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Regenerative Medicine For Peripheral Artery Disease

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Regenerative Medicine for Peripheral Artery Disease

Regenerative Medicine for Peripheral Artery Disease Book
Author : Emile R Mohler,Brian Annex
Publisher : Academic Press
Release : 2016-06-15
ISBN : 0128014873
Language : En, Es, Fr & De

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Book Description :

Regenerative Medicine for Peripheral Artery Disease is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of peripheral arterial disease. This reference includes a general overview of regenerative medicine and covers important vascular topics, including intermittent claudication and critical limb ischemia, with important mechanisms clearly presented in full color images throughout the book. This important reference includes clear and concise information on both human clinical trials, as well as important and pertinent animal studies, and is a must-have reference for researchers and practitioners of peripheral artery disease. Compiles and explains the rationale and history of different regenerative treatment concepts for peripheral artery disease in one reference Presents pertinent animal studies and human clinical trials in the area of regenerative medicine for peripheral arterial disease, addressing both safety and efficacy of the clinical trials Provides full-color images that demonstrate covered mechanisms Includes access to a full-color website for further study

Employing PFUS for Treatment of Peripheral Arterial Disease Via Homing of Infused Bone Marrow Stromal Cells

Employing PFUS for Treatment of Peripheral Arterial Disease Via Homing of Infused Bone Marrow Stromal Cells Book
Author : Pamela A. Tebebi
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Peripheral artery disease (PAD) manifests from vascular blockage or trauma to a region causing restricted flow of oxygen-rich blood to tissues and organs. Treatment options for PAD include lifestyle modification, pharmacotherapy, and revascularization, but they often fail. Clinical data shows that administration of bone marrow stromal cells (BMSC) can provide therapeutic benefits to promote regeneration of damaged tissue, treat inflammation, and induce angiogenesis. However “3% of IV-infused cells arrive at the target site. Pulsed focused ultrasound (pFUS) has been used as a noninvasive and nondestructive modality to enhance tissue permeability and retention in drug delivery through physical alterations in tissue. The goal of the proposed research is to employ pFUS exposures to elicit local molecular responses for enhancing homing and retention of BMSC in PAD tissues to improve vascularization and reestablish perfusion blood flow. Hamstrings of healthy mice were treated with pFUS and harvested at various time points to characterize the biological response of tissue. The results demonstrated significant elevations in chemoattractants (homing factor) as early as 10min and subsided by 60hrs post-pFUS. From this data, an optimal time window for maximal BMSC homing to pFUS treated site was suggested. Maximum homing of IV-infused BMSC occurred pre-pFUS and up to 16 post-pFUS demonstrating enhance homing of cells by pFUS. After creation and validation of the PAD model using laser Doppler perfusion imaging, the ischemic limb was treated and harvested at various days after ischemic induction to demonstrate the feasibility of generating a transient inflammatory response outside innate inflammatory response of the disease. Fourteen days after the induction of PAD, the innate inflammatory response had subsided and pFUS was used to stimulate an inflammatory response and enhance cell homing to pFUS treated site. When therapeutic efficacy was tested for 7 weeks in aged (e"12 months) mice with PAD and treatment, (BMSC+pFUS), given 14days after ischemic induction, perfusion blood flow was significantly enhanced in the treatment group versus control. The results demonstrated the therapeutic benefits of combining pFUS and cells that can be translated in other vascular disease models. The implications of this research have the potential to enhance regenerative medicine.

Stem Cells and Regenerative Medicine

Stem Cells and Regenerative Medicine Book
Author : D. George,J. Magdalou,J.-F. Stoltz
Publisher : IOS Press
Release : 2021-06
ISBN : 1643680277
Language : En, Es, Fr & De

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Book Description :

Most human tissues do not regenerate spontaneously, but the development of biotherapies using stem cells may offer promising alternatives. Among the possible medium-term therapeutic applications for this technique are: cardiac insufficiency, preparation of small diameter arteries, treatment of atherosclerosis, bone repair, cartilage defects, burns, diabetes, liver or bladder regeneration, and neurodegenerative disorders. This concept of regenerative medicine is an emerging multidisciplinary field involving surgery medicine, biology, chemistry, mechanics and engineering, and can be seen as a way of improving health and quality of life by restoring, maintaining, or enhancing tissue and organ function. This book presents the proceedings of the 9th China-France Symposium on Stem Cells and Regenerative Medicine, held in Strasbourg, France, from 2-4 October 2019.The aim of the symposium was to provide researchers, clinicians and students with a comprehensive, up-to-date overview of stem cells and potential medical applications in cellular and tissue engineering for the treatment of various chronic diseases. It also brought together scientists from various disciplines and experiences to discuss recent advances in the use and applications of stem cells. The contributions presented here divide into three main themes: cells; tissue engineering; and clinical applications. Important complementary aspects such as ethics and cell marketing are also discussed. Illustrating the challenges and recent progress achieved in the characterization of stem cells, the book will be of interest to all those working in the field.

Principles of Regenerative Medicine

Principles of Regenerative Medicine Book
Author : Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem
Publisher : Academic Press
Release : 2010-12-16
ISBN : 9780123814234
Language : En, Es, Fr & De

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Book Description :

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

A Manual for Current Therapies in Regenerative Medicine

A Manual for Current Therapies in Regenerative Medicine Book
Author : Jan-Thorsten Schantz,Dietmar W Hutmacher
Publisher : World Scientific Publishing Company
Release : 2013-04-30
ISBN : 9814520632
Language : En, Es, Fr & De

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Book Description :

The emerging field of regenerative medicine has led to a paradigm shift in therapeutic procedures. Scientific discovery in stem cell biology and material sciences, as well as in genetics have resulted in clinical concepts that focus on regeneration rather than repair. Also, translational research provided mankind with therapeutic tools to grow complex tissues and organs for transplantation into patients. These new technologies not only benefited patients but they also have significant socioeconomic potential. This manual aims to provide an overview on a variety of clinically applied strategies in the current field of regenerative medicine, and it also contains concise key data for a rapidly growing industry. As such, both patients and doctors will find the information contained within this manual to be useful and relevant. The editors are both international leaders in the field of regenerative medicine, and both possess a broad spectrum of experience from basic research to clinical application and commercialization.

Encyclopedia of Tissue Engineering and Regenerative Medicine

Encyclopedia of Tissue Engineering and Regenerative Medicine Book
Author : Anonim
Publisher : Academic Press
Release : 2019-06-03
ISBN : 0128137002
Language : En, Es, Fr & De

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Book Description :

Encyclopedia of Tissue Engineering and Regenerative Medicine provides a comprehensive collection of personal overviews on the latest developments and likely future directions in the field. By providing concise expositions on a broad range of topics, this encyclopedia is an excellent resource. Tissue engineering and regenerative medicine are relatively new fields still in their early stages of development, yet they already show great promise. This encyclopedia brings together foundational content and hot topics in both disciplines into a comprehensive resource, allowing deeper interdisciplinary research and conclusions to be drawn from two increasingly connected areas of biomedicine. Provides a ‘one-stop’ resource for access to information written by world-leading scholars in the fields of tissue engineering and regenerative medicine Contains multimedia features, including hyperlinked references and further readings, cross-references and diagrams/images Represents the most comprehensive and exhaustive product on the market on the topic

Cells and Materials for Disease Modeling and Regenerative Medicine

Cells and Materials for Disease Modeling and Regenerative Medicine Book
Author : Ander Abarrategi,Senentxu Lanceros-Mendez
Publisher : MDPI
Release : 2021-05-05
ISBN : 3036502629
Language : En, Es, Fr & De

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Book Description :

Materials science and engineering are strongly developing tools with increasing impact in the biotechnological and biomedical areas. Interestingly, research in molecular and cellular biology is often at the core of the design and development of materials-based approaches, providing biological rationale. Focused on research relying on biology–materials interaction, IJMS launched a Special Issue named “Cells and Materials for Disease Modeling and Regenerative Medicine”. The aim of the Special Issue was to generate a compilation of in vitro and in vivo strategies based on cell–material interactions. This book compiles the papers published in that Special Issue and includes a selection of six original scientific experimental articles and six comprehensive reviews. We are convinced that this collection of articles shows representative examples of the state of the art in the field, unveiling the relevance of materials research in generating new regenerative medicine and disease modeling approaches.

The Foot in Diabetes

The Foot in Diabetes Book
Author : Andrew J. M. Boulton,Gerry Rayman,Dane K. Wukich
Publisher : John Wiley & Sons
Release : 2020-04-09
ISBN : 1119445884
Language : En, Es, Fr & De

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Book Description :

Fully revised and updated edition of this popular book, addressing all issues concerning the diabetic foot, one of the most prevalent problems in diabetes, with a strong emphasis on practical aspects of delivering care.

Principles of Regenerative Medicine

Principles of Regenerative Medicine Book
Author : Anthony Atala,Robert Lanza,Tony Mikos,Robert Nerem
Publisher : Academic Press
Release : 2018-08-09
ISBN : 0128098937
Language : En, Es, Fr & De

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Book Description :

Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies. Comprehensively covers the interdisciplinary field of regenerative medicine with contributions from leaders in tissue engineering, cell and developmental biology, biomaterials sciences, nanotechnology, physics, chemistry, bioengineering and surgery Includes new chapters devoted to iPS cells and other alternative sources for generating stem cells as written by the scientists who made the breakthroughs Edited by a world-renowned team to present a complete story of the development and promise of regenerative medicine

Frontiers in Stem Cell and Regenerative Medicine Research

Frontiers in Stem Cell and Regenerative Medicine Research Book
Author : Atta-ur Rahman,Shazia Anjum
Publisher : Bentham Science Publishers
Release : 2017-05-11
ISBN : 1681084759
Language : En, Es, Fr & De

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Book Description :

Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in the 21st century to combat diseases such as cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. Frontiers in Stem Cell and Regenerative Medicine Research is essential reading for researchers seeking updates in stem cell therapeutics and regenerative medicine. The fifth volume of this series features reviews on vascular regeneration, neuronal tissue grafting in animal CNS disease models, template mediated biomineralization in bones, corneal endothelium differentiation and stem cell uses for managing hepatocellular carcinoma.

Cardiac Regeneration

Cardiac Regeneration Book
Author : Masaki Ieda,Wolfram-Hubertus Zimmermann
Publisher : Springer
Release : 2017-10-27
ISBN : 3319561065
Language : En, Es, Fr & De

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Book Description :

This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Vascularization for Regenerative Medicine

Vascularization for Regenerative Medicine Book
Author : Andrea Banfi,Wolfgang Holnthoner,Mikaël M. Martino,Seppo Ylä-Herttuala
Publisher : Frontiers Media SA
Release : 2019-02-08
ISBN : 288945746X
Language : En, Es, Fr & De

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Book Description :

Download Vascularization for Regenerative Medicine book written by Andrea Banfi,Wolfgang Holnthoner,Mikaël M. Martino,Seppo Ylä-Herttuala, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Regenerative Medicine and Plastic Surgery

Regenerative Medicine and Plastic Surgery Book
Author : Dominik Duscher,Melvin A. Shiffman
Publisher : Springer Nature
Release : 2019-11-26
ISBN : 3030199584
Language : En, Es, Fr & De

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Book Description :

This book discusses the current research concepts and the emerging technologies in the field of stem cells and tissue engineering. It is the first authoritative reference documenting all the ways that plastic surgical practice and regenerative medicine science overlap or provide a road map for the future of both specialties. The Editors have provided a valuable service by gathering in one place the leading voices in these two fields in clear and concise manner. Divided into five parts, the book opens with a description of the elements of regenerative medicine including definitions, basic principles of soft and bone tissue regeneration, biomaterials and scaffolds. Current research concepts are explored in the second part of this book, for example mechanotransduction and the utility of extracellular vesicles. In the third part, the editors present the emerging technologies and highlight the novel perspectives on bionic reconstruction and biomimetics in surgery and regenerative medicine. Part four deals with translational aspects including practical information on moving scientific findings from bench to bedside. The final part then describes in detail applications in clinical plastic surgery. Written by leading experts this book is an invaluable resource for researchers, students, beginners and experienced clinicians in a range of specialties. "In your hands is a comprehensive encyclopedia of two rapidly converging fields. Drs Duscher and Shiffman have done an outstanding job of highlighting the interdependent relationship between plastic surgery and regenerative medicine. Ultimately, this is to the benefit of both fields." - Geoffrey C. Gurtner, MD, FACS Johnson and Johnson Distinguished Professor of Surgery Professor (by courtesy) of Bioengineering and Materials Science Inaugural Vice Chairman of Surgery for Innovation Stanford University School of Medicine

The SAGE Encyclopedia of Stem Cell Research

The SAGE Encyclopedia of Stem Cell Research Book
Author : Eric E. Bouhassira
Publisher : SAGE Publications
Release : 2015-06-15
ISBN : 150630124X
Language : En, Es, Fr & De

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Book Description :

The SAGE Encyclopedia of Stem Cell Research, Second Edition is filled with new procedures and exciting medical breakthroughs, including executive orders from the Obama administration reversing barriers to research imposed under the Bush administration, court rulings impacting NIH funding of research based on human embryonic stem cells, edicts by the Papacy and other religious leaders, and the first success in cloning human stem cells. Stem cell biology is clearly fueling excitement and potential in traditional areas of developmental biology and in the field of regenerative medicine, where they are believed to hold much promise in addressing any number of intractable medical conditions. This updated second edition encyclopedia will expand on information that was given in the first edition and present more than 270 new and updated articles that explore major topics in ways accessible to nonscientists, thus bringing readers up-to-date with where stem cell biology stands today, including new and evolving ethical, religious, legal, social, and political perspectives. This second edition reference work will serve as a universal resource for all public and academic libraries. It is an excellent foundation for anyone who is interested in the subject area of stem cell biology. Key Features: Reader’s Guide, Further Readings, Cross References, Chronology, Resource Guide, Index A Glossary will elucidate stem cell terminology for the nonscientist Statistics and selected reprints of major journal articles that pertain to milestones achieved in stem cell research Documents from Congressional Hearings on stem cells and cloning Reports to the President’s Council on Bioethics, and more

Applied Genomics and Public Health

Applied Genomics and Public Health Book
Author : George P. Patrinos
Publisher : Academic Press
Release : 2019-11-13
ISBN : 0128136960
Language : En, Es, Fr & De

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Book Description :

Applied Genomics and Public Health examines the interdisciplinary and growing area of how evidence-based genomic knowledge can be applied to public health, population health, healthcare and health policies. The book gathers experts from a variety of disciplines, including life sciences, social sciences, and health care to develop a comprehensive overview of the field. In addition, the book delves into subjects such as pharmacogenomics, genethics, big data, data translation and analysis, economic evaluation, genomic awareness and education, sociology, pricing and reimbursement, policy measures and economic evaluation in genomic medicine. This book is essential reading for researchers and students exploring applications of genomics to population and public health. In addition, it is ideal for those in the biomedical sciences, medical sociologists, healthcare professionals, nurses, regulatory bodies and health economists interested in learning more about this growing field. Explores the growing application of genomics to population and public health Features internationally renowned contributors from a variety of related fields Contains chapters on important topics such as genomic data sharing, genethics and public health genomics, genomics and sociology, and regulatory aspects of genomic medicine and pharmacogenomics

Biomaterial Stem Cell Approaches to Augment Regeneration

Biomaterial Stem Cell Approaches to Augment Regeneration Book
Author : Drew Kuraitis
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Diseases affecting striated muscle are prevalent and deadly in both the Western and developing worlds. Such diseases include peripheral arterial disease and coronary artery disease, characterized by reduced blood flow to extremities and heart muscle, respectively, all of which manifest as reduced function & quality-of-life. Although promising in animal models, many clinical trials of stem cell therapy have yielded modest results at best. Growing evidence suggests that in a disease state, improvements in local environments using natural methods that already exist in the body hold great promise for supporting recovery and regeneration. This may be accomplished by exploiting natural progenitor cell functions and interactions with endogenous extracellular matrix (ECM) components, pro-regenerative cytokines and ligands. This thesis uses ECM-mimicking, collagen-based matrices to improve the regenerative response. Specifically, such a matrix is demonstrated to improve the potency of ex vivo expanded circulating angiogenic cells for treatment of ischemic muscle (Chapter 2). Matrices were also functionalized to release chemoattractant molecules to improve the recruitment of progenitor cells (Chapter 3) and to present progenitor cell-binding ligands for improved cell retention in ischemic muscle (Chapter 4), with the ultimate goal of restoring perfusion. Matrices were also observed to improve muscle function and augment muscle regeneration in models of ischemic and dystrophic muscle (Chapters 4 & 5). The results of this thesis provide insights into the ability to modulate regeneration in vivo with treatment of biomaterials that have been designed to exploit and amplify progenitor cell responses. Specifically, this thesis contains some of the first reports for the use of ECM-based biomaterials to stimulate passive enrichment of circulating angiogenic cells, functional regeneration of muscle, and a potential method of benefitting from necrosis. These data provide an interesting pilot perspective on improvements or alternatives to cell therapy, and future studies will seek to better tune these prospective therapies so that one day they may be clinically available.

Engineering Strategies for Regenerative Medicine

Engineering Strategies for Regenerative Medicine Book
Author : Tiago G. Fernandes,Maria Margarida Diogo,Joaquim M. S. Cabral
Publisher : Academic Press
Release : 2019-11-14
ISBN : 0128166703
Language : En, Es, Fr & De

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Book Description :

Engineering Strategies for Regenerative Medicine considers how engineering strategies can be applied to accelerate advances in regenerative medicine. The book provides relevant and up-to-date content on key topics, including the interdisciplinary integration of different aspects of stem cell biology and technology, diverse technologies, and their applications. By providing massive amounts of data on each individual, recent scientific advances are rapidly accelerating medicine. Cellular, molecular and genetic parameters from biological samples combined with clinical information can now provide valuable data to scientists, clinicians and ultimately patients, leading to the development of precision medicine. Equally noteworthy are the contributions of stem cell biology, bioengineering and tissue engineering that unravel the mechanisms of disease, regeneration and development. Considers how engineering strategies can accelerate novel advances in regenerative medicine Takes an interdisciplinary approach, integrating different aspects of research, technology and application Provides up-to-date coverage on this rapidly developing area of medicine Presents insights from an experienced and cross-disciplinary group of researchers and practitioners with close links to industry

Regenerative Medicine

Regenerative Medicine Book
Author : Mahmood S Choudhery
Publisher : BoD – Books on Demand
Release : 2020-09-16
ISBN : 1838819274
Language : En, Es, Fr & De

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Book Description :

Regenerative medicine is a promising interdisciplinary field that applies basic principles of engineering and life sciences to repair, replace, or regenerate damaged or lost tissues and organs. Unlike conventional medicine, regenerative medicine uses human cells and other substances to regrow tissues or restore their functions. Regenerative medicine combines approaches such as the use of cell-based, cell-free soluble molecules, stem cells from different sources, gene therapy, tissue engineering, reprogramming of cells, and, more recently, cell-free regenerative therapies. Regenerative Medicine provides details of the recent advancements in regenerative therapies for regenerative medicine applications.

Nanotechnology in Cardiovascular Regenerative Medicine

Nanotechnology in Cardiovascular Regenerative Medicine Book
Author : Wuqiang Zhu,Wenguo Cui,Aijun Wang,Chao Zhao
Publisher : Frontiers Media SA
Release : 2020-12-24
ISBN : 2889662772
Language : En, Es, Fr & De

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Book Description :

Download Nanotechnology in Cardiovascular Regenerative Medicine book written by Wuqiang Zhu,Wenguo Cui,Aijun Wang,Chao Zhao, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Regenerative Medicine Using Pregnancy Specific Biological Substances

Regenerative Medicine Using Pregnancy Specific Biological Substances Book
Author : Niranjan Bhattacharya,Phillip Stubblefield
Publisher : Springer Science & Business Media
Release : 2010-12-25
ISBN : 1848827180
Language : En, Es, Fr & De

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Book Description :

The proposed book is a holistic review of the clinical use of placental substances, amniotic fluid, the umbilical cord and its contents. It is intended to be a unique presentation of the current advances as well as also discussing the future applications of these substances. Attention is yet to be focused on the widespread clinical use of pregnancy-related biological substances. The aim for this book is to inform clinicians of the use of such materials and increase awareness of their therapeutic benefits. As such, this reference resource will be of great value to hematologists, rheumatologists, cardiologists, transplant technologists and all involved in regenerative medicine.