and juvenile animals Postnatal developmental milestones FDA perspective on risk assessment Extensive glossaries of developmental defect terminology Previous books on this subject have largely been academically oriented and not intended to guide the practicing developmental or reproductive toxicologist. Useful and informative, this book blends the theoretical foundation with insights gained from hands-on experience. It includes tables of comparative developmental milestones - both pre- and postnatal, glossaries of descriptive terms used in developmental toxicity evaluation, and both US and international regulatory guidelines. Bridging the gap between theory and application, this is a handy single-source of essential information to use in planning, conducting, and interpreting studies.

Developmental and Reproductive Toxicology

Developmental and Reproductive Toxicology Book
Author : Ali S. Faqi
Publisher : Humana Press
Release : 2017-08-18
ISBN : 9781493972067
Language : En, Es, Fr & De

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Book Description :

This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab. Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resource for researchers working in this vital field of study./div

Computational Methods for Reproductive and Developmental Toxicology

Computational Methods for Reproductive and Developmental Toxicology Book
Author : Donald R. Mattison
Publisher : CRC Press
Release : 2015-12-02
ISBN : 1439861080
Language : En, Es, Fr & De

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Book Description :

Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology. The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development. The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods. The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.

Handbook of Developmental Toxicology

Handbook of Developmental Toxicology Book
Author : Ronald D. Hood
Publisher : CRC Press
Release : 1996-10-23
ISBN : 9780849301353
Language : En, Es, Fr & De

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Book Description :

Developmental toxicology, an increasingly important area, encompasses the study of toxicant effects on development, from conception through puberty. The Handbook of Developmental Toxicology provides useful insights gained from hands-on experience, as well as a theoretical foundation. In this convenient reference you will find information not previously gathered in one source-including comparative developmental milestones, historical data, and a glossary of terms used in developmental toxicity evaluation. This handbook is a practical guide for individuals who are responsible for testing chemical agents and for regulatory scientists who must evaluate studies, interpret data, and perform risk assessments. Packed with features, the Handbook of Developmental Toxicology is ideal for training students and technicians in developmental toxicology.

A Clinical Guide to Reproductive and Developmental Toxicology

A Clinical Guide to Reproductive and Developmental Toxicology Book
Author : AR. Scialli
Publisher : Unknown
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download A Clinical Guide to Reproductive and Developmental Toxicology book written by AR. Scialli, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Reproductive Toxicology

Reproductive Toxicology Book
Author : Jesús del Mazo
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 1489900896
Language : En, Es, Fr & De

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Book Description :

Numerous reports demonstrate that the reproductive system could be affected by multiple potential toxicological agents. The volume includes different aspects of the development of new approaches to in vitro testing using sperm cells and systems involved on reproduction in mammals. Comparative analysis of in vivo and in vitro methods has been included to take steps towards the further development of and applications of new systems for germline toxicology.

Mechanisms of Reproductive and Developmental Toxicology

Mechanisms of Reproductive and Developmental Toxicology Book
Author : Jeanne M. Manson,Richard F. Walker
Publisher : Unknown
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Mechanisms of Reproductive and Developmental Toxicology book written by Jeanne M. Manson,Richard F. Walker, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A Clinical Guide to Reproductive and Developmental Toxicology

A Clinical Guide to Reproductive and Developmental Toxicology Book
Author : Anthony R. Scialli
Publisher : CRC Press
Release : 1991-11-22
ISBN : 9780849367373
Language : En, Es, Fr & De

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Book Description :

Reproduction, the most important process in nature, is the result of a superbly coordinated series of events. The modern era has seen the introduction of chemical and physical agents that can disrupt these events and impair normal reproduction. The public has become increasingly aware of the possibilities of adverse reproductive outcomes as a result of being exposed to medications; chemicals in the workplace and in the environment; and physical agents, such as X-rays, microwaves, and heat. Clinicians need to become familiar with toxicological issues so that they can properly answer the questions their patients may ask regarding reproductive risks. A Clinical Guide to Reproductive and Developmental Toxicology satisfies the clinician's need to understand toxicology and its effect on human reproduction by explaining the lingo of the bench researcher and teaching the clinician how to use basic research in practice. The book emphasizes how to use this information when there is a patient sitting in front of you. All aspects of reproduction are discussed and difficult issues are addressed. For example, is it possible to use animal studies when counseling humans? How likely are male exposures to cause abnormalities in the offspring? How can workplaces be evaluated for reproductive risks? These are only a few of the important questions addressed in this important book for physicians, nurses, counselors, industrial hygienists, and public policymakers.

Biomarkers in Reproductive and Developmental Toxicology

Biomarkers in Reproductive and Developmental Toxicology Book
Author : United States. Environmental Protection Agency,United States. Agency for Toxic Substances and Disease Registry,National Research Council (U.S.)
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomarkers in Reproductive and Developmental Toxicology book written by United States. Environmental Protection Agency,United States. Agency for Toxic Substances and Disease Registry,National Research Council (U.S.), available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Reproductive and Developmental Toxicology

Reproductive and Developmental Toxicology Book
Author : Anonim
Publisher : Unknown
Release : 2022-01-21
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Reproductive and Developmental Toxicology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity

Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity Book
Author : Subcommittee on Reproductive and Developmental Toxicity,Committee on Toxicology,Board on Environmental Studies and Toxicology,Commission on Life Sciences,Division on Earth and Life Studies,National Research Council
Publisher : National Academies Press
Release : 2001-03-27
ISBN : 9780309073165
Language : En, Es, Fr & De

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Book Description :

The United States Navy has been concerned for some time with protecting its military and civilian personnel from reproductive and developmental hazards in the workplace. As part of its efforts to reduce or eliminate exposure of Naval personnel and their families to reproductive and developmental toxicants, the Navy requested that the National Research Council (NRC) recommend an approach that can be used to evaluate chemicals and physical agents for their potential to cause reproductive and developmental toxicity. The NRC assigned this project to the Committee on Toxicology, which convened the Subcommittee on Reproductive and Developmental Toxicology, to prepare this report. In this report, the subcommittee recommends an approach for evaluating agents for potential reproductive and developmental toxicity and demonstrates how that approach can be used by the Navy. This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the NRC's Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: James Chen (National Center for Toxicological Research), George Daston (Procter and Gamble Company), Jerry Heindel (National Institute of Environmental Health Sciences), Grace Lemasters (University of Cincinnati), and John Young (National Center for Toxicological Research).

Current Issues in Reproductive and Developmental Toxicology

Current Issues in Reproductive and Developmental Toxicology Book
Author : Cindy E. Lumley,Stuart R. Walker
Publisher : Unknown
Release : 1991-01-01
ISBN : 9781856420730
Language : En, Es, Fr & De

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Book Description :

Download Current Issues in Reproductive and Developmental Toxicology book written by Cindy E. Lumley,Stuart R. Walker, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Reproductive and Developmental Toxicity of Metals

Reproductive and Developmental Toxicity of Metals Book
Author : Thomas W. Clarkson,Gunnar F. Nordberg,Polly R. Sager
Publisher : Unknown
Release : 1983-12
ISBN : 9781461593478
Language : En, Es, Fr & De

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Book Description :

Download Reproductive and Developmental Toxicity of Metals book written by Thomas W. Clarkson,Gunnar F. Nordberg,Polly R. Sager, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Dynamic In Vitro Models for Reproductive and Developmental Toxicology

Dynamic In Vitro Models for Reproductive and Developmental Toxicology Book
Author : Susanna Holley Wegner
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

As in vitro models play an increasingly important role in evaluation of potential developmental and reproductive toxicants, it is essential that we define how well these models can capture developmental stages and processes that are vulnerable to toxicant perturbation. In this research we evaluate two dynamic in vitro models: a primary co-culture of neonatal rat testis and a human progenitor cell model of neuronal differentiation. Longterm viability, morphological characteristics, and expression of cell type- and stage-specific proteins in in vitro cultures were characterized by live/dead cell staining, immunofluorescent imaging, and western blotting. We then defined a framework for quantifying dynamic changes in pathways through time in normal development in vivo. Gene expression and pathway dynamics distilled from microarray data were used to anchor the in vitro models to in vivo developmental processes. Striking similarities were found between in vivo and in vitro models in gene expression for key pathways associated with each developmental process. Basic characterization revealed that testicular co-cultures survive up to 21 days in culture and contain spermatogonial germ cells, Sertoli cells and Leydig cells, form tube-like structures in vitro and actively produce testosterone through the first week in culture. Pathway analysis of gene expression data through time reveals that the testicular co-culture captures key developmental processes that can be targeted by male reproductive toxicants, including Sertoli cell and Leydig cell differentiation, testosterone production, immune activity, signal transduction, tube formation, and tight junction formation. Basic characterization of differentiating neural progenitor cells indicates that the cells survive and differentiate through 21 days in culture, increasingly expressing protein associated with differentiated neurons, adopting neuronal morphology and forming complex neural networks. Pathway analysis reveals that differentiating neural progenitor cells successfully capture differentiation towards a forebrain identity, expressing receptors associated with specific neuronal subtypes. In addition to identifying processes that are clearly captured in vitro, we also define the limits of these models by identifying gene expression dynamics found only in vitro or only in vivo. By further defining the domain of applicability for each of these in vitro models, we can help to ensure that these models are used effectively and appropriately for identification of potential chemical hazards.

Reproductive and Developmental Toxicity

Reproductive and Developmental Toxicity Book
Author : WAN EZUMI,SITI AMRAH,SYED MOHSIN
Publisher : LAP Lambert Academic Publishing
Release : 2011-04
ISBN : 9783844311433
Language : En, Es, Fr & De

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Book Description :

Labisia pumila var. alata (LPA) or Kacip Fatimah has been listed by the government of Malaysia as one of the priority species for a multi-disciplinary scientific investigation towards the development of scientific, evidence-based herbal medicine. The present work described in this book is part of the preclinical assessment of LPA to evaluate its safety profile using animal model. The potential immediate and latent effects of aqueous extract of LPA on reproductive system and development of progenies were thoroughly evaluated in female Sprague Dawley rats. Toxicological assessment with wide range of observations and parameters were performed at various stages of reproductive period including pregnancy and non-pregnancy states of rats.The collection of data compiled in this book is meant to provide some basis for the development of the safety profile of LPA and thereby help to alleviate concerns over its possible toxicity.